Clinical trials: Narcotic-Related Disorders
Opioid-Related Disorders, Drug Overdose
Repeated-dose Behavioral Intervention to Reduce Opioid Overdose
REBOOT is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients with opioid use disorder.
- Trial name
- REBOOT (NCT03838510)
- Testing
- REBOOT
- Where
- 2 sites in United States
- Volunteers
- 268 people
- Sponsor
- San Francisco Department of Public Health
Opioid-Related Disorders
Abuse Potential of Buprenorphine and Naloxone in Non-Dependent Opioid Users
Buprenorphine is a medication used to treat opioid addiction, but individuals who use this drug are at risk of abusing it. A buprenorphine and naloxone combination may reduce the likelihood of buprenorphine addiction.
- Trial name
- NCT00158236
- Testing
- Buprenorphine, Buprenorphine and Naloxone, Hydromorphone
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Opioid-use Disorder
Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization
Investigators will test a novel protocol for starting BUP (buprenorphine-naloxone) treatment. The BUP microdose induction protocol has participants start very low doses of BUP without stopping other opioids that they are taking.
- Conditions
- Substance Use Disorders, Opioid-use Disorder, Chronic Pain
- Trial name
- Micro-bupe (NCT05118204)
- Testing
- BUP microdose induction, TAU, Linkage to outpatient BUP treatment
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Montefiore Medical Center
Opioid Use Disorder, Pregnancy Related
Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE)
The goal of this clinical trial is to compare buprenorphine patch for induction (starting) of buprenorphine in pregnant patients with opioid use disorder. The main questions it aims to answer are: 1.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- Patch BRIDGE (NCT05790252)
- Testing
- Buprenorphine Transdermal Matrix Patch
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Washington University School of Medicine
Hiv, Opioid Use Disorder
Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP
The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention…
- Trial name
- MOST (NCT05669534)
- Testing
- community-friendly health recovery program, Pre-Exposure Prophylaxis and Post-Exposure Prophylaxis
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Connecticut
Opioid Overdose
Project OOPEN: Opioid Overdose Prevention, Education and Intervention
This prospective, randomized emergency department trial will study the effectiveness of an intervention that combines opioid overdose prevention, education and intervention that includes take home naloxone with brief behavioral…
- Trial name
- OOPEN (NCT01788306)
- Testing
- OOPEN+BBCC
- Where
- 3 sites in United States
- Volunteers
- 256 people
- Sponsor
- University of Washington
Opioid-Related Disorders
Evaluation of a Medication Disposal Program in Primary Care
Evidence from recent trials primarily in the post-surgical patient population prescribed opioids for acute pain suggest patients more often properly dispose of unused opioids if instructed by a healthcare professional, if…
- Trial name
- NCT04320004
- Testing
- Education, Education with Reminder, Education + Disposal Bag
- Where
- United States
- Volunteers
- 1,159 people
- Sponsor
- Geisinger Clinic
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder
Intervention to Facilitate MMT/HIV Service Decentralization in Vietnam
Vietnam is currently decentralizing its methadone maintenance therapy (MMT) dispensing network to its local commune health centers (CHC), which provides a window of opportunity to study decentralization of harm reduction and…
- Trial name
- NCT04798534
- Testing
- Service decentralization facilitation intervention
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Opiate-Related Disorders, Opiate Use Disorder
MedSMA℞T Mobile ED
The goal of this clinical trial is to learn if a new smartphone-based intervention can help with factors related to opioid misuse in parents and adolescent/early adult children.
- Conditions
- Opiate-Related Disorders, Opiate Use Disorder, Opioid
- Trial name
- NCT06848504
- Testing
- MedSMA℞T Mobile
- Where
- 3 sites in United States
- Volunteers
- 244 people
- Sponsor
- Olufunmilola Abraham
Opioid Use Disorder
PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study
The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV) among persons who inject drugs.
- Trial name
- CHORUS+ (NCT05769218)
- Testing
- CHORUS+, Standard of care
- Where
- 2 sites in United States
- Volunteers
- 284 people
- Sponsor
- Boston Medical Center
Opioid-Induced Constipation
Colonic Motor Patterns in Healthy Volunteers
Characterization of motor patterns with opioid agonists (codeine) ingestion, and their reversal by a peripherally acting mu-opioid receptor antagonist (Naloxegol).
- Trial name
- NaloxegolHRM (NCT05770960)
- Testing
- Naloxegol, codeine phosphate
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Opioid Use Disorder
PEX010-Assisted Therapy for Opioid Use Disorder (OUD): a Feasibility Study
The goal of this clinical trial is to learn if it is feasible to use PEX010 for the treatment of opioid use disorder in adults. The study will also assess the safety of PEX010.
- Trial name
- NCT06608459
- Testing
- PEX010-Assisted Therapy
- Volunteers
- 10 people
- Sponsor
- Filament Health Corp.
Opioid Abuse
Buprenorphine Induction and Naloxone Distribution Program-Combined With Warm Hand-Off Referral to Continued Treatment
This study is a collaboration between the University of Utah and Castleview Hospital in Price, Utah. Buprenorphine is a medication approved by the FDA to treat Opioid Use Disorder (OUD).
- Trial name
- BINDeR-TX (NCT06087991)
- Testing
- Implementation of the BINDeR-Tx service model
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Jerry Cochran
Opioid Addiction
Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support
TCN PATHS will recruit an anticipated 400 participants who are prescribed MOUD who are released from detention facilities. Each individual will be randomized to either 1) standard primary care (SPC) or 2) a Transitions Clinic…
- Trial name
- TCN-PATHS (NCT04309565)
- Testing
- Transitions Clinic Network Primary Care, Standard Primary Care
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 398 people
- Sponsor
- Yale University
Opiate Dependence, Stimulant Dependence
Atomoxetine for ATS and Opioid Dependence During Buprenorphine Maintenance Treatment in Malaysia
To evaluate the tolerability, acceptability and potential effect size of the efficacy of 4 months of atomoxetine treatment for patients with co-occurring ATS and heroin dependence (COATS) receiving buprenorphine maintenance…
- Trial name
- NCT01863251
- Testing
- Atomoxetine
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- Yale University
Opioid Dependence
Opioid Maintenance Medications Comparison Study
A 17 week, double-blind, randomized, parallel group, four arm design outpatient study comparing LAAM, buprenorphine and two dose levels of methadone for the treatment of opioid dependence.
- Trial name
- NCT00344812
- Testing
- LAAM. buprenorphine and methadone
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Johns Hopkins University
Stigma, Social, Opioid Use
SMART Trial: Intrapersonal and Interpersonal Stigma Reduction
The goal of this project is to develop a multicomponent stigma reduction intervention to address intrapersonal (individual) stigma regarding Opioid Use Disorder (OUD).
- Conditions
- Stigma, Social, Opioid Use, Opioid-use Disorder, Substance Use Disorders
- Trial name
- NCT04693416
- Testing
- Intrapersonal Stigma Reduction, Interpersonal Stigma Reduction
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Tennessee
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Counseling
Improving Treatment and Recovery Services for Individuals With Opioid Problems
Participants include persons receiving buprenorphine treatment and Recovery Guide counseling in a Federally Qualified Health Center or buprenorphine treatment by telemedicine and Recovery Guide counseling in a church or…
- Trial name
- NCT05129813
- Testing
- Recovery Guide Counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Howard University