Clinical trials: NERVES
Glioma
Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline High Grade Gliomas
The objective of this expanded access program is to provide ONC201 to eligible patients with previously-treated glioma that exhibits the H3 K27M mutation and/or that is located in the midline region of the brain.
- Trial name
- NCT03134131
- Testing
- ONC201
- Where
- United States
- Sponsor
- Jazz Pharmaceuticals
Brain and Central Nervous System Tumors
Temozolomide in Treating Patients With Recurrent Oligodendroglial Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of temozolomide in treating patients with recurrent…
- Trial name
- NCT00003731
- Testing
- temozolomide
- Where
- 24 sites in Belgium, France and 7 more
- Volunteers
- 39 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Glioblastoma
A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma
The objectives of this phase I first-in-human trial are to evaluate safety, feasibility, and preliminary efficacy of an individualized Bvax vaccine in addition to standard of care chemoradiation in patients with newly diagnosed…
- Trial name
- Bvax (NCT07422896)
- Testing
- B-cell vaccination
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Catalina Lee Chang
Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of alvespimycin hydrochloride in treating patients with metastatic or unresectable solid tumors.
- Conditions
- Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Basal Cell Carcinoma of the Lip, Recurrent Breast Cancer
- Trial name
- NCT00089362
- Testing
- alvespimycin hydrochloride, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Neuromuscular Diseases, Respiratory Failure
Establishment of a Non-invasive and Indirect Measure of Volitional Pimax
Respiratory failure is the main death cause in muscular diseases. Non-invasive and volitional measures of inspiratory muscles strength include the nasal pressure with an occluded nostril and the maximal inspiratory pressure…
- Trial name
- PI MAX STIM (NCT02242162)
- Testing
- phrenic nerves magnetic stimulations
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Carpal Tunnel Syndrome (CTS)
Radial Pressure Wave Therapy With or Without Parameter Modulation for Carpal Tunnel Syndrome.
This study aims to evaluate the clinical effects of radial pressure wave therapy in patients with a confirmed diagnosis of mild to moderate carpal tunnel syndrome.
- Trial name
- RPWT in CTS (NCT07070661)
- Testing
- Fixed-Dose Radial Pressure Wave Therapy., Modulated-Dose Radial Pressure Wave Therapy.
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Armando Tonatiuh Avila Garcia
Glioblastoma, Gliosarcoma, Adult
A Study Assessing if it is Safe and Possible to Treat Brain Cancer Patients With Immunotherapy Before They Receive the Standard Treatment.
WinGlio is a phase I study investigating neoadjuvant (before surgery) ipilimumab ( a type of immunotherapy drug) in patients with newly diagnosed glioblastoma (a form of brain cancer).
- Conditions
- Glioblastoma, Gliosarcoma, Adult, Glioblastoma - Category
- Trial name
- WinGlio-ipi (NCT07134842)
- Testing
- Ipilimumab (3 mg/kg)
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University College, London
Pheochromocytoma and Paraganglioma (PPGL)
Safety and Efficacy of Belzutifan in Preoperative Preparation for Patients With Pheochromocytoma/Paraganglioma (PPGL)
It is preliminarily clarified that belzutifan exerts an inhibitory effect on catecholamine synthesis in pheochromocytoma and paraganglioma (PPGL), and its safety is simultaneously confirmed, thereby providing preliminary…
- Trial name
- NCT07907341
- Testing
- Belzutifan
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Longfei Liu，MD
Skin Cancer Face, Skin Cancer Scalp
Comparing Numbing Techniques in Mohs Micrographic Surgery
This study seeks to determine whether adjunct regional nerve blocks reduce pain and anxiety in adult patients undergoing Mohs micrographic surgery for face and scalp skin cancers.
- Trial name
- NCT07222241
- Testing
- Nerve Block
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Cancer, Colon Cancer
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
This pilot clinical trial studies copper Cu 64 anti-carcinoembryonic antigen (CEA) monoclonal antibody M5A positron emission tomography (PET) in diagnosing patients with CEA positive cancer.
