Clinical trials: Nasal High Flow Therapy
Chronic Obstructive Pulmonary Disease
High Flow Nasal Cannula During Pulmonary Rehabilitation
The primary purpose of this study is to compare and assess the immediate and long-term effects on pulmonary rehabilitation training with the usage of HFNC or conventional oxygen therapy device.
- Trial name
- NCT03237962
- Testing
- High Flow Nasal Cannula, Nasal Cannula
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people
- Sponsor
- Chang Gung University
Deep Sedation, Oxygen Therapy
HFNC Vs LFNC in Patients with AF Undergoing RFCA Under Deep Sedation.
Oxygen supplementation through high flow nasal cannula (HFNC) may reduce the incidence of desaturation and hypoxemia during deep sedation at radiofrequency catheter ablation (RFCA procedures).This study is designed to test the…
- Conditions
- Deep Sedation, Oxygen Therapy, Radiofrequency Ablation
- Trial name
- NCT04842253
- Testing
- High flow nasal cannula
- Where
- Netherlands
- Volunteers
- 141 people
- Sponsor
- Maastricht University Medical Center
Acute Bronchiolitis
Comparison of High Flow Nasal Cannula and Standard Face Mask Oxygen Therapy in Children With Bronchiolitis
The study aims to compare the efficacy of two different oxygenation methods on decrease respiratory rate, heart rate, and clinical respiratory score in children with moderate to severe bronchiolitis requiring oxygen therapy. 1.
- Trial name
- NCT04245202
- Testing
- HFNCOT, St-FMOT
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Ege University
Healthy Volunteers
Gas Composition in the Hypopharynx During High-flow or Standard Oxygen Therapy Through Face Mask in Healthy Volunteers
The COVID-19 pandemic has become a huge global problem, affecting all spheres of human life, resulting in enormous social, economic consequences and human tragedies.
- Trial name
- O2-OXIMETRY (NCT07019701)
- Testing
- High flow oxygen through nasal cannula and face mask and standard oxygen therapy through non-rebreather face mask, and measurement of oxygen and carbon dioxide fraction in the hypopharynx
- Where
- Russia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Carbon Monoxide Poisoning
The Role of High-flow Nasal Cannula Therapy in the Treatment of Acute Carbon Monoxide Poisoning
The aim of the study is to test whether oxygen therapy delivered through high-flow nasal cannula devices in patients admitted to the emergency department for acute carbon monoxide poisoning is superior to the non-rebreathing…
- Trial name
- NCT03818841
- Testing
- High-flow nasal cannula device, Non-rebreathing oxygen mask group
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Acute Respiratory Failure
External Nasal Dilator and Oxygen Therapy in Respiratory Failure
Acute respiratory failure secondary to bronchiolitis and asthma is one of the most common diagnoses in children admitted to pediatric intensive care unit.
- Trial name
- HFNC (NCT02662387)
- Testing
- External nasal dilator (END), High flow nasal cannula (HFNC)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Loma Linda University
Decompensated Heartfailure, Cardio-renal Syndrom
Nasal High Flow at Acute Hart Failure
The pilot study aims to compare the results of using a new respirator (OPTIFLOW TM-High-Flow-Machine) with those from Standard-Oxygen-Therapy during the stabilization of patients who have been hospitalized due to acute heart…
- Trial name
- NCT02058810
- Testing
- Nasal high flow, Conventional nasal oxygen
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Regensburg
Laryngoscopy, Child
Airway Interventions During Intravenous Anesthesia in Children Undergoing Direct Laryngoscopy for Surgical Procedures Using High Flow Nasal Versus Low Flow Oxygen. A Pilot Study.(Flowkid)
The goal of this clinical trial is to evaluate possible differences in airway responses and interventions during intravenous anesthesia for direct laryngoscopy in children when comparing two oxygenation methods (conventional low…
- Conditions
- Laryngoscopy, Child, Oxygen Therapy
- Trial name
- NCT06037915
- Testing
- low flow oxygen with nasopharyngeal tube, high flow oxygen with OptiflowTM Nasal High Flow
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
COVID-19 Pneumonia, COVID-19 Acute Respiratory Distress Syndrome
High-flow Nasal Oxygenation and Non-invasive Ventilation Strategies for the Treatment of Covid-19 Pneumonia
HFNO and NIV strategies are the most commonly used strategies for the treatment of hypoxia in patients with a diagnosis of COVID-19 who are still followed in the intensive care unit, but there is no study comparing the two yet.
- Trial name
- NCT05137431
- Testing
- HFNO and NIV
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Medipol University
RDS - Infants, TTN
Effect of Cannula Size on Oxygen Saturation During Nasal High Flow Therapy in Newborns
Treatment with nasal high flow therapy (NHF) is an increasingly popular method of respiratory support in newborns. Safe and effective use of NHF requires selection of an appropriate nasal prong-to-nares ratio because leak can…
- Trial name
- NCT04459429
- Testing
- Change of cannula size
- Where
- Armenia
- Volunteers
- 25 people
- Sponsor
- Erebouni Medical Center
Hypercapnic Respiratory Failure, Acute Copd Exacerbation
Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure
Current evidence suggests a mechanistic and physiological rationale for the use of high flow nasal cannula (HFNC) in acute respiratory hypoxemic failure (AHRF) based on physiological studies in airway models, healthy volunteers…
- Trial name
- NCT05497986
- Testing
- High flow nasal cannula, Conventional low flow oxygenation
- Where
- 3 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Hôpital de Verdun
COPD
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
Parallel-group, prospective, randomized, controlled phase III trial of home High flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care vs.
- Trial name
- NCT05204888
- Testing
- myAirvo3, Pulse oximeter
- Where
- 27 sites in United States, Canada
- Volunteers
- 642 people
- Sponsor
- Temple University
High Flow Nasal Cannula, Obstructive Sleep Apnea
High Flow Nasal Cannula and Conventional Oxygen Therapy in the Postoperative Management of Patients With Mild to Moderate Obstructive Sleep Apnea
This study aims to compare the effectiveness of conventional oxygen therapy oxygen and high-flow nasal cannula therapy on oxygen saturation (SpO2), measuring number of SpO2 drop >4% of base line oxygen saturation (o2 desaturation…
- Trial name
- NCT06306651
- Testing
- High flow nasal cannula therapy group, Conventional oxygen therapy group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Respiratory Failure
The Efficacy of the Whisperflow CPAP System Versus Nasal High Flow in Patients at High Risk for Postextubation Failure
The purpose of this study is to compare the effect of continuous positive airway pressure (CPAP) delivered by the variable generator WhisperFlow System with high flow nasal cannula oxygen therapy in mechanically ventilated…
- Trial name
- NCT02918786
- Testing
- Nasal high-flow, CPAP
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Ramathibodi Hospital
Colonoscopy
High Flow Nasal Cannula in Patients Undergoing Colonoscopy
During colonoscopy, the insertion of the fiberscope and colon distension required to perform the examination may induce modifications to respiratory mechanics, respiratory effort and breathing pattern.
- Trial name
- NCT05687045
- Testing
- High Flow Nasal Cannula, Conventional Oxygen Therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University Magna Graecia
Central Sleep Apnea, Cheyne-Stokes Respiration
Treatment of Central Sleep Apnoea in Patients With Heart Failure With Nasal High Flow Therapy (nHFT)
To investigate whether nHFT is an effective treatment for patients with Chronic Heart Failure (CHF) and central sleep apnea (CSA).
- Trial name
- RELAX (NCT03085641)
- Testing
- Nasal high flow oxygen therapy
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- University Medical Center Groningen
Sleep Apnea, Obstructive
Heated Humidified High Flow Nasal Cannula for Children With Obstructive Sleep Apnea
The purpose of this study is to determine whether heated humidified high flow nasal cannula (HHHFNC) is effective as a treatment of obstructive sleep apnea syndrome (OSAS) compared to continues positive airway pressure (CPAP)…
- Trial name
- NCT02515409
- Testing
- HHHFNC, CPAP
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Respiratory Failure With Hypercapnia
Extra-Corporeal Carbon Dioxide Removal in Exacerbations of Chronic Obstructive Pulmonary Disease
Around 20% of the patients requiring hospitalization for Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) develop hypercapnia, which is associated with an increased risk of death.
- Trial name
- NCT03990155
- Testing
- HFNCOT+ECCO2R
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT
Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study
This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.
- Conditions
- Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT, Consent of Patients, Arterial Line
- Trial name
- HiFloLUS (NCT01702779)
- Testing
- mechanical ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand