Clinical trials: Natural History
Human Papillomavirus
Natural History of HPV Infection in Men: The HIM Study
The purpose of this study is to learn about the natural history of Human Papillomavirus (HPV) infection in men. The study will also find out what factors are linked to HPV in men including other sexually transmitted diseases…
- Trial name
- NCT00786760
- Testing
- Cohort: 3000 men examined every 6 months for 4 years., Pilot study: 150 men examined every 6 months for 4 years.
- Where
- United States
- Volunteers
- 1,431 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Neoplasms, Lymphomas
Collection of Tissue Samples for Cancer Research
Background: -Patients who are being evaluated and/or treated at the NIH Clinical Center and adult patients at participating sites will be entered onto this tissue procurement protocol for collection of tissue specimens.
- Conditions
- Neoplasms, Lymphomas, Multiple Myeloma, Myelodysplastic Syndrome
- Trial name
- NCT00900198
- Testing
- Biopsy
- Where
- 17 sites in United States, Canada
- Volunteers
- 5,000 people
- Sponsor
- National Cancer Institute (NCI)
Merosin Deficient Congenital Muscular Dystrophy
Retrospective Natural History Study of Infants and Toddlers With LAMA2-CMD
This retrospective chart review study of 75-120 LAMA2-CMD patients will expand the investigators understanding of the natural history of this disease.
- Trial name
- LAMA2 rNHS (NCT04299321)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Prothelia, Inc.
Immune Defects
Detection and Characterization of Host Defense Defects
This protocol is designed to evaluate selected patients with documented recurrent or unusual infections and their family members for clinical and laboratory correlates of immune abnormalities.
- Trial name
- NCT00001355
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Normal Physiology
NIEHS Repository of Stored Biological Samples for Future Use
Background: Laboratory tests that use blood and urine can provide a great deal of information about human health and disease. To develop even better tests and to improve the ways samples are handled for testing researchers need…
- Trial name
- NCT05666739
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Osteogenesis Imperfecta
Registry of Osteogenesis Imperfecta
ROI is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains…
- Trial name
- ROI (NCT04115774)
- Testing
- bisphosphonates
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
Hepatic Cancer, Pancreatic Ductal Cancer
The Natural History of Solid Organ Cancer Stem Cells (SOCSC)
Background: Researchers are trying to learn what causes certain types of cancer to spread to other organs in the body (metastasis).
- Conditions
- Hepatic Cancer, Pancreatic Ductal Cancer, Colorectal Cancer, Breast Cancer
- Trial name
- NCT00923052
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- National Cancer Institute (NCI)
Fragile X Syndrome, Healthy Volunteers
Protein Synthesis in the Brain of Patients With Fragile X Syndrome
Biosynthesis of proteins is essential for growth and continued maintenance of the entire neuron including axons, dendrites, and synaptic terminals, and it is clearly one of the important biochemical processes underlying adaptive…
- Trial name
- NCT00362843
- Testing
- [15-O]water
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- National Institute of Mental Health (NIMH)
Neurodegenerative Disease, Hereditary, Mitochondrial Diseases
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy
The purpose of the study is to systematically characterize the clinical course of the progressive neuropathy and optic atrophy observe in pediatric and adult patients with biallelic mutations in the solute carrier family 25…
- Conditions
- Neurodegenerative Disease, Hereditary, Mitochondrial Diseases, Optic Atrophy
- Trial name
- NCT04594590
- Testing
- Mutation analysis
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- State University of New York at Buffalo
Neoplasms, Solid Tumors
Mobile Sensor Technologies to Assess General Symptomology of People With Cancer
Background: Many digital devices, such as smartphones and activity monitors, have sensors to collect and track health data. Researchers believe these devices may be able to transform the quality of clinical research and…
- Conditions
- Neoplasms, Solid Tumors, Prostate Cancer, Lung Cancer
- Trial name
- NCT04465214
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Cancer Institute (NCI)
Lymphoma, Lymphoid Hyperplasia
Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins
BACKGROUND: Lymphomas are comprised of a diversity of tumors with different pathologic and clinical features. While distinct differences in gene expression profiles have been elucidated in different lymphomas, there has been…
- Trial name
- NCT01563874
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Asphyxiating Thoracic Dystrophy
Natural History of Asphyxiating Thoracic Dystrophy (DTJ)
The aim of the project is to prospectively analyze at a clinical and molecular level a series of 50 asphyxiating thoracic dysplasia (ATD) patients and 20 fetuses to further define the natural history of the disorder and to…
- Trial name
- DTJ (NCT00948376)
- Testing
- IFT80 screening
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Disease
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST): Prospective COVID-19 Natural History Study
Background: The COVID-19 pandemic infected and killed African Americans at higher rates than other Americans. Researchers want to understand why.
- Trial name
- NCT05484882
- Where
- 2 sites in United States
- Volunteers
- 431 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Cockayne Syndrome
Observational Study to Assess Natural History in Cockayne Syndrome Patients
This is an Observational Study of children under the age of 11 diagnosed with Cockayne Syndrome to assess the natural progression of Cockayne Syndrome disease, with special attention to hearing and physical changes in length or…
- Trial name
- NCT00985413
- Where
- 4 sites in United States, France and 1 more
- Volunteers
- 40 people
- Sponsor
- DNage B.V.
Immunity, Mucosal, Immune System Processes
VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older
Background: The Vaccine Research Center (VRC) is dedicated to understanding immune responses associated with prevention and treatment of infectious diseases.
- Conditions
- Immunity, Mucosal, Immune System Processes, Blood Specimen Collection
- Trial name
- NCT01132859
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Genetic Disease
Genetic Studies in the Amish and Mennonites
The purposes of this study are to identify the genes responsible for several inherited disorders commonly seen in the Amish and Mennonite populations and learn more about the natural history (medical problems that develop over…
- Trial name
- NCT00359580
- Where
- 2 sites in United States
- Volunteers
- 157 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Dystonia
Dystonia Coalition Projects
Dystonia is a disorder characterized by excessive involuntary contraction of muscles with repetitive and patterned movements. The primary focal dystonias are the most common type of dystonia and include Limb dystonias (like…
- Trial name
- NCT04156022
- Testing
- Dystonia Coalition is an observational study.
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Severe Aplastic Anemia
Retrospective Study of Patients With Severe Aplastic Anemia Who Relapsed After Immunosuppressive Therapy
Background: Severe aplastic anemia (SAA) is a form of bone marrow failure. It usually results from a cytotoxic T cell attack on the marrow stem cell. Two treatments can be used for most people with SAA.
- Trial name
- NCT04436380
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cystic Fibrosis
Natural History Study of Exocrine Pancreatic Function in Infants With Cystic Fibrosis (CF)
The purpose of the study is to evaluate the natural history of exocrine pancreatic function by assessing Fecal elastase-1 (FE-1) in infants with CF during their first year of life.
- Trial name
- NCT06506773
- Where
- 50 sites in United States, Australia and 9 more
- Volunteers
- 79 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Diabetes Mellitus, Obesity
Early Tracking of Childhood Health Determinants (ETCHED) Study
Background: Children s weight has increased sharply in recent years. This may put them at higher risk for health problems. High blood glucose in a pregnant mother and too much weight gain during pregnancy also may have long-term…
- Conditions
- Diabetes Mellitus, Obesity, Fatty Liver
- Trial name
- NCT03481829
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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