Clinical trials: NPH (Normal Pressure Hydrocephalus)
Normal Pressure Hydrocephalus
Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus
The research project is designed to determine which combination of tests will enable physicians to predict whether a patient with symptoms of normal pressure hydrocephalus (NPH) will improve with a shunt.
- Trial name
- NPH (NCT00613886)
- Testing
- Programmable Shunt Insertion (Codman, Medtronic), Assessments in physical therapy, occupational therapy, and speech therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Irvine
Normal Pressure Hydrocephalus
Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH
Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. Urinary symptoms in normal pressure hydrocephalus are mainly represented by overactive bladder, which…
- Trial name
- PLHPN (NCT03877107)
- Testing
- Urinary symptoms profile questionnaire, Micturition calendar
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- EssaiClinique_PL-HPN
Idiopathic Normal Pressure Hydrocephalus (INPH)
Efficacy in iNPH Shunting (PENS) Trial
The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt surgery to…
- Trial name
- PENS (NCT05081128)
- Testing
- programmable CSF shunt valve
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 99 people
- Sponsor
- Johns Hopkins University
Normal Pressure Hydrocephalus Patients, Normal Pressure Hydrocephalus
Non-invasive Diagnostics of Shunt Obstruction in Adult Hydrocephalus
The goal of this RCT is to test whether volumetric assessment of magnetic resonance imaging (MRI) could diagnose shunt obstruction in Adult Hydrocephalus patients, and in addition to explore correlations of blood biomarkers…
- Trial name
- NCT07172841
- Testing
- Intervention group "Virtual OFF", Control group (no change in shunt setting)
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Idiopathic Normal Pressure Hydrocephalus
Intracranial Pressure Waves Via Lumbar Puncture
Patients are subjected to simultaneous intracranial and lumbar puncture pressure measurements. This study focus on intracranial pulse amplitude.
- Trial name
- NCT01374048
- Volunteers
- 10 people
- Sponsor
- Umeå University
Normal Pressure Hydrocephalus
Cerebrospinal Fluid Proteome in Hydrocephalus
PROLIPHYC is a collaborative prospective study that aims at discovering deep cerebrospinal fluid (CSF) proteome with a new clinically-compatible proteomics strategy, in a cohort of 100 patients suspected of neurodegenerative…
- Trial name
- PROLIPHYC (NCT02016352)
- Testing
- patient CSF extraction with hydrocephalus, witness CSF extraction
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Normal Pressure Hydrocephalus
Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery
The idea is to assess the predictive value of flow magnetic resonance imaging (flow MRI) for patient suffering normal pressure hydrocephalus (NPH) planned for surgery.
- Trial name
- NCT01815775
- Testing
- clinical and imaging examinations
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Intracranial Pressure
Estimation of Intracranial Pressure Using Non-invasive Fundus Videos
The purpose of this pilot study is to assess whether the intracranial pressure (ICP) can be detected by using a non-invasive retinal fundus scanner, recording the vessels of the eye entering from the optic disc.
- Trial name
- NCT03382860
- Testing
- Fundus videos
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Odense University Hospital