Clinical trials: Nail Diseases
Pachyonychia Congenita
A Study Evaluating the Safety and Pharmacokinetics of QTORIN Rapamycin 3.9% Anhydrous Gel in the Treatment of Adults With Pachyonychia Congenita
PALV-08 is a multicenter, open-label treatment (OLT) study enrolling adults with Pachyonychia Congenita (PC) with genotyped keratin mutations KRT6A, KRT6B, KRT6C or KRT16 who were previously enrolled in the PALV-05 (VAPAUS)…
- Trial name
- NCT05643872
- Testing
- PTX-022
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Palvella Therapeutics, Inc.
Onychomycosis
Topical Gel Anti-Fungal Agent for Tinea Unguium
The purpose of this study is to compare, in a controlled fashion, the response to two anti-fungal agents, naftifine or terbinafine, with vehicle in novel topical gel formulations in the treatment of subjects with distal subungual…
- Trial name
- NCT00253305
- Testing
- Organogel of naftifine, 2%, Organogel of terbinafine, 2%, Organogel of naftifine, 6%
- Where
- 5 sites in United States
- Volunteers
- 75 people
- Sponsor
- MediQuest Therapeutics
Breast Cancer
Nail Changes Associated With Chemotherapy and Prevention of Nail Pigmentation by Ice Water Immersion
Anthracyclines combined with cyclophosphamide or taxane-containing regimens may cause nail pigmentation which reduces quality of life in breast cancer patients.
- Trial name
- NIPPER (NCT04215744)
- Testing
- Ice water immersion
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Psoriasis
A Study To Evaluate The Effects And Safety Of Treatment, Treatment Withdrawal, Followed By Re-Treatment With CP-690,550 In Subjects With Moderate To Severe Chronic Plaque Psoriasis
The primary objectives of the study are to 1) compare the efficacy responses of CP 690,550 (5 mg BID and 10 mg BID) versus placebo following 24 weeks of CP 690,550 treatment and subsequent withdrawal of active treatment at…
- Trial name
- NCT01186744
- Testing
- CP-690,550
- Where
- 87 sites in United States, Argentina and 10 more
- Volunteers
- 666 people
- Sponsor
- Pfizer
Onychomycosis of Toenail
Safety and Efficacy of Next Science Gel on Toenail Fungus
This is a 52 week, 20-patient open-label pilot study on the safety and efficacy of Next Science Wound gel in the treatment of mild to moderate Distal Subungual Onychomycosis.
- Trial name
- NCT04042857
- Testing
- Next Science Treatment Gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Next Science TM
Onychomycosis
Effectiveness and Safety of Nailner Brush 2in1 in Onychomycosis
Evaluate the effectiveness of Nailner Brush 2-in-1 in the treatment of onychomycosis based on the blinded evaluation of the percentage of healthy nail surface after 6 months of treatment compared to baseline.
- Trial name
- NCT05560841
- Testing
- topical treatment
- Where
- 2 sites in Tunisia
- Volunteers
- 50 people
- Sponsor
- Karo Pharma AB
Onychomycosis
Laser Therapy for Onychomycosis in Patients Wih Diabetes at Risk for Diabetic Foot Complications
In a sham controlled double-blind trial we aim to establish the efficacy and safety of local application of laser therapy in patients with diabetes with onychomycosis and risk factors for diabetes related foot complications.
- Trial name
- LASER-1 (NCT01996995)
- Testing
- Nd:YAG laser pulse therapy
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Medical Research Foundation, The Netherlands
Psoriatic Arthritis, Psoriasis
Psorcast Mobile Study
The purpose of this study is to understand variation in the symptoms of psoriasis and psoriatic arthritis using simple, scalable smartphone-based measurements.
- Conditions
- Psoriatic Arthritis, Psoriasis, Psoriatic Conditions, Dermatologic Disease
- Trial name
- NCT05621369
- Testing
- Participant self-assessment surveys, Psoriasis Draw, Psoriasis Area Photo
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sage Bionetworks
Fingernail Psoriasis
Dose Response and Safety Study of Topical Methotrexate for the Treatment of Fingernail Psoriasis
The purpose of this clinical study is to compare the efficacy and safety of three concentrations of topical methotrexate for the treatment of fingernail psoriasis.
- Trial name
- NCT00666354
- Testing
- Methotrexate
- Where
- 7 sites in United Kingdom
- Volunteers
- 83 people
- Sponsor
- MediQuest Therapeutics
Onychomycosis
Efficacy Study of LIQUICURE™ to Treat Toe Nail Fungus
There is a major clinical need for an inexpensive topically-applied product that can inhibit the growth of the dermatophytes that cause nail fungus.
- Trial name
- CT001 (NCT00960089)
- Testing
- LIQUICURE
- Where
- 4 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chesson Laboratory Associates, Inc
Onychomycosis
Fractional CO₂ Laser or 40% Urea With Topical Fluconazole Microemulsion in Onychomycosis
To evaluate the efficacy and safety of topical fluconazole microemulsion enhanced by fractional CO₂ laser versus by 40% urea ablation in treatment of Onychomycosis.
- Trial name
- NCT07033962
- Testing
- "Fractional CO2 laser" and "topical fluconazole microemulsion", "Urea 40%" and "topical fluconazole microemulsion"
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes Mellitus, Type 2, Onychomycosis
Laser Treatment for Onychomycosis in Diabetes
Fungal infections of the toe affect one in three people with diabetes. Current treatments for fungal toe infections include oral medications, but these drugs often interact with other common medications.
- Trial name
- NCT02019446
- Testing
- Laser Treatment YAG laser, Standard Treatment (control group) terbinafine hydrochloride tablets
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- BCDiabetes.Ca
Melanoma
Etude rétrospective Monocentrique MATRIX
"Monocentric retrospective study.Analysis of a case series of patients who underwent nail resection with dermal matrix and skin graft reconstruction in the setting of nail bed malignancy.
- Trial name
- NCT06415929
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Nails, Ingrown, Hyaluronic Acid
Hyaluronic Acid in Postoperative Cures in the Phenol/Alcohol Technique
The purpose of this study is to compare the efficacy of a postoperative treatment protocol with hyaluronic acid-based ointment compared to the standard protocol (betadine gel) in partial chemical matricectomies with phenol…
- Trial name
- EHAPAT (NCT04812457)
- Testing
- Hialucic, Betadine gel
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Malaga
Psoriasis
Open Label Study of the Effects of Secukinumab on Nail Psoriasis and Non-Invasive Measures of Enthesitis (Phase IV)
This study will be an open label study of secukinumab for the treatment of nail psoriasis. Secukinumab is an FDA-approved treatment for psoriasis.
- Trial name
- NCT04535999
- Testing
- Secukinumab Auto-Injector
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pennsylvania
Onychomycosis, Tinea Pedis
Spread of Dermatophytes Among Families
The objective is to demonstrate person-to-person spread of dermatophytes of the skin and nails among family members, as measured by fungal culture and DNA typing of the dermatophytes isolated.
- Trial name
- NCT00233493
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Distal Subungual Onychomycosis, Fungal Infection
A Trial Involving Treatment of BB2603 in Subjects With Distal Subungual Onychomycosis of the Toenail
This study will be a multicenter, international, randomized, vehicle-controlled, parallel-group, double-blinded study. Subjects who are eligible to participate with a confirmed diagnosis of Distal Subungual onychomycosis (DSO) of…
- Conditions
- Distal Subungual Onychomycosis, Fungal Infection, Fungus, Nail
- Trial name
- NCT04188574
- Testing
- BB2603-1, BB2603-3, BB2603-10
- Where
- 20 sites in Czechia, Germany and 1 more
- Volunteers
- 111 people
- Sponsor
- Blueberry Therapeutics
Onychomycosis
A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail
Approximately 40 qualified subjects with mild-to-moderate great toenail fungus infection will be treated for 48 weeks with lacquer application to at least one affected great toenail.
- Trial name
- NCT00385502
- Testing
- EcoNail™ (econazole 5%/SEPA® 18% nail lacquer)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Abeona Therapeutics, Inc
Ingrown Toenail
Effectiveness of Lavage With Alcohol - Chlorhexidine for Chemical Matricectomy
To compare the efficacy of the lavage with 70% alcohol plus 0.5% chlorhexidine versus 70% alcohol in the surgical treatment of ingrown toenails.
- Trial name
- NCT01844141
- Testing
- 70% alcohol, 70% alcohol - 0.5% clorhexidine
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Moderate to Severe Nail Psoriasis
Study of Safety, Tolerability, and Efficacy of Secukinumab in Subjects With Moderate to Severe Nail Psoriasis
This purpose of this study was to demonstrate the efficacy of secukinumab versus placebo on nail psoriasis and to assess long-term efficacy, safety and tolerability of secukinumab.
- Trial name
- TRANSFIGURE (NCT01807520)
- Testing
- Secukinumab
- Where
- 40 sites in United States, Australia and 7 more
- Volunteers
- 198 people
- Sponsor
- Novartis Pharmaceuticals