Clinical trials: Nasal High Flow Therapy
Hypoxia
High Flow Nasal OXygen Therapy in High Risk Patients of Hypoxia Undergoing Diagnostic BRONCHOscopy
The purpose of this study is to determine the efficacy and safety of nasal high flow oxygen therapy during diagnostic bronchoscopy.
- Trial name
- HFNOT (NCT01650974)
- Testing
- HFNOT
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Seoul National University Hospital
Physical Therapy in Cardiac Surgery Patients
Impact of Physiotherapy Session in Cardiac Surgery Patients
This work consists, first of all, in making an inventory of the physiotherapy of the patient undergoing cardiac surgery under high flow oxygenation at the CHRU NANCY.
- Trial name
- NCT04793802
- Testing
- PHYSIO
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Central Hospital, Nancy, France
Oxygen Inhalation Therapy
Effect of a Modified Oxygen Mask Associated to Nasal Prongs During a High Flow Oxygenation Method
The aim of this study is to determine the effect (on PaO2) of a modified mask associated to nasal cannula used for high flow oxygenation.
- Trial name
- NCT03319602
- Testing
- Double trunk mask add above a nasal canulae
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Laboratory of Movement, Condorcet, Tournai, Belgium
Acute Lung Injury, Acute Respiratory Failure
Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)
The aim of the study is to compare, in patients with acute respiratory failure/acute lung injury the efficacy of three different methods of oxygenation to prevent endotracheal intubation : 1.
- Trial name
- FLORALI (NCT01320384)
- Testing
- O2 conventional, O2-HFN : high flow nasal oxygen therapy, O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
- Where
- France
- Volunteers
- 313 people
- Sponsor
- Poitiers University Hospital
Acute Respiratory Failure With Hypoxia
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF.
- Trial name
- IRAvista (NCT04664322)
- Testing
- non invasive ventilation and high flow nasal canulae oxygen therapy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Rouen
Healthy Volunteers, Diaphragm
High Flow Oxygen Therapy Effect on Healthy Subjects
The use of high-flow nasal cannula (HFNC) has increased. Diaphragmatic ultrasonography is a tool that, as a noninvasive complement to esophageal pressure (Pes) measurement, allows the evaluation of diaphragm function and…
- Conditions
- Healthy Volunteers, Diaphragm, Respiratory Rate
- Trial name
- NCT06086769
- Testing
- High flow nasal canula
- Where
- Argentina
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Argentinian Intensive Care Society
Hypoxia, Oxygen Therapy
Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia
High-flow nasal cannula (HFNC) that uses heated and humidified oxygen was recently introduced for bedside care. It has been shown to be associated with reduced risks of tracheal intubation rates and mortality in adult hypoxic…
- Conditions
- Hypoxia, Oxygen Therapy, High Flow Nasal Cannula, Ventilation
- Trial name
- NCT02943863
- Testing
- HFNC followed by conventional nasal cannula, Conventional nasal cannula followed by HFNC
- Volunteers
- 24 people
- Sponsor
- Asan Medical Center
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure with Hypoxia
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease.
- Trial name
- NCT06694311
- Testing
- CPAP, HFNO 50 L/min
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Ricard Mellado Artigas
Oxygen Titration in Preterm Infants to Manage Lung Disease
IntellO2 vs Manual Control for Optimizing Oxygenation in Infants
The overall objective of this study is to demonstrate that the IntellO2 device providing automated control of fraction of inspired oxygen (FiO2) adjustments in spontaneously breathing infants with fluctuating arterial blood…
- Trial name
- NCT02074774
- Testing
- IntellO2, Manual control
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- Vapotherm, Inc.
Healthy Volunteers
Examining the Effects of Nasal High Flow Oxygen Therapy Compared to Non-invasive Ventilation in Health Volunteers
Respiratory failure is characterized by low levels of oxygen and high levels of carbon dioxide in the blood which causes difficulty breathing.
- Trial name
- NCT03902639
- Testing
- Phase 1 and 2, Phase 3
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Bronchiolitis
Treatment Of Bronchiolitis With Heated Humidified High Flow Nasal Cannula - Prospective And Retrospective Research
Bronchiolitis is an acute lower airway infection caused by a viral infection. It is a major cause of winter admissions to pediatric wards.
- Trial name
- NCT02366715
- Testing
- HeatedHumidifiedHighFlowNasalCannula
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rabin Medical Center
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Obstructive Sleep Apnea
Clinical Efficacy of High-flow Nasal Cannula Oxygen Therapy in Patients With Obstructive Sleep Apnea
Patients meeting the criteria of obstructive sleep apnea were included, and all patients signed informed consent, which met the requirements of the ethics Committee of our unit. All subjects were hospitalized patients.
- Trial name
- NCT05549245
- Testing
- high-flow nasal cannula oxygen therapy,, CPAP
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Qilu Hospital of Shandong University
Pulmonary Hypertension
Hemodynamic Effect of Nasal High-flow in Patients Suspected or Followed for a Precapillary Pulmonary Hypertension
In this study, the investigators aim to describe the hemodynamic consequences of nasal high-flow measured during right heart catheterization and echocardiography.
- Trial name
- HighFlowHD (NCT06079151)
- Testing
- Nasal high-flow
- Where
- France
- Volunteers
- 20 people
- Sponsor
- ADIR Association
Acute Respiratory Failure, Acute-on-chronic Respiratory Failure
VICOR Study-High Frequency Chest Wall Oscillations (HFCWO) in Patients With Acute Respiratory Failure and Hypersecretion
The study aims to evaluates if the treatment with HFCWO Via The Vest® Airway Clearance System, in addition to standard care in critically ill patients admitted in the Respiratory Intensive Care Unit for acute respiratory failure…
- Conditions
- Acute Respiratory Failure, Acute-on-chronic Respiratory Failure, Airway Clearance Impairment
- Trial name
- VICOR2 (NCT05751707)
- Testing
- High Frequency Chest Wall Oscillations via The Vest® Airway Clearance System
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Raffaele Scala
Respiratory Failure
Physiologic Effects of High Flow Nasal Therapy in Patients With Acute Hypoxemic Respiratory Failure (OPTIFLOW)
The aim of the study is to assess, in patients with acute hypoxemic respiratory failure, the short term physiologic effects of the high flow oxygen nasal therapy (Optiflow), in term of inspiratory muscle effort, gas exchange…
- Trial name
- NCT01056952
- Testing
- O2stand, CPAP, Optiflow
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bordeaux
Apnea, Anesthesia
Functional Residual Capacity Under Apnoeic Oxygenation with Different Flow Rates in Children
During induction of general anaesthesia physiological breathing stops and needs to be artificially established with facemask ventilation, and finally tracheal intubation or placement of a supraglottic airway.
- Conditions
- Apnea, Anesthesia, Intubation Complication, Children, Only
- Trial name
- FUTURE (NCT05672329)
- Testing
- 0.2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 2 L/kg/min, FiO2 1.0 + continuous jaw thrust, 4 L/kg/min, FiO2 1.0 + continuous jaw thrust
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- Thomas Riva
End-Expiratory Lung Impedance, Respiratory Rate
Asymmetrical High Flow Nasal Cannula and End-Expiratory Lung Impedance
Objective: The primary aim is to assess end-expiratory lung impedance (EELI) changes during the application of high-flow oxygen therapy using asymmetric nasal cannulae, comparing conditions with the mouth closed and open in…
- Conditions
- End-Expiratory Lung Impedance, Respiratory Rate, Diaphragm Thickness Fraction, Diaphragm Excursion
- Trial name
- EELI and AHFNC (NCT06674629)
- Testing
- High flow oxygen therapy
- Where
- Argentina
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Argentinian Intensive Care Society
Respiratory Insufficiency, Hypoxia
Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation
1. To determine the lowest nasal cannula flow rate in which upper airway deadspace is reduced. Hypothesis - The lowest flow rate of high flow nasal cannula (HFNC) will reduce upper airway (extrathoracic) deadspace and improve…
- Trial name
- HFNC (NCT02460653)
- Testing
- HFNC Flow Rate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Acute Respiratory Distress Syndrome, COVID-19
Prone Position in Patients on High-flow Nasal Oxygen Therapy for COVID-19 (HIGH-PRONE-COVID-19)
Acute Respiratory Distress Syndrome (ARDS) induces high mortality, particularly in the context of COVID-19 disease. Preliminary data from patients with ARDS related to COVID-19 disease appear to show significant effectiveness of…
- Trial name
- NCT04358939
- Testing
- Prone decubitus
- Where
- 24 sites in France
- Volunteers
- 405 people
- Sponsor
- University Hospital, Tours