Clinical trials: Natural History
Clostridium Difficile Infection, Health Care Associated Infection
Natural History of Clostridioides Difficile Infection
Aim: To investigate if host factors, such as composition and diversity of intestinal microbiota and/or genetic determinants, are associated with a higher risk of recurrence of Clostridioides difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, Health Care Associated Infection, Nosocomial Infection
- Trial name
- NCT04801862
- Where
- 15 sites in Spain
- Volunteers
- 750 people
- Sponsor
- Hospital Universitario de Valme
LCAT Deficiency
LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study
The purpose of the LCAT (Lecithin cholesterol acyl transferase) Natural History Study (LCAT NHS) is to help identify people with a mutation in a gene called LCAT, collect and store information about their medical history and…
- Trial name
- LCAT NHS (NCT06217588)
- Testing
- Demographics, diagnosis type, genotype, lipid profile, renal function profile, treatment allocation, ophthalmology exam, country of residence.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Rod Cone Dystrophy
Natural History Study of Advanced RCD
ECSTASI is a Natural History Study, which will be monitoring how standard of care (SoC) affect advanced rod-cone dystrophy (RCD), a type of eye disease also known as retinitis pigmentosa.
- Trial name
- ECSTASI (NCT07854899)
- Testing
- Eye examinations, Questionnaire
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 100 people
- Sponsor
- SparingVision
Adult Diffuse Astrocytoma, Adult Mixed Glioma
Natural History of Brain Function, Quality of Life, and Seizure Control in Patients With Brain Tumor Who Have Undergone Surgery
This trial studies the natural history of brain function, quality of life, and seizure control in patients with brain tumor who have undergone surgery.
- Conditions
- Adult Diffuse Astrocytoma, Adult Mixed Glioma, Adult Oligodendroglioma, Cognitive/Functional Effects
- Trial name
- NCT01417507
- Testing
- cognitive assessment, magnetic resonance imaging, laboratory biomarker analysis
- Where
- 41 sites in United States, Canada
- Volunteers
- 82 people
- Sponsor
- Radiation Therapy Oncology Group
Chronic Pancreatitis, Complication
The Natural History of Chronic Pancreatitis
Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications.
- Conditions
- Chronic Pancreatitis, Complication, Risk Factors
- Trial name
- NCT03324698
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Changhai Hospital
Fucosidosis
A Long-Term Observational Study of Patients With Fucosidosis
The purpose of this observational research study is to learn more about the natural history of fucosidosis, its symptoms, and how it develops over time.
- Trial name
- NCT07615400
- Where
- 16 sites in United States, India and 4 more
- Volunteers
- 57 people
- Sponsor
- JCR Pharmaceuticals Co., Ltd.
Late Onset Sporadic Cerebellar Ataxia
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
The key goals of SPORTAX-NHS is to compare the phenotype of multiple system atrophy of cerebellar type (MSA-C) and sporadic adult onset ataxia of unknown aetiology (SAOA) and to determine the rate of disease progression in both…
- Trial name
- SPORTAX-NHS (NCT02701036)
- Where
- 14 sites in Austria, Germany and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ataxia Study Group
Pneumonia, Pulmonary Disease
Study of Lung Proteins in Patients With Pneumonia
This study will examine the different types of proteins present in the lungs of patients with pneumonia to explore the causes of different types of the disease.
- Conditions
- Pneumonia, Pulmonary Disease, Lung Disease
- Trial name
- NCT00077909
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
PI3KCD, CTLA4
Novel Genetic Disorders of the Immune System
Background: The immune system helps the body fight infection and disease. People with immune system problems can get infections, blood disorders, and other health problems.
- Conditions
- PI3KCD, CTLA4, STAT3GOF, MAGT1
- Trial name
- NCT02257892
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nemaline Myopathy
Natural History Study for Patients With Nemaline Myopathy in Belgium
This is a prospective, longitudinal, observational study designed to characterize the natural history of Nemaline Myopathy (NM), a rare congenital neuromuscular disorder.
- Trial name
- Acti-Nemaline (NCT07201636)
- Testing
- Motor Function Assessments, Syde, Respiratory Assessments
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Adrenal Gland Neoplasm, Hypertension
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium.
- Conditions
- Adrenal Gland Neoplasm, Hypertension, Bone Diseases, Metabolic, Cardiovascular Disease
- Trial name
- NCT03374215
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
XLHED
A Cross-Sectional Natural History Study to Evaluate Sweat Volume and Other Phenotypic and Genetic Characteristics in Patients Affected by XLHED
The proposed natural history study will enroll male patients with a diagnosis of XLHED, female carriers of XLHED and healthy volunteers.
- Trial name
- NCT03912792
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dermelix Biotherapeutics, LLC.
Hearing Loss, Deafness
Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.
Background: People with hearing, balance, and taste, smell, voice, speech, language, and other Ear, Nose, and Throat (ENT) disorders may seek treatment at the National Institute on Deafness and Other Communication Disorders…
- Trial name
- NCT05670496
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Adrenal Gland Neoplasm
Study of Adrenal Gland Tumors
The adrenal glands, located atop the kidneys, normally produce several types of hormones. Tumors of these glands may or may not secrete hormones.
- Trial name
- NCT00005927
- Where
- United States
- Volunteers
- 690 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Generalized Arterial Calcification of Infancy
Natural History Study of ENPP1 Deficiency and the Early-onset Form of ABCC6 Deficiency
The purpose of this prospective study is to characterize the natural history of ENPP1 Deficiency and the early-onset form of ABCC6 Deficiency longitudinally.
- Conditions
- Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Generalized Arterial Calcification of Infancy, Autosomal Recessive Hypophosphatemic Rickets, Adenosine Triphosphate Binding Cassette Transporter Protein Subfamily C Member 6
- Trial name
- NCT05050669
- Testing
- No Intervention for this observational study
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 12 people
- Sponsor
- Inozyme Pharma
Atherosclerosis
Natural History of Atherosclerosis
20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.
- Trial name
- NCT00918541
- Where
- 3 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Parkinson Disease, Dystonia
Clinical and Physiological Studies of Tremor Syndromes
Background: Researchers have some data on how the brain controls movement and why some people have tremor. But the causes of tremor are not fully known.
- Conditions
- Parkinson Disease, Dystonia, Essential Tremor
- Trial name
- NCT03027310
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Blood Donors, Apheresis
Collection and Distribution of Blood Components From Healthy Donors for In Vitro Research Use
Background: Many different research projects need a steady supply of human blood. Blood donated by screened, healthy people may be used to test new drugs, for example, or to learn how blood cells work.
- Trial name
- NCT07877259
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hypercholesterolemia, Atherosclerosis
Causes and Natural History of Dyslipidemias
This study will evaluate people with dyslipidemias - disorders that affect the fat content in the blood. Fats, or lipids, such as cholesterol and triglycerides, are carried in the blood in particles called lipoproteins.
- Trial name
- NCT00353782
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Rett Syndrome, MECP2 Duplication dIsorder
Natural History of Rett Syndrome & Related Disorders
The purpose of this study is to advance understanding of the natural history of Rett syndrome (RTT), MECP2-duplication disorder (MECP2 Dup), CDKL5, FOXG1, and individuals with MECP2 mutations who do not have RTT including the…
- Conditions
- Rett Syndrome, MECP2 Duplication dIsorder, CDKL5 Disorder, FOXG1 Syndrome
- Trial name
- NCT02738281
- Where
- 14 sites in United States
- Volunteers
- 1,044 people
- Sponsor
- University of Alabama at Birmingham
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