Clinical trials: Myocardial Strain
Ischemic Heart Disease
Correlation Between Left Ventricular Global Strain Measured by Speckle Tracking Echocardiography and Scar Burden Measured by Cardiac Magnetic Resonance Imaging in Patients With Ischemic Heart Disease
To verify whether GLS and LV mechanical dispersion, measured by two-dimensional speckle-tracking echocardiography (2D-STE) correlate with LV scar burden measured by cardiac MRI in patients with ischemic heart disease.
- Trial name
- NCT04970017
- Testing
- Cardiac MRI, Echocardiography
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Assiut University
Postoperative Complications
Left Ventricular Global Longitudinal Strain and Postoperative Myocardial Injury
To use left ventricular global longitudinal strain as a means of monitoring myocardial exercise function during anaesthesia in patients with coronary artery disease, to explore the association with the occurrence of postoperative…
- Trial name
- NCT05392426
- Testing
- Left Ventricular Global Longitudinal Strain, EF CO SV EDV ESV
- Where
- 2 sites in China
- Volunteers
- 58 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Coronary Artery Disease, Anesthesia
Myocardial Strain Analysis in Anaesthetized Coronary Artery Disease Patients During Hyperoxia and Normoxaemia
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients with coronary artery disease.
- Trial name
- Strecho-O₂ (NCT04424433)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease, Coronary Artery Ectasia
Evaluation of Emotional Status and Coronary Flow Characteristics by TIMI Frame Count Method
This study evaluates the effects of emotional status on coronary flow in patients undergoing elective coronary angiography. Patients whom undergoing elective coronary angiography will fulfill the Beck Anxiety Inventory, Beck…
- Conditions
- Coronary Artery Disease, Coronary Artery Ectasia, Slow-Flow Phenomenon, Endothelial Dysfunction
- Trial name
- STRAIN-TIMI (NCT02831153)
- Testing
- coronary angiography
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Ertan YETKIN
Duchenne Muscular Dystrophy
2D Strain Evaluation: Children With Duchenne Muscular Dystrophy Versus Healthy Children
Compare systolic function of left ventricle (LV) and right ventricle (VD) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.
- Trial name
- NCT02418338
- Testing
- speckle tracking (2D strain) echocardiography
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Coronary Disease With Diabetes Mellitus
Effects of SGLT2 Inhibitor in Diabetic Patients With Coronary Artery Disease
The aim of this study is to explore the effect of newly added SGLT2I medication or placebo, to standard medication regimen in diabetic patients with documented stable coronary disease.
- Trial name
- NCT03398577
- Testing
- Dapagliflozin 10 MG [Farxiga]
- Where
- Israel
- Volunteers
- 61 people
- Sponsor
- Sheba Medical Center
Ischemic Heart Disease, Valvular Heart Disease
Milrinone on Right Ventricular Strain in Cardiac Surgery
The purpose of this study is to analyze the changes in right ventricular strain before and after milrinone administration in order to find out whether milrinone improves RV systolic performance in patients undergoing cardiac…
- Trial name
- NCT06077721
- Testing
- Milrinone
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Konkuk University Medical Center
Ischemia, Myocardial
Quantitative Stress Echocardiography to Diagnose Myocardial Ischaemia
Patients with chest pain on exertion need a reliable non-invasive test to identify if they have inducible myocardial ischaemia. This would reduce the use of diagnostic coronary arteriography, avoid its risks and costs, and guide…
- Trial name
- DEVISE (NCT03659526)
- Testing
- Deformation imaging
- Where
- 4 sites in Belgium, Sweden and 1 more
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University Hospital of Wales
Pulmonary Hypertension, Echocardiography
Cardiac Speckle Tracking Myocardial Strain Balance
The investigators intend to evaluate the function of left heart and right heart and the motion balance between four chambers of the heart by speckle tracking technique during the follow-up of patients with pulmonary hypertension…
- Trial name
- NCT03464591
- Where
- China
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Coronary Artery Disease
The Effect of Nicorandil on Left Ventricular Myocardial Strain in Patients With Coronary Chronic Total Occlusion
Background Nicorandil is recommended as a second-line treatment for stable angina, but randomized-controlled trials (RCTs) to evaluate the benefit of nicorandil for patients with chronic total occlusion (CTO) are still lack.
- Trial name
- NCT05087797
- Testing
- nicorandil
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Peking University Third Hospital
Breast Cancer
Carvedilol for the Prevention of Anthracycline/Anti-HER2 Therapy Associated Cardiotoxicity Among Women With HER2-Positive Breast Cancer Using Myocardial Strain Imaging for Early Risk Stratification
The purpose of this study is to find out the effects, good and/or bad, of a beta blocker (carvedilol) on heart function during treatment with anti-HER2 medication(s) including trastuzumab (Herceptin).
- Trial name
- NCT02177175
- Testing
- Carvedilol
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction
Sex Related Differences in Cardiac Function
The aim of the study is to investigate sex-specific differences in LV and RV function (systolic and diastolic) with regarding the development and progression of heart failure with preserved ejection fraction based on a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05796050
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Angina Pectoris, Left Ventricular Wall Motion Abnormalities
Hybrid Intraprocedural Imaging Based on 2 Different Imaging Methods
The investigators will check the feasibility of an intraprocedural vitality diagnostics and the identification of an indication for Percutaneous transluminal coronary angioplasty (PTCA).
- Trial name
- NCT01389674
- Testing
- 2D-strain echo
- Where
- Germany
- Sponsor
- RWTH Aachen University
Acute Myocardial Infarction
Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction
The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in…
- Trial name
- 137-2005 (NCT00752713)
- Testing
- cardiac MRI
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Myocardial Fibrosis
Association of T1-mapping and LV Strain Analysis by CMR
The association of T1-mapping (both native and ECV) and strain analysis of LV and RV by CMR will be assessed. Results from strain analysis will be investigated in terms of their prognostic value.
- Trial name
- NCT03405987
- Testing
- Strain analysis by CMR
- Where
- Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
Myocardial Dysfunction
Effects of L-arginine on Myocardial Energetic Efficiency and Global Longitudinal Strain
The study is designed to evaluate the effects of L-arginine on myocardial structure and function and circulating microRNAs in patients with arterial hypertension.
- Trial name
- BIOCARDIO (NCT04626375)
- Testing
- Bioarginine
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federico II University
Heart Failure
The Determination of Important Mechanical Patterns of Left Ventricular Efficiency-MV02 Study
The purpose of this study is to determine if analysis of heart ultrasound images with new software programs will provide better understanding as to the specific heart problems that lead to symptoms of heart failure.
- Trial name
- DIMPLE (NCT01807819)
- Testing
- Heart Failure
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- University of Florida
Myocardial Infarction, Acute, Myocardial Strain
Assessment of the Effects of Long-term Lipid-lowering Therapy in Patients With Primary STEMI or NSTEMI
In a single-center, open-label, prospective, controlled, clinical study, it is planned to include 300 patients hospitalized in the cardiology department of SBHI Penza regional clinical hospital n.a. N.N. Burdenko.
- Conditions
- Myocardial Infarction, Acute, Myocardial Strain, Arterial Stiffness, Quality of Life
- Trial name
- CONTRAST-2 (NCT04347434)
- Testing
- Atorvastatin 80mg
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Penza State University
Aging, Heat Stress
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as…
- Conditions
- Aging, Heat Stress, Hyperthermia, Heat Strain
- Trial name
- NCT06842784
- Testing
- Ambient heat stress
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Myocardial Inflammation, Rheumatoid Arthritis
Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study
Rheumatoid arthritis (RA) patients have a higher prevalence of subclinical atherosclerosis than the general population. In addition, RA patients experience higher rates of heart failure with preserved ejection fraction (HFpEF).
- Conditions
- Myocardial Inflammation, Rheumatoid Arthritis, Coronary Artery Disease, Myocardial Strain
- Trial name
- NCT03776682
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic