Clinical trials: NERVES
Lumbar Facet Syndrome
A Prospective Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves Versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
Chronic, non-neurogenic low back pain (CLBP) is a common condition that affects many individuals across their lives. The lumbar facet joint has been implicated as an important source of CLBP, with a prevalence of 15-45%.
- Trial name
- NCT03614793
- Testing
- Cooled Radiofrequency Ablation of Medial Branch Nerves versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Utah
Brain Tumors
Neuradiab® Combined With Bevacizumab (Avastin) Therapy in Patients With Recurrent Glioblastoma Multiforme
Bradmer Pharmaceuticals, Inc. (Bradmer) is requesting approval to study the safety of Neuradiab® when combined with Bevacizumab (Avastin) therapy given at a minimum of 30 days after Neuradiab administration in patients with a…
- Trial name
- NCT00906516
- Testing
- Neuradiab in combination with Bevacizumab (Avastin)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Bradmer Pharmaceuticals Inc.
ITCH
Pain Sensitivity and Pruritus of Peripheral Nerves
Previous research has demonstrated that itch and pain share several underlying neural pathways and signaling molecules. Understanding these common mechanisms is important for developing more effective therapeutic strategies…
- Trial name
- NCT07887906
- Testing
- Mepyramine cream, Histamine Dihydrochloride (HDC), Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Obstructive Sleep Apnea, Sleep Apnea
Hypoglossal Nerve Stimulation Therapy in Patients With Obstructive Sleep Apnea: Belgian Registry
Hypoglossal nerve stimulation (HNS) therapy (Inspire system) is intended for the treatment of patients with moderate to severe obstructive sleep apnea (OSA) who cannot be effectively treated with the first-line treatment options.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea
- Trial name
- B-HNS (NCT06332404)
- Testing
- Hypoglossal nerve stimulation Inspire system (Inspire Medical Systems Inc., USA)
- Where
- 2 sites in Belgium
- Volunteers
- 225 people
- Sponsor
- University Hospital, Antwerp
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer
This phase I trial is studying the side effects and best dose of erlotinib hydrochloride when given together with cetuximab and to see how well they work in treating patients with advanced gastrointestinal cancer, head and neck…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix
- Trial name
- NCT00397384
- Testing
- cetuximab, erlotinib hydrochloride, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Cancer Institute (NCI)
Surgical Pathology of the Leg or the Foot.
Pharmacokinetic of levobupivacaïne After Sciatic Nerve Block in Children
Levobupivacaïne (Chirocaine®) is a new local anaesthetic recently marketed in France. The goal of this prospective work is to study the pharmacokinetic aspect of this drug after injection around the sciatic nerve (subgluteal way).
- Trial name
- NCT00682344
- Testing
- Levobupivacaïne
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ischemic Cardiomyopathy, Hibernating Myocardium
Prediction of ARrhythmic Events With Positron Emission Tomography
The hypothesis of PAREPET is that hibernating myocardium (viable myocardium with reduced resting flow) and/or viable but denervated myocardium can predict the risk of sudden death in subjects with ischemic cardiomyopathy.
- Conditions
- Ischemic Cardiomyopathy, Hibernating Myocardium, Nerve; Disorder, Sympathetic
- Trial name
- PAREPET (NCT01400334)
- Testing
- Positron Emission Tomography
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- State University of New York at Buffalo
Germ Cell Tumors, Hepatic Cancer
Recombinant Human Thrombopoietin in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy
Life-threatening thrombocytopenia (low platelet count) and neutropenia (low white blood count) remain the major dose-limiting toxicities following chemotherapy treatment for cancer.
- Conditions
- Germ Cell Tumors, Hepatic Cancer, Neuroblastoma, Osteosarcoma
- Trial name
- NCT00187109
- Testing
- Recombinant Human Thrombopoietin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Jude Children's Research Hospital
Glioblastoma
TTFields In GErmany in Routine Clinical Care
The purpose of this post-authorisation medical device study is to obtain real life data on the use of tumor-treating fields (TTFields) in patients with newly diagnosed GBM in routine clinical care in Germany.
- Trial name
- TIGER (NCT03258021)
- Testing
- TTFields
- Where
- Germany
- Volunteers
- 710 people
- Sponsor
- NovoCure Ltd.
Metastatic Melanoma
A Phase I/II Study of GMX1777 in Combination With Temozolomide for the Treatment of Metastatic Melanoma
Obatoclax Mesylate (GMX1777) is a water-soluble, intravenously-administered pro-drug of GMX1778. GMX1777 is rapidly converted to GMX1778 in vivo.
- Trial name
- NCT00724841
- Testing
- Obatoclax Mesylate, Temozolomide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Gemin X
Malignant Melanoma, Melanoma (Skin)
SCIB1 and iSCIB1+ in Melanoma Patients Receiving Nivolumab With Ipilimumab or SCIB1 With Pembrolizumab (The SCOPE Study)
The purpose of this study is to find out if two new treatment cancer vaccines called SCIB1 and iSCIB1+ can be used safely when added to nivolumab (Opdivo) with ipilimumab (Yervoy), or SCIB1 with pembrolizumab (Keytruda).
- Conditions
- Malignant Melanoma, Melanoma (Skin), Melanoma Stage III, Melanoma Stage IV
- Trial name
- NCT04079166
- Testing
- SCIB1 or iSCIB1+ DNA vaccine
- Where
- 15 sites in United Kingdom
- Volunteers
- 173 people
- Sponsor
- Scancell Ltd
Neoplasm of Lateral Wall of Urinary Bladder
Safety Study of Bipolar Versus Monopolar Transurethral Resection of Bladder Tumors
This is a single-center, prospective, randomized, controlled trial comparing two established transurethral electrical resection methods of urinary bladder tumors regarding their risk of stimulating the obturator nerve.
- Trial name
- NCT01446822
- Testing
- Bipolar transurethral resection of the urinary bladder (PlasmaKinetic, Gyrus, Fresenius), Monopolar transurethral resection of the urinary bladder (Storz GmbH &Co., Erbotom, Purisole)
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- Daniel Stephan Engeler
Hemiplegic Shoulder Pain
Comparison of Effectiveness of Low Dose Laser and Transcutaneous Electrical Stimulation in Hemiplegic Shoulder
The primary aim of this study is to compare the efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) and Low Level Laser Therapy (LLLT), which are analgesic modalities that play an important role in the treatment of…
- Trial name
- NCT07203222
- Testing
- Low Dose Laser, TENS, Conventional physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara Etlik City Hospital
Neuroblastoma
A Study of a Vaccine in Combination With β-glucan and GM-CSF in People With Neuroblastoma
The purpose of the study is to explore the combination of a bivalent vaccine, a sugar called beta-glucan (β-glucan), and a protein called granulocyte-macrophage colony stimulating factor (GM-CSF) as an effective treatment for…
- Trial name
- NCT04936529
- Testing
- β-glucan, GM-CSF, OPT-821
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Carcinoma, Non-Small -Cell Lung, Ovarian Neoplasms
Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers
Background: Chemotherapy damages cancer cell deoxyribonucleic acid (DNA) so the cells die, and the tumor shrinks. But it may stop working in some people over time.
- Conditions
- Carcinoma, Non-Small -Cell Lung, Ovarian Neoplasms, Small Cell Lung Carcinoma, Uterine Cervical Neoplasms
- Trial name
- NCT02487095
- Testing
- Topotecan, VX-970 (M6620)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Pain, Postoperative, Cardiac Surgery
Pectoral Nerves Block to Relieve Post-sternotomy Pain After Cardiac Surgery
The primary objective of this study is to determine if the addition of PECS2 block provides superior post-operative analgesia for cardiac surgery patients after midline sternotomy compared to only standard-of-care post-operative…
- Trial name
- NCT04282239
- Testing
- PECS2 block, Ropivacaine 0.5% Injectable Solution, Lidocaine Epinephrine
- Where
- United States
- Sponsor
- NYU Langone Health
Glioblastoma Multiforme
Safety Study of Cetuximab, Radiotherapy and Temozolomide in Primary Glioblastoma Multiforme(GERT)
GERT is a one-armed single-center phase I/II trial. In a first step, dose-escalation of TMZ from 50 mg/m2 to 75mg/m2 together with radiotherapy and cetuximab will be performed.
- Trial name
- NCT00311857
- Testing
- Cetuximab, Temozolomide, Radiation therapy
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Heidelberg University
Pain Intensity Assessment, Interscalene Nerve Block
Comparison of Interscalene and Anterior Shoulder Capsule Block
Due to the development and easy availability of ultrasonography devices, regional nerve blocks are routinely used by anesthesiologists among multimodal analgesia techniques.
- Conditions
- Pain Intensity Assessment, Interscalene Nerve Block, Shoulder Anterior Capsule Block (SHAC Block), Pericapsular Nerve Group Block (PENG)
- Trial name
- NCT06827912
- Testing
- Interscalene Nerve Block, Shoulder Anterior Capsule Block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Amasya University
Brain and Central Nervous System Tumors, Breast Cancer
Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00019019
- Testing
- carboxyamidotriazole, paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Chronic Constipation
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation
The worldwide prevalence of chronic constipation (CC) is 15%, and women are more likely to develop the disease than men. CC have a significant impact on quality of life and increase the burden of national health insurance.
- Trial name
- NCT05723731
- Testing
- taVNS, Laxative Agent
- Where
- 5 sites in China
- Volunteers
- 106 people
- Sponsor
- Air Force Military Medical University, China
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