Clinical trials: Myopathy
Duchenne Muscular Dystrophy
Safety and Efficacy of KER-065 in Participants With Duchenne Muscular Dystrophy
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of KER-065 administered to adult and pediatric ambulatory and nonambulatory male participants with…
- Trial name
- NCT07704099
- Testing
- KER-065
- Where
- 2 sites in New Zealand
- Volunteers
- 36 people
- Sponsor
- Keros Therapeutics, Inc.
Muscle Weakness
Mitigating Neural Hypoexcitability and Weakness During Disuse in Women
Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in…
- Trial name
- MiND (NCT07166198)
- Testing
- Wrist immobilization, Resistance training, Resistance training rehabilitation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Muscle Weakness, Anesthesia
The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response
The effect of surgery, in contrary to critical illness, on muscle weakness hasn't been thoroughly investigated. Recent data suggest that elective surgery may also induce muscle weakness.
- Conditions
- Muscle Weakness, Anesthesia, Anesthesia, Local, Surgery
- Trial name
- MUSCLE (NCT03600454)
- Testing
- General anesthesia, Spinal anesthesia, General anesthesia and epidural analgesia
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Ziekenhuis Oost-Limburg
Amyotrophic Lateral Sclerosis
Neuromuscular Magnetic Stimulation in ALS Patients
Aim of the study is to verify whether neuromuscular magnetic stimulation can improve muscle function in spinal-onset Amyotrophic Lateral Sclerosis (ALS) patients.
- Trial name
- NMS-ALS (NCT03618966)
- Testing
- Neuromuscular magnetic stimulation (NMMS)
- Volunteers
- 22 people
- Sponsor
- University of Roma La Sapienza
Impacted Third Molar Tooth, Temporomandibular Joint Dysfunction Syndrome
Feasibility Testing of a New Way to Support the Jaw During 3rd Molar Extractions
Cross sectional observational study to assess the feasibility of using the functional prototype of the restful jaw support device to support the jaw when extracting mandibular 3rd molars using moderate/deep sedation.
- Trial name
- NCT03512769
- Testing
- Restful Jaw Device
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Osgood-Schlatter Disease
Effectiveness of Dextrose Injection for Osgood-Schlatter Disease
Objective: To examine the potential of dextrose injection versus lidocaine injection versus supervised usual care to change pain/function/activity levels in adolescent athletes with Osgood-Schlatter Disease (OSD).
- Trial name
- NCT01300754
- Testing
- Dextrose Injection, Lidocaine Injection, Usual Care
- Where
- Argentina
- Volunteers
- 54 people
- Sponsor
- Universidad Nacional de Rosario
Musculoskeletal Pain, Osteoarthritis
Clinical Outcomes of Autologous Bone Marrow Aspirate Concentrate Injections for Musculoskeletal Conditions
The use of Bone Marrow Autologous Collection (BMAC) in musculoskeletal conditions including osteoarthritis and tendon injuries has been growing. Outcome evidence continues to be sparse.
- Conditions
- Musculoskeletal Pain, Osteoarthritis, Tendinopathy, Sprains Strain
- Trial name
- NCT02981394
- Testing
- Bone Marrow Aspirate Concentrate Injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Idiopathic Inflammatory Myositis (IIM), DERMATOMYOSITIS OR POLYMYOSITIS
Safety and Efficacy of ULSC on Disease Severity and Steroid Tapering in Participants With Dermatomyositis/ Polymyositis (DM/PM), Also Known as Idiopathic Inflammatory Myopathy (IIM)
The goal of this clinical trial is to learn about how an umbilical cord lining-derived stem cell (ULSC) product performs when treating Dermatomyositis/Polymyositis (DM/PM), also known as idiopathic inflammatory myopathy (IIM) in…
- Trial name
- IIMPACT (NCT07160205)
- Testing
- ULSC (1.5 x 10^8 cells/dose)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Restem, LLC.
Fibromyalgia
Anti-inflammatory Nutritional Intervention in Patients With Fibromyalgia
This is a randomized clinical trial, aimed to analyse the effects of a potentially anti-inflammatory nutritional intervention in disease assessment parameters, inflammatory markers, and quality of life of Fibromyalgia patients.
