Clinical trials: Myopia; Refractive Error, open to volunteers
Myopic Choroidal Neovascularisation, Anti-VEGF Treatment
The Treatment Burden of Myopic Choroidal Neovascularization
Pathologic myopia (PM) is characterized by progressive eye elongation associated with degenerative changes in the retinal and choroidal tissue.
- Conditions
- Myopic Choroidal Neovascularisation, Anti-VEGF Treatment, Burden
- Trial name
- mCNV burden (NCT07009574)
- Testing
- anti-VEGF intravitreal treatment in patients affected by myopic choroidal neovascularization
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Policlinico Gaspare Rodolico - San Marco Catania
Myopia, High Myopia
Clinical Results of Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia
Small Incision Lenticule Extraction (SMILE) was introduced in 2011 using the VISUMAX femtosecond laser (Carl Zeiss Meditec, Jena, Germany). It is designed for correction of myopia and myopic astigmatism.
- Trial name
- NCT04110067
- Testing
- Small Incision Lenticule Extraction (SMILE) with Visumax (Carl Zeiss Meditec, Jena)
- Where
- Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Suphi Taneri
Myopia
Myopia Control Using Novel Soft Contact Lenses
The goal of this study is to investigate the myopic control efficacy of two study soft contact lenses in children. Participants will be prescribed Lens A, Lens B or single vision contact lenses for the first year.
- Trial name
- NCT07547085
- Testing
- Lens A, Lens B
- Where
- Hong Kong
- Volunteers
- 126 people
- Sponsor
- The Hong Kong Polytechnic University
Myopia, Pre-myopia
Early-Onset Myopia Intervention Project
The prevalence of myopia among children has been increasing year by year, which has become a globle public health issue. Studies have shown that defocusing lenses and atroping eyedrops can control the progression of myopia, but…
- Trial name
- EOM (NCT07176949)
- Testing
- 0.01% atropine eye drops, 0.05% atropine eye drops, Spectacle lenses with highly aspherical lenslets
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia
Multicenter Evaluation of Near Vision and Outdoor Time in Kids Study
Currently, optical and pharmacological interventions have been developed to prevent the progression of childhood myopia. However, no myopia control strategy has been shown to have complete efficacy in controlling myopia…
- Trial name
- MENOK (NCT06119243)
- Testing
- Vivior
- Where
- 5 sites in United States, Australia
- Volunteers
- 230 people
- Sponsor
- The University of New South Wales
Myopia, Anisometropia
Assessing the Magnitude of Anisometropia in Patients Wearing Misight 1 Day Contact Lens
The effectiveness of Misight 1 Day Contact Lens in retarding anisometropic progression has not been investigated before. This study is aimed to elucidate the efficacy of Misight 1 Day Contact Lens for anisometropia control.
- Trial name
- NCT06744478
- Testing
- Misight 1 Day Contact Lens
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Cataract, High Myopia
Artificial Intelligence for Highly Myopic Cataract
This study aims to establish a multi-center artificial intelligence model for the accurate calculation of intraocular lens and its clinical application in highly myopic cataract, so as to improve the accuracy of the prediction of…
- Conditions
- Cataract, High Myopia, Myopia, Automatic Judgement
- Trial name
- AI-HMC (NCT06616506)
- Testing
- newly-invented AI model
- Where
- China
- Volunteers
- 500,000 people
- Sponsor
- Shanghai High Myopia Study Group
Myopia
Study on Safety and Efficacy of Focused LED-Based Red-Light Therapy in Myopic Adults
This research project is a prospective, single-arm, open-label pilot study designed to evaluate the efficacy and safety of focused LED-based repeated low-level red-light (fLED-RLRL) therapy in myopic adults.
- Trial name
- NCT07369804
- Testing
- fLED-based red-light therapy
- Where
- China
- Volunteers
- 14 people
- Sponsor
- The Hong Kong Polytechnic University
Progressive Myopia, Pediatric Myopia
Efficacy of Different Interventions for Progressive Myopia After Orthokeratology Lens Wear
Myopia has emerged as a significant concern impacting the visual health of children and adolescents on a global scale. According to research conducted by Holden BA et al., it is projected that by the year 2050, the worldwide…
- Conditions
- Progressive Myopia, Pediatric Myopia, Orthokeratology-related Myopia Progression
- Trial name
- NCT07494799
- Testing
- OK Lens Continuation Group, OK Lens + 0.01% Atropine Group, OK Lens with Reduced Optical Zone Group
- Volunteers
- 3,890 people
- Sponsor
- Tianjin Medical University Eye Hospital
Myopia
Using Contact Lenses and Spectacle Lenses as Myopia Interventions.
Effect of alternating contact lenses and spectacles for myopia control.
- Trial name
- NCT07845721
- Testing
- Test Spectacle Lens & Contact Lens, Control Spectacle Lens & Contact Lens
- Where
- 2 sites in Canada, United Kingdom
- Volunteers
- 58 people
- Sponsor
- CooperVision International Limited (CVIL)
Myopia
Effect of MyopiaEd Messaging on Improving Eye-use Behavior and Myopia Control Among Primary School Students in China
Myopia represents a significant global public health challenge, with China experiencing particularly high myopia prevalence among children and adolescents.
- Trial name
- NCT07211893
- Testing
- Send myopia-related health education message
- Volunteers
- 1,330 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia
Safety and Efficacy Study of A Viscoelastic-free Method for Implantable Collamer Lens (ICL) Implantation
This study evaluates the safety and efficacy of a viscoelastic-free method for Implantable Collamer Lens(ICL) implantation to treat high myopia.
- Trial name
- NCT03059043
- Testing
- viscoelastic-free implantation system, standard viscoelastic-assisted Implantation system
- Where
- 5 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Myopia, Ear Acupressure Pellets
Effects of Auricular Point Pressing With Pellets in Children With Insufficient Hyperopia Reserve
This project aims to address the trend of early onset and high myopia among children in China by focusing on insufficient hyperopia reserve, a key early warning indicator for myopia.
- Conditions
- Myopia, Ear Acupressure Pellets, Hyperopia Reserve, Low-concentration Atropine Eye Drops
- Trial name
- NCT07475585
- Testing
- Ear acupoint pressure pellet intervention group, Atropine intervention group, Joint intervention Group
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Myopia
Evaluation of the Efficacy of Red Light in Adult Patients With High and Extreme Myopia
This study, led by Jie ying from the Ophthalmology Department of Beijing Tongren Hospital Affiliated to Capital Medical University, is a researcher-initiated clinical trial (IIT) designed to evaluate the therapeutic efficacy of…
- Trial name
- NCT07412678
- Testing
- Red light, Single vision spectacle lenses
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Beijing Tongren Hospital
Myopia
Pharmacological and Non-pharmacological Treatment Effects on Children With Different Predicted Myopia Progression Rate
The goal of this clinical trial is to compare pharmacological and non-pharmacological treatment effects on the children with different predicted myopia progression rate measured by modified multifocal electroretinogram.
- Trial name
- NCT06282848
- Testing
- Atropine 0.05%, DIMS lens
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Blindness,Visual Impairment, Refractive Error, Cataract, High Myopia, Aging
Shanghai Eye Study for Adults
Blindness and visual impairment severely impact the visual health and life quality of people, particularly the 2.566 million senior citizens aged at 65 and above in Shanghai.
- Trial name
- SESA (NCT03455478)
- Testing
- spectacles
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Refractive Errors
School-based Myopia Prevention Trial for Children With Adequate Hyperopic Reserve
This is a prospective, school-based randomized controlled trial designed to evaluate a wearable device-supported outdoor activity program for myopia prevention in primary school students with adequate hyperopic reserve.
- Conditions
- Myopia, Refractive Errors, Hyperopia
- Trial name
- SPARK (NCT07746752)
- Testing
- Wearable Device-Supported Myopia Prevention Program, Eye Health Education
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Moderate, Myopic Astigmatism
A Prospective, Randomized Clinical Study of Two Phakic Toric Implantable Lenses
Primary Objective: To compare the efficacy and the residual refractive error of EYECRYLTM Phakic toric versus Visian® Toric ICL in moderate to high myopic patient with co-existing astigmatism.
- Conditions
- Myopia, Moderate, Myopic Astigmatism, Myopia, Degenerative
- Trial name
- NCT06839898
- Testing
- EYECRYLTM Phakic Toric Intraocular Lens Treatment Arm, Visian® Toric ICL Treatment Arm
- Where
- 4 sites in Germany, India
- Volunteers
- 172 people
- Sponsor
- Biotech Healthcare Holding Gmbh
Myopia, High-Grade, Myopia; Refractive Error
AOSLO-Based Precise Measurement of Retinal Hemodynamics: Development and Application Assessment
Changes in retinal hemodynamics play a key role in the development of various eye diseases. Currently, mainstream hemodynamic evaluation techniques have low resolution and poor measurement accuracy, limiting their widespread…
- Trial name
- NCT07051317
- Volunteers
- 120 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myopia Progressing
Clinical Efficacy and Mechanism Exploration of MR-61 in Delaying the Progression of Myopia
To investigate whether probiotic MR-61 can assist in slowing down the progression rate of myopia (a prospective randomized controlled study).
- Trial name
- NCT07298824
- Testing
- Investigational Bifidobacterium Preparation MR-61
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital of Nanchang University