Clinical trials: NAD
Covid19, Stage 1 Acute Kidney Injury
Phase 2a MIB-626 vs. Placebo COVID-19
The proposed phase 2a trial will determine whether MIB-626 treatment in adults with COVID-19 infection and stage 1 acute kidney injury is more efficacious than placebo in preventing worsening of kidney function, as assessed by…
- Trial name
- NCT05038488
- Testing
- MIB-626, Home Treatment
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Metro International Biotech, LLC
Multiple Sclerosis
31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.
REPAIR-MS is a single-center open label, sequential group, investigator and patient blinded study to assess the CNS metabolic effects, safety, pharmacokinetics, and pharmacodynamics of CNM-Au8 in patients who have been diagnosed…
- Trial name
- REPAIR-MS (NCT03993171)
- Testing
- gold nanocrystals
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Clene Nanomedicine
Healthy Adults
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
We are doing this research to learn how healthy younger and older adults use two forms of vitamin B3-called nicotinamide mononucleotide (NMN) and nicotinamide (NAM)-to make NAD+.
- Trial name
- NCT06882096
- Testing
- Nicotinamide Mononucleotide (NMN), Nicotinamide (NAM)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Metro International Biotech, LLC
Metabolic Syndrome, Premature Aging
The Safety and Efficacy Study of RiaGev in Healthy Adults
This current randomized, double-blind, comparator-controlled, cross over study investigates the efficacy and safety of RiaGev™ via evaluation of NAD+, ATP, glucose, insulin, glutathione, and cortisol levels in healthy adults of…
- Trial name
- NCT04483011
- Testing
- RiaGev
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bioenergy Life Science, Inc.
Health Adult Subjects, Healthy Participants
Renewal-NAD+: A Study of Oral NAD+ and Its Multi-omic Impact in a Healthy Cohort
The goal of this 5 day interventional study was to investigate the effects on multiple biological molecules (multi-omics) of Bryleos's commercially available oral LathMized™ Nicotinamide adenine dinucleotide (LNAD+) supplement in…
- Trial name
- Renewal-NAD+ (NCT07336836)
- Testing
- LathMized TM NAD+ (LNAD+)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BioNADrx Holdings, Inc. Bryleos
Healthy Adult
Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement
The objective of this study is to evaluate nicotinamide adenine dinucleotide (NAD+) in response to a proprietary nutritional supplement in generally healthy adults, compared to placebo.
- Trial name
- NCT07428889
- Testing
- Proprietary Nutritional Supplement
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Shaklee Corporation
Healthy
Effect of Oral NAD+ Precursors Administration on Blood NAD+ Concentration in Healthy Adults
Nicotinamide adenine dinucleotide (NAD) is a coenzyme playing a central role in human metabolic pathways. A recognized approach to increase NAD level is through oral supplementation of its precursors promoting NAD synthesis in…
- Trial name
- NCT05517122
- Testing
- Nicotinamide (NAM), Nicotinamide Riboside (NR), Nicotinamide Mono Nucleotide (NMN)
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Covid19, Long COVID-19
Pilot Study Into LDN and NAD+ for Treatment of Patients With Post-COVID-19 Syndrome
Pilot study into low dose naltrexone (LDN) and NAD+ for treatment of patients with post-COVID-19 syndrome.
- Conditions
- Covid19, Long COVID-19, Post-COVID-19 Syndrome
- Trial name
- NCT04604704
- Testing
- Naltrexone, NAD+
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- AgelessRx
Epigenetics
Biomarker Study to Evaluate Correlations Between Epigenetic Aging and NAD+ Levels in Healthy Volunteers
This is a single center, prospective study to evaluate correlations between epigenetic aging (as measured via DNA methylation) and NAD+ levels in healthy volunteers.
- Trial name
- NCT04220658
- Testing
- Biomarker study
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Chronic Kidney Diseases, Acute Kidney Injury
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression
Chronic kidney disease CKD is estimated to affect nearly over 800 million people globally today (with roughly 125,000 people ending up annually on dialysis in the United States alone.
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Kidney Failure
- Trial name
- NAD agent (NCT06866236)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Ebima Clifford Okundaye
NAD+ Levels in the Blood
Effectiveness of Qualia NAD+ Supplementation on Intracellular NAD Levels
The goal of this clinical trial is to determine if Qualia NAD+ effectively increases NAD+ levels in the blood and to evaluate its safety.
