Clinical trials: Myopathies
Dermatomyositis, Polymyositis
Adult and Juvenile Myositis
This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their cause and the immune system changes and medical problems associated with them.
- Conditions
- Dermatomyositis, Polymyositis, Inclusion Body Myositis
- Trial name
- NCT00017914
- Where
- 4 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Intraabdominal Hypertension, Breast Neoplasms
DIEP Flap Surgery and Intraabdominal Pressure
Aim: The primary aim of this study is to test if closure of the abdominal donor site increases the Intraabdominal Pressure (IAP) in women undergoing secondary Deep Inferior epigastric perforator (DIEP) flap breast reconstruction.
- Trial name
- NCT05764577
- Testing
- DIEP flap surgery
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Aalborg University Hospital
Tendinopathy
Exercise and Shoe Orthoses in Treatment of Posterior Tibial Tendon Dysfunction
Posterior tibial tendon dysfunction (PTTD) is the most common cause of painful and debilitating acquired flatfoot deformity in adults.
- Trial name
- NCT00279630
- Testing
- Orthoses and Exercise
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Southern California
Spasticity
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of lower limb spasticity, in adults followed by an open-label extension…
- Trial name
- NCT04099667
- Testing
- Phase 2; Low Dose MYOBLOC (15,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 40 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Temporomandibular Disorder
Urdu Version of Fonseca Anamnestic Index: Reliability and Validity Study
The aim of study is to translate and culturally adapt Fonseca Anamnestic Index into Urdu language and to investigate the reliability and validity in Pakistani population over the age 18 years.
- Trial name
- NCT05431829
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- Riphah International University
Fibromyalgia Syndrome
Self Soft Tissue Therapy for Fibromyalgia Syndrome
The main aims of this preliminary research are to determine if combined self-soft tissue therapy (SSTT) alongside an established 6 week FMS Coping Skills Programme (FCSP) is a feasible and acceptable treatment approach for FMS.
- Trial name
- NCT02881411
- Testing
- Self-soft tissue therapy, Fibromyalgia coping skills programme
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of the West of England
Fibromyalgia
Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia
A 9-week randomized double-blind, multi-center study of 172 patients, who after 1 week baseline evaluation are randomized to either fixed dose pregabalin starting at 75 mg BID for one week and increased to 150 mg BID for 7 weeks…
- Trial name
- Flexdose (NCT01226667)
- Testing
- Pregabalin
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- Osteoporosis Medical Center, Beverly Hills, CA
Fibromyalgia
Study Evaluating DVS SR in Patients With Fibromyalgia Syndrome
The primary objective is to evaluate the long-term safety of desvenlafaxine succinate sustained-release (DVS SR) during open-label treatment in adult outpatients with fibromyalgia syndrome.
- Trial name
- NCT00424892
- Testing
- Desvenlafaxine Sustained Release
- Where
- 59 sites in United States
- Volunteers
- 600 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Proteomics, Exercise
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an…
- Conditions
- Proteomics, Exercise, Atrophy, Disuse, Hypertrophy
- Trial name
- HYPAT (NCT04514744)
- Testing
- Knee bracing, Unilateral Resistance Exercise Training
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscle Soreness
The Effects of Swedish Massage and Manual Lymph Drainage on Muscle Fatigue
12 healthy men aged 18-30 will be included in the study. Participants will be selected from students who regularly train and do active sports at the Faculty of Sports Sciences. All participants will do nordic hamstring exercise.
- Trial name
- NCT06112899
- Testing
- Nordic Hamstring Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Temporomandibular Disorders (TMD), Disc Displacement
Differential Impact of TMJ Disc Displacement and Muscle Disorders on Pain, Function, and Quality of Life in TMD Patients
This study aims to explore the relationship between the position of the temporomandibular joint (TMJ) disc and key clinical outcomes in patients with temporomandibular disorders (TMD).
- Conditions
- Temporomandibular Disorders (TMD), Disc Displacement, Functional Impairment
- Trial name
- DPTMD (NCT06758479)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- King Khalid University
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents
This protocol matches child subjects with peer mentors of similar age who have learned to function successfully with a chronic pain disorder.
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01118988
- Testing
- Mentorship
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Tendinopathy, Chronic Pain
Managing Chronic Tendon Pain by Metformin
The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain.
- Conditions
- Tendinopathy, Chronic Pain, Achilles Tendinopathy
- Trial name
- NCT06100822
- Testing
- Metformin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- James Wang
Myofascial Trigger Point Pain, Myofascial Pain Syndrome
Dry Needling and Functional Improvement
Dry Needling (DN) is a skilled intervention that uses acupuncture filiform needles that are inserted into myofascial trigger points or other tissues underneath the skin.
- Trial name
- DN (NCT02838394)
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham Young University
Temporomandibular Joint Disorders, Orofacial Pain
Computed Guided Prolotherapy Versus Conventional Prolotherapy
The aim of that study is to compare between conventional prolotherapy and computed guided prolotherapy in treatment of temporomandibular joint (TMJ) internal derangement.
- Trial name
- NCT06132594
- Testing
- Conventional arthrocentesis followed by I-PRF injection, 3d surgical guided Arthrocentesis followed by I-PRF injection
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Fibromyalgia, Pain
Frequency of Sexual Intercourse,Women With Fibromyalgia
Does frequency of sexual intercourse affect symptom severity in female patients with fibromyalgia?
- Conditions
- Fibromyalgia, Pain, Depression
- Trial name
- NCT05915403
- Testing
- Fibromyalgia Impact Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Konya Beyhekim Training and Research Hospital
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Fibromyalgia
Hyperbaric Oxygen and Fibromyalgia: Randomised Prospective Clinical Trial
The aim of the study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on patients suffering from chronic pain syndrome (Fibromyalgia).
- Trial name
- NCT01827683
- Testing
- Hyperbaric oxygen
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Temporomandibular Disorder, Temporomandibular Joint Disorders
Proprioceptive Neuromuscular Facilitation Exercises in Temporomandibular Dysfunction
Individuals who were diagnosed with reduction disc displacement by Research Diagnostic criteria for Temporomandibular Disorder (TMD / RDC) were included in the study.
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Disorders, Pain
- Trial name
- NCT04967131
- Testing
- PNF exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Istanbul Medipol University Hospital
Duchenne Muscular Dystrophy
Bone Marrow-Derived Autologous Stem Cells for the Treatment of Duchenne Muscular Dystrophy
This study is single arm, single center trial to study the safety and efficacy of bone marrow-derived autologous specific populations of stem cells and mesenchymal stem cells for the treatment of Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT03067831
- Testing
- Stem Cells
- Where
- Jordan
- Volunteers
- 20 people
- Sponsor
- Stem Cells Arabia
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