- Conditions
- Breast Cancer, Colon Cancer, Extrahepatic Bile Duct Cancer, Gallbladder Cancer
- Trial name
- NCT02293954
- Testing
- radionuclide imaging, positron emission tomography, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Injury of Nerve Root of Lumbar and Sacral Spine
Comparison of Exercise Intervention Effects Following Lumbar Microdiscectomy
Low back pain is common, costly and affecting up to 80% of the population with the lumbar discectomy being a frequent spinal procedure for disc herniations.
- Trial name
- NCT02731196
- Testing
- Exercise Intervention
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Glioma
Evaluate the Effectiveness and Safety of Raman IVD Analyzer in the Molecular Diagnosis of Gliomas During Surgery
To distinguish various molecular subtypes of gliomas by spectra data obtained from Raman analyzer, including IDH mutant, 1p/19q-codeleted, ATRX deletion, TERT promoter mutation, MGMT promoter methylation, EGFR amplification, H3…
- Trial name
- NCT06363162
- Testing
- Immunohistochemistry or genetic test
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Glioblastoma, Recurrent Glioblastoma
Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma
This clinical trial uses a type of imaging scan called magnetic resonance imaging (MRI) to study brain tumor biology in patients with glioblastoma that can be removed by surgery (resectable).
- Conditions
- Glioblastoma, Recurrent Glioblastoma, Resectable Glioblastoma
- Trial name
- NCT06090903
- Testing
- Biospecimen Collection, Magnetic Resonance Imaging, Medical Chart Review
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Head and Neck Cancer, Neck Dissection
Axoguard HA Plus Nerve Protector to Reduce Post-operative Neck and Shoulder Dysfunction in Patients Undergoing Neck Dissection
In this prospective study, patients with head and neck cancers undergoing neck dissection will have the nerve to the shoulder wrapped with the Axoguard HA+ Nerve Protector at time of surgery.
- Trial name
- NCT07283861
- Testing
- Spinal Accessory Nerve Protection utilizing Axoguard HA+
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Matthew Spector
Median Nerve
Diffusion of Local Anesthetic After Median Nerve Block
Median nerve block is widely practised, avoiding general anaesthesia in a number of cases and producing excellent post-operative analgesia in orthopedic surgery.
- Trial name
- Echoalr (NCT00651170)
- Where
- 2 sites in France
- Volunteers
- 103 people
- Sponsor
- Hopital Foch
Carcinoid Tumor
A Study of Axitinib in Advanced Carcinoid Tumors
The main purpose of this study is to see whether Axitinib will help prolong the time that the patient's carcinoid tumors remain stable, and to examine their treatment response through testing.
- Trial name
- NCT01435122
- Testing
- Axitinib
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Carcinoma, Head and Neck Cancer
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery
This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with…
- Conditions
- Breast Carcinoma, Head and Neck Cancer, Melanoma (Skin), Squamous Cell Carcinoma, Skin
- Trial name
- GASVERT (NCT02997553)
- Testing
- Indocyanine green, Technetium99, Optonuclear probe
- Where
- France
- Volunteers
- 744 people
- Sponsor
- Institut de Cancérologie de Lorraine
Acute Pulpitis
Pain Measured by NRS and EEG in Acute Pulpitis
The aim of the proposed study is to investigate and comprehensively understand pain perception in patients diagnosed with symptomatic acute pulpitis who are resistant to inferior alveolar nerve block (IANB).
- Trial name
- NCT06526572
- Testing
- Brain wave analysis using electroencephalography (EEG)., Numerical rate Scale (NRS)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cleveland Dental Institute
IUD Insertion Pain
Efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Reduction During Intrauterine Device (IUD) Insertion in Outpatient Gynecology
Pain with intrauterine device (IUD) insertion is very common and there are few options for patients to help reduce this pain. Transcutaneous electric nerve stimulators (TENS) are a non-invasive procedure that may help reduce the…
- Trial name
- NCT06335823
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS
Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)
This is an open-label phase 1 safety and feasibility study that will employ multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA)…
- Conditions
- Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS, Embryonal Tumor With Multilayered Rosettes, Pineoblastoma
- Trial name
- IMPACT (NCT06193759)
- Testing
- Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA), Group A Standard-of-Care Backbone Therapy, Group B Salvage Backbone Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's National Research Institute
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