Clinical trials: Narcotic Use, open to volunteers
Opioid Abuse (Disorder)
A Unique, Co-Designed Family-Based Therapy
The goal of this pilot trial is to evaluate the feasibility and acceptability of an adapted MDFT intervention with women who report prior OUD and sex trade involvement participating in specialty court treatment programs.
- Trial name
- NCT07587359
- Testing
- Adapted Multi-Dimensional Family Therapy, Specialty Treatment Court Program Services
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Chronic Pain, Chronic Insomnia
Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
The goal of this study is to test two behavioral interventions for chronic insomnia in individuals with chronic pain and use prescribed opioid medication to treat their chronic pain.
- Conditions
- Chronic Pain, Chronic Insomnia, Opioid Use
- Trial name
- NCT06345872
- Testing
- CBT-I, Treatment as usual, Tapered Withdrawal
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Opioid Use
Opioid Use Post-Discharge After Ambulatory Distal Arm Surgery
The aim of this study is to determine if a standardized evidence-based opioid prescription following elective hand and forearm surgery at Toronto Western Hospital (TWH) will decrease the number of unused opioid pills consumed by…
- Trial name
- NCT04044820
- Testing
- Standardized Prescription
- Where
- Canada
- Volunteers
- 292 people
- Sponsor
- University Health Network, Toronto
HIV-1-infection, Opioid Use Disorder
Evaluation of Switch to Dolutegravir/Lamivudine (DTG/3TC) From Current Suppressive Antiretroviral Therapy in People Living With HIV (PLWH) Receiving Opioid Agonist Therapy (OAT)
The goal of this clinical trial is to determine the efficacy of Dolutegravir/Lamivudine (DTG/3TC), or "Dovato", in virally-suppressed (HIV-1 RNA < 200 copies/mL) individuals receiving opioid agonist therapy such as methadone…
- Trial name
- NCT06580873
- Testing
- DOVATO
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Opioid Use Disorder, Pregnancy
Technology-Enhanced Therapy vs. Medication Monitoring for Buprenorphine Retention in Pregnant Persons
This study involves testing how useful a technology-enhanced therapy is for pregnant people prescribed buprenorphine for the treatment of opioid use disorder, compared to medication monitoring.
- Trial name
- NCT06999811
- Testing
- Empowering Pregnant Women and People Receiving medications for opioid use disorder (EMPWR), Medication monitoring (control)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Medical University of South Carolina
Post Operative Pain, Spinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and…
- Trial name
- MEND (NCT07222072)
- Testing
- Methadone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
HIV Pre-exposure Prophylaxis, HEPATITIS C (HCV)
Trauma-informed, Resilience-based Telehealth Intervention for Improving HIV Prevention and HCV Care for Persons Who Inject Drugs in the Deep South (Pilot Testing: Aim3)
Evaluate the feasibility, acceptability, and usability of the intervention (primary outcomes) and coping skills and resilience (secondary outcomes) of the telehealth intervention over two months (8 weekly sessions) in a…
- Conditions
- HIV Pre-exposure Prophylaxis, HEPATITIS C (HCV), Opioid Use Disorder
- Trial name
- NCT06799702
- Testing
- Telehealth Behavioral Intervention for promoting HIV and HCV care and MOUD among Persons who inject drugs (PWID)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Opioid Withdrawal, Opioid Use Disorder
Assessing a Clinically-meaningful Opioid Withdrawal Phenotype
Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.
- Conditions
- Opioid Withdrawal, Opioid Use Disorder, Opioid Craving
- Trial name
- NCT05027919
- Testing
- Hydromorphone, Naloxone + lofexidine pretreatment, Lofexidine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Orthopedic Trauma Surgery Patients, Postoperative Pain
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
The goal of this clinical trial is to learn if ketamine, given during surgery, can help improve recovery for adults with serious orthopedic trauma.
- Conditions
- Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use, Depression
- Trial name
- NCT06903819
- Testing
- Ketamine, standard general anesthesia
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Texas Tech University Health Sciences Center
Opioid Use Disorder, Staff
Methadone Patient Access to Collaborative Treatment
The trial of Methadone Patient Access to Collaborative Treatment (MPACT) will establish the impact of the intervention on patient outcomes of methadone treatment retention and in treatment overdose.
- Conditions
- Opioid Use Disorder, Staff, Patients
- Trial name
- MPACT (NCT06556602)
- Testing
- MPACT
- Where
- United States
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Arizona
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Interpersonal Brain Function in Opioid Use
The purpose of this study is to assess dyadic physiological coherence and subjective empathic attunement during meditation practices and their association with opioid-related outcomes.
- Trial name
- NCT07386769
- Testing
- Meditation, Psychoeducation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Opioid Use Disorder
Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic
This exploratory project will assess the acceptability and feasibility of monthly extended-release subcutaneous buprenorphine (BRIXADI; XR-B) to treat opioid use disorder (OUD) among persons in the community receiving care on a…
- Trial name
- NCT07176351
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Opioid Withdrawal, Opioid Use Disorder
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
The primary objective of this trial is to measure changes in physiologic signals to quantify the status of the autonomic nervous system during opioid withdrawal and cravings.
- Trial name
- NCT06487533
- Testing
- EmbracePlus Smartwatch, Corti Sensor
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Spark Biomedical, Inc.
Major Depressive Disorder, Opioid Use Disorder
Cortical rTMS as a Treatment for Depression
Depression is a leading cause of disability worldwide with a 19% lifetime prevalence in the United States. Dysfunctional reward processing is one of the core features of depression.
- Conditions
- Major Depressive Disorder, Opioid Use Disorder, Suicidality
- Trial name
- NCT05487911
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Opioid Use Disorder
Measurement Based Care in Opioid Treatment Programs
The goal of this HEAL Initiative study is to enhance the measurement, quality, and equity of care delivered in 20 community opioid treatment programs (OTPs) by creating and using measurement-based care (MBC) tools and systems.
- Trial name
- NCT06965010
- Testing
- Measurement-based care, Measurement As Usual
- Where
- United States
- Volunteers
- 3,650 people
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder, Opioid Use Disorder
TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)
The study aims to explore the potential of Transcranial Magnetic Stimulation (TMS), particularly Theta Burst Stimulation (TBS), as an adjunctive treatment to enhance recovery outcomes (consumption and craving; withdrawal…
- Trial name
- TMS4OUDAUD (NCT07171359)
- Testing
- TMS Low-Dose, TMS High-Dose
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington State University
Opioid Use Disorder
PEX010-Assisted Therapy for Opioid Use Disorder (OUD): a Feasibility Study
The goal of this clinical trial is to learn if it is feasible to use PEX010 for the treatment of opioid use disorder in adults. The study will also assess the safety of PEX010.
- Trial name
- NCT06608459
- Testing
- PEX010-Assisted Therapy
- Volunteers
- 10 people
- Sponsor
- Filament Health Corp.
Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks)
Does Pre-operative Gastric Ultrasound Influence Anaesthetic Decision-Making in Chronic Pain Patients? A Prospective Observational Cohort.
Gastric POCUS has been validated and shown to be an accurate diagnostic tool in both healthy individuals and medically complex patient populations.
- Conditions
- Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks), Gastric Ultrasound in Poorly Controlled Acute-on-chronic Pain, Gastric Ultrasound in Acute Opioid Administration Within 24 Hours Prior to the Procedure
- Trial name
- NCT07537582
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Danat Al Emarat Hospital
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.