Clinical trials: Nasolabial Folds
Nasolabial Fold
Tissue Repositioning Versus Tissue Support in Thread Lifting for Nasolabial Fold Correction: A Randomized, Evaluator-Blinded, Parallel-Group Controlled Trial
This randomized clinical trial compares two minimally invasive thread-lifting procedures for improving moderate-to-severe nasolabial folds, the lines that run from the sides of the nose toward the corners of the mouth.
- Trial name
- NCT07877870
- Testing
- predominantly tissue-repositioning thread lifting, predominantly tissue-support thread-lifting
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Nasolabial Fold Wrinkles
DL6049 vs CosmoPlast in the Treatment of Nasolabial Fold Wrinkles
This study is being undertaken to: evaluate the degree of correction attainable with DL6049 (injectable poly-L-lactic acid)compared to a commercially available CosmoPlast™ Collagen Implant in the treatment of dermal nasolabial…
- Trial name
- NCT00444210
- Testing
- DL6049 (injectable poly-L-lactic acid)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Bausch Health Americas, Inc.
Facial Wrinkles
Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds
This is a randomized, double-blind pivotal study to evaluate the safety and effectiveness of CosmetaLife injectable dermal filler for the correction of wrinkles and folds, such as nasolabial folds (i.e., smile lines).
- Trial name
- NCT00414544
- Testing
- CosmetaLife, Restylane
- Where
- 5 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Cosmeta
Wrinkles
Safety Study of Cosmetic Tissue Augmentation in People of Color
Elevess is intended for all skin types. However, further study of all soft tissue fillers is needed in people of color because of the increasing use of cosmetic dermal filler products.
- Trial name
- NCT01147172
- Testing
- Elevess
- Where
- 9 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Anika Therapeutics, Inc.
Wrinkles in the Nasolabial Folds
Effectiveness and Safety of YVOIRE Y-Solution 540
To Evaluate the Effectiveness and Safety of YVOIRE Y-Solution 540 versus YVOIRE volume plus in Nasolabial Folds Injection
- Trial name
- NCT04855188
- Testing
- YVOIRE Y-Solution 540, YVOIRE volume plus
- Where
- China
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- LG Chem
Nasolabial Folds
Juvederm Ultra With Lidocaine Compared With Restylane for the Correction of Nasolabial Folds
Comparison of the safety and effectiveness of Juvederm Ultra with lidocaine compared with Restylane in the correction of nasolabial folds.
- Trial name
- NCT00850889
- Testing
- Hyaluronic acid gel (24 mg/mL) with 0.3% lidocaine, A gel of hyaluronic acid (concentration of 20 mg/mL)
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Allergan Medical
Nasolabial Fold, Cheek Augmentation
Preliminary Safety and Effectiveness of SMI-01 as a Tissue Filler
Multicenter (two clinical sites), unblinded, no control group, prospective feasibility study. Subject participation may last up to 24 months after enrollment.
- Trial name
- NCT04534660
- Testing
- SMI-01
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Sofregen Medical, Inc.
Nasolabial Folds
A Study Comparing Lafullen15 and Lafullen for Temporary Nasolabial Fold Improvement
The objective of this clinical trial is to verify the safety and efficacy of Lafullen15 in the temporary improvement of nasolabial Folds
- Trial name
- NCT06295172
- Testing
- Lafullen15, Lafullen
- Volunteers
- 73 people
- Sponsor
- Samyang Biopharmaceuticals Corporation
Nasolabial Folds, Lipoatrophy
Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers
This Phase 1, randomized, placebo-controlled, double-blind, healthy volunteer study tested the safety, tolerability, and plasma pharmacokinetics of two different concentrations of TAT4 Gel administered once daily to 50 cm2 of…
- Conditions
- Nasolabial Folds, Lipoatrophy, Lipodystrophy
- Trial name
- NCT02647853
- Testing
- TAT4 Gel concentration A, TAT4 Gel concentration B
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Topokine Therapeutics, Inc.
Correction of Moderate to Severe Nasolabial Folds (NLFs)
Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Moderate to Severe Nasolabial Folds
Effectiveness: The purpose of this study is to demonstrate the non-inferiority of Radiesse (CaHA) to Restylane (HA) following subdermal implantation for the correction of moderate to severe facial wrinkles and folds, such as…
- Trial name
- NCT04647721
- Testing
- Radiesse injectable implant (dermal filler), Restylane injectable implant (dermal filler)
- Where
- 7 sites in China
- Volunteers
- 134 people
- Sponsor
- Merz North America, Inc.
