Clinical trials: Natural History
Liver Cirrhosis, Hepatocellular Carcinoma
Natural History of Liver Cirrhosis Diagnosed by Transient Elastography in HIV/HCV-coinfected Patients
Prospective multicenter cohort recruiting consecutive patients from 7 hospitals in Andalusia, southern Spain, according to following criteria: 1) HIV infection, 2) Chronic active HCV infection, 3) Older than 18 years, 4) New…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, HIV, HCV Coinfection
- Trial name
- NCT02693847
- Where
- 8 sites in Spain
- Volunteers
- 446 people
- Sponsor
- Hospital Universitario de Valme
Follicular Lymphoma
Clonal Evolution in Follicular Lymphoma
Background: Follicular lymphoma is a type of cancer of the lymph nodes. Lab studies are important for cancer research. They help scientists better understand differences in the cancer biology of different patients.
- Trial name
- NCT03190928
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Cancer Institute (NCI)
TNNT1-associated Myopathy, Infantile-onset Nemaline Rod Myopathy
WiTNNess - TNNT1 Myopathy Natural History Study
WiTNNess is designed to accurately document the natural course and variation of muscle disease caused by pathogenic changes of the TNNT1 gene.
- Conditions
- TNNT1-associated Myopathy, Infantile-onset Nemaline Rod Myopathy, Myopathies, Nemaline, Myopathy
- Trial name
- WiTNNess (NCT06374719)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Clinic for Special Children
Spinocerebellar Ataxia Type 3, Machado-Joseph Disease
Astrocytic Markers and the Pre-ataxic Period of SCA3/MJD - BIGPRO Study Astrocytes
The study will consist of a prospective observation of subjects in a natural history design. The investigators will monitor changes of clinical scales, quality of life, messenger ribonucleic acid (mRNA) of candidate genes (CCL11…
- Conditions
- Spinocerebellar Ataxia Type 3, Machado-Joseph Disease, SCA3, MJD
- Trial name
- NCT04419974
- Testing
- Molecular Diagnosis, Clinical Scales - Baseline, Blood Draw - Baseline
- Where
- Brazil
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Body Weight
Patient Perspectives and Doctor Visits
Background: We are studying people s psychological experiences and how these relate to the way people respond have when they see information communicated in different ways.
- Trial name
- NCT01888913
- Where
- United States
- Volunteers
- 1,464 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer
Studies on Tumors of the Thyroid
Participants in this study will be patients diagnosed with or suspected to have a thyroid nodule or thyroid cancer. The main purpose of this study is to further understand the methods for the diagnosis and treatment of thyroid…
- Conditions
- Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer, Follicular Thyroid Cancer, Thyroid Cancer
- Trial name
- NCT00001160
- Testing
- 68-Gallium Dotatate
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Epilepsy
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients…
- Trial name
- NCT02107989
- Testing
- MRI, MEG
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ebola Virus Disease
PREVAIL VI: Identification of Host Genetic Factors Underlying Ebola Virus Disease Risk, Mortality, Long-term Sequelae, Viral RNA Persistence, Humoral Immunity, and Ebola Vaccine Response
Background: Genes are instructions that tell the body how to work and grow. They can affect how the body responds to infection. Researchers want to learn more about genes that affect how the body responds to the Ebola virus.
- Trial name
- NCT03098862
- Where
- 4 sites in Liberia
- Volunteers
- 4,830 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19 Virus Disease
Natural History Study of COVID-19 Using Digital Wearables
Background: People with COVID-19 have varying degrees of illness. It can range from no or mild symptoms to critical illness and death.
- Trial name
- NCT04927442
- Where
- United States
- Volunteers
- 464 people
- Sponsor
- National Institute on Minority Health and Health Disparities (NIMHD)
Metabolic Disorders, Cancer
A Natural History Study of Metabolic Sizing in Health and Disease
Background: Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate.
- Conditions
- Metabolic Disorders, Cancer, Chronic Kidney Disease, Diabetes
- Trial name
- NCT05398783
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Liver Cirrhosis, Hepato-Renal Syndrome
Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal Disease
The aim of this retrospective study is to evaluate the treatment response to terlipressin and albumin in patients with suspicion of HRS-AKI and signs of chronic parenchymal kidney disease (HRS-AKI-like syndrome) compared to…
- Conditions
- Liver Cirrhosis, Hepato-Renal Syndrome, Chronic Kidney Diseases
- Trial name
- Terli-CKD (NCT06161766)
- Testing
- terlipressin or noradrenalin plus albumin
- Where
- 4 sites in Germany
- Volunteers
- 490 people
- Sponsor
- University Hospital Freiburg
Phelan-McDermid Syndrome, Autism Spectrum Disorder
Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome
The purpose of this study is to comprehensively characterize PMS using standardized medical, cognitive, and behavioral measures and to track the natural history of the syndrome using repeated longitudinal assessments.
- Conditions
- Phelan-McDermid Syndrome, Autism Spectrum Disorder, Intellectual Disability
- Trial name
- NCT02461420
- Where
- 5 sites in United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Non-Medullary Thyroid Cancer
Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer
Background: Researchers are studying types of thyroid cancer that seem to cluster in families. Non-medullary thyroid cancer accounts for the vast majority of all types of thyroid cancer, but little is known about possible genes…
- Trial name
- NCT01109420
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pyruvate Kinase Deficiency, Congenital Non-Spherocytic Hemolytic Anemia
Pyruvate Kinase Deficiency Natural History Study
The purpose of this study is to describe the range and incidence of symptoms, treatments, and complications related to pyruvate kinase deficiency (PKD).
- Trial name
- PKD NHS (NCT02053480)
- Where
- 30 sites in United States, Canada and 4 more
- Volunteers
- 254 people
- Sponsor
- Boston Children's Hospital
Cardiometabolic Risk Factors, Mental Health
A Natural History of Cardiometabolic Disease Among US Bhutanese: Developing the Cross-Sectional Bhutanese Community of Central Ohio Health Study to Understand Acculturation as Synergizing Socioenvironmental and Biobehavioral Risk Factors Propagating ...
Background: As of 2021, almost 45 million people in the United States were foreign-born immigrants. South Asians, including people from Bhutan, are the fastest-growing immigrant subgroup in the US.
- Trial name
- NCT06991751
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Lyme Disease
Evaluation, Treatment, and Follow-up of Patients With Lyme Disease
This study is designed to establish a population of patients with Lyme disease for evaluation, treatment and follow-up to learn more about the infection. Patients with active Lyme disease may be eligible for this study.
- Trial name
- NCT00028080
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Astrocytoma, Oligodendroglioma
Natural History of Patients With Brain and Spinal Cord Tumors
This study offers evaluation of patients with brain and spinal cord tumors. Its purpose is threefold: 1) to allow physicians in NIH s Neuro-Oncology Branch to increase their knowledge of the course of central nervous system…
- Conditions
- Astrocytoma, Oligodendroglioma, Glioblastoma, Glioma
- Trial name
- NCT00009035
- Where
- United States
- Volunteers
- 3,050 people
- Sponsor
- National Cancer Institute (NCI)
Healthy Volunteers, HIV
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
This study will collect blood plasma and white blood cells from individuals using a procedure called apheresis. Apheresis is a method of collecting larger quantities of certain blood components that can safely be collected…
- Trial name
- NCT00114647
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronary Artery Perforation, Coronary Stent Occlusion
Glasgow Natural History Study Of Covered Coronary Interventions
Covered stents (CS) are a potentially lifesaving treatment for grade III coronary perforation but delivery can be challenging, and the long-term durability and safety including risk of acute stent thrombosis are unknown.
- Conditions
- Coronary Artery Perforation, Coronary Stent Occlusion, Stent Thrombosis
- Trial name
- GNOCCI (NCT03862352)
- Testing
- Covered coronary stent
- Where
- United Kingdom
- Volunteers
- 161 people
- Sponsor
- NHS National Waiting Times Centre Board
Leukemia, Lymphoma
Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant
Background: After an allogeneic hematopoietic stem cell transplant (HSCT), the donor genome is found in the recipient s circulation and tissues.
- Conditions
- Leukemia, Lymphoma, Hematologic Malignancy
- Trial name
- NCT06856226
- Testing
- Arm 1
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
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