Clinical trials: Myocardial Ischemic Reperfusion Injury
Post Myocardial Infarction
Daily REmote Ischaemic Conditioning Following Acute Myocardial Infarction
Remote ischaemic conditioning (RIC) is known to reduce infarct size post MI when used in the peri/immediate post infarct period.
- Trial name
- DREAM (NCT01664611)
- Testing
- Remote Ischaemic Conditioning administered via the inflation of a blood pressure cuff on the upper arm
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Leicester
Acute Myocardial Infarction
Acetaminophen to Prevent Ischemic Oxidative Reperfusion Injury During Percutaneous Coronary Intervention for Acute Myocardial Infarction
The purpose of this study is to test the hypothesis that acetaminophen will reduce lipid peroxidation and isoprostane formation during reperfusion after percutaneous revascularization for acute myocardial infarction.
- Trial name
- APRIORI Pilot (NCT01120769)
- Testing
- Acetaminophen
- Where
- United States
- Sponsor
- Vanderbilt University
Myocardial Infarction, Reperfusion Injury
Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction
Despite advances in the treatment of heart attacks the complications and death rates from failure of the heart to pump properly after treatment remain high.
- Conditions
- Myocardial Infarction, Reperfusion Injury, Myocardial Ischemia, Cardiovascular Diseases
- Trial name
- NITRITE-AMI (NCT01584453)
- Testing
- Sodium Nitrite
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Barts & The London NHS Trust
Myocardial Ischemia, Coronary Disease
Efficacy of FX06 in the Prevention of Myocardial Reperfusion Injury
The purpose of the study is to evaluate whether FX06 is capable of limiting infarct size following balloon catheterization for acute myocardial infarction.
- Conditions
- Myocardial Ischemia, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00326976
- Testing
- FX06, Percutaneous coronary intervention
- Where
- 32 sites in Austria, Belgium and 9 more
- Volunteers
- 234 people
- Sponsor
- Fibrex Medical Research & Development GmbH
Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS)
Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers
Oxygen treatment is widely used in acutely ill patients, both pre-hospital and in hospital. The indication for oxygen is sometimes unquestionable, such as in many hypoxic patients, but in other situations its use is more of a…
- Conditions
- Acute Myocardial Infarction (AMI), Acute Coronary Syndrome (ACS), ST Elevation (STEMI) Myocardial Infarction, Ischemic Reperfusion Injury
- Trial name
- DETO2X-bio (NCT02290080)
- Testing
- Oxygen
- Where
- 2 sites in Sweden
- Volunteers
- 175 people
- Sponsor
- Karolinska Institutet
Myocardial Infarction, Reperfusion Injury, Myocardial
Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction
A heart attack (myocardial infarction) occurs when an artery supplying blood to the heart is suddenly blocked resulting in damage to the heart muscle.
- Trial name
- STEMI-Cool (NCT06128993)
- Testing
- Transcoronary cooling and dilution, Standard of care
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Myocardial Infarction
Intracoronary Darbepoetin-alpha to Reduce The Infarct Size and Post-Infarct Remodeling
Prospective, randomized and open label trial Hypothesis Infusion of intracoronary darbepoetin-alpha at the time of reperfusion may reduce infarct size and post-infarct pathologic left ventricular remodeling in patients with…
- Trial name
- NCT01538771
- Testing
- Darbepoetin alfa, Control Saline
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Cardiogenic Shock, Extracorporeal Life Support
Post-Surgery Extracorporeal Life Support
Extracorporeal Life Support (ECLS) may provide pulmonary and circulatory support for patients with acute heart failure refractory to conventional medical therapy.
- Conditions
- Cardiogenic Shock, Extracorporeal Life Support, Extracorporeal Membrane Oxygenation Complication, Post Cardiac Arrest Syndrome
- Trial name
- PC-ECLS (NCT04330651)
- Testing
- ECLS
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Myocardial Ischemia
The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
Ischemia reperfusion injury may be attenuated by HO-1 induction. Our previous data confirmed strong HO-1 induction in peripheral blood cells following heme arginate infusion in healthy humans.
- Trial name
- NCT02314780
- Testing
- Heme arginate 3mg/kg, Heme arginate 1mg/kg
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Martin Andreas, M.D.
ST-elevation Myocardial Infarction
Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size
Heart attacks, or myocardial infarcts, are a major cause of death and disability in the UK. Immediate unblocking of the obstructed heart vessel with a balloon catheter and implantation of a mesh scaffold (stent) in heart centers…
- Trial name
- MINIMISE-STEMI (NCT01882179)
- Testing
- Mineralocorticoid receptor antagonist potassium-canrenoate
- Where
- 4 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- University College, London
Myocardial Reperfusion Injury
Delayed Postconditioning
The investigators previously reported that angioplasty postconditioning reduces infarct size (cardiac enzyme release) in STEMI patients with a fully occluded coronary artery at hospital admission.