Nasolabial Folds, Wrinkles
Study of JTM104 Injection vs. Juvederm in Treating Moderate to Severe Nasolabial Folds
Study of JTM104 Injection vs. Juvederm in Treating Moderate to Severe Nasolabial Folds
- Trial name
- NCT07265791
- Testing
- JTM104, Juvederm® ULTRA PLUS XC
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Jetema Co., Ltd.
Nasal Disease, Nasal Surgery
Medical Device Pivotal Study to Injection With SkinPlus-HYAL Implant Lidocaine vs RESTYLANE Lidocaine in of Nasolabial Folds
Purpose : This investigation intends to demonstrate that the investigational device, SkinPlus-HYAL Implant Lidocaine, is non-inferior to the comparator device, RESTYLANE Lidocaine, in terms of temporary wrinkle reduction effect…
- Trial name
- BPLUS-02 (NCT06305520)
- Testing
- Investigational medical device (SkinPlus-HYAL Implant Lidocaine), Active Comparator: Active Comparator Medical Device (RESTYLANE Lidocaine)
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bioplus
Nasolabial Folds
Clinical Study on Hyaluronic Acid With Lidocaine for the Treatment of Moderate to Severe Nasolabial Folds
This will be a pre-CE mark controlled, prospective, randomized, blinded evaluator, single centre, split-face clinical investigation.
- Trial name
- NCT05252325
- Testing
- hyaluronic acid plus lidocaine, hyaluronic acid without lidocaine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centro Medico Polispecialistico
Nasolabial Folds
A Post Market Evaluation After Treatment of Nasolabial Folds
This is an open, non-comparative study to evaluate effectiveness and safety of Restylane in correction of nasolabial folds up to 12 months after the initial treatment, and to evaluate the safety of repeat treatment of the…
- Trial name
- NCT02179736
- Testing
- Restylane
- Where
- China
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Facial Wrinkles
A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique.
To assess the likelihood of keloid and scar formation, pigmentation disorders and hypersensitivity reactions in patients with skin of color undergoing correction of facial soft tissue contour deficiencies with Hylaform, Hylaform…
- Trial name
- NCT00293163
- Testing
- Hylaform, Hylaform Plus (hylan B gel)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Genzyme, a Sanofi Company
Nasolabial Folds
Evaluate the Safety and Efficacy of 'BRFS-18G-S100WH' as Compared to 'MINT Lift FINE+' in Subject With Nasolabial Folds
Evaluate the Safety and Efficacy of 'BRFS-18G-S100WH' as Compared to 'MINT Lift FINE+' in Subject With Nasolabial Folds.
- Trial name
- NCT06216418
- Testing
- BRFS-18G-S100WH, MINT Lift FINE+
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Hugel
Nasolabial Fold Wrinkles
CelluJuve® for the Treatment of Moderate to Severe NLFs
Single-center, open-label proof of concept study assessing the safety and effectiveness of CelluJuve® for the treatment of moderate to severe NLFs
- Trial name
- NCT07545980
- Testing
- CelluJuve®
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Spiderwort Biotechnologies Inc.
Nasolabial Folds
Dermal Evaluation of Facetem™ S in Nasolabial Folds Esthetics Improvement: DEFINE Study
This is a multicenter, prospective, non-randomized, uncontrolled post-market clinical follow-up (PMCF) study designed to evaluate the performance and safety of Facetem S dermal filler for the correction of moderate-to-severe…
- Trial name
- DEFINE (NCT07855224)
- Testing
- Facetem S
- Where
- 5 sites in France, Spain
- Volunteers
- 100 people
- Sponsor
- CGBio Inc.
Nasolabial Fold
Open, Non-comparative Study to Evaluate the Effectiveness and Safety of the Medical Device KOS® L in Correcting Moderate or Severe Nasolabial Folds
The utilization of minimally invasive techniques has brought about a transformative shift in the approach to face rejuvenation, potentially representing one of the most notable advancements in facial plastic surgery in recent…
- Trial name
- NCT06828224
- Testing
- KOS® L
- Where
- Romania
- Volunteers
- 34 people
- Sponsor
- Quantum Beauty Kozmetik
Nasolabial Folds
A Study to Assess Adverse Events and Effectiveness of HAC 20L Injections in Adult Participants for the Treatment of Nasolabial Folds
Nasolabial folds (NLF) are the two skin folds that run from each side of the nose to the corners of the mouth. Prominent NLFs distort the contour of the midface, giving a fatigued and aged appearance.
- Trial name
- NCT06018987
- Testing
- No-Treatment Control, HAC 20L
- Where
- 10 sites in Germany
- Volunteers
- 61 people
- Sponsor
- AbbVie