Clinical trials: Natural Pregnancy
Infertility, Female Infertility
What is the Optimal Cycle Regimen for Frozen- Thawed Embryo Transfer Cycles
Investigators will be comparing artificial (HRT) frozen-thawed embryo transfer cycles to correctly conducted spontaneous natural cycles after the transfer of a chromosomally normal embryo.
- Conditions
- Infertility, Female Infertility, Pregnancy Early
- Trial name
- NCT03954587
- Where
- United Arab Emirates
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Recurrent Miscarriage
Effect of Prednisolone Treatment on Uterine Natural Killer Cells
This study aims to investigate the role of uNK cells and the association with prednisolone.
- Trial name
- NCT03902912
- Testing
- Prednisolone
- Where
- Hong Kong
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sarcoma, Endocrine Tumors
Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies
Background: Laboratory investigators who are studying common childhood cancers are interested in developing a tissue repository to collect and store blood, serum, tissue, urine, or tumors of children who have cancer or adults who…
- Conditions
- Sarcoma, Endocrine Tumors, Neuroblastoma, Retinoblastoma
- Trial name
- NCT01109394
- Where
- 5 sites in United States
- Volunteers
- 6,035 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Advanced Solid Tumor, Metastatic Cancer
Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers
The purpose of the Phase 1/2a study is to evaluate the safety and tolerability of SNK01 in combination with trastuzumab or cetuximab in order to determine the maximum tolerated dose (MTD)/recommended Phase 2 dose (RP2D), and the…
- Conditions
- Advanced Solid Tumor, Metastatic Cancer, HER2-positive Breast Cancer, HER2-positive Gastric Cancer
- Trial name
- NCT04464967
- Testing
- SNK01, Trastuzumab, Cetuximab
- Sponsor
- NKGen Biotech, Inc.
Ivf, Frozen Embryo Transfer (FET)
Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus Progesterone
Background: The capability to transfer frozen embryos reduces embryo loss following in vitro fertilization (IVF) and results in higher pregnancy rates compared to a single IVF cycle.
- Trial name
- NCT06870266
- Testing
- Nafarelin nasal spray, Utrogestan®
- Volunteers
- 150 people
- Sponsor
- Shaare Zedek Medical Center
Infertility, Female
Impact of Serum Progesterone in Modified Natural Cycles and Stimulated Cycles on Ongoing Pregnancy Rate
Prospective cohort unicentric study including infertile patients undergoing an embryo transfer in the context of natural or stimulated cycles and receiving luteal phase support with vaginal natural progesterone following the…
- Trial name
- CORPUS-LUTEUM (NCT04259996)
- Testing
- PROGESTERONE AND ESTRADIOL SERUM CONCENTRATION MEASUREMENT
- Where
- Spain
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Alport Syndrome Patients With eGFR Between 45-90 ml/Min/1.73 m2
ATHENA: Natural History of Disease Study in Alport Syndrome Patients
There is limited published clinical data about the natural history of renal disease in Alport syndrome. The RG012-01 study will collect data to characterize the progression of renal dysfunction in Alport syndrome patients.
- Trial name
- RG012-01 (NCT02136862)
- Where
- 15 sites in United States, Australia and 4 more
- Volunteers
- 165 people
- Sponsor
- Genzyme, a Sanofi Company
Placenta Previa, Placenta Previa Accreta
The Cervix as a Natural Tamponade in Postpartum Hemorrhage Caused by Placenta Previa and Placenta Previa Accreta
Placenta previa and placenta accrete carry significant maternal and fetal morbidity and mortality. Several techniques have been described in the literature for controlling massive bleeding associated with placenta previa cesarean…
- Trial name
- NCT02590484
- Testing
- The cervix as a natural tamponade (cervical inversion)
- Where
- Egypt
- Sponsor
- Minia University
Cystocele
A Novel Suturing Technique of Cystocele Treatment
The rug weaving-like plication technique may offer a viable alternative for cystocele repair without mesh, utilizing natural tissue.
- Trial name
- cystosel (NCT06410469)
- Testing
- rug weaving-like plication technique
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Ankara City Hospital Bilkent
Urinary Tract Infections
An Open-label Trial to Evaluate the Safety of an Essential Oil Infused Perineal Towel
The purpose of this study is to assess the safety (absence of skin irritation) of a feminine hygiene product for perineal hygiene prior to undertaking a clinical effectiveness trial.
