Clinical trials: Nasal Surgery
Chronic Rhinosinusitis, Intraoperative Bleeding
Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy
Functional endoscopic sinus surgery (FESS), or sinusoscopy, is a standard surgical procedure used to treat chronic rhinosinusitis and other conditions of the nasal sinuses.
- Conditions
- Chronic Rhinosinusitis, Intraoperative Bleeding, Blood Loss, Surgical
- Trial name
- NCT07866274
- Testing
- Ascorbic acid
- Volunteers
- 78 people
- Sponsor
- Assiut University
Rhinosinusitis Chronic, Wound Healing
Evaluation of the Safety and Performance of a Bioresorbable Nasal Dressing Containing Mometasone Furoate
The objective of this study is to investigate the safety and performance of OCEAN® as an adjunct in wound healing after nasal/sinus surgery by using OCEAN® in patients undergoing nasal/sinus surgery.
- Conditions
- Rhinosinusitis Chronic, Wound Healing, Sinus Surgery, Mometasone Furoate
- Trial name
- ENHANCE (NCT06642116)
- Testing
- OCEAN
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Polyganics BV
Sinusitis Chronic
GLS-1200 Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery
This clinical trial will evaluate the safety, tolerability and effectiveness of GLS-1200 nasal spray in addition to the standard of care after endoscopic sinus surgery in people with chronic sinusitis.
- Trial name
- NCT04060316
- Testing
- GLS-1200
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- GeneOne Life Science, Inc.
Polyp of Ethmoidal Sinus, Surgery
RESPIMER® Netiflow® vs. Saline Solutions During Nasal Irrigation Following Bilateral Ethmoidectomy (Nasal Polyposis)
The main objective of this study is to compare the effects of RESPIMER® NetiFlow® solution and device versus saline solution (0.9% NaCl), the standard treatment, used with RESPIMER® NetiFlow® device, both used postoperative care…
- Trial name
- NETIFLOW (NCT02559284)
- Testing
- A postoperative care after ethmoid sinus surgery
- Where
- 8 sites in France
- Volunteers
- 189 people
- Sponsor
- Laboratoire de la Mer
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Ileostomy; Complications
A Randomized Parallel-controlled Study Comparing the Ileostomy "Dumpling Suture Method" With Traditional Suture Method in Rectal Anterior Resection Surgery With Specimen Extraction Via Stoma
Natural Orifice Specimen Extraction Surgery (NOSES), which involves obtaining specimens from the abdominal cavity without any incisions, has attracted much attention in recent years, and it has been widely popularized in the…
- Trial name
- NCT05985499
- Testing
- Suturing of ileostomy using "Dumpling suture method", Suturing of ileostomy using Traditional suture method
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Surgical Site Infections, Surgical Wound Infection
Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections
This is a Phase 3 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major…
- Conditions
- Surgical Site Infections, Surgical Wound Infection, Infections, Anti-Infective Agents
- Trial name
- LANTERN (NCT06702878)
- Testing
- nasal antimicrobial photodisinfection therapy
- Where
- 14 sites in United States
- Volunteers
- 4,787 people
- Sponsor
- Ondine Biomedical Inc.
Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps
Comparison of Laryngeal Mask and Tracheal Intubation With and Without Topical Lidocaine Application
The study aims to identify the advantages and disadvantages of each of the three methods of airway management during FESS.
- Conditions
- Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps, Deviated Nasal Septum, Osteoma of the Paranasal Sinuses
- Trial name
- NCT07548866
- Testing
- anesthesia of the respiratory tract with lidocaine, tracheal intubation, laryngeal mask placement
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Chronic Rhinosinusitis With Nasal Polyposis
Study in Adults With Severe Chronic Rhinosinusitis With Nasal Polyposis Treated With Dupilumab in France
This is a multicentre, non-interventional, single arm study that aims to describe the treatment patterns in France: patients' characteristics, disease characteristics, prior treatments for Severe chronic rhinosinusitis with nasal…
- Trial name
- OPALE (NCT06393946)
- Testing
- Dupilumab
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Sanofi
Cardiac Surgery
High Flow Nasal Oxygen Therapy (Optiflow™) in High-risk Cardiac Surgical Patients
Background: High risk patients with lung disease who undergo cardiac surgery are at significant risk of postoperative complications leading to prolonged hospital stay.
