Clinical trials: Nasal High Flow Therapy
Acute Respiratory Failure, Electrical Impedance Tomography (EIT)
Predicting High-Flow Nasal Oxygen Failure Within 72 Hours Using a Physiology-Informed Dual-Domain Model at 30 Minutes
This is a single-center, ambispective observational cohort study of adults with acute hypoxemic respiratory failure (AHRF) receiving high-flow nasal oxygen (HFNO) as initial respiratory support. The study includes three stages.
- Conditions
- Acute Respiratory Failure, Electrical Impedance Tomography (EIT), High-Flow Nasal Oxygen Therapy
- Trial name
- EFI-HFNO (NCT07366541)
- Testing
- High-Flow Nasal Oxygen Therapy, Electrical Impedance Tomography Monitoring
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Ruijin Hospital
Respiratory Failure
Nasal High-flow Versus Venturi Mask Oxygen Therapy in the Post-extubation Period
The aim of the study is to compare two devices for oxygen therapy, nasal high-flow and Venturi mask, in critically ill patients in the post-extubation period.
- Trial name
- NCT01575353
- Testing
- Venturi mask, Nasal high-flow
- Where
- 2 sites in Italy
- Volunteers
- 105 people
- Sponsor
- Catholic University of the Sacred Heart
Intensive Care Unit, Mechanical Ventilation
Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients
Dexmedetomidine and ketamine are both suggested for sedation and analgesia in ICU patients. Recent studies suggest that low-dose dexmedetomidine or ketamine/esketamine may improve sleep quality of ICU patients.
- Conditions
- Intensive Care Unit, Mechanical Ventilation, Dexmedetomidine, Esketamine
- Trial name
- NCT05718024
- Testing
- Dexmedetomidine-esketamine, Routine sedation and analgesia
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Peking University First Hospital
Hypoxemia
Comparative Study on the Effectiveness, Comfort and Compliance of HFNC and Noninvasive Mechanical Ventilation BiPAP Mode in the Treatment of Hypoxemia Patients
Patients who met the inclusion criteria were included and signed an informed consent form, which complied with the requirements of the ethics committee of our unit. All subjects were inpatients.
- Trial name
- NCT05784636
- Testing
- Non-invasive BiPAP ventilation, HFNC
- Where
- China
- Volunteers
- 243 people
- Sponsor
- Qilu Hospital of Shandong University
Cerebral Infarction, Sleep Apnea, Obstructive
High-flow Nasal Cannula Oxygen Therapy for Ischemic Stroke Patients With Dysphagia and Obstructive Sleep Apnea
High flow nasal cannula (HFNC) ventilation therapy was found to improve the severity of obstructive sleep apnea in non-stroke subjects.
- Conditions
- Cerebral Infarction, Sleep Apnea, Obstructive, Deglutition Disorders
- Trial name
- NCT04173767
- Testing
- high flow nasal cannula ventilation
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- Chang Gung Memorial Hospital
Airway Extubation, Oxygen Inhalation Therapy
High Flow Nasal Cannula in Immediately Post Extubation
The aim of the study is to determine the incidence of failure of extubation in high-risk patients using High Flow Nasal Cannula (HFNC) to prevent such failure in the Intensive Care Unit. A prospective cohort study was performed.
- Trial name
- HFNC (NCT03495947)
- Testing
- high flow nasal cannula
- Where
- Argentina
- Volunteers
- 165 people
- Sponsor
- Hospital Italiano de Buenos Aires
Patients With Respiratory Insufficiency
High Flow Nasal Cannulae Oxygen Therapy in Respiratory Insufficiency Patients
Chronic respiratory insufficiency in patients with advanced disease to the late treatment depends mainly on mechanical ventilation and other high intensity respiratory support therapy.
- Trial name
- NCT02972021
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Acute Respiratory Failure, Cancer
Oxygenation Methods and Non-invasive Ventilation in Patients With Acute Respiratory Failure and a do Not Intubate Order
ICU care of patients considered "palliative" but without contraindications to admission to intensive care, for whom a do-not intubate order decision was made upon admission represents a particular target for non-invasive…
- Conditions
- Acute Respiratory Failure, Cancer, Hematologic Malignancy, Cardiac Insufficiency
- Trial name
- OXYPAL (NCT03673631)
- Testing
- NIV, NFHC-O2
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Poitiers University Hospital
Premature Infant, Ventilation Therapy
High Flow Nasal Cannula for Stabilization of Extremely Premature Infants
A prospective observational study evaluates the safety and efficacy of using High-Flow Nasal Cannula to stabilize extremely preterm infants immediately after birth.
