Clinical trials: Nausea With Vomiting Chemotherapy-Induced
Chemotherapy-induced Nausea and Vomiting
Evaluation of Predictive Risk Factors of Chemotherapy-induced Nausea and Vomiting
The most common toxicity of chemotherapy is nausea and vomiting, and appropriate management of these toxicities can help patients improve tolerance for chemotherapy.
- Trial name
- NCT01993381
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- The Catholic University of Korea
Chemotherapy-induced Nausea and Vomiting
A Phase 1, 2-Part, Single Ascending Dose Assessment of the Safety, Tolerability, and Pharmacokinetics of Rolapitant Intravenous in Healthy Volunteers
The purpose of this study is to assess the safety and tolerability of single increasing doses of intravenously administered rolapitant in healthy male and female subjects.
- Trial name
- NCT02382666
- Testing
- Rolapitant
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tesaro, Inc.
Cancer, Malignancy
Ramosetron, Aprepitant and Dexamethasone Versus Ondansetron, Aprepitant and Dexamethasone
The purpose of this study is to assess the efficacy and safety of Ramosetron, Aprepitant and Dexamethasone therapy versus Ondansetron, Aprepitant and Dexamethasone therapy for preventing of nausea and vomiting in highly…
- Trial name
- ROAD (NCT01536691)
- Testing
- ramosetron, ondansetron
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Hallym University Medical Center
Chemotherapy-Induced Nausea and Vomiting (CINV)
Fosrolapitant Combined With Palonosetron to Prevent Trastuzumab Rezetecan Related CINV
This study is a prospective, single-arm, multicenter, exploratory clinical trial divided into a screening phase, a treatment phase, and a follow-up phase.
- Trial name
- NCT07726433
- Testing
- Fosrolapitant and Palonosetron Hydrochloride for Injection
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Chemotherapy-induced Nausea and Vomiting
Ph3 Safety/Efficacy Study of Rolapitant for the Prevention of CINV in Subjects Receiving Highly Emetogenic Chemotherapy
This is a Phase 3, multicenter, randomized, parallel-group, double-blind, active-controlled study of rolapitant in subjects receiving HEC.
- Trial name
- HEC (NCT01500213)
- Testing
- Rolapitant, Granisetron, Dexamethasone
- Where
- United States
- Volunteers
- 555 people
- Sponsor
- Tesaro, Inc.
Chemotherapy-induced Nausea and Vomiting
Feasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy
Olanzapine is frequently used off-label as an adjunct antiemetic in clinical oncology settings. North American oncology guidelines recommend it as salvage therapy and as add-on to the standard triple regimen; some suggest it may…
- Trial name
- FORESIGHT (NCT04075955)
- Testing
- Zyprexa® (OLANZapine 5MG), Emend® (Aprepitant)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- CR-CSSS Champlain-Charles-Le Moyne
Chemotherapy-induced Nausea and Vomiting
Proof-of-Concept Trial of Palonosetron and Olanzapine Without Dexamethasone for the Prevention of CIN
The purpose of this study is to determine whether Palonosetron and Olanzapine without dexamethasone for the Prevention of moderate risk Chemotherapy-Induced Nausea and vomiting.
- Trial name
- NCT02970643
- Testing
- Olanzapine, Palonosetron
- Volunteers
- 48 people
- Sponsor
- Hee Jun Kim
Chemotherapy-induced Nausea and Vomiting
Oral Akynzeo® vs Standard of Care in Preventing CINV in High-risk MEC Patients (MyRisk)
MyRisk: Efficacy and safety evaluation of oral Akynzeo® in patients receiving MEC at high risk of developing CINV based on a prediction tool. A multinational and multicenter study.
- Trial name
- CINV (NCT04817189)
- Testing
- NEPA (300mg netupitant/0.5mg palonosetron), Granisetron, 2 mg (oral) or 1 mg (IV) OR Palonosetron, 0.5 mg (oral), 0.25mg (IV) OR Ondansetron, 16 mg (oral) or 8 mg (IV) OR Dolasetron 100 mg (oral) OR Tropisetron 5 mg (oral or IV), Dexamethasone, 8 mg (oral) or equivalent IV dose
- Where
- 19 sites in China, Czechia and 5 more
- Volunteers
- 414 people
- Sponsor
- Helsinn Healthcare SA
Nausea and Vomiting, Aromatherapy
Effect of Inhaled Aromatherapy on Chemo-Induced Nausea Vomiting (NCVI): CINVAROM (Chemotherapy Induced Nausea Vomiting and AROMatherapy)
The investigator wish to provide a blend of two essential oils with comparable antiemetic properties; Peppermint essential oil (Mentha x Piperita) and lemon tree essential oil (Citrus Limon).
- Conditions
- Nausea and Vomiting, Aromatherapy, Essential Oil, Suportive Care
- Trial name
- CINVAROM (NCT04560114)
- Testing
- Essential oils
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Francois Baclesse
Chemotherapy-induced Nausea and Vomiting, Nausea Post Chemotherapy
Prevention of Unmitigated Chemotherapy-induced Emesis
Chemotherapy-induced nausea and vomiting (CINV) remains a major obstacle to patient care and continues to decrease quality of life.
- Trial name
- PUCE (NCT03996863)
- Testing
- Otoband
- Where
- United States
- Sponsor
- Otolith Labs
Chemotherapy-induced Nausea and Vomiting
An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects
The objective of this Open Label Study is to evaluate effects of Rolapitant IV solution, and its metabolite, on the pharmacokinetics (PK) of the P-gp substrate (digoxin), the BCRP substrate (sulfasalazine), and multiple…
- Trial name
- NCT02434861
- Testing
- Rolapitant, Digoxin, Sulfasalazine
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Tesaro, Inc.
Leukemia
Peppermint Inhalation Versus Swedish Massage on Chemotherapy Induced-Nausea and Vomiting in Children With Leukemia
Clinical trials was used to compare the effect of peppermint inhalation and Swedish massage on chemotherapy induced-nausea and vomiting in children with leukemia.
- Trial name
- NCT06095726
- Testing
- Peppermint Inhalation, Swedish Massage
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Alexandria University
Children, Chemotherapy-induced Nausea and Vomiting
Stimulation of Acupuncture Points by Athermic Laser Therapy for the Prevention of Chemotherapy Induced Nausea and Vomiting in Children
Poor control of chemotherapy-induced nausea and vomiting has a major clinical and psychological impact in patients treated with chemotherapy.
- Conditions
- Children, Chemotherapy-induced Nausea and Vomiting, Malignant Tumor
- Trial name
- NAUVOLA (NCT03354741)
- Testing
- laser therapy
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Electroacupuncture, Olanzapine-contained Four-drug Antiemetic
Electroacupuncture Plus Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer
This study explores the effectiveness of combining electroacupuncture with olanzapine-containing four-drug antiemetic therapy to mitigate chemotherapy-induced nausea and vomiting (CINV) in patients with breast cancer.
- Conditions
- Electroacupuncture, Olanzapine-contained Four-drug Antiemetic, Nausea and Vomiting
- Trial name
- NCT06314906
- Testing
- Electroacupuncture, Antiemetic Therapy
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Feixue Song
Chemotherapy Induced Nausea and Vomiting
Prevention of Breakthrough CINV in Patients Receiving Moderately or Highly Emetogenic Chemotherapy
The purpose of the proposed study is to provide a clinical approach to chemotherapy induced nausea and vomiting (CINV) prophylaxis in cycle 2 of moderately emetogenic chemotherapy or highly emetogenic chemotherapy for patients…
- Trial name
- NCT06065722
- Testing
- Akynzeo
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Simon Williamson Clinic
Extrahepatic Bile Duct Cancer, Nausea
Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Chemotherapy and Radiation Therapy for Pancreatic Cancer
This pilot clinical trial is studying how well aprepitant works in preventing nausea and vomiting in patients undergoing chemotherapy and radiation therapy for pancreatic cancer.
- Conditions
- Extrahepatic Bile Duct Cancer, Nausea, Vomiting, Stage II Pancreatic Cancer
- Trial name
- NCT01534637
- Testing
- aprepitant, gemcitabine hydrochloride, capecitabine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Nausea Post Chemotherapy, Vomiting
TRANSCUTANEOUS ELECTRICAL ACUPOINT STIMULATION FOR CISPLATIN- CHEMOTHERAPY INDUCED NAUSEA AND VOMITING
The purpose of this study is to evaluate the therapeutic efficacy of transcutaneous electrical acupoint stimulation for cisplatin- chemotherapy induced nausea and vomiting.
- Conditions
- Nausea Post Chemotherapy, Vomiting, Transcutaneous Electrical Acupoint Stimulation, Acupuncture
- Trial name
- NCT07509905
- Testing
- Transcutaneous electrical nerve stimulation, Antiemetic
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Central Nervous System Tumor, Pediatric, Chemotherapy-induced Nausea and Vomiting
Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy
RATIONALE: Acupressure wristbands may prevent or reduce nausea and caused by chemotherapy. It is not yet known whether standard care is more effective with or without acupressure wristbands in controlling acute and delayed…
- Conditions
- Central Nervous System Tumor, Pediatric, Chemotherapy-induced Nausea and Vomiting, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- SCUSF1202 (NCT01346267)
- Testing
- Real Acupressure Band
- Where
- 25 sites in United States, Canada
- Volunteers
- 187 people
- Sponsor
- University of South Florida
Chemotherapy-Induced Nausea and Vomiting
Comparative Study of Palonosetron With Granisetron as a Control in Patients Receiving Highly Emetogenic Chemotherapy
To compare palonosetron with granisetron hydrochloride as a control in the efficacy of intravenous single dose in preventing acute and delayed gastro-intestinal disorders, such as nausea and vomiting induced by highly emetogenic…
- Trial name
- NCT00359567
- Testing
- palonosetron, granisetron hydrochloride
- Where
- Japan
- Volunteers
- 1,140 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
Anxiety, Chemotherapy-induced Nausea and Vomiting
Use of Aromatherapy to Reduce Symptom Burden
The purpose of this study is to evaluate the effect of inhaled aromatherapy on symptoms of nausea/vomiting and anxiety in patients who have received a stem cell transplant.
- Trial name
- NCT05251337
- Testing
- Essential oils
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Indiana University