Clinical trials: NASAL SURGICAL PROCEDURES
Sinusitis, Chronic Sinusitis
Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery
This study will compare the incidence of post-op infection after sinus surgery using conventional post-op oral antibiotics to the incidence of infection after sinus surgery when a bio-resorbable antibiotic soaked nasal sponge is…
- Trial name
- NCT00705354
- Testing
- Bacitracin, Nasopore sponge soaked with saline
- Where
- United States
- Sponsor
- Lahey Clinic
Chronic Rhinosinusitis, Intraoperative Bleeding
Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy
Functional endoscopic sinus surgery (FESS), or sinusoscopy, is a standard surgical procedure used to treat chronic rhinosinusitis and other conditions of the nasal sinuses.
- Conditions
- Chronic Rhinosinusitis, Intraoperative Bleeding, Blood Loss, Surgical
- Trial name
- NCT07866274
- Testing
- Ascorbic acid
- Volunteers
- 78 people
- Sponsor
- Assiut University
Polyp of Ethmoidal Sinus, Surgery
RESPIMER® Netiflow® vs. Saline Solutions During Nasal Irrigation Following Bilateral Ethmoidectomy (Nasal Polyposis)
The main objective of this study is to compare the effects of RESPIMER® NetiFlow® solution and device versus saline solution (0.9% NaCl), the standard treatment, used with RESPIMER® NetiFlow® device, both used postoperative care…
- Trial name
- NETIFLOW (NCT02559284)
- Testing
- A postoperative care after ethmoid sinus surgery
- Where
- 8 sites in France
- Volunteers
- 189 people
- Sponsor
- Laboratoire de la Mer
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Surgical Site Infections, Surgical Wound Infection
Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections
This is a Phase 3 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major…
- Conditions
- Surgical Site Infections, Surgical Wound Infection, Infections, Anti-Infective Agents
- Trial name
- LANTERN (NCT06702878)
- Testing
- nasal antimicrobial photodisinfection therapy
- Where
- 14 sites in United States
- Volunteers
- 4,787 people
- Sponsor
- Ondine Biomedical Inc.
Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps
Comparison of Laryngeal Mask and Tracheal Intubation With and Without Topical Lidocaine Application
The study aims to identify the advantages and disadvantages of each of the three methods of airway management during FESS.
- Conditions
- Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps, Deviated Nasal Septum, Osteoma of the Paranasal Sinuses
- Trial name
- NCT07548866
- Testing
- anesthesia of the respiratory tract with lidocaine, tracheal intubation, laryngeal mask placement
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Cardiac Surgery
High Flow Nasal Oxygen Therapy (Optiflow™) in High-risk Cardiac Surgical Patients
Background: High risk patients with lung disease who undergo cardiac surgery are at significant risk of postoperative complications leading to prolonged hospital stay.
- Trial name
- NCT02496923
- Testing
- High flow nasal oxygen therapy (Optiflow™), Standard oxygen therapy (Hudson Type face mask or nasal prongs)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Postoperative Pain
Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries.
Efficacy of fentanyl soaked nasal packs on postoperative pain in nasal surgeries.
- Trial name
- NCT06531759
- Testing
- Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University
OSA
Efficacy of HFNC as an Alternative to CPAP Therapy in Surgical Patients With Suspected Moderate to Severe OSA
High flow, humidified, temperature-regulated nasal insufflation is not a new concept. It is used widely in the treatment of hypoxaemic respiratory failure in critically ill patients, as an alternative to non-invasive positive…
- Trial name
- NCT05075668
- Testing
- CPAP face mask, High flow nasal cannula (HFNC)
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Changi General Hospital
Nasal Polyps
Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS
This study aimed to show the effect of sphinopalatine ganglion blockade on surgical field, hemodynamics and postoperative pain in FEES operation.
- Trial name
- NCT04996576
- Testing
- infrazygomatic approach sphinopalatine ganglion block, intranasal injection approach of sphinopalatine ganglion block
- Where
- 2 sites in Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Endoscopic Ultrasound
Comparison of Oxygenation Between Nasal PAP vs Nasal During Propofol-based Sedation for EUS
Randomized controlled single site study involves oxygenation, continuous positive airway pressure, and ventilation of subject via nasal mask and oxygenationvia closed facemask.
