Clinical trials: Nausea and Vomiting, Chemotherapy-Induced
Nausea and Vomiting Chemotherapy-Induced
Medical Cannabis Observational Study for Antiemetic Intervention in Chemotherapy
The goal of this observational study is to evaluate the associations between patient-directed medical cannabis use and chemotherapy-induced nausea and vomiting (CINV), as well as other treatment-related symptoms, among patients…
- Trial name
- MOSAIC (NCT07374939)
- Testing
- Medical Cannabis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Neoplasms
Efficacy of Thalidomide in Preventing Chemotherapy-induced Delayed Nausea and Vomiting
This study was aimed to evaluate efficacy and tolerability of thalidomide in improving prevention of chemotherapy-induced delayed nausea and vomiting in chemotherapy-naive patients after highly emetogenic chemotherapy.
- Trial name
- NCT02203253
- Testing
- Thalidomide, Palonosetron and Dexamethasone
- Where
- 11 sites in China
- Volunteers
- 642 people
- Sponsor
- China Medical University, China
Anxiety, Chemotherapy-induced Nausea and Vomiting
Use of Aromatherapy to Reduce Symptom Burden
The purpose of this study is to evaluate the effect of inhaled aromatherapy on symptoms of nausea/vomiting and anxiety in patients who have received a stem cell transplant.
- Trial name
- NCT05251337
- Testing
- Essential oils
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Indiana University
Chemotherapy-induced Nausea and Vomiting, Highly Emetogenic Chemotherapy
NEPA Combined With Olanzapine, Dexamethasone-sparing for the Effect of CINV in Patients Receiving HEC Regimens
The objective of this Prospective, randomized, non inferiority phase III trial is to confirm the efficacy and saftey of dexamethasone-sparing combined with netupitant/palonostron and olanzapine for the prevention of…
- Trial name
- NCT06331520
- Testing
- Netupitant / Palonosetron Oral Capsule [Akynzeo], Olanzapine, Dexamethasone Oral
- Where
- China
- Volunteers
- 644 people
- Sponsor
- Fudan University
Nausea and Vomiting, Chemotherapy-Induced
A Study in Healthy Subjects to Assess How Dosing of Rifampin Affects What the Body Does to a Dose of GW679769 (Casopitant).
This study will examine what the body does while taking GW679769 alone and together with rifampin in healthy adult subjects.
- Trial name
- NCT00405080
- Testing
- GW679769 (Casopitant) oral tablets, Rifampin oral capsules
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Leukemia, Lymphoma
AMENO-2: Aprepitant Plus Palonosetron Versus Granisetron in the