- Trial name
- NCT06505967
- Testing
- Qualia NAD+
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Increase in Blood Levels of Nicotinamide Adenine Dinucleotide (NAD+)
Open-label Study to Assess Increasing Levels of NAD+(Nicotinamide Adenine Dinucleotide)
The purpose of this study is to assess an effective single oral supplement or combination of oral supplements for increasing whole blood NAD+ levels.
- Trial name
- NCT03707652
- Testing
- Oral supplement A, Oral supplement B, Oral supplement C
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
NAD
Method Optimization for the Quantification of the NAD
Method optimization for the quantification of the NAD metabolome in human whole blood, and evaluation of baseline inter and intra-subject variability.
- Trial name
- NCT05561712
- Testing
- Laboratory method validation
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
T2DM (Type 2 Diabetes Mellitus)
The Efficacy Nad Safety of DWP16001 Compared to Active Drug in the Treatment of Type 2 Diabetes Mellitus
The purpose of this study is to determine the efficacy and safety of DWP16001 compared to active drug in the treatment of type 2 diabetes mellitus.
- Trial name
- NCT04654390
- Testing
- DWP16001 Amg
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
NAD+ Bioavailability, NAD+ Safety
A Clinical Trial to Assess the Absorption, Safety, and Efficacy of an Oral Nicotinamide Adenine Dinucleotide (NAD+) Supplement in Healthy Adults
The goal of this clinical trial is to assess the absorption, safety, and efficacy of an NAD+ supplement in healthy adults. The main question it aims to answer is: What is the change in NAD+ levels in whole blood from baseline to…
- Conditions
- NAD+ Bioavailability, NAD+ Safety, NAD+ Efficacy
- Trial name
- NCT07692633
- Testing
- NAD+
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Reus Research
Healthy Adults
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults
This is a single center, open label (i.e. participants and study staff will not be masked to the intervention) single ascending dose study to evaluate the safety, tolerability, pharmaokinetics and pharmacodynamics of MIB-725 in…
- Trial name
- NCT06815991
- Testing
- MIB-725
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Metro International Biotech, LLC
NAD, NAD+ Levels in the Blood
Comparison of Three Qualia NAD⁺ Formulations on Intracellular NAD⁺ Levels
This is a double-blind, placebo-controlled, parallel-group study evaluating the effects of three distinct Qualia NAD⁺ formulations on intracellular NAD⁺ levels in healthy adults aged 35-75 years.
- Trial name
- NCT07132801
- Testing
- Qualia NAD⁺ version 1, Qualia NAD⁺ version 2, Qualia NAD⁺ version 3
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Skin Aging on Face, Skin Care Dermocosmetics
Efficacy of Topical Niacinamide Riboside on the Signs of Facial Skin Aging
Niacinamide riboside (topical NR, also known as nicotinamide riboside) is an endogenous compound and a precursor (building block) to the essential cellular co-enzyme, nicotinamide adenine dinucleotide (NAD+).
- Conditions
- Skin Aging on Face, Skin Care Dermocosmetics, Skin Care, Fine Lines and Wrinkles
- Trial name
- NR-RADIANCE (NCT07774000)
- Testing
- Topical niacinamide riboside
- Where
- South Africa
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- ChromaDex, Inc.
Intracellular NAD+ Levels
Effectiveness of Qualia NAD+ Supplementation on NAD Levels
The current study is designed as a double-blind placebo-controlled parallel trial. It aims to investigate the efficacy of Qualia NAD+ on intracellular NAD levels in blood samples (primary outcomes) and health-related quality of…
- Trial name
- NCT06812416
- Testing
- Qualia NAD+
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Healthspan Improvement, Aging
Combination Gerotherapeutic Interventions for Healthspan Improvement
This study is a 90-day interventional, randomized, controlled pilot trial exploring multi-modal gerotherapies and their impact on longevity-related outcomes.
- Conditions
- Healthspan Improvement, Aging, Longevity
- Trial name
- NCT07475546
- Testing
- Rapamycin, Naltrexone, Metformin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AgelessRx