- Trial name
- SuperNo2VA (NCT04306211)
- Testing
- SuperNO2VA
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Indiana University
Chronic Rhinitis, Inflammation of the Nasal Mucosa
Surgical Reduction of the Inferior Turbinates for Nasal Obstruction
The primary goal of this post-marketing surveillance study is to assess whether surgical turbinate reduction performed using a Coblation® device is associated with reduced nasal obstruction symptoms.
- Conditions
- Chronic Rhinitis, Inflammation of the Nasal Mucosa, Inflammation of Nasal Tissue
- Trial name
- NCT00737906
- Testing
- Surgical turbinate reduction procedure
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- ArthroCare Corporation
Chronic Rhinosinusitis (Diagnosis), Surgery
A Study of Different Endoscopic Surgery Procedures in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
CRS remains a common challenging clinical entity due to variable phenotypes with different underlying mechanisms that lead to persistence or recurrence polyps.
- Trial name
- NCT03878355
- Testing
- radical endoscopic sinus surgery (RESS) plus Draf 3 surgery., radical endoscopic sinus surgery (RESS), functional endoscopic sinus surgery (FESS)
- Volunteers
- 27 people
- Sponsor
- Beijing Tongren Hospital
Shellfish Hypersensitivity, Epistaxis
NOVAPAK Nasal Packing in Shellfish Allergic Patients
NOVAPAK is a sponge-like material made from materials found in shellfish. It is commonly used after nasal surgery or in nasal bleeding, as it promotes healing, decreases bleeding, and has antibacterial properties.
- Trial name
- NCT05343650
- Testing
- NOVAPAK nasal packing applied to forearm, NOVAPAK nasal packing applied to nasal cavity
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Surgery, Hypoventilation
A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques
The estimation of the partial pressure of carbon dioxide (PCO2) in the arterial blood is used to judge the adequacy of ventilation during spontaneous and controlled ventilation.
- Trial name
- NCT00954733
- Testing
- Arterial blood draw
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Patellofemoral Osteoarthritis
Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators.
ENCANTO is a randomized, controlled, multi-center phase II clinical trial for the treatment of patellofemoral osteoarthritis (PFOA) with an Advanced Therapy Medicinal Product (ATMP), nasal chondrocyte-based tissue engineered…
- Trial name
- ENCANTO (NCT06576583)
- Testing
- Engineered cartilage graft (N-TEC), Autologous Matrix Induced Chondrogenesis (AMIC), Patellofemoral Arthroplasty (PFA)
- Where
- 11 sites in Austria, Croatia and 6 more
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Post-operative Pulmonary Complications
Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
The Investigators goal was to study the effect of high flow nasal cannula oxygen (HFNC) on the rate of post-operative pulmonary complications in thoracic surgical patients.
- Trial name
- NCT03024112
- Testing
- Heated humified high-flow nasal cannula Oxygen, Standard oxygen therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Colorado, Denver
Epistaxis
Trial of a Novel Chitosan Hemostatic Sealant in the Management of Complicated Epistaxis
Purpose: This study is a prospective clinical trial to investigate the efficacy of a chitosan-coated nasal packing (ChitoFlex® used in conjunction with the HemCon Nasal Plug) in the management of difficult spontaneous epistaxis…
- Trial name
- NCT00863356
- Testing
- 2009-I-Epistaxis-1
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HemCon Medical Technologies, Inc
Controlled Hypotension for Nasal Surgeries
Effect of Hypotensive Anesthesia on the Perfusion Index
Controlled hypotension has been used as a mean of reducing intraoperative blood loss and better visualization of the surgical field in nasal surgeries.
- Trial name
- NCT03059316
- Testing
- Massimo device, Nitroglycerin drug, Labetalol
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mean Arterial Pressure
Low Dose Magnesium Sulphate
This clinical trial aims to compare Patients who receive propranolol 1-2 mg to Patients who receive propranolol 1-2 mg in addition to magnesium sulphate infusion 10 mg/kg to see if IV magnesium can stability mean arterial blood…
- Trial name
- NCT06621004
- Testing
- Patients will receive propranolol 1-2 mg., Patient receives magnesium sulphate
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University