Clinical trials: NSAIDs
Post Partum Pain
Retrospective Review of NSAIDS in the Postpartum Period
Chart review of women who have delivered an infant in a single health care system to determine if NSAID use increases blood pressures in the postpartum period.
- Trial name
- NCT03026673
- Testing
- NSAID use
- Where
- United States
- Sponsor
- St. Louis University
Endoscopic Biliary Sphincterotomy, Bleeding
Antihemostatic Therapy and Endoscopic Biliary Sphincterotomy Induced Bleeding
The aim of the study is to observe the effects of antihemostatic therapy including nonsteroidal antiinflammatory, anticoagulant and antiaggregant therapy and other patient and procedure related factors on the risk of endoscopic…
- Trial name
- NCT01098617
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people
- Sponsor
- Yuksek Ihtisas Hospital
Dysmenorrhea, Chronic Pelvic Pain
NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL)
The goal of this clinical trial is to learn if NSAIDs (i.e. naproxen sodium) can treat menstrual pain and prevent the development of chronic pelvic pain in menstruating adults with painful periods.
- Conditions
- Dysmenorrhea, Chronic Pelvic Pain, Pelvic Pain
- Trial name
- NSAIDHEAL (NCT06861920)
- Testing
- Naproxen Sodium 550mg, Extended Release Acetaminophen (650 mg)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Endeavor Health
Arthritis, Psoriatic
Psoriatic Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to NSAIDs or Non-biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) Therapy
The purpose of this study is to characterize the safety, efficacy and dose response of BMS-945429 in subjects with active Psoriatic Arthritis and an inadequate response to Nonsteroidal anti-inflammatory drugs (NSAIDs) and…
- Trial name
- NCT01490450
- Testing
- BMS-945429
- Where
- 49 sites in United States, Argentina and 11 more
- Volunteers
- 165 people
- Sponsor
- CSL Behring
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Pain
Comparison of Pain Sensation During Single Use of Two Topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Different case reports are showing that depending on the drug used for eye drops, it might provoke a painful sensation. Actually two leading NSAIDs are used in ophthalmology.
- Trial name
- NCT00869219
- Testing
- Nevanac, Acular LS
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Santa Casa de Misericordia de Santos
Esophageal Cancer, Perioperative Analgesia
Perioperative Analgesia Modes in Minimally Invasive Esophagectomy
This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.
- Conditions
- Esophageal Cancer, Perioperative Analgesia, NSAIDs, Opioid
- Trial name
- NCT05504265
- Testing
- Preemptive flurbiprofen axetil, Postoperative flurbiprofen axetil, Patient-controlled analgesia pump
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Intraocular Pressure
Evaluation of Comfort With Xibrom (Bromfenac Ophthalmic Solution)0.09% and Nevanac (Nepafenac Ophthalmic Suspension) 0.1% Following Selective Laser Trabeculoplasty (SLT)
The objective of this study is to evaluate and compare the comfort of bromfenac or nepafenac following SLT.
- Trial name
- NCT00828477
- Testing
- Xibrom, Nevanac
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Dyspepsia
Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-steroidal Anti-inflammatory Drugs
The principal investigator hypothesizes that participants receiving NSAID drugs with dyspeptic symptoms have increased production of gastric levels of free radicals.
- Trial name
- NCT00443963
- Testing
- Esomeprazole Magnesium
- Where
- United States
- Sponsor
- Medstar Health Research Institute
Migraine Disorders
Non-steroidal Anti-inflammatory Drugs Alone or With a Triptan and Reports of Transition From Episodic to Chronic Migraine
Chronic Migraine (CM), or 15 or more migraine headaches per month, is common in tertiary headache care and is associated with a number of deleterious outcomes, especially higher disability and poorer quality of life, relative to…
- Trial name
- NCT01435941
- Testing
- Non-steroidal anti-inflammatory drug (NSAID), Triptan
- Volunteers
- 11,249 people
- Sponsor
- GlaxoSmithKline
Pulpitis - Irreversible
The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo
Aim. To compare the outcome of preoperative administration of single-dose ketorolac, non-steroidal anti-inflammatory drug and placebo on postoperative pain in teeth with irreversible pulpitis and apical periodontitis.
- Trial name
- PreOp (NCT03116672)
- Testing
- one dose ketorolac 10 mg, One dose Diclofenac
- Where
- Mexico
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Acute Pain Due to Trauma
NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management
The purpose of this study is to: Compare the effect of paracetamol alone against NSAIDs alone against the association of paracetamol + NSAIDs in the treatment of traumatic pain.
- Trial name
- NCT03222518
- Testing
- Paracetamol, NSAID, paracetamol-NSAID
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Acute Non-specific Low Back Pain
Milgamma® and Milgamma® Compositum Step-therapy in Patients With Acute Non-specific Low Back Pain Receiving Modern NSAID
The purpose of this study is to assess the effectiveness and safety of add-on Milgamma®/ Milgamma® compositum step-therapy in patients with acute non-specific low back pain receiving modern NSAIDs in routine medical practice.
- Trial name
- NCT03892707
- Testing
- Exposure of interest (within routine clinical practice):Vitamin B complexes Milgamma® and Milgamma® compositum
- Where
- 21 sites in Russia
- Volunteers
- 500 people
- Sponsor
- Woerwag Pharma LLC
Rheumatoid Arthritis
Oral Collagen for Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by swelling and inflammation of the joints. In RA, the immune system attacks a person's own cells inside joints, eventually leading to joint damage and disability.
- Trial name
- NCT00000401
- Testing
- Oral bovine type II collagen
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Tennessee
Peptic Ulcer, NSAID-Induced Peptic Ulcer
Fexuclue for Prevention of NSAIDs-Induced Peptic Ulcer in Real-World Practice
This study is a prospective, multi-center, observational study to evaluate the efficacy and safety of Fexuclue Tablet 20 mg in patients requiring prevention of NSAIDs-induced peptic ulcer in real-world clinical practice in Korea.
- Trial name
- NCT07558707
- Where
- South Korea
- Volunteers
- 7,000 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Preeclampsia Severe, Preeclampsia Postpartum
Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial
A randomized non-inferiority trial of women with preeclampsia with severe features to determine if the addition of nonsteroidal anti-inflammatory drugs is inferior or non-inferior to standard analgesic bundles in their impact on…
- Trial name
- PANDA (NCT03978767)
- Testing
- Ibuprofen 600 mg, Ketorolac, Acetaminophen
- Where
- United States
- Volunteers
- 287 people
- Sponsor
- Washington University School of Medicine
Peptic Ulcer
Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers
The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID)…
- Trial name
- NCT00153712
- Where
- China
- Volunteers
- 391 people
- Sponsor
- Chinese University of Hong Kong
Myofascial Pain Syndromes
Myofascial Pain:Acupuncture Versus Trigger Point Injection Combined With Dipyrone and Cyclobenzaprine
CONTEXT AND OBJECTIVE: Myofascial syndrome is the most frequent condition of chronic pain. The objective of the present study was to compare the analgesic action of acupuncture and trigger point injection combined with…
- Trial name
- ACP (NCT00635037)
- Testing
- bupivacaine and acupuncture
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Axial Spondyloarthritis, Axial Spondyloarthritis, Non-Radiographic
Effectiveness and Safety of Acemetacin in Active Axial Spondyloarthritis: A Real-world Study
The goal of this observational study is to evaluate the effectiveness and safety of acemetacin in adults (18-65 years) with active axial spondyloarthritis (axSpA) who meet the 2025 ASAS-SPARTAN revised classification criteria and…
- Conditions
- Axial Spondyloarthritis, Axial Spondyloarthritis, Non-Radiographic, Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA)
- Trial name
- ARISE (NCT07582146)
- Testing
- Acemetacin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese PLA General Hospital
Preeclampsia, Gestational Hypertension
Postpartum NSAIDS and Maternal Hypertension
Previous studies have suggested that NSAID use causes an increase in blood pressure. Further, blood pressure elevation has been noted in women with pregnancy related hypertensive disease during the postpartum period.
- Conditions
- Preeclampsia, Gestational Hypertension, Superimposed Preeclampsia, Chronic Hypertension in Obstetric Context
- Trial name
- NCT03824119
- Testing
- Ibuprofen 600 mg, Standard Postpartum Care without NSAIDs
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Southern California