- Trial name
- NCT02496923
- Testing
- High flow nasal oxygen therapy (Optiflow™), Standard oxygen therapy (Hudson Type face mask or nasal prongs)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Postoperative Pulmonary Atelectasis, Surgery
Prophylactic nCPAP Following Bowel Surgery (Bio-REB File 11-27)
The purpose of this study is to determine whether prophylactic nasal continuous positive airway pressure (nCPAP) in the post-anaesthesia care unit (PACU) improves post-operative pulmonary function following elective bowel…
- Trial name
- NCT01316575
- Testing
- nCPAP, Low Flow Oxygen
- Volunteers
- 40 people
- Sponsor
- University of Saskatchewan
Neurectomy
Graft Reinforcement for Posterior Nasal Nerve Neurectomy in Allergic Rhinitis Surgeries
Rhinitis is defined clinically as having two or more symptoms of anterior or posterior rhinorrhea, sneezing, nasal blockage and/or itching of the nose during two or more consecutive days for more than 1 h on most days.
- Trial name
- NCT05880134
- Testing
- conventional posterior nerve neurectomy, cartilage graft reinforcement after posterior nerve neurectomy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Kafrelsheikh University
Patients, Sinusitis
The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
The treatment of eosinophilic sinusitis with nasal polyps is difficult and challenging. After endoscopic sinus surgery(ESS), complications such as edema, scar formation, adhesions, sinus stenosis and recurrence of polyps are…
- Conditions
- Patients, Sinusitis, Nasal Polyps
- Trial name
- NCT03943121
- Testing
- Steroid-eluting stent implant, Without Steroid-eluting stent implant
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Tongren Hospital
Paranasal Sinus Disease
Effectiveness of Antibiotic Delivery Via Bio-absorbable Sponge
This study will evaluate the efficacy of a nasopore sponge dressing soaked in Bacitracin VS a sponge soaked in Saline / and the administration of oral antibiotics.
- Trial name
- NCT01222832
- Testing
- Bacitracin
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Postoperative Pain
Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries.
Efficacy of fentanyl soaked nasal packs on postoperative pain in nasal surgeries.
- Trial name
- NCT06531759
- Testing
- Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University
OSA
Efficacy of HFNC as an Alternative to CPAP Therapy in Surgical Patients With Suspected Moderate to Severe OSA
High flow, humidified, temperature-regulated nasal insufflation is not a new concept. It is used widely in the treatment of hypoxaemic respiratory failure in critically ill patients, as an alternative to non-invasive positive…
- Trial name
- NCT05075668
- Testing
- CPAP face mask, High flow nasal cannula (HFNC)
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Changi General Hospital
Postoperative Pulmonary Atelectasis, Surgery
Prophylactic nCPAP in the PACU Following Elective Laparotomy for Bowel Surgery
The purpose of this study is to determine whether prophylactic nasal continuous positive airway pressure (nCPAP) in the post-anaesthesia care unit (PACU) improves post-operative pulmonary function following elective bowel…
- Trial name
- NCT02077842
- Testing
- Nasal Continuous Positive Airway Pressure, Low Flow Oxygen
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Saskatchewan
Endoscopic Frontal Sinus Surgery, Chronic Rhinosinusitis With Nasal Polyps
Endoscopic Frontal Sinus Surgery Draf III in Moderate to Severe Eosinophilic Chronic Rhinosinusitis With Polyps
The aim of this study is to evaluate the effect of the primary endoscopic frontal sinus surgery on the clinical outcome in patients having moderate to severe eosinophilic chronic rhinosinusitis with polyps with primary outcome…
- Conditions
- Endoscopic Frontal Sinus Surgery, Chronic Rhinosinusitis With Nasal Polyps, Draf III, Draf I or IIa
- Trial name
- NCT05979662
- Testing
- Endoscopic frontal sinus surgery grade 6(Draf III)., Endoscopic frontal sinus surgery grade 1-3(Draf I or IIa)
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Ibrahim Talal Elshamy
Orthognathic Surgery
Accuracy of Maxillary Fixation Using Custom Plates on Nasal Buttress Only Via Minimally Invasive Approach Versus Custom Plates on Nasal and Zygomatic Buttresses Via Conventional Approach in Orthognathic Surgeries
The goal of this clinical trial is to evaluate of the accuracy maxilla fixation using custom plates on nasal buttress only via minimally invasive approach versus using custom plates on nasal and zygomatic buttresses via…
- Trial name
- NCT07311785
- Testing
- minimally invasive maxillary fixation, Maxilla fixation using custom plates on nasal and zygomatic buttresses via conventional vestibular approach.
- Volunteers
- 30 people
- Sponsor
- Cairo University
Knee Replacement Surgery
The Effect of Nasal Continuous Positive Airway Pressure (N-CPAP) on Arterial pCO2 During Spinal Anesthesia
The proposed study intends to investigate several aspects of the respiratory effects of intravenous sedation of patients undergoing spinal anesthesia for knee replacement surgery.
- Trial name
- NCT01622647
- Testing
- Nasal Continuous Positive Airway Pressure (NCPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pediatrix