- Trial name
- WIPEAWAY (NCT02509403)
- Testing
- Essential oils infused Perineal Hygiene wipe
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Prenatal Care, Premature Birth
Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longtitudinal Study
Preterm delivery, preeclampsia and intrauterine growth restriction are leading causes of perinatal morbidity and mortality. Efforts to treat these syndromes have not been effective, most likely becuase these obstetric…
- Trial name
- NCT00340899
- Where
- Chile
- Volunteers
- 19,134 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Gynecologic Disease, Inflammation
Inflammatory Markers in Natural Orifice Hysterectomies
The authors aimed to detect inflammatory marker changes in two natural orifice hysterectomies: single-port laparoscopic hysterectomy (SLH) and vaginal hysterectomy (VH).
- Trial name
- NCT04221308
- Testing
- Single port laparoscopic systems
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Derince Training and Research Hospital
Pregnancy Outcome
NIH Intramural Research Program s Pregnancy Registry Protocol for Subjects and Their Partners
Background: In 2018, the NIH intramural research program had almost 23,000 people taking part in active clinical research studies. Half of those people were female. More than a third were of child-bearing age.
- Trial name
- NCT04977466
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
LCAT Deficiency
LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study
The purpose of the LCAT (Lecithin cholesterol acyl transferase) Natural History Study (LCAT NHS) is to help identify people with a mutation in a gene called LCAT, collect and store information about their medical history and…
- Trial name
- LCAT NHS (NCT06217588)
- Testing
- Demographics, diagnosis type, genotype, lipid profile, renal function profile, treatment allocation, ophthalmology exam, country of residence.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Miscarriage, Frozen Embryo Transfer
Natural Cycle Versus Hormone Replacement Therapy Cycle for a Frozen-thawed Embryo Transfer in PGT Patients
The aim of the current study is to compare miscarriage rates (before 8 weeks) between a true natural cycle (awaiting spontaneous LH surge) and a hormone replacement therapy cycle prior to blastocyst transfer in preimplantation…
- Conditions
- Miscarriage, Frozen Embryo Transfer, Natural Cycle, Hormone Replacement Therapy Cycle
- Trial name
- NCT03976544
- Testing
- Estradiol Valerate, Micronized progesterone
- Where
- Belgium
- Volunteers
- 362 people
- Sponsor
- CRG UZ Brussel
Pregnancy
Idealizing Pregnancy Outcome With Single Blastocyst Transfer in a FET Cycle
Single embryo transfer (SET) has been advocated as a means of reducing the risk of multiple pregnancies, but has meant a reduction in pregnancy risk per embryo transfer.
- Trial name
- NCT01987856
- Testing
- Blastocyst morphology
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Antalya IVF
Lung Cancer, Breast Cancer
Clinical Study on Anti-tumor Effect Induced by Activated Primary Natural Killer（NK）Cells
This study will analyze and evaluate the following items: 1. The safety of natural killer（NK） cells for treatment of subjects with solid tumors.
- Conditions
- Lung Cancer, Breast Cancer, Colon Cancer, Pancreatic Cancer
- Trial name
- NCT03634501
- Testing
- Activated NK
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Metastatic Melanoma, Metastatic Kidney Cancer
Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney Cancer
Background: Natural killer (NK) cells are large lymphocytes (a type of white blood cell) that are important in the immune response to cancer.
- Trial name
- NCT00328861
- Testing
- Natural Killer (NK) Lymphocytes, IL-2, Cyclophosphamide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Metabolic Disorders, Cancer
A Natural History Study of Metabolic Sizing in Health and Disease
Background: Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate.
- Conditions
- Metabolic Disorders, Cancer, Chronic Kidney Disease, Diabetes
- Trial name
- NCT05398783
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Liver Cirrhosis, Hepato-Renal Syndrome
Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal Disease
The aim of this retrospective study is to evaluate the treatment response to terlipressin and albumin in patients with suspicion of HRS-AKI and signs of chronic parenchymal kidney disease (HRS-AKI-like syndrome) compared to…
- Conditions
- Liver Cirrhosis, Hepato-Renal Syndrome, Chronic Kidney Diseases
- Trial name
- Terli-CKD (NCT06161766)
- Testing
- terlipressin or noradrenalin plus albumin
- Where
- 4 sites in Germany
- Volunteers
- 490 people
- Sponsor
- University Hospital Freiburg