Clinical trials: NERVES
Dry Eye Disease, Tear Film
Corneal and Tear Film Changes in Chinese Patients With Type 2 Diabetes
Diabetes mellitus has been associated with ocular surface damage and exacerbates dry eye disease (DED) pathology. To investigate clinical and inflammatory changes in the ocular surface of insulin-independent type II diabetic…
- Conditions
- Dry Eye Disease, Tear Film, Corneal Nerve
- Trial name
- NCT06218992
- Where
- China
- Volunteers
- 80 people
- Sponsor
- He Eye Hospital
Nerve Injury, Digital Pulp Defect
Free Dorsal Digital Flap for Reconstruction of Volar Soft Tissue Defect of Digits
The aim of the current report is to investigate the feasibility of transferring the free dorsal digital flap, including both dorsal branches of the proper digital nerves (PDNs), to reconstruct the volar soft tissue defect of…
- Trial name
- NCT01533337
- Testing
- Free dorsal digital flap
- Volunteers
- 12 people
- Sponsor
- The Second Hospital of Tangshan
Vagus Nerve Stimulation in Reward Learning
Pulsed tVNS Protocol and Reinforcement Learning
The aim of this study is to investigate the potential of a phasic taVNS stimulation protocol for reinforcement learning. The investigators will disentangle its effects on learning actions and outcomes through the administration…
- Trial name
- NCT06205108
- Testing
- taVNS stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Musculoskeletal Diseases, Median Nerve Disease
Efficacy of Ultrasound-Guided Hydrodissection in Carpal Tunnel Syndrome
The aim of our study is to determine the effectiveness of US-guided hydrodissection of the median nerve in different contents and volumes in patients diagnosed with mild to moderate carpal tunnel syndrome.
- Conditions
- Musculoskeletal Diseases, Median Nerve Disease, Carpal Tunnel Syndrome, Ultrasound-Guided Injection
- Trial name
- NCT05222126
- Testing
- Ultrasound-guided Hydrodissection (HD) with 5 cc 5% Dextrose, Ultrasound-guided Hydrodissection (HD) with 5 cc Normal Saline, Ultrasound-guided Hydrodissection (HD) with 10 cc 5% Dextrose
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Afyonkarahisar Health Sciences University
Surgery, Plastic, Mastectomy
Nerve Blocks in Alloplastic Breast Reconstruction
Pain management is a major concern in oncologic breast surgery and reconstruction. Significant risks for acute and chronic pain after surgery might be reduced through improved pain control pre-operatively.
- Conditions
- Surgery, Plastic, Mastectomy, Nerve Block, Breast Reconstruction
- Trial name
- NCT04860843
- Testing
- Thoracic paravertebral block, Pecs block
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Peripheral Nerve Injury, Nerve Injury
Polyethylene Glycol to Improve Sensation Following Digital Nerve Laceration
PEG is a fusogen, a type of chemical that aids in mediating cell fusion. PEG helps nerve cells recover neuronal continuity by removing plasmalemmal-bound water which opens the axonal ends on both sides of the injury.
- Trial name
- NCT04270019
- Testing
- Polyethylene Glycol 3350, Normal Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Long COVID, Vagus Nerve Stimulations
Vagus Nerve Stimulation for Post-COVID Syndrome
The aim of this study is to increase parasympathetic activity and decrease the severity of symptoms by providing vagal stimulation with the t-VNS method in order to suppress the increased sympathetic activity in patients with…
- Conditions
- Long COVID, Vagus Nerve Stimulations, Heart Rates, Autonomic Nervous System Disorders
- Trial name
- NCT05679505
- Testing
- Auricular transcutaneous vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Head and Neck Neoplasms, Accessory Nerve Injury
Therapeutic Resistance Group Exercise Training for Head & Neck Cancer Survivors
The investigators will conduct a randomized controlled trial examining 12-week, 24-week and one year outcomes from a combined therapeutic and physical exercise program that aims to bridge head-and-neck cancer survivors from acute…
- Conditions
- Head and Neck Neoplasms, Accessory Nerve Injury, Fatigue
- Trial name
- TARGET (NCT02647021)
- Testing
- Therapeutic Exercise, Therapeutic + Lower Body Exercise
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Lidocaine, Optic Nerve Sheath Diameter
Lidocaine Infusion on Optic Nerve Sheath Diameter in Laparoscopic Hysterectomy in Trendelenburg Position
We hypothesize that intravenous lidocaine infusion may have beneficial effect to patients undergoing laparoscopic surgeries in Trendelenburg position by preventing ICP elevation.
- Conditions
- Lidocaine, Optic Nerve Sheath Diameter, Laparoscopic Hysterectomy, Trendelenburg
- Trial name
- NCT05690087
- Testing
- Lidocaine, sodium chloride 0.9% solution
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Nerve Injury, Laser Therapy
Histopathological, Biochemical And Electrophysiological Evaluation Of Single Or Combined Use Of Diode Laser/Steroid Treatment On Facial Nerve Injury
The objective of the study will be to investigate the effect of low-level diode laser therapy (LLLT) and steroid on facial nerve injury.
- Conditions
- Nerve Injury, Laser Therapy, Methylprednisolone, Facial Nerve Injuries
- Trial name
- facial nerve (NCT06185426)
- Testing
- Methyprednisolon and low level laser theraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Lumbar Erector Spinae Plane Block, Pericapsular Nerve Group Block (PENG Block)
Combined Lumbar Erector Spinae Plane Block and Pericapsular Nerve Group Block in Patients Undergoing Hip Surgeries
The investigators are going to evaluate the postoperative analgesic efficacy of combined LESPB and PENG block after hip surgeries.
- Trial name
- NCT05930171
- Testing
- Ultrasound guided L-ESPB and PENG block using Bupivacaine, Postoperative conventional analgesia in form of Acetaminophen
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Headache, Pregnancy Related
Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
This is an open label randomized controlled trial evaluating response to bupivacaine occipital nerve block compared to Tylenol/Caffeine cocktail in treatment of pregnant patients seeking care of headache.
- Conditions
- Headache, Pregnancy Related, Occipital Nerve Block
- Trial name
- NCT03951649
- Testing
- Occipital Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Traumatic Optic Neuropathy
The Neuroprotective Effect of PEG-GCSF in the Traumatic Optic Neuropathy
The clinical trial will be a phase 1, semi-experimental trial, which will be performed in Hualien Tzu Chi Hospital. Twenty patients will be recruited in this study starting from the 2nd year of the project to the 3rd year of the…
- Trial name
- NCT06168188
- Testing
- Neulasta® (pegfilgrastim)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Relapsing Multiple Sclerosis
A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis
Open-label, long-term extension study available to participants who have completed CNMAu8.201.
- Trial name
- VISIONMS-LTE (NCT04626921)
- Testing
- CNM-Au8
- Where
- 5 sites in Australia
- Volunteers
- 55 people
- Sponsor
- Clene Nanomedicine
Cutaneous Neurofibroma, Neurofibromatosis Type 1
Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma
This pilot phase II trial studies how well selumetinib works in treating patients with neurofibromatosis type 1 and cutaneous neurofibromas.
- Conditions
- Cutaneous Neurofibroma, Neurofibromatosis Type 1, Optic Nerve Glioma
- Trial name
- NCT02839720
- Testing
- Laboratory Biomarker Analysis, Selumetinib Sulfate
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Femoral Fracture, Femoral Nerve Block
Effect of the Early Ultrasound-guided Femoral Nerve Block Performed by Emergency Physicians on Pre-operative Opioids Usage in Patients With Proximal Femoral Fractures
In France, approximately 80,000 patients with a fracture of the upper extremity of the femur (femoral neck or trochanter) are admitted in the emergency department.
- Trial name
- FORELEG (NCT05515718)
- Testing
- Standard pain management, Femoral nerve block
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Diabetic Retinopathy, Neurodegeneration
Glycemic Control and Retinal Microvascular Changes
The goal of this prospective, observational study is to compare in the association of glycemic control and retinal microvascular changes in patients with type 2 diabetes mellitus (T2DM) without diabetic retinopathy (DR).
- Conditions
- Diabetic Retinopathy, Neurodegeneration, Blood Sugar; High
- Trial name
- NCT06150495
- Where
- South Korea
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Postoperative Pain, Nerve Block
Effect of Perineural Dexamethasone on the Duration of Popliteal Nerve Block for Anesthesia After Ankle Surgery
Effect of perineural dexamethasone on the duration of popliteal nerve block after ankle/foot surgery
- Trial name
- NCT03332316
- Testing
- Dexamethasone Sodium Phosphate, Ropivacaine Hydrochloride Inj 2 mg/ml, Sodium Chloride 9mg/mL
- Where
- Finland
- Volunteers
- 84 people
- Sponsor
- Tampere University Hospital
Parotid Tumors, Facial Nerve Paresis
Intra-parotid Facial Nerve Imaging in Parotidectomy
In this study, the investigators will evaluate the clinical usefulness of 3 dimensional double echo steady state MRI (3D-DESS MRI) for functional preservation of the facial nerve during parotidectomy.
- Trial name
- NCT03822728
- Testing
- 3D-DESS MRI (3 dimensional double echo steady state MRI)
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Samsung Medical Center
Tinnitus, Subjective, Vagus Nerve Stimulation
Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus
This clinical study is a prospective, multicenter, randomized, controlled, double-blind clinical study. Sun Yat Sen Memorial Hospital of Sun Yat sen University was the central unit, and Nanjing First Hospital, Sun Yat Sen…
- Conditions
- Tinnitus, Subjective, Vagus Nerve Stimulation, Music Therapy, Double-Blind Method
- Trial name
- NCT05417711
- Testing
- Transcutaneous Vagus Nerve Stimulation Paired with Tailor-Made Notched Music Therapy, Tailor-made Notched Music Training
- Volunteers
- 388 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University