- Trial name
- PRIME (NCT01483755)
- Testing
- Postconditioning, Percutaneaous intervention
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- Hospices Civils de Lyon
Myocardial Infarction
Relationship Between CMR-derived Parameters of Ischemia / Reperfusion Injury and Timing of CMR in STEMI
This a prospective observational study including patients with ST-segment elevation myocardial infarction undergoing cardiovascular magnetic resonance for clinical reason during the index hospitalization.
- Trial name
- NCT03522116
- Testing
- No intervention
- Volunteers
- 220 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Myocardial Infarction, Myocardial Reperfusion Injury
Optimized Cardioprotection Therapy in Obese Subjects With AMI
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With acute myocardial infarction (AMI) Who Have Undergone Percutaneous Coronary Intervention (PCI).
- Conditions
- Acute Myocardial Infarction, Myocardial Reperfusion Injury, Obesity, Adiposis; Heart
- Trial name
- NCT04570514
- Testing
- PCI
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Patients With Elective Aortic Valve Replacement
Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery
The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium
- Trial name
- NCT01946087
- Testing
- Remote ischemic preconditioning at left upper arm, Control group
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Yonsei University
Myocardial Reperfusion Injury, Myocardial Ischemia
Remote Postconditioning in Patients With Acute Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention (PCI)
Background: Experimental studies suggest that remote limb ischaemic postconditioning (RemPostCon) can reduce infarct size in pigs.
- Conditions
- Myocardial Reperfusion Injury, Myocardial Ischemia, Myocardial Infarction
- Trial name
- RemPostCon (NCT00865722)
- Testing
- Remote Postconditioning
- Where
- 2 sites in Italy
- Volunteers
- 96 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Heart Defects, Congenital, Cardiac Surgical Procedures
Myocardial Protection With Adenosine Preconditioning
Adenosine has been proved to be an important mediator of myocardial protection induced by ischemic preconditioning. The hypothesis of this study is that adenosine preconditioning can provide additional myocardial protection in…
- Conditions
- Heart Defects, Congenital, Cardiac Surgical Procedures, Myocardial Reperfusion Injury, Adenosine
- Trial name
- NCT00881686
- Testing
- adenosine
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Xijing Hospital
Myocardial Reperfusion Injury
Concomitant Milrinone and Esmolol Treatment in Patients with Acute Myocardial Infarction
Heart attack is the leading cause of death in the developed world. Following heart attack, re-establishing blood flow in a clogged heart vessel using percutaneous coronary intervention (PCI) is the standard of care.
- Trial name
- COMET-AMI (NCT02098629)
- Testing
- Milrinone, Esmolol, Saline Infusion
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Shantou University Medical College
Myocardial Ischemia-Reperfusion Injury
OR6A2 on Monocytes and Cardiovascular Outcomes in Myocardial Ischemia-Reperfusion Injury
This study examines how the interaction between octanal (an OR6A2 receptor activator) and OR6A2 expression influences inflammation and clinical outcomes in Myocardial Ischemia-Reperfusion Injury patients.
- Trial name
- NCT07100457
- Testing
- Blood Biomarker Profiling and Prognostic Follow-up
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southeast University, China
Myocardial Ischemic-reperfusion Injury
Immunometabolic Pattern of Intermittent Hypoxia During ST-segment Elevation Myocardial Infarction
The aim of this study is to characterize the protective pattern of intermittent hypoxia, angina pectoris and remote ischemic conditioning, in reperfusion injury by determining and monitoring the plasma immunometabolic parameters…
- Trial name
- NCT05230966
- Testing
- Remote Ischemic Conditioning (RIC)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Platelet Aggregation Inhibitors, Anti-inflammatory Agent
ACCEL-LOADING-ACS Study
The purpose of this study is to determine whether adjunctive cilostazol loading/maintenance to standard treatment (aspirin, clopidogrel, and statin) is effective in reduction of major adverse cardiovascular events, platelet…
- Conditions
- Platelet Aggregation Inhibitors, Anti-inflammatory Agent, Myocardial Reperfusion Injury
- Trial name
- NCT01354808
- Testing
- Dual Anti-Platelet Therapy (DAPT), Triple Anti-Platelet Therapy (TAPT)
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Gyeongsang National University Hospital