Clinical trials: Myocardial Ischemia
Coronary Artery Disease
ABSORB II Randomized Controlled Trial
Prospective, randomized (2:1), active control, single blinded, parallel two-arm, multi-center clinical investigation using Abbott Vascular ABSORB Everolimus Eluting Bioresorbable Vascular Scaffold System (ABSORB BVS); compared to…
- Trial name
- ABSORB II (NCT01425281)
- Testing
- Abbott Vascular XIENCE Everolimus Eluting Coronary Stent System, Abbott Vascular ABSORB Everolimus Eluting Bioresorbable Vascular Scaffold System
- Where
- Belgium
- Volunteers
- 501 people
- Sponsor
- Abbott Medical Devices
Myocardial Ischemia
Computed TomogRaphic Evaluation of Atherosclerotic DEtermiNants of Myocardial IsChEmia
The study seeks to determine the accuracy of using anatomic and physiologic information measurable by computed tomography features of stenosis, plaque, fractional flow reserve-CT and to compare this measure to stress testing for…
- Trial name
- CREDENCE (NCT02173275)
- Where
- 18 sites in United States, Canada and 6 more
- Volunteers
- 618 people
- Sponsor
- Weill Medical College of Cornell University
Ischemic Heart Disease
One Versus Twice Daily Administration of Multiple Cardiovascular Agents in Patients With Ischemic Heart Disease
Patients with ischemic heart disease are often treated with multiple cardiovascular agents, including aspirin, statins, ezetimibe, Angiotensin Converting Enzyme (ACE) inhibitors or beta-blockers.
- Trial name
- ONCE (NCT04148820)
- Testing
- Aspirin, Atorvastatin, Perindopril
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Diabetes Mellitus, Hypertension
Impact of INsulin Sensitivity on Cardiovascular Risk Markers During 10-20 Years of FOllow up
The purpose of this study is to identify risk factors for insulin resistance and to investigate the influence of insulin sensitivity on development of cardiovascular risk markers like blood pressure, heart rate, body build…
- Conditions
- Diabetes Mellitus, Hypertension, Ischemic Heart Disease, Stroke
- Trial name
- INFO (NCT01412554)
- Where
- Norway
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
In-stent Restenosis, Ischemic Heart Disease
The PREVAIL Study
To evaluate the clinical safety and efficacy of a new Medtronic Coronary Drug-Coated Balloon Catheter in the treatment of de novo lesions, small vessel disease or In-Stent Restenosis with coronary lesions previously treated with…
- Conditions
- In-stent Restenosis, Ischemic Heart Disease, Coronary Artery Disease
- Trial name
- PREVAIL (NCT03260517)
- Testing
- Medtronic Coronary Drug-Coated Balloon Catheter
- Where
- 10 sites in Belgium, Italy and 1 more
- Volunteers
- 50 people
- Sponsor
- Medtronic Vascular
Coronary Artery Disease, Myocardial Ischemia
Comparison of Biomatrix and Orsiro Drug Eluting Stent
The primary objective of the BIODEGRADE study is to evaluate clinical efficacy of the Orsiro drug-eluting stent compared with Biomatrix drug-eluting stent, both of which have biodegradable polymer for the treatment of all-comers'…
- Trial name
- BIODEGRADE (NCT02299011)
- Testing
- Orsiro drug eluting stent, Biomatrix drug eluting stent
- Where
- South Korea
- Volunteers
- 2,341 people
- Sponsor
- Seoul National University Bundang Hospital
Ischemic Heart Disease
Diagnostic Performance and Prognostic Ability of the QFR
1. The primary technical endpoint was the diagnostic performance of the QFR against the FFR. 2. The primary clinical endpoint was target vessel failure (TVF) between two groups distributed by a QFR cut-off value of 0.8
- Trial name
- NCT04102917
- Testing
- QFR assessment
- Where
- South Korea
- Volunteers
- 915 people
- Sponsor
- Seoul St. Mary's Hospital
Ischemic Heart Disease
Arrhythmia in on Pump vs. Off Pump Coronary Artery Bypass Grafting
The aim of this research is to know the incidence of arrhythmias in on vs. off pump CABG and to know their relations to the patient's morbidity and mortality, hospital stay and hospital costs.
- Trial name
- NCT04093817
- Testing
- cardio pulmonary bypass machine
- Volunteers
- 50 people
- Sponsor
- Assiut University
Acute Coronary Syndrome, Ischemic Heart Disease
Risc Optimisation- Acute cor5onary Syndrome
This study evaluates the percentage of patients that reach the objective levels of LDL cholesterol, glycosylated hemoglobin and blood pressure recommended by clinical guidelines after an acute coronary syndrome, following…
- Trial name
- RiskOp-ACS (NCT03619395)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Chronic Ischemic Heart Disease, Coronary Artery Disease
Cell Therapy in Severe Chronic Ischemic Heart Disease
Patients with advanced coronary artery disease usually undergo incomplete myocardial revascularization due to the extension and diffuseness of the disease, with very poor distal arterial beds unsuitable for direct…
- Conditions
- Chronic Ischemic Heart Disease, Coronary Artery Disease, Angina Pectoris
- Trial name
- MiHeart (NCT01727063)
- Testing
- Cell Therapy
- Where
- Brazil
- Volunteers
- 143 people
- Sponsor
- Ministry of Health, Brazil
Myocardial Ischemia
Absolute Quantification of Coronary Flow Reserve by Stress Perfusion MRI
Coronary artery disease (CAD, coronary heart disease) is the leading cause of death in the U.S., causing 1 in 5 deaths in 2005. The current method for diagnosing coronary artery disease that is considered most accurate is…
- Trial name
- NCT01655043
- Testing
- Regadenoson, gadofoveset trisodium
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Ischemic Heart Disease
Sequential Treatment of Extra-Corporeal Shock Wave Combined With aUtologous Bone marRow Mesenchymal Stem Cells on Patients With ischEmic Heart Disease : the S-CURE Study
This study is designed to evaluate the efficacy, safety and tolerability of autologous bone marrow derived mesenchymal stem cells compared to placebo (sham operation) when administered via percutaneous coronary infusion to…
- Trial name
- S-CURE (NCT03397095)
- Testing
- CSWT+BMMSCs
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai 10th People's Hospital
Coronary Artery Disease, Myocardial Ischemia
Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent
The purpose of the study is to demonstrate that Custodiol-HTK is not inferior to cold cardioplegic solution in patients undergoing cardiovascular surgery requiring cardioplegic arrest.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- NCT01681095
- Testing
- Custodiol HTK, Cold Blood Cardioplegia
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Marc Sakwa, MD
Cardiovascular Risk Factors, Stroke
The "Know Your Numbers" Program in Atahualpa
Persons voluntarily attending the Community Center of the Atahualpa Project during one calendar year will be evaluated by trained personnel to check their cardiovascular health status.
- Conditions
- Cardiovascular Risk Factors, Stroke, Ischemic Heart Disease
- Trial name
- NCT01831908
- Testing
- Lifestyle counseling
- Where
- Ecuador
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Hospital Clínica Kennedy
Coronary Artery Disease, Ischemic Heart Disease
Brief Behavioral Health Intervention Program for Patients With Stable Coronary Artery Disease
The purpose of this study is to examine the effectiveness of a lifestyle intervention for patients living with stable coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Coronary Heart Disease
- Trial name
- NCT03629158
- Testing
- CLIMB intervention
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Central Florida
Chest Pain, Coronary Artery Disease
Trial of Cardiac CT in Acute Chest Patients With Intermediate Level Initial High-sensitivity Cardiac Troponin
Patients who present to the emergency department (ED) with acute chest pain (ACP) possibly due to Coronary artery disease (CAD), with a normal heart tracing (ECG), need to have further troponin blood tests to confirm or exclude a…
- Conditions
- Chest Pain, Coronary Artery Disease, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- PROTECCT (NCT03583320)
- Testing
- Cardiac CT angiogram
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Myocardial Ischemia
Microvascular Coronary Disease In Women: Impact Of Ranolazine
1. To evaluate the impact of ranolazine extended-release tablets in women with subendocardial ischemia due to microvascular endothelial dysfunction on myocardial ischemia (Cardiac Magnetic Resonance (CMR) extent, severity. 2.
- Trial name
- NCT00570089
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
All Cause Mortality, MACE
ROOBY Trial Follow-up Extension
The Department of Veterans Affairs "Randomized On/Off Bypass" (ROOBY) Trial (CSP #517) was funded in 2001. ROOBY was designed to compare the short-term (30-day) and intermediate-term (1-year) outcomes for patients undergoing…
- Trial name
- NCT01924442
- Where
- United States
- Volunteers
- 2,203 people
- Sponsor
- VA Office of Research and Development
Acute Myocardial Infarction
Clinical Outcomes of Angioplasty Postconditioning
We previously demonstrated that postconditioning by coronary angioplasty can decrease infarct size (as measured by cardiac enzyme release) in patients with ongoing acute myocardial infarction.
- Trial name
- NCT00419198
- Testing
- Postconditioning, standard angioplasty
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Hospices Civils de Lyon
Aortic Valvular Surgery
Pharmacological Postconditioning During the Aortic Valvular Surgery
Primary objective: To evaluate the efficacy of the cyclosporin A administration to induce a cardioprotection during the valvular surgery.
- Trial name
- PC Pharma CVA (NCT00987207)
- Testing
- cyclosporine A, No injection
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon