Clinical trials: NERVES
Urological Disease, Anesthesia
To Map Human Lower Thoracic Dermatomes by Epidural Block
Significant differences exist among various dermatome maps. In addition, there were no anatomical landmarks to evaluate the dermatome at the back.
- Trial name
- LTDEP (NCT03022136)
- Testing
- cold sensation method
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tongji Hospital
Melanoma, Secondary Malignant Neoplasm of Lymph Node
Videoscopic Ilioinguinal Lymphadenectomy for Melanoma
Groin lymph node dissection for melanoma patients is burdened by high post-operative morbidity, mainly related to wound. This is a prospective pilot trial investigated feasibility and postoperative outcomes of videoscopic…
- Trial name
- NCT02508909
- Testing
- Videoscopic ilioinguinal dissection
- Volunteers
- 23 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
PolG, Primary Mitochondrial Myopathy
Mitochondrial Video Assessment Source Material Study
Source material collection of videos to develop the Mitochondrial Video Assessment (MVA) for patients with mitochondrial myopathies.
- Trial name
- NCT06180421
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The Emmes Company, LLC
Heart Failure
The Effect of a Five Week Electrical Myostimulation Program in Chronic Diseases
Patients afflicted with Chronic Heart Failure (HF) typically do not maintain stable cardiac function for the remainder of their life and consequently require continuous medical management and intermittent hospital admissions.
- Trial name
- NCT01695421
- Testing
- Medium-frequency alternating current, Burst-modulated alternating current, Functional electrical stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Brasilia
Glioblastoma Multiforme, Anaplastic Astrocytoma
Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
This study assesses the safety and efficacy of repeat monthly dosing of super-selective intra-arterial cerebral infusion (SIACI) of cetuximab and bevacizumab in patients < 22 years of age.
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Fibrillary Astrocytomas, Oligodendroglioma
- Trial name
- NCT05956821
- Testing
- SIACI of cetuximab and bevacizumab
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Miami
Blepharoptosis, Device Usability
A Feedback-enabled Magnetic Device for Temporary Management of Blepharoptosis
To develop a feedback-enabled magnetic device for management of blepharoptosis and evaluate its efficacy and safety, including the gain of palpebral fissure height, visual field obstruction, blurred vision, foreign body sensation…
- Trial name
- NCT03812016
- Testing
- Feedback-enabled magnetic device
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- E-DA Hospital
Uveal Melanoma, High-risk Uveal Melanoma
High-precision Radiosurgery Followed by Minimally Invasive Surgical Approach in Patients With High-prominence Uveal Melanoma: Modern Radiation Techniques and Outcomes
High-precision radiosurgery followed by minimally invasive surgical approach in patients with high-prominence uveal melanomas: modern radiation techniques and outcomes.
- Conditions
- Uveal Melanoma, High-risk Uveal Melanoma, Prominent Uveal Melanoma
- Trial name
- PRIME (NCT07913412)
- Where
- 3 sites in Germany
- Volunteers
- 250 people
- Sponsor
- University Hospital, Essen
Diabetes Type 2
Evaluation of Block Duration in Type 2 Diabetes Patients
Diabete animal studies demonstrated a longer period recovery after local anesthetic injection (perineural administration). No clinical study demonstrated a prolonged nerve block duration in diabete type 2 patients after…
- Trial name
- Diabeteblock (NCT01704612)
- Testing
- ropivacaine
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Pierre and Marie Curie University
Brain and Central Nervous System Tumors, Intraocular Melanoma
Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer
RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody 3F8, can find tumor cells and carry tumor-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Intraocular Melanoma, Lung Cancer, Melanoma (Skin)
- Trial name
- NCT00445965
- Testing
- DNA analysis, immunologic technique, pharmacological study
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Glioblastoma Multiforme
CT-322 in Combination With Radiation Therapy and Temozolomide to Treat Newly Diagnosed Glioblastoma Multiforme
Rationale: In light of the demonstrated activity of anti-angiogenesis agents in rGBM, it is reasonable to postulate that adding these agents to standard RT and chemotherapy in the up-front management of newly diagnosed GBM may…
- Trial name
- NCT00768911
- Testing
- CT-322, Temozolomide, Radiation Therapy
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Adnexus, A Bristol-Myers Squibb R&D Company
Injury of Anterior Cruciate Ligament
Comparison of Infiltration Analgesia With Femoral Nerve Block After Hamstrings Anterior Cruciate Ligament Reconstruction
Pain treatment after anterior cruciate ligament reconstruction - Comparison of infiltration analgesia with femoral nerve block after.
- Trial name
- NCT01260363
- Testing
- Femoral nerve block, Local infiltration analgesia
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Ulcerative Colitis
Exploratory Clinical Trial of Safety and Efficacy of Sacral Nerve Stimulation in Patients With Ulcerative Colitis.
Although the incidence of inflammatory bowel disease is stable in North American and European countries, the incidence of inflammatory bowel disease is increasing in newly industrialized countries, especially in China.
- Trial name
- NCT05895981
- Testing
- G132 system, Beijing PINS Medical Co., China
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Xijing Hospital
Melanoma
Study to Evaluate the Safety and Efficacy of Two Different Dosing Schedules of Pembrolizumab (MK-3475) Compared to Ipilimumab in Participants With Advanced Melanoma (MK-3475-006/KEYNOTE-006)
This study will evaluate the safety and efficacy of 2 different dosing schedules of pembrolizumab (MK-3475), every 2 weeks (Q2W) and every 3 weeks (Q3W), and compare the 2 schedules to treatment with ipilimumab in…
- Trial name
- NCT01866319
- Testing
- Pembrolizumab, Ipilimumab
- Volunteers
- 834 people
- Sponsor
- Merck Sharp & Dohme LLC
Cancer Pediatric
Ultrasound-guided Selective Supraclavicular Nerve Block for Postoperative Pain Control in Pediatric Patients.
This prospective randomized controlled trial aims to investigate the effect of ultrasound-guided selective supraclavicular nerve block on pain control after Hickman catheter, chemoport, or Perm cath insertion in children.
- Trial name
- NCT05015907
- Testing
- Ropivacaine, Control (without intervention)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Brain Tumor, Recurrent, Vestibular Schwannoma
Vegetative Monitoring During Brainstem-associated Surgery
Intraoperative Monitoring of Heart rate variability, Blood pressure variability, Baroreceptorsensivity etc.
- Conditions
- Brain Tumor, Recurrent, Vestibular Schwannoma, Brainstem Neoplasm, Brainstem Glioma
- Trial name
- NCT03666507
- Testing
- Intraoperative Monitoring during resection of brain tumor
- Where
- Germany
- Volunteers
- 103 people
- Sponsor
- University Hospital Tuebingen
Astrocytoma, Glioma
Qualitative, Qualitative, and Functional Studies Over the First Year in Measuring Immune System Response During the First Year of Therapy in Patients With Brain Tumors
This research trial studies qualitative, qualitative, and functional studies over the first year in measuring immune system response in patients with brain tumors.
- Conditions
- Astrocytoma, Glioma, Oligodendroglioma
- Trial name
- NCT02747407
- Testing
- Hepatitis A Vaccine, Laboratory Biomarker Analysis, Tetanus Toxoid Vaccine
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Wake Forest University Health Sciences
Lentigo Maligna
Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream
This study investigates the efficacy of photodynamic therapy (PDT) in the treatment of lentigo maligna (LM). Hyperspectral imaging system (HIS) will be used to determine the margins of LM and to rule out possible invasion.
- Trial name
- LM PDT (NCT02685592)
- Testing
- 5-aminolevulinic acid nanoemulsion
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Vestibular Schwannoma
Triamcinolone Levels in Cochlear Perilymph, Lateral Canal and CSF
Patients undergoing surgery of a vestibular schwannoma will be included in the study. Patients will receive triamcinolone acetonide 24h before surgery.
- Trial name
- NCT04658836
- Testing
- Triamcinolone Acetonide 40mg/mL
- Where
- Austria
- Volunteers
- 21 people
- Sponsor
- Medical University of Vienna
Psoriatic Arthritis
Transcutaneous Auricular Vagus Nerve Stimulation in Psoriatic Arthritis
This prospective single-center interventional study aims to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on disease activity, pain, quality of life, autonomic dysfunction symptoms, and…
- Trial name
- NCT07653009
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University
Pituitary, Cancer
Clinical-pathological Evaluation of Pit-NETs
Pituitary adenomas, namely pituitary neuroendocrine tumors (PitNETs), are recognized as rare neoplasia by national and international institutions.
- Conditions
- Pituitary, Cancer, Neuroendocrine Tumors
- Trial name
- PitNET2024 (NCT06607198)
- Testing
- grading & staging, PitNET morphology analysis, Radiomics
- Where
- Italy
- Volunteers
- 940 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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