Clinical trials: Myocardial Ischemia
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients
In the last decade, venoarterial extracorporeal membrane oxygenation (VA-ECMO) has become the first-line therapy in patients with refractory cardiogenic shock.
- Trial name
- LEVOECMO (NCT04728932)
- Testing
- Levosimendan
- Where
- 3 sites in France
- Volunteers
- 206 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Carotid Plaque
Association Between Carotid Plaque Length and Cardiovascular Outcomes
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No.
- Trial name
- NCT05843487
- Where
- 5 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Changhai Hospital
Cardiovascular Diseases, Heart Diseases
Framingham Heart Study
The Framingham Heart Study was initiated to study the factors associated with the development of cardiovascular disease by employing long-term surveillance of an adult population in Framingham, Massachusetts.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00005121
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction
Efficacy of Early Administration of Clotinab in Acute Myocardial Infarction
The ADMIRAL (Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction) study demonstrated that early administration of abciximab in patients with ST elevation acute myocardial infarction…
- Trial name
- ECLAT-STEMI (NCT00841438)
- Testing
- Clotinab
- Where
- 31 sites in South Korea
- Volunteers
- 786 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Randomized Controlled Trial of Moderate-Intensity Rosuvastatin With Ezetimibe Combination Therapy Versus High-Intensity Rosuvastatin on Progression of Coronary Atherosclerotic Plaque
The aim of this prospective, open-label, randomized, single center study is to compare the effect of usual dose rosuvastatin plus ezetimibe and high-dose rosuvastatin on modifying atherosclerotic plaque.
- Trial name
- Rosuzet-IVUS (NCT03169985)
- Testing
- Rosuvastatin 10 mg plus ezetimibe 10 mg orally once a day, Rosuvastatin 20 mg orally once a day
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Samsung Medical Center
Coronary Heart Disease, Physical Activity
Psychodynamic Motivation and Training Program
The purpose of this study is to examine the effectiveness of a Psychodynamic Motivation and Training Program (PMT) for the improvement of physical fitness in patients with stable coronary heart disease as compared to advice in…
- Trial name
- PMT (NCT01445808)
- Testing
- Psychodynamic Motivation and Training Program (PMT), Advice in Exercise Training (+Ex), Treatment as usual (TAU)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Johannes Gutenberg University Mainz
Myocardial Infarction
Prolonged Enoxaparin in Primary Percutaneous Coronary Intervention
This is a feasibility study aiming to generate pilot data on safety and efficacy of a novel anticoagulant regimen (enoxaparin bolus and prolonged infusion) compared to the local standard-of-care in opiate-treated patients…
- Trial name
- PENNYWISE (NCT03568838)
- Testing
- Enoxaparin
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Diabetes, Coronary Artery Disease
Evaluation of ALT-2074 in Subjects With Type-2 Diabetes, Haptoglobin Type 2-2 Genotype and Coronary Artery Disease
ALT-2074 (BXT-51072) belongs to a class of drugs called "glutathione peroxidase mimics." ALT-2074 works by imitating a substance produced in various tissues in the body, which prevents damage of the heart and blood vessels.
- Trial name
- NCT00491543
- Testing
- ALT-2074
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Synvista Therapeutics, Inc
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Hungary Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES)
- Trial name
- NCT01892917
- Where
- 13 sites in Hungary
- Volunteers
- 2,000 people
- Sponsor
- Biotronik Hungária Kft.
STEMI, Primary PCI
Early Administration of Heparin At FMC for PPCI of STEMI Patients
Heparin is the first choice of anticoagulation drug for primary PCI of STEMI patients. However, the priority of use of hepairn in first medical contact or in Cathlab has not yet studied.
- Trial name
- HELP-PCI (NCT05329155)
- Testing
- Heparin Sodium Injection
- Where
- China
- Volunteers
- 1,145 people
- Sponsor
- Renmin Hospital of Wuhan University
Chronic Heart Failure, Coronary Artery Disease
The Influence of Metformin on Chronic Heart Failure Clinical Course in Patients With Prediabetes
It is well known fact, that prediabetes is a predictor of high cardiovascular mortality, increasing the risk of developing such adverse cardiovascular events as myocardial infarction, stroke and sudden cardiac death.
- Conditions
- Chronic Heart Failure, Coronary Artery Disease, PreDiabetes
- Trial name
- NCT04549415
- Testing
- Metformin Hydrochloride, lifestyle modification
- Where
- Kyrgyzstan
- Volunteers
- 97 people
- Sponsor
- National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
Coronary Heart Disease
The VA HDL Intervention Trial (HIT): Secondary Prevention of Coronary Heart Disease in Men With Low HDL-Cholesterol and Desirable LDL-Cholesterol
This was a double-blind randomized trial comparing 1200 mg per day of gemfibrozil with placebo in 2531 men with coronary heart disease, an HDL-C of 40mg/dl or less, an LDL-C of 140 mg/dl or less, and triglycerides of 300mg/dl or…
- Trial name
- HIT (NCT00283335)
- Testing
- gemfibrozil
- Where
- United States
- Volunteers
- 2,531 people
- Sponsor
- VA Office of Research and Development
Cardiovascular Diseases, Coronary Disease
Green Tea Consumption and Coronary Heart Disease
To examine the prospective association of green tea consumption to the incidence and mortality of coronary heart disease (CHD) using multivariate analysis while controlling for the potential confounding effects of cholesterol…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00005548
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Heart Disease
Ticagrelor Versus Clopidogrel for CMD in Patients With AMI: A Retrospective Study Based on the Angio-IMR
Coronary microvascular dysfunction (CMD) is increasingly recognized as an important indicator for long-term prognosis in patients with acute myocardial infarction (AMI).
- Trial name
- NCT05978726
- Testing
- Dual antiplatelet therapy with aspirin and either ticagrelor or clopidogrel
- Where
- China
- Volunteers
- 325 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Heart Disease
QWISE - Study of Quinapril in Women With Chest Pain, Coronary Flow Reserve Limitations and Evidence of Myocardial Ischemia
INDICATION Microvascular angina. OBJECTIVES To investigate the effect of ACE (angiotensin converting enzyme) inhibition (quinapril) in improving coronary microvascular function.
- Trial name
- NCT00150826
- Testing
- Quinapril
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Florida
Myocardial Infarction, Coronary Artery Disease
Protocol in Reeducation Occupational Therapist in Coronary Patients
The quality of life, linked to physical, social and mental performance in people with coronary heart disease represents the primary goals in terms of rehabilitation.
- Trial name
- NCT04774276
- Testing
- cardiac rehabilitation protocol without occupational therapist, cardiac rehabilitation protocol with occupational therapist
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery
Cardiac Rehabilitation Peer Mentorship
The current study is a randomized controlled trial, being conducted at two hospitals in Toronto, Ontario, Canada, involving the randomization of cardiac inpatients into an intervention group, in which they will receive mentorship…
- Conditions
- Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery, Acute Coronary Syndrome, Chronic Stable Heart Failure
- Trial name
- NCT02204449
- Testing
- Cardiac Rehabilitation Peer Mentorship
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- University Health Network, Toronto
Acute Cardiovascular Disease, Acute Coronary Syndrome
Naples Federico II Intensive Cardiac Care Unit Registry (Naples FED2-ICCU Registry)
This protocol proposes to prospectively evaluate current epidemiology, pharmacologic and invasive management and clinical outcomes of patients with acute cardiovascular diseases admitted at our ICCU.
- Conditions
- Acute Cardiovascular Disease, Acute Coronary Syndrome, Acute Heart Failure, Cardiogenic Shock
- Trial name
- NCT06162247
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Federico II University
Coronary Arterial Disease (CAD)
AVS Pulse Intravascular Lithotripsy™ (Pulse IVL™) to Open Vessels With Calcific Walls and Enhance Vascular Compliance and Remodeling for Coronary Artery Disease
A prospective, open-label, multi-site, FIH with up to fifteen (n=15) patients to assess the safety and preliminary effectiveness of the AVS Pulse Intravascular Lithotripsy™ System (Pulse IVL™ System) when used for the treatment…
- Trial name
- POWER CAD I (NCT07510438)
- Testing
- Pulse Intravascular Lithotripsy (Pulse IVL)
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 15 people
- Sponsor
- Amplitude Vascular Systems, Inc.
Pulmonary Edema, Myocardial Infarction
Non-Invasive Ventilation in Pulmonary Edema
This randomized controlled trial is primarily aimed at assessing the rate of acute myocardial infarction with the two noninvasive ventilatory techniques, non-invasive intermittent positive pressure ventilation and non-invasive…
- Trial name
- NCT00453947
- Testing
- CPAP and Non Invasive Ventilation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Ospedale S. Giovanni Bosco
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