Clinical trials: Natural History
Movement Disorder
Human Movement Database
This study will collect information on the different ways people control limb and body movements. This information will be used to develop a database on normal movements and adaptive movements of people who have diseases that…
- Trial name
- NCT00001252
- Where
- United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Mood Disorder
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
This study seeks to learn more about the symptoms of severe mood dysregulation in children and adolescents ages 7-17. Children and adolescents with severe mood dysregulation (SMD) display chronic anger, sadness, or irritability…
- Trial name
- NCT00025935
- Testing
- Lithium
- Where
- United States
- Volunteers
- 2,350 people
- Sponsor
- National Institute of Mental Health (NIMH)
Pearson Syndrome, Single Large Scale Mitochondrial DNA Deletion Syndromes (SLSMDS)
SLSMDS Natural History Study
The Single Large-Scale mtDNA Deletion Sydrome: Natural History Study (PS-NHS) aims to collect data on standardized clinical outcomes, store data on the Champ Foundation Registry (CFR) and make this data available to researchers…
- Trial name
- NCT05029843
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Champ Foundation
Spinal and Bulbar Muscular Atrophy, Kennedys Disease
Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)
Background: SBMA is an inherited chronic disease. It affects males in mid to late adulthood. It causes slowly progressive weakness of muscles and hand tremors. Researchers want to learn more about the effects of SBMA.
- Conditions
- Spinal and Bulbar Muscular Atrophy, Kennedys Disease, Motor Neuron Disease
- Trial name
- NCT04944940
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cirrhosis
Deciphering the Mechanisms Involved in Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis
Background: Hepatitis C infection (HCV) is a leading cause of liver disease. Normal bacteria from the intestines may spread to the liver and blood during liver disease. This is called bacterial translocation (BT).
- Trial name
- NCT02400216
- Testing
- dual cholate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Solid Tumors, Hematologic Malignancy
Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment
Background: Many advances have been made in cancer treatments, but more research is needed. Comparing samples of cancerous tissue to samples of normal, noncancerous tissues may help find differences between them.
- Conditions
- Solid Tumors, Hematologic Malignancy, Gastrointestinal Cancer, Liver Cancer
- Trial name
- NCT05600933
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Cancer Prevention, Cervical Cancer
A Cervical Cancer Prevention Program in Kenya
Cervical cancer is caused by oncogenic, or "high-risk" (HR) human papillomavirus (HPV), and is the main cause of cancer-related death among Kenyan women.
- Trial name
- Merck-3 (NCT06411938)
- Testing
- High Risk HPV DNA Testing, Visual Inspection with acetic acid (VIA) and possible cervical biopsy, Gardisil-9
- Where
- Kenya
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nemaline Myopathy
Natural History Study for Patients With Nemaline Myopathy in the UK
The goal of this study is to to learn more about what assessments would be useful to measure for NM and what normally happens during the lives of people with NM to support future clinical trial development.
- Trial name
- NatHis-NM-MDUK (NCT06670378)
- Where
- 4 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Oxford
Prion Diseases
PROSPECT Registry for Individuals at Risk for Genetic Prion Disease
PROSPECT is a prospective observational registry and longitudinal natural history study of adults at risk for genetic prion disease.
- Trial name
- PROSPECT (NCT07732608)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Brian Appleby
Immunohematology
Molecular Immunohematology in Ethiopian Sub-Populations
Alloimmunization to blood products in transfused patients is a recognized management challenge in the clinical setting. In particular the ethnic and racial specificity of RBC antigens and the limited availability of matched…
- Trial name
- NCT01282021
- Where
- Ethiopia
- Volunteers
- 95 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Systemic Lupus Erythematosus (Sle), Primary Ovarian Insufficiency (Poi)
Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires
Background: Systemic lupus erythematosus (SLE) is a disease that affects females nine times more often than males. People with SLE are often treated with cyclophosphamide (CYC).
- Trial name
- NCT05567198
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
HIV, Brain Tumors
Analysis of Data Collected From Individuals Administered Neurobehavioral Assessments
Background: People with chronic illness often are at risk for developing neurobehavioral problems due to effects of the disease or associated treatments.
- Conditions
- HIV, Brain Tumors, Neurofibromatosis Type 1
- Trial name
- NCT01445314
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Amyloidosis, Leukocyte Chemotactic Factor 2 Amyloidosis
A Study of the Natural History of Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Disease
The purpose of this study is to characterize the natural history of leukocyte chemotactic factor 2 amyloidotic (ALECT2) disease. In this observational study participants with ALECT2 disease will be enrolled.
- Trial name
- NCT03774784
- Where
- 31 sites in United States, Egypt and 4 more
- Volunteers
- 26 people
- Sponsor
- Alnylam Pharmaceuticals
Stigma, Activity Space
Health Outcomes by Neighborhood - Baltimore
Background: Researchers have been studying patterns of mood and drug use in specific neighborhoods. This study will look at environmental factors that may affect drug use, addiction, and treatment seeking in Baltimore…
- Conditions
- Stigma, Activity Space, Social Networks, HIV Status
- Trial name
- NCT01571752
- Where
- United States
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pearson Syndrome
Natural History of Pearson Syndrome
The purpose of this 3-year, multi-site, non-randomized, prospective, observational study is to characterize the natural history of Pearson Syndrome.
- Trial name
- NCT02327364
- Volunteers
- 11 people
- Sponsor
- Sumit Parikh
SLE - Systemic Lupus Erythematosus
Does Belimumab Modify the Natural History of SLE? A Propensity Score-matched, Real-world Study
This will be a combined retrospective and prospective cohort study, that will evaluate the incidence of de novo Systemic Lupus Erythematosus major organ manifestations (defined as BILAG A flares) in patients receiving belimumab…
- Trial name
- NCT07056621
- Where
- Greece
- Volunteers
- 684 people
- Sponsor
- Biomedical Research Foundation, Academy of Athens
Alcoholic Liver Disease
Study of Alcohol-related Liver Disease in Europe
Alcohol-induced liver injury is made up of fatty liver, fibrosis and alcoholic hepatitis (AH), elementary lesions that may occur separately, simultaneously or sequentially in a same patient.
- Trial name
- SALVE (NCT04400604)
- Where
- France
- Volunteers
- 7,500 people
- Sponsor
- University Hospital, Lille
Pneumonia, Pulmonary Disease
Study of Lung Proteins in Patients With Pneumonia
This study will examine the different types of proteins present in the lungs of patients with pneumonia to explore the causes of different types of the disease.
- Conditions
- Pneumonia, Pulmonary Disease, Lung Disease
- Trial name
- NCT00077909
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cancer, Fatigue
Characterizing Fatigue Experienced by Cancer Patients Receiving Primary Treatment and Cancer Survivors
Background: Fatigue is a common side effect of cancer and its treatment. Up to 96% of patients with cancer have fatigue. The cause of fatigue in people with cancer or those receiving treatment is poorly understood, making fatigue…
- Conditions
- Cancer, Fatigue, Prostate Cancer, Breast Cancer
- Trial name
- NCT01231932
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- National Institute of Nursing Research (NINR)
Friedreich Ataxia
A Natural History Study to TRACK Brain and Spinal Cord Changes in Individuals with Friedreich Ataxia (TRACK-FA)
This is a natural history study prospectively investigating neuroimaging markers of disease progression in children and adults with Friedreich ataxia (FA). There will be three assessment periods (baseline, 12 and 24 months).
- Trial name
- (TRACK-FA) (NCT04349514)
- Testing
- Natural history
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Monash University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.