Clinical trials: Nausea
Breast Neoplasms
Chinese Herbal Acupoint Application Combined With Triple Antiemetic Therapy for Prevention of Chemotherapy-Induced Nausea and Vomiting in Breast Cancer
The goal of this clinical trial is to learn whether Chinese herbal acupoint application, when added to standard three-drug anti-nausea treatment, can prevent nausea and vomiting caused by chemotherapy in people with breast…
- Trial name
- NCT07848984
- Testing
- Chinese Herbal Acupoint Application, Standard Triple Antiemetic Therapy
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Nausea and Vomiting Chemotherapy-Induced, Nausea Post Chemotherapy
Study With IV NEPA (Fosnetupitant/Palonosetron) for the Prevention of Chemotherapy-induced Nausea and Vomiting in Paediatric Cancer Patients Undergoing Highly Emetogenic Chemotherapy (HEC)
Chemotherapy often causes nausea and vomiting (CINV), and this is a major problem for the children being treated for cancer. To prevent this, a combination of two substances in fixed proportion (IV NEPA) was developed.
- Trial name
- NCT06904235
- Testing
- IV NEPA (fosnetupitant/palonosetron), Reference Treatment: IV ondansetron infusion, Reference Treatment: IV fosaprepitant infusion
- Where
- 20 sites in Greece, Poland and 2 more
- Volunteers
- 95 people
- Sponsor
- Helsinn Healthcare SA
Postoperative Nausea and Vomiting
Effects of taVNS Combined With Dexmedetomidine on POVN
To explore the effects and possible mechanisms of dexmedetomidine combined with taVNS on the incidence of postoperative nausea and vomiting in female patients undergoing laparoscopic surgery
- Trial name
- NCT07271147
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulator, Dexmedetomidine
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Affiliated Hospital of Nantong University
Vomiting in Infants and/or Children, Nausea
RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents.
- Conditions
- Vomiting in Infants and/or Children, Nausea, Hematopoietic System--Cancer, Oncology
- Trial name
- NCT03118986
- Testing
- Olanzapine
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 161 people
- Sponsor
- The Hospital for Sick Children
Arthritis Knee, Postoperative Nausea
Oral Dexamethasone as an Intervention for Postoperative Pain and Nausea Management in Total Knee Arthroplasty
This study aims to determine if oral dexamethasone provides clinically significant improvement in postoperative outcomes, specifically nausea and pain scores.
- Conditions
- Arthritis Knee, Postoperative Nausea, Postoperative Pain
- Trial name
- NCT04432259
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Henry Ford Health System
Digestive System Disorder, Dyspepsia
Domperidone in Treating Patients With Gastrointestinal Disorders
This phase III trial studies how well domperidone works in treating patients with gastrointestinal disorders. Domperidone may help control chronic gastrointestinal disorders and their symptoms, such as pain, bloating, and nausea…
- Conditions
- Digestive System Disorder, Dyspepsia, Esophagitis, Gastroesophageal Reflux Disease
- Trial name
- NCT01696734
- Testing
- Domperidone, Questionnaire Administration
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- M.D. Anderson Cancer Center
Idiopathic Gastroparesis, Diabetic Gastroparesis
Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
To investigate the safety and efficacy of tradipitant versus placebo in relieving nausea and other symptoms of gastroparesis.
- Conditions
- Idiopathic Gastroparesis, Diabetic Gastroparesis, Gastroparesis
- Trial name
- NCT04028492
- Testing
- Tradipitant, Open Label Tradipitant
- Where
- 36 sites in United States
- Volunteers
- 979 people
- Sponsor
- Vanda Pharmaceuticals
Vomiting, Nausea
Inhaled Isopropyl Alcohol for Treatment of Nausea
To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.
- Conditions
- Vomiting, Nausea, Children, Only
- Trial name
- NCT05418244
- Testing
- Inhaled Isopropyl Alcohol, Oral Ondansetron
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Nausea and Vomiting in Pregnancy
Effect of Moringa Oleifera, Zingiber Officinale, and Curcuma Xanthorrhiza Extracts for Nausea and Vomiting in First-Trimester Pregnancy
This retrospective cohort study will evaluate the association between adjunctive Moringa oleifera, Zingiber officinale, and Curcuma xanthorrhiza extracts and changes in Pregnancy-Unique Quantification of Emesis and Nausea (PUQE)…
- Trial name
- NCT07833371
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Maranatha Christian University
Obese Patients With Bariatric Surgery
The Effect of Cold Application on Nausea and Vomiting After Bariatric Surgery
Obesity is a chronic disease resulting from an excess of body fat mass relative to lean body mass, characterized by a deterioration in the individual's quality of life and health (Kayar and Utku, 2013; Usta and Çavdar, 2013; Tam…
- Trial name
- NCT07825779
- Testing
- ICE
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Post Operative Pain, Postoperative Nausea and Vomiting
Postoperative Analgesia in Hip Arthroplasty
The goal of this clinical trial is to compare the analgesic effectiveness of two blocks in hip arthroplasty. The main question it aims to answer is -Which block is more efficient? Researchers will compare the suprainguinal fascia…
- Conditions
- Post Operative Pain, Postoperative Nausea and Vomiting, Hip Osteoarthritis
- Trial name
- NCT07153575
- Testing
- suprainguinal fascia iliaca block, Pericapsular nerve group (PENG) block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Balikesir University
Chemotherapy-Induced Nausea and Vomiting (CINV)
QLM2010 Comparative Pharmacokinetic Study With 2-Minute Intravenous Administration
This is a single-center, single-dose, randomized, open-label, crossover study. Forty-two healthy male and female participants will be enrolled.
- Trial name
- NCT07817004
- Testing
- apripitant and palonosetron injectable emulsion, palonosetron hydrochloride injection, apripitant injection (CINVANTI)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical (Hainan) Co., Ltd.
Chronic Sinusitis, Postoperative Pain
Opioid-Free Anesthesia in FESS: A Prospective ERAS Study
1. Information for Patients and Families What is this study about? When patients undergo functional endoscopic sinus surgery (FESS), strong pain relievers called opioids are traditionally used during anesthesia.
- Conditions
- Chronic Sinusitis, Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Surgical Field Visibility
- Trial name
- OFA-FESS (NCT07812389)
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Filiz Kaya
Postoperative Nausea and Vomiting
Efficacy of Palonosetron Plus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Gynaecological Laparoscopic Surgery
Postoperative nausea and vomiting (PONV) is a common complication after general anaesthesia, especially among female patients undergoing laparoscopic surgery.
- Trial name
- NCT07813897
- Testing
- Palonosetron and Dexamethason, Palonosetron
- Where
- Bangladesh
- Volunteers
- 76 people
- Sponsor
- Bangladesh Medical University
Local Application/Packing Too Cold, Patient Satisfaction
The Effect of Cold Application on Nausea and Vomiting in the Early Postoperative Period
As a result of the literature review, it has been seen that it has not yet been clarified whether cold application methods are effective on postoperative nausea and vomiting, and academic studies on this subject are needed.
- Conditions
- Local Application/Packing Too Cold, Patient Satisfaction, Postoperative Nausea and Vomiting
- Trial name
- NCT05888818
- Testing
- Cold application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Post Operative Nausea and Vomiting (PONV)
Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery
Amisulpride is a potent antagonist of dopamine D2 and D3 receptors, both implicated in the emetic response when activated. It is currently used intravenously for the prevention of chemotherapy-induced and postoperative nausea and…
- Trial name
- NCT06887621
- Testing
- Encapsulated amisulpride 50 mg (matched for color, weight, smell and size)
- Where
- Brazil
- Volunteers
- 276 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Postoperative Delirium (POD), Postoperative Pain
Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery
This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients…
- Conditions
- Postoperative Delirium (POD), Postoperative Pain, PONV, Burst Suppression
- Trial name
- NCT07357480
- Testing
- Target Controlled Infusion, Total Intravenous Anesthesia(TIVA)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Istanbul University - Cerrahpasa
Solid Tumours, Olanzapine
Olanzapine Dose Comparison for the Prevention of HER-INV: A Network Meta-Analysis
Olanzapine is an effective antiemetic agent for preventing highly emetogenic regimens-induced nausea and vomiting (HER-INV) in patients receiving highly emetogenic regimens (HER).
- Conditions
- Solid Tumours, Olanzapine, Nausea and Vomiting
- Trial name
- NCT07403370
- Testing
- Olanzapine (dose comparison: 2.5 mg, 5 mg, 10 mg)
- Where
- China
- Volunteers
- 2,493 people
- Sponsor
- Shandong Cancer Hospital and Institute
PONV
Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.
The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.
- Trial name
- NCT07806162
- Testing
- Opioid Free Anaesthesia, conventential opioid-based anaesthesia (OBA,
- Volunteers
- 120 people
- Sponsor
- Sohag University
Postoperative Nausea and Vomiting
Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy
The goal of this superiority randomized controlled trial (RCT) is to learn if one dual-drug arm increases patient comfort (time to needing rescue medication for nausea/vomiting) more effectively than the other in adults with…
- Trial name
- NCT07638527
- Testing
- ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg
- Where
- Pakistan
- Volunteers
- 264 people
- Sponsor
- Faisalabad Medical University