Clinical trials: Natural History
TSA, Bruise
Natural History of Pain After Shoulder Arthroplasty Conducted With Multimodal Analgesia
This study aims to identify the timeline of pain following total shoulder replacement with the goal of developing data for a subsequent randomized trial.
- Conditions
- TSA, Bruise, Pain, Postoperative
- Trial name
- TSA (NCT03021096)
- Testing
- Surveys
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Neurodevelopmental Disorders, Intellectual Disability
Longitudinal Study of Neurogenetic Disorders
The purpose of this study is to analyze patterns in individuals with hnRNP (and other) genetic variants, including their neurological comorbidities, other medical problems and any treatment.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Developmental Delay, Autism Spectrum Disorder
- Trial name
- NCT03492060
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Columbia University
Opioid-Related Disorders, Alcohol-Related Disorders
Imaging Biomarker for Addiction Treatment Outcome
Background: Many people suffer from drug addiction. But currently, treatments are not very effective. One group of patients in this study are enrolled in addiction treatment through physician health programs (PHPs).
- Trial name
- NCT03427424
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Multiple Myeloma, Leukemia
Specimen Collection for Agricultural Health Study Cohort Pesticide Exposure Study
Background: Multiple myeloma (MM), a type of cancer that affects the white blood cells, is often preceded by a precancerous disorder known as monoclonal gammopathy of undetermined significance (MGUS).
- Conditions
- Multiple Myeloma, Leukemia, MGUS, Monoclonal B-Cell Lymphocytosis
- Trial name
- NCT01139476
- Where
- United States
- Volunteers
- 1,892 people
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Disease, Arterial Stiffness
Natural History Study of CADASIL
Background: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy) is a genetic disorder. It causes narrowing of the small blood vessels and can lead to strokes and dementia.
- Conditions
- Cardiovascular Disease, Arterial Stiffness, Germline Mutation in the NOTCH 3 Gene, Pathogenesis of CADASIL
- Trial name
- NCT05072483
- Testing
- MRI
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Alcoholic Intoxication, Alcohol-Related Disorders
Longitudinal Changes in the Oral and Gut Microbiome of Individuals With Alcohol Dependence
Background: Many bacteria live in the gut. The gut is the tube that moves food from the mouth through the stomach to the intestines. Heavy alcohol use disturbs these bacteria.
- Trial name
- NCT02911077
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Breast Cancer, Diabetes
Risk Communication Within Mexican-American Families
This study will examine what methods work best for encouraging Mexican-American family members to talk about their risk for diabetes, heart disease, breast cancer and colon cancer.
- Conditions
- Breast Cancer, Diabetes, Colon Cancer, Cardiovascular Disease
- Trial name
- NCT00469339
- Testing
- Family Health History
- Where
- United States
- Volunteers
- 498 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Spinal Muscular Atrophy
Natural History of Types 2 and 3 SMA in Taiwan
The primary objective of this study is to investigate the natural history of spinal muscular atrophy (SMA) types 2 and 3 patients in Taiwan. This study will provide further insights into the clinical course SMA.
- Trial name
- NCT03300869
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Pregnancy, Preterm Labor
Biomarkers in Obstetrical Complications
Objective: To study the natural history of normal pregnancy and the most frequent pregnancy complications responsible for the excessive rate of perinatal morbidity and mortality, in order to develop models to predict the…
- Conditions
- Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
- Trial name
- NCT03480139
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Parkinson's Disease, Multiple System Atrophy, Parkinson Variant
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
The objective of this study is to describe disease progression in study participants diagnosed with early Parkinson's Disease or Multiple System Atrophy - Parkinsonian Type up to 18 months as delineated by clinical and…
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Parkinson Variant, Multiple System Atrophy
- Trial name
- NCT05699460
- Testing
- This is an observational study.
- Where
- 11 sites in United States, Poland
- Volunteers
- 73 people
- Sponsor
- AskBio Inc
Neutropenia, Agranulocytosis
Natural History Study for BEN
In recent decades, hematologists have noticed that persons of African descent sometimes have lower white blood cell counts of a certain type, called granulocytes. These cells help to fight infections.
- Conditions
- Neutropenia, Agranulocytosis, Hematologic Diseases, Leukocyte Disorders
- Trial name
- NCT00059423
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Parkinson's Disease, Functional Movement Disorders
Clinical Correlates of COVID-19 Pandemic in Patients With Functional Movement Disorder (FMD) and Parkinson's Disease (PD)
The purpose of this study is to investigate the clinical correlates of the effects of the COVID-19 pandemic on patients with Functional movement disorder (FMD) and Parkinson s Disease (PD).
- Conditions
- Parkinson's Disease, Functional Movement Disorders, COVID-19
- Trial name
- NCT04565080
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Immune Defects
Detection and Characterization of Host Defense Defects
This protocol is designed to evaluate selected patients with documented recurrent or unusual infections and their family members for clinical and laboratory correlates of immune abnormalities.
- Trial name
- NCT00001355
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Psoriasis, Psoriatic Arthritis
Study of Psoriatic Arthritis
This study will examine the genetic and immune factors involved in the cause and development of psoriatic arthritis-a disease of both the skin and joints.
- Trial name
- NCT00001420
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Hearing Disorder
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan
Objective: One objective of this study is to genetically map and identify mutated genes for human hereditary hearing loss. A second objective is to study the function of these genes in the auditory system using mouse models.
- Trial name
- NCT00341874
- Where
- Pakistan
- Volunteers
- 18,009 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Brain Disease
Inflammatory and Infectious Diseases of the Nervous System
Background: Inflammation is how the body reacts to infection or injury. Infections or inflammation in the brain and nerves can be serious. There aren t always good tests to detect this.
- Trial name
- NCT02435810
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mucolipidosis Type IV
The Natural History and Pathogenesis of Mucolipidosis Type IV
Mucolipidosis Type IV (ML-IV) is a metabolic disorder that causes mental and motor retardation as well as visual impairment. There is storage of material in practically all the cells of the body, causing problems in the brain and…
- Trial name
- NCT00015782
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystrophic Epidermolysis Bullosa
Prospective, Longitudinal Natural History Study in Dystrophic Epidermolysis Bullosa
The objective of this study is to characterize the extent and severity of disease in subjects with DEB and the progression of disease over a timeframe relevant to interventional studies.
- Trial name
- NCT01768026
- Where
- United States
- Sponsor
- Lotus Tissue Repair, Inc.
Cancer, Neoplasms
Machine Learning to Analyze Facial Imaging, Voice and Spoken Language for the Capture and Classification of Cancer/Tumor Pain
Background: Cancer pain can have a very negative effect on people s daily lives. Researchers want to use machine learning to detect facial expressions and voice signals.
- Conditions
- Cancer, Neoplasms, Solid Tumors
- Trial name
- NCT04442425
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- National Cancer Institute (NCI)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.