Clinical trials: Myopathies
Myotonic Dystrophy 1, Excessive Daytime Sleepiness
Safety and Efficacy of Pitolisant on Excessive Daytime Sleepiness and Other Non-Muscular Symptoms in Patients With Myotonic Dystrophy Type 1
The primary objective of this study is to evaluate the safety and efficacy of pitolisant compared with placebo in treating excessive daytime sleepiness (EDS) in patients with Myotonic Dystrophy Type 1 ages 18 to 65 years.
- Trial name
- NCT04886518
- Testing
- Pitolisant Oral Tablet
- Where
- 13 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Harmony Biosciences Management, Inc.
Facioscapulohumeral Muscular Dystrophy, Limb Girdle Muscular Dystrophy
Study to Evaluate the Long-Term Safety, Tolerability, and Biological Activity of ATYR1940 in Participants With Limb Girdle and Facioscapulohumeral Muscular Dystrophy (FSHD)
ATYR1940-C-006 is a multi-national, multicenter study being conducted at centers in the United States (US) and Europe who participated in Study ATYR1940-C-003 (Stage 1 only) or Study ATYR1940-C-004 (that is, the parent studies).
- Trial name
- FSHD (NCT02836418)
- Testing
- ATYR1940
- Where
- 5 sites in United States, Denmark and 1 more
- Volunteers
- 8 people
- Sponsor
- aTyr Pharma, Inc.
Trigger Finger
Function and Scar in Trigger Finger Release
Trigger finger is a common upper limb impairment associated with a significant decrease in quality of life, hand dexterity and strength as well as increased pain while complying daily activities of living.
- Trial name
- NCT05477290
- Testing
- Trigger Finger Release through Transverse Incision, Trigger Finger Release through Oblique Incision, Trigger Finger Release through Vertical Incision
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- McMaster University
Temporomandibular Joint Disorders, Facial Pain
Efficacy of Combining Low-Level Laser Therapy With a Self-Management Program on Myalgia in Temporomandibular Disorders
The purpose of this study is to evaluate the efficacy of combining low-level laser therapy and the self-management program for patients with temporomandibular joint disorders using a randomized controlled design.
- Trial name
- LASER-SM (NCT06419738)
- Testing
- Self-Management Program, Low level laser therapy combined with Self-Management Program, Occlusal Splint combined with Self-Management Program
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- Hanoi Medical University
Mental Fatigue, Fatigue
Effect of Ginko and Cistanche Against Fatigue Symptoms
To evaluate the efficacy of Nutrilite® ginkgo biloba cistanche tablets in relieving the symptoms of chronic fatigue syndrome(CFS), the investigators randomly recruit189 subjects with CFS, aged 35-60 yrs.
- Conditions
- Mental Fatigue, Fatigue, Chronic Fatigue Syndrome
- Trial name
- GkoCist (NCT02807649)
- Testing
- Experimental: Nutrilite® Low dose, Experimental: Nutrilite® High dose
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Musculoskeletal Pain
Pain Catastrophizing as a Cause for Systemic Inflammation
Research shows that the immune system is involved in chronic pain. The immune system is involved in the process of inflammation.
- Trial name
- NCT00823147
- Testing
- Pain Catastrophizing Induction
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Beth Darnall, PhD
Dry Needling, Soreness, Muscle
Physiotherapy in the Reduction of Post-needling Soreness
Dry needling is a minimally invasive technique which generates good results and neuromuscular benefits. Its application involves a highly prevalent effect called post-needling soreness.
- Conditions
- Dry Needling, Soreness, Muscle, Trigger Point Pain, Myofascial
- Trial name
- NCT04695548
- Testing
- Concentric contraction exercise, Isometric contraction exercise, Eccentric contraction exercise
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Alcala
Fibromyalgia
Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia
The purpose of this study is to evaluate the durability of effect of milnacipran for the treatment of fibromyalgia in patients receiving long-term milnacipran treatment and to characterize the effects of milnacipran on multiple…
- Trial name
- NCT01014585
- Testing
- Milnacipran
- Where
- 58 sites in United States
- Volunteers
- 340 people
- Sponsor
- Forest Laboratories
Cerebral Palsy, Spasticity
Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy
The aim of our work is to investigate whether electrical Lateral Cord Stimulation (LCS) causes an inhibitory and modulatory action by indirect cerebellar activation, so releasing spasticity and the spastic syndrome in selected…
- Trial name
- Andreani1 (NCT02199015)
- Testing
- Lateral spinal cord surgical implant of electrodes
- Where
- 2 sites in Argentina, Germany
- Volunteers
- 40 people
- Sponsor
- Juan Carlos M. Andreani MD
Systemic Sclerosis, Diaphragm Defect
Muscular Respiratory Involvement and Systemic Sclerosis
Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors.
- Conditions
- Systemic Sclerosis, Diaphragm Defect, Respiratory Insufficiency, Pulmonary Function Test
- Trial name
- SIROCO (NCT04118725)
- Testing
- Pulmonary function test
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Poitiers University Hospital
Low Back Pain, Headache
Pain Quality Study
One way to better understand how various treatments for pain differ is to determine the effects of these treatments on different pain qualities or characteristics.
- Conditions
- Low Back Pain, Headache, Fibromyalgia
- Trial name
- NCT01321190
- Where
- United States
- Volunteers
- 307 people
- Sponsor
- University of Washington
Rotator Cuff Tears, Tendon Thickening
Perianchor Cyst Formation, Tendon Healing, and Clinical Outcomes Following Arthroscopic Rotator Cuff Repair
Perianchor cyst formation is frequently observed after arthroscopic rotator cuff repair; however, its clinical significance remains unclear.
- Conditions
- Rotator Cuff Tears, Tendon Thickening, Tendon Injuries, Muscle Weakness
- Trial name
- NCT07661680
- Testing
- MRI
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Fibromyalgia
Cefaly® Device in the Treatment of Patients With Fibromyalgia.
The objective of this pilot open trial was to assess the efficacy and safety of external trigeminal nerve stimulation (e-TNS) with the Cefaly® device in fibromyalgia.
- Trial name
- NCT02546362
- Testing
- Cefaly
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cefaly Technology
Critical Illness, Muscle Weakness
Progressive Mobility Program and Technology to Improve the Level of Physical Activity and Functionality of ICU Patients
The purpose of this study is to verify if a protocol of early and progressive mobility which includes the use of technology is able to increase the level of physical activity and improve functionality and respiratory and muscular…
- Trial name
- NCT02889146
- Testing
- Conventional Physical Therapy, Early and progressive mobilization program, Respiratory therapy
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Sao Paulo General Hospital
Subacromial Impingement Syndrome, Musculoskeletal Diseases
Comparison of Two Different Treatment Methods
A number of previous studies investigated the effects of kinesiotaping (KT) in subacromial impingement syndrome (SIS).
- Conditions
- Subacromial Impingement Syndrome, Musculoskeletal Diseases, Musculoskeletal Injury, Musculoskeletal Pain
- Trial name
- NCT05071469
- Testing
- Kinesiotaping, Mulligan Mobilization Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Banu BAYAR
Fibromyalgia, Autonomic Dysfunction
Association Between Autonomic Dysfunction and Choroidal Vascularity Index in Fibromyalgia
Fibromyalgia is frequently accompanied by autonomic nervous system dysfunction, often characterized by sympathetic predominance.
- Trial name
- NCT07345546
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Lateral Epicondylitis, Tennis Elbow
Efficacy of Vitamin C Supplement vs Spinal Manipulation to Treatment in Lateral Epicondylitis
A randomized clinical trial will be conducted. 130 subjects diagnosed with lateral epicondylitis will be studied. 3 intervention groups will be formed.
- Trial name
- NCT04445727
- Testing
- Vitamin C, spinal manipulation, Transcutaneous electrical nerve stimulation (TENS)
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Universidad Rey Juan Carlos
Carpal Tunnel Syndrome, Trigger Finger
Wound Closure Study in Carpal Tunnel and Trigger Finger Surgery
Does a difference in patient satisfaction and cosmetic outcome exist between wound closure with absorbable or non-absorbable sutures.
- Trial name
- NCT03781141
- Testing
- Wound closure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Fibromyalgia, Secondary
Work-Related Fibromyalgia
The research is about fibromyalgia prevalency in working population and searching work-related fibromyalgia.
- Trial name
- NCT03535454
- Testing
- working hours
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Spasticity
Adult Subjects Suffering From Lower Limb Spasticity Following Stroke
The purpose of the protocol is to assess the responder rate as defined by the achievement of the primary goal from the Goal Attainment Scale following one botulinum toxin type-A (BoNT-A) injection cycle in accordance with routine…
- Trial name
- VALGAS (NCT01444794)
- Where
- 24 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Ipsen
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