Clinical trials: Myocarditis
Myocarditis, Viral Myocarditis
PET-FDG in Myocarditis
This study evaluates the diagnostic performance of 18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) with rest perfusion imaging for the diagnosis of myocarditis.
- Trial name
- PETMYO (NCT03777839)
- Testing
- FDG PET/CT
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Montreal Heart Institute
Myocardial Infarction, Ventricular Dysfunction
Cologne Register of Wearable Defibrillator (CRWD)
The wearable cardiac defibrillator (WCD) is an alternative to the implantation of cardioverter defibrillator (ICD) for patients at high risk for sudden cardiac death (mostly bridging therapy).
- Conditions
- Myocardial Infarction, Ventricular Dysfunction, Myocarditis
- Trial name
- NCT02073942
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Immune Checkpoint Inhibitors Related Myocarditis
ICIAM Rehabilitation Program Study: A Randomized Controlled Trial
Immunotherapy has become a cornerstone in oncology; however, managing its associated adverse events poses a significant clinical challenge.
- Trial name
- NCT07280429
- Testing
- rehabilitation protocol
- Volunteers
- 60 people
- Sponsor
- China-Japan Friendship Hospital
Atrial Remodeling, Myocardial Dysfunction
Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvation
Sacubitril-valsartan, an Angiotensin Receptor Blocker-Neprilysin Inhibitor (ARNI), currently marketed for the management of heart failure, has been shown to reduce cardiovascular morbidity and mortality in stage C heart failure…
- Conditions
- Atrial Remodeling, Myocardial Dysfunction, Left Ventricular Remodeling, Left Ventricular Diastolic Dysfunction
- Trial name
- PARABLE (NCT04687111)
- Testing
- Sacubitril-Valsartan, Valsartan
- Where
- 2 sites in Ireland
- Volunteers
- 250 people
- Sponsor
- Mark Ledwidge
Myocardial Inflammation, Rheumatoid Arthritis
Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study
Rheumatoid arthritis (RA) patients have a higher prevalence of subclinical atherosclerosis than the general population. In addition, RA patients experience higher rates of heart failure with preserved ejection fraction (HFpEF).
- Conditions
- Myocardial Inflammation, Rheumatoid Arthritis, Coronary Artery Disease, Myocardial Strain
- Trial name
- NCT03776682
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Myocarditis Acute
Analysis of Cardiac Damage Post Infection With SARS-CoV-2 and Post Vaccination Against COVID-19
From May 2020 to May 2021, the investigators retrospectively evaluated clinical cardiac magnetic resonance (CMR) examinations performed in patients with suspected cardiac involvement post COVID-19.
- Trial name
- NCT05124223
- Testing
- Cardiac MRI
- Where
- Germany
- Volunteers
- 131 people
- Sponsor
- Sebastian Kelle
Enterovirus Infections
Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection
Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet.
- Trial name
- NCT00426699
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sarcoidosis, Arrhythmogenic Right Ventricular Cardiomyopathy
PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare condition in which the heart muscle cells especially of the main pumping chamber (the 'ventricle') is replaced by fat and scar tissue.
- Trial name
- NCT02989480
- Testing
- PET CT, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
SARS-CoV 2, COVID-19
Cardiac COVID-19 Health Care Workers
The study will analyze the prevalence of cardiac involvement of health care workers from the University Hospital of Salamanca (HUSA) who have overcome SARS-CoV-2 infection.
- Conditions
- SARS-CoV 2, COVID-19, Coronavirus, Cardiac Magnetic Resonance
- Trial name
- CCC (NCT04413071)
- Testing
- Passed infection of SARS-CoV-2
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- AORTICA Group
Myocarditis Acute, Inflammatory Cardiomyopathy
Creation of a National Multicenter Platform for the Study of Inflammatory Myocardial Disease: Pre-MYO Cohort
The objectives of this project are: 1) to comprehensively characterize a large national cohort of patients with suspected myocarditis, their clinical phenotype, care management, blood and imaging biomarkers, epidemiological…
- Trial name
- PREMYO (NCT06898762)
- Testing
- characterization of a large national cohort of patients with suspected myocarditis or inflammatory cardiomyopathy.
- Where
- Spain
- Volunteers
- 3,000 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Cancer
Study to Determine if the Flu Vaccine Increases the Risk of Muscle Damage in Participants Taking Drugs That Block Certain Proteins Made by Some Types of Immune System Cells
A retrospective, observational study conducted on cancer patients receiving a drug that blocks certain proteins made by some types of immune system cells
- Trial name
- NCT03644498
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 1,056 people
- Sponsor
- Bristol-Myers Squibb
Myocardial Injury, COVID-19
Myocardial Injury and Dysfunction Associated With COVID-19 Vaccination
The overall goal of the study is to investigate the characteristics and potential mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19 vaccination.
- Conditions
- Myocardial Injury, COVID-19, Vaccine Reaction
- Trial name
- MIDAVAX (NCT05359250)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Sarcoidosis With Myocarditis, Sarcoidosis
Cell Free DNA in Cardiac Sarcoidosis
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing…
- Conditions
- Sarcoidosis With Myocarditis, Sarcoidosis, Healthy, ST Elevation Myocardial Infarction
- Trial name
- cfDNA in CS (NCT03858777)
- Testing
- cell free DNA
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nabeel Hamzeh
Post Viral Fatigue, Viral Myocarditis
Post-COVID-19 Outpatient Care and Biomarkers
The aims of this case-control, non-randomized study including patients with post-COVID-19 persisting symptoms are 1) to establish the large blood biobank, 2) to examine levels of circulating inflammatory biomarkers and different…
- Conditions
- Post Viral Fatigue, Viral Myocarditis, POTS
- Trial name
- POSTCOV (NCT05398952)
- Testing
- Laboratory investigations
- Where
- Austria
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Inflammation, Cardiovascular Diseases
Inflammation in Acute Cardiovascular Diseases - the CArdiovascular Inflammation Registry (CAIR)
Following acute cardiovascular injury, inflammation is vital to activate reparative mechanisms. However, there is compelling evidence implicating excessive inflammation and dysregulated resolution in fibrosis, ventricular…
- Conditions
- Inflammation, Cardiovascular Diseases, Myocarditis, Pericarditis
- Trial name
- CAIR (NCT06411340)
- Testing
- Observation
- Volunteers
- 1,000 people
- Sponsor
- King's College London
Acute Cellular Graft Rejection, Cardiac Sarcoidosis
[68Ga]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
Acute myocardial inflammation is an heterogenic syndrome involving different clinical pathologies with different outcome. For the purpose of this study protocol, we focuse on three entities of this syndrome, namely the acute…
- Conditions
- Acute Cellular Graft Rejection, Cardiac Sarcoidosis, Myocarditis Due to Drug
- Trial name
- NCT05499637
- Testing
- [68Ga]Ga-PentixaFor PET/CT
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- John O. Prior
Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis
Medicine-induced Cardiac Hemodialysis on COVID-19
The clinical trial studies the human pathogen of SARS-CoV-2, with a specificity in the circulating Spike 2 protein in the human system.
- Conditions
- Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis, Vaccines, Myocarditis Allergic
- Trial name
- NCT05711810
- Testing
- Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Yang I. Pachankis
Myocarditis
Covid-19 Vaccine Associated Myocarditis and Pericarditis in Norway
This is a national multicenter study in Norway investigating of individuals with Covid-19 vaccine associated myocarditis (VAM) and pericarditis in Norway.
- Trial name
- NCT05610423
- Testing
- no intervention
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2, Acute Refractory Heart Failure Related to SARS-CoV 2
Extracorporeal Membrane Oxygenation (ECMO) and Coronavirus Disease (COVID) 19
The role of ECMO in the treatment of patients with severe COVID-19 (Acute Respiratory Distress Syndrome (ARDS) and/or acute refractory heart failure) is not yet known.
- Trial name
- ECMO-SARS (NCT04397588)
- Where
- 44 sites in France
- Volunteers
- 761 people
- Sponsor
- Rennes University Hospital
Cardiac Sarcoidosis, Sarcoidosis of the Heart
Exosome-based Omic Signatures of Disease Activity in Cardiac Sarcoidosis (EXODACS)
The purpose of this study is to develop a prospective cohort of patients with and without cardiac sarcoidosis as well as active and inactive disease to develop a prospective biobank from which exosome analysis of peripheral blood…
- Conditions
- Cardiac Sarcoidosis, Sarcoidosis of the Heart, Sarcoidosis With Myocarditis, Sarcoidosis, Cardiac
- Trial name
- EXODACS (NCT07604220)
- Testing
- Exosome Analysis
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Mayo Clinic