- Trial name
- NCT04007705
- Testing
- Anti-inflammatory and low FODMAPs diet, General healthy eating
- Where
- Portugal
- Volunteers
- 46 people
- Sponsor
- Universidade do Porto
Lateral Epicondylitis
Comparison of the Efficacy of Dextrose Prolotherapy and Mesotherapy in Lateral Epicondylitis
A total of 84 patients with lateral epicondylitis were included in the study. The patients were randomly assigned to 3 treatment groups: mesotherapy (n = 28), prolotherapy (n = 28), and control (n = 28).
- Trial name
- NCT06538194
- Testing
- Mesotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Polyostotic Fibrous Dysplasia
Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome
This study will investigate how a gene mutation (change in DNA) causes the abnormal bone in fibrous dysplasia-a condition in which areas of normal bone are replaced with a fibrous growth similar to a scar.
- Trial name
- NCT00001973
- Where
- United States
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Temporomandibular Joint Disorders, Pain
A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders
Temporomandibular disorders (TMD) are one of the most important Public Health issues in the world and its incidence has increased over the years.
- Trial name
- NCT05272488
- Testing
- Manual therapy and vagus nerve stimulation, Manual therapy
- Where
- 3 sites in Spain
- Volunteers
- 60 people
- Sponsor
- University of Alcala
Muscle Atrophy, Muscle Weakness
Evaluating Muscle Function After Ankle Surgery
Patients who are forced to rest or reduce activity as a result of illness, injury, or surgery often experience resulting muscle weakness.
- Conditions
- Muscle Atrophy, Muscle Weakness, Fractures
- Trial name
- NCT00060970
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Temporomandibular Joint Dysfunction Syndrome, Pain, Face
Effects of Low-Level Laser Therapy on Mouth Opening and Surface Electromyography in Temporomandibular Disorders
This is a one year followup study that aims to assess the efficacy of low level laser therapy (LLLT) on pain, mouth opening and masticatory muscle activity in cases of temporomandibular dysfunction (TMD) as compared to soft…
- Trial name
- NCT04831346
- Testing
- Low level laser, Soft occlusive splint
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Spinal Cord Injuries, Neurological Injury
Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning
The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity…
- Conditions
- Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
- Trial name
- NCT05094362
- Testing
- Spinal Reflex Operant Down Conditioning
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Myofascial Pain Syndromes, Cancer
Efficacy of Myofascial Pain Syndrome Treatment in Patients With Cancer in Palliative Care
Palliative Care is active holistic care offered to people who are in intense suffering related to their health, resulting from a serious life-threatening illness, with a focus on improving the quality of life.
- Trial name
- NCT04703803
- Testing
- 1% lidocaine injection in trigger points
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Spasticity Post Stroke
Spinal Cord Stimulation for Poststroke Spasticity
The goal of this clinical trial is to learn whether spinal cord stimulation (SCS) is effective in treating post-stroke spasticity in adults. It will also evaluate the safety of the implanted SCS system.
- Trial name
- SCS-PSS (NCT07744659)
- Testing
- Active spinal cord stimulation
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Elbow Tendinopathy, Ankle Sprains
Hyaluronic Acid for Soft Tissue Injuries
Soft Tissue Adapted Biocompatible Hyaluronic Acid, or STABHA™, has demonstrated varying degrees efficacy in patients treated for common musculoskeletal tendinopathies and ligament injuries, such as ankle sprains, lateral elbow…
- Trial name
- SAFE (NCT05278897)
- Testing
- Soft Tissue Adapted Biocompatible Hyaluronic Acid
- Volunteers
- 200 people
- Sponsor
- Global Research Solutions
Sarcopenia, Gait Disorders in Old Age
A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT)
The main objective of the study is to evaluate the effect of two daily doses of BIO101 versus placebo on mobility function as measured by gait speed using the 400MW test.
- Conditions
- Sarcopenia, Gait Disorders in Old Age, Muscle Weakness
- Trial name
- SARA-INT (NCT03452488)
- Testing
- BIO101
- Where
- 22 sites in United States, Belgium
- Volunteers
- 233 people
- Sponsor
- Biophytis
Fibromyalgia
Clinical Outcomes After Dry Needling on Cervical Muscles, and Quality of Life, in Patients With Fibromyalgia Syndrome.
Objectives: The purpose of the current randomized clinical trial is to compare the effectiveness of dry needling versus myofascial release therapy on myofascial trigger points (MTrPs) in cervical muscles, quality of life…
- Trial name
- NCT03015662
- Testing
- Dry Needling Therapy, Myofascial Release Therapy
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Universidad de Almeria