Clinical trials: Myopathies
Fibromyalgia
Study of Milnacipran Added to Pregabalin for Treatment of Fibromyalgia
To evaluate the safety, tolerability, and efficacy of milnacipran when taken with another drug called pregabalin in people with fibromyalgia.
- Trial name
- NCT00797797
- Testing
- No Treatment Added, Milnacipran Added
- Where
- 60 sites in United States
- Volunteers
- 364 people
- Sponsor
- Forest Laboratories
Muscle Spasticity, Stroke
Long-Term Study of OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity
This is a long-term safety and efficacy study of onabotulinumtoxinA in poststroke patients with upper limb spasticity.
- Trial name
- NCT02145689
- Testing
- onabotulinumtoxinA
- Sponsor
- Allergan
Muscle Soreness
A Study to Understand the Analgesic Properties of Topically Applied Menthol When Used in a Marathon.
The purpose of the research study is to gather the opinions and/or perceptions relating to the use of topically applied menthol and experience of pain during and after a marathon in adult runners (18+ years) participating in the…
- Trial name
- NCT07565246
- Testing
- Observational
- Where
- United States
- Volunteers
- 367 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Spasticity Post Stroke
Spinal Cord Stimulation for Poststroke Spasticity
The goal of this clinical trial is to learn whether spinal cord stimulation (SCS) is effective in treating post-stroke spasticity in adults. It will also evaluate the safety of the implanted SCS system.
- Trial name
- SCS-PSS (NCT07744659)
- Testing
- Active spinal cord stimulation
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Fibrodysplasia Ossificans Progressiva, FOP
A Study to Investigate the Safety, Pharmacokinetics (PK), and Efficacy of Garetosmab in Children and Adolescents With Fibrodysplasia Ossificans Progressiva (FOP)
This study is researching an experimental drug called garetosmab, referred to as "study drug". The study is focused on children and adolescent participants with FOP.
- Trial name
- OPTIMA-2 (NCT07559513)
- Testing
- garetosmab
- Volunteers
- 18 people
- Sponsor
- Regeneron Pharmaceuticals
Compartment Syndromes
SWISS_CLEARANCE - Compartment Compressibility Monitoring Using CPM#1
Compartment syndrome is a very serious musculoskeletal disorder, which can lead to potentially devastating consequences, such as limb amputation and life- threatening conditions.
- Trial name
- NCT05483946
- Testing
- Measurement of compartment compressibility
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Compremium AG
Fibromyalgia
Treatment of Fibromyalgia With the FibroNova Neuromodulation Device
Fibromyalgia (FM) is a chronic disorder that affects the musculoskeletal system, causing widespread pain, tenderness, and fatigue. It is estimated to affect 1-5% of the population.
- Trial name
- NCT06271746
- Testing
- FibroNova (Active mode)
- Where
- 4 sites in United States, Israel
- Volunteers
- 170 people
- Sponsor
- Theranica
Muscle Spasticity
CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase1)
The purpose of this study is to evaluate the safety and pharmacodynamic of CORETOX® in the treatment of post-stroke upper limb spasticity
- Trial name
- NCT05164003
- Testing
- CORETOX®, BOTOX®
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Medy-Tox
Polymyositis, Dermatomyositis
A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis
This was a Phase 2 randomized, double-blind, placebo-controlled, crossover, multicenter study to evaluate the safety, tolerability, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of treatment with KZR-616 in patients…
- Trial name
- PRESIDIO (NCT04033926)
- Testing
- KZR-616
- Where
- 14 sites in United States, Czechia and 1 more
- Volunteers
- 25 people
- Sponsor
- Kezar Life Sciences, Inc.
Temporomandibular Disorders
Treatment Outcomes for Temporomandibular Disorders (TMD) Via the Clayton Intra-aural Device (CID) Clinical Trial
The purpose of this study is to characterize the safety profile and assess the effectiveness of the CID in treating subjects with temporomandibular disorders (TMDs).
- Trial name
- NCT00815776
- Testing
- Clayton Intra-aural Device (CID), Mouth Splint, Exercise Group
- Where
- Mexico
- Volunteers
- 152 people
- Sponsor
- Ascentia Health, Inc.
Tendinopathy
Study of Efficacy, Safety and Tolerability of AIN457 in Patients With Active Overuse Tendinopathy
This was a randomized, double-blind, placebo-controlled, multi-center, Phase II study of s.c. secukinumab 300 mg in 98 randomized patients with overuse rotator-cuff tendinopathy without systemic inflammatory disease.
- Trial name
- NCT03344640
- Testing
- secukinumab
- Where
- 12 sites in United States, Czechia and 3 more
- Volunteers
- 96 people
- Sponsor
- Novartis Pharmaceuticals
Idiopathic Inflammatory Myopathies, Inflammatory Myopathies
A Study of Imvotamab in Active, Refractory Idiopathic Inflammatory Myopathies
The purpose of this study is to determine the safety and tolerability of imvotamab in patients with Moderate-Severe Idiopathic Inflammatory Myopathies who have failed prior therapies.
- Trial name
- NCT06524687
- Testing
- Imvotamab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- IGM Biosciences, Inc.
Dermatomyositis
A Study In Adults With Moderate To Severe Dermatomyositis
A Study looking at Investigational drug and Placebo administered to adult Patients with moderate to severe Dermatomyositis
- Trial name
- NCT03181893
- Testing
- PF-06823859 low, PF-06823859 high
- Where
- 41 sites in United States, Germany and 3 more
- Volunteers
- 75 people
- Sponsor
- Pfizer
Myofascial Pain Syndromes
EMINEM: Efficacy of Muscoril In NEck Myofascial Syndromes
Study objective: To demonstrate, in patients with myofascial pain syndrome in cervical region, the degree of efficacy of thiocolchicoside ointment administered to trigger point regions compared with the trigger point injection.
- Trial name
- NCT00272532
- Testing
- Thiocolchicoside
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Sanofi
Pigmented Villonodular Synovitis, TGCT
A Study to Evaluate Safety and Efficacy of AMB-05X Injections in Subjects With TGCT
AMB-051-07 is an open-label, adaptive, dose-ranging study with long-term extension in adults with tenosynovial giant cell tumor
- Conditions
- Pigmented Villonodular Synovitis, TGCT, Tenosynovial Giant Cell Tumor
- Trial name
- NCT05349643
- Testing
- AMB-05X
- Where
- 6 sites in United States, Australia and 1 more
- Volunteers
- 20 people
- Sponsor
- AmMax Bio, Inc.
Facioscapulohumeral Muscular Dystrophy
Safety, Tolerability, Pharmacokinetics (PK), and Activity of ATYR1940 in Participants With Muscular Dystrophy - Study Extension
The purpose of this study is to assess the safety and tolerability profile of ATYR1940 in the treatment of adult participants with molecularly defined genetic muscular dystrophies.
- Trial name
- NCT02531217
- Testing
- ATYR1940
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 9 people
- Sponsor
- aTyr Pharma, Inc.
Spasticity
Continuous Intrathecal Baclofen Infusion for Chronic Spasticity
The purpose of this clinical investigation is to demonstrate product performance of the Prometra Programmable Pump System in the delivery of intrathecal Lioresal® (baclofen) for the management of severe spasticity.
- Trial name
- CIBI (NCT01051128)
- Testing
- Prometra Programmable Implantable Pump System
- Sponsor
- Flowonix Medical
Severe Spasticity
Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump
Safety study to assess the 3 mg/mL baclofen injection (intrathecal) using a programmable pump
- Trial name
- NCT01520545
- Testing
- Gablofen® 3 mg/mL (baclofen injection), SynchroMed® II Programmable Pump
- Where
- 13 sites in United States
- Volunteers
- 153 people
- Sponsor
- Piramal Critical Care, Ltd.
Musculoskeletal Pain, Fear of Falling
Free From Pain Exercise Programme Study
To determine the effectiveness of the "Free from Pain" exercise and information programme. The complete programme provides exercises and information for people over the age of 60 to reduce early osteoarthritic and generalised…
- Trial name
- NCT05091671
- Testing
- Free From Pain Exercise Programme Variation 1, Free From Pain Exercise Programme Variation 2
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Talita Cumi Ltd.
Back Pain Lower Back Chronic, Chronic Pain
Examining the Impact of a Digital Health Program and TENS Device for Patients With Chronic Low Back Pain
The goal of this study is to examine the extent to which Hinge Health, a digital musculoskeletal program, and Enso, a wearable pain relief device, have clinically significant impact on the pain, function, and health care use…
- Conditions
- Back Pain Lower Back Chronic, Chronic Pain, Musculoskeletal Pain
- Trial name
- NCT07011537
- Testing
- Digital Musculoskeletal (MSK) Program, Transcutaneous Electrical Nerve Stimulation (TENS), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hinge Health, Inc