- Conditions
- Premature Infant, Ventilation Therapy, High Flow Nasal Canula
- Trial name
- SIMPLSAFE2 (NCT06683677)
- Testing
- High-Flow Nasal Cannula
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Acute Cardiogenic Pulmonary Edema, Hypercapnic Respiratory Failure
High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema
The purpose of this study is to determine whether high flow nasal oxygen (HFNO) therapy is non inferior to non invasive ventilation (NIV) in the immediate treatment of patients with acute hypercapnic cardiogenic pulmonary edema…
- Trial name
- OPTICAP (NCT02874339)
- Testing
- High flow nasal oxygen therapy, Non invasive ventilation
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
Undefined
Gastric Volume in Paralyzed Obese Patients After High-flow Nasal Oxygen Therapy
Preoperative preoxygenation is performed using High-flow nasal oxygen therapy, and the gastric volume before and after High-flow nasal oxygen therapy is measured by ultrasound and compared in obese patients undergoing surgery…
- Trial name
- NCT06216912
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Bronchiolitis, Pneumonia
Airway Pressure During Humidified High Flow Nasal Cannula Therapy in Children
Humidified High Flow Nasal Cannula (HHFNC) is a new modality of respiratory support for children with respiratory failure. Despite its extensive use in pediatric and adult population, the exact mechanism of work of HHFNC is not…
- Conditions
- Bronchiolitis, Pneumonia, Bronchial Asthma
- Trial name
- NCT02387632
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Respiratory Failure
The Physiologic Effect of the Flow Generated by High Flow Nasal Cannula in Mild Respiratory Failure
High flow nasal cannula (HFNC) oxygen therapy is increasingly used for hypoxemic respiratory failure and is proving useful in avoiding or delaying intubation and mechanical ventilation.
- Trial name
- NCT05708287
- Testing
- HFNC
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Hadassah Medical Organization
Cystic Fibrosis
HFNT During Exercise in CF
Cystic fibrosis (CF) is a genetic condition characterised by recurrent lung infections, inflammation and progressive lung damage.
- Trial name
- NCT03965832
- Testing
- HFNT during exercise, Standard oxygen therapy/RA
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Hypoxemia, Hemodynamic Instability
High-Flow Nasal Oxygen During Endoscopic Retrograde Cholangiopancreatography In Geriatric Patients
This prospective, single-centre, randomized controlled trial evaluates whether high-flow nasal oxygen (HFNO) reduces hypoxaemia compared with conventional low-flow oxygen therapy (COT) during endoscopic retrograde…
- Trial name
- HFNO ERCP (NCT07493811)
- Testing
- HFNO, Conventional Oxygen Therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Respiratory Failure, Respiratory Insufficiency
Comparison of High-flow Oxygen vs. BiPAP in Type II (Hypercapnic) Respiratory Failure
A retrospective cohort study of all patients treated for type II (hypercapnic) respiratory failure with either High-Flow Oxygen Therapy or Non-Invasive Ventilation in a general adult hospital.
- Conditions
- Respiratory Failure, Respiratory Insufficiency, Respiratory Tract Diseases, COPD
- Trial name
- NCT03443479
- Testing
- Non-Invasive Ventilation, High-Flow Nasal Cannula
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Hôpital de Verdun
Sleep Apnea, Obstructive
High Flow Nasal Cannula as a Treatment for Obstructive Sleep Apnea
A single center, prospective study to assess the efficacy of high flow nasal cannula (HFNC) in improving obstructive sleep apnea (OSA) parameters in patients with reduced tolerance to continuous positive airway pressure (CPAP)…
- Trial name
- NCT03017859
- Testing
- High flow nasal cannula
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
Chronic Obstructive Pulmonary Disease (COPD), Nasal High Flow Oxygen Therapy
Efficacy of HFNC Combined With Sequential NIV in Patients With COPD Complicated With Type II Respiratory Failure
The goal of this clinical trial is to investigate the efficacy of high-flow nasal cannula oxygen therapy (HFNC) combined with sequential non-invasive ventilation (NIV) in patients with chronic obstructive pulmonary disease…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Nasal High Flow Oxygen Therapy, Noninvasive Ventilation, Respiratory Failure
- Trial name
- NCT06992479
- Testing
- high-flow nasal cannula oxygen therapy (HFNC) combined with sequential non-invasive ventilation (NIV), NIV routine treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing YouAn Hospital
High-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation
The Physiological Effect of High Flow Oxygen Therapy
Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or…
- Conditions
- High-flow Nasal Cannula, Non-invasive Positive Pressure Ventilation, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Trial name
- NCT04212182
- Testing
- HFNC, NPPV
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University