Clinical trials: Natural History
Inflammation, Pathologic Processes
Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults
This study will collect information about markers of inflammation, blood clotting and blood vessel function in HIV-infected adults and healthy volunteers.
- Trial name
- NCT00776412
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dermatomyositis, Polymyositis
Study and Treatment of Inflammatory Muscle Diseases
This study of inflammatory muscle diseases-polymyositis and dermatomyositis and related disorders-will examine what causes these diseases and describe the clinical features (signs and symptoms) associated with them.
- Trial name
- NCT00001265
- Where
- United States
- Volunteers
- 1,325 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Coronary Artery Disease, Coronary Disease
Prospective Multicenter Registry On Radiation Dose Estimates Of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)
Background: CCTA is a common way to evaluate coronary artery disease. It stands for coronary computed tomography angiography. It uses scanning to look at the arteries that supply blood to the heart.
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Arterial Occlusive Diseases
- Trial name
- NCT03253692
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Kidney Disease, Nephrotic Syndrome
Immune System Related Kidney Disease
Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders.
- Trial name
- NCT00001979
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypoglycemia, Insulinoma
Diagnosing and Treating Low Blood Sugar Levels
Hypoglycemia is the term used to refer to lower than normal levels of blood sugar. This study will continue to research the causes of hypoglycemia.
- Trial name
- NCT00001276
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
MELAS or m.3243 A>G Mitochondrial DNA Mutation Carrier
Natural History Study - Mitochondrial Disease
Carriers of the m.3242A>G mutation often have clinical symptoms which can include migraines, seizures, strokes, hearing loss, balance issues, gastrointestinal issues, and many other symptoms.
- Trial name
- NCT01532791
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cognitive Fatigue
Immersive VR Environments to Induce and Evaluate Cognitive Fatigability
Background: Immersive virtual reality (VR) technology is used by researchers to measure how people respond to complex stimuli in a controlled environment.
- Trial name
- NCT04883359
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Breast Cancer Female
Facial Skin Health Tracking Feasibility in Breast Cancer Patients
This feasibility study will assess if tracking objective and subjective facial skin changes over time is acceptable to pre and perimenopausal women undergoing chemotherapy and/or endocrine therapy for breast cancer.
- Trial name
- NCT04035408
- Testing
- Skin health assessment
- Where
- United States
- Sponsor
- University of Colorado, Denver
Chemically-Induced Disorders, Substance-Related Disorders
Study of Structural Imaging
Background: The way alcohol affects brain structure has been widely studied. But the way it affects all parts of the brain is still unknown.
- Conditions
- Chemically-Induced Disorders, Substance-Related Disorders, Mental Disorders, Alcohol Dependence
- Trial name
- NCT02564991
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Chronic Graft vs. Host Disease
Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease
Background: Chronic graft-versus-host disease (cGVHD) is a multi-organ alloimmune and autoimmune disorder that occurs following allogeneic hematopoietic stem cell transplantation (alloHSCT).
- Trial name
- NCT00092235
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- National Cancer Institute (NCI)
Stroke, Ischemic, Inflammatory Response
TSPO PET as a Measure of Post-stroke Brain Inflammation: a Natural History Cohort
DESIGN: exploratory, prospective, natural history, imaging cohort study BACKGROUND: Stroke causes a strong inflammatory response in the brain which is thought to contribute to permanent brain damage in stroke patients.
- Conditions
- Stroke, Ischemic, Inflammatory Response, Stroke, Acute
- Trial name
- NCT03662750
- Testing
- Brain Imaging
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Imperial College London
Polycythemia Vera, ET (Essential Thrombocythemia)
MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)
The MPN PROGRESSion Registry is a multi-year, observational research study designed to improve understanding of myeloproliferative neoplasms (MPNs)-a group of rare, chronic blood cancers that include polycythemia vera (PV)…
- Conditions
- Polycythemia Vera, ET (Essential Thrombocythemia), Polycythemia Vera (PV), Essential Thrombocythemia (ET)
- Trial name
- NCT07362225
- Where
- 2 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- MPN Research Foundation
Alcoholism
Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot Study
Background: Alcohol use disorder (AUD) affects about 10 percent of people in the U.S. Studies show a relationship between the bacteria (microbiota) in the gut and the brain. Researchers think this may influence AUD.
- Trial name
- NCT03152760
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatitis C, Chronic
Impact of the Sustained Viral Response of Chronic Hepatitis c After Treatment With Direct Action Antivirals
The purpose of this study is to evaluate the evolution of liver injury with fibrosis data obtained using non-invasive serological markers in patients who achieved SVR after treatment with direct-acting antivirals.
- Trial name
- Hepatitis (NCT05062408)
- Where
- Spain
- Volunteers
- 321 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Xeroderma Pigmentosum, Basal Cell Carcinoma
Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum
This study will determine if family members of patients with xeroderma pigmentosum (XP) have various abnormalities, including: skin abnormalities; nervous system abnormalities, such as hearing problems; skin, eye, or internal…
- Conditions
- Xeroderma Pigmentosum, Basal Cell Carcinoma, Squamous Cell Carcinoma, Melanoma
- Trial name
- NCT00046189
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- National Cancer Institute (NCI)
Neuronal Ceroid Lipofuscinosis, Batten Disease
Natural History and Longitudinal Clinical Assessments in NCL / Batten Disease, the International DEM-CHILD Database
This is an observational study that aims at assessing the natural history of NCL diseases as part of the international DEM-CHILD Database. 1.
- Conditions
- Neuronal Ceroid Lipofuscinosis, Batten Disease, CLN1 Disease, CLN2 Disease
- Trial name
- NCT04613089
- Testing
- Natural History
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Sickle Cell Disease, Venous Thrombosis
Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait
Background: Venous thromboembolism (VTE) includes the abnormal clotting of blood in a deep vein of the upper or lower limbs (deep vein thrombosis) that may travel to and block a blood vessel in the lung (pulmonary embolism).
- Conditions
- Sickle Cell Disease, Venous Thrombosis, Sickle Cell Trait, Hypercoagulable State
- Trial name
- NCT04349189
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Danon Disease
The Natural History of Danon Disease
Danon disease (DD) is a rare, X-linked disorder associated with severe cardiomyopathy, and in many cases, skeletal myopathy, and cognitive impairment caused by mutations in the LAMP2 gene.
- Trial name
- NCT03766386
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Hypolipoproteinemia, Hypercholesterolemia
Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabolism and the role it plays in…
- Conditions
- Hypolipoproteinemia, Hypercholesterolemia, Dyslipidemia, Hyperlipidemia
- Trial name
- NCT00001154
- Where
- United States
- Volunteers
- 759 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Cancer
Development of a Biologic Specimen Bank for the Study of Early Markers of Lung Cancer Among Tin Miners in Yunnan, China
The overall goal of this project is to identify strategies to reduce lung cancer incidence and mortality. Using a high-risk occupational cohort, our specific objectives are 1) to establish a biologic specimen bank and data bank…
- Trial name
- NCT00340405
- Where
- China
- Volunteers
- 9,759 people
- Sponsor
- National Cancer Institute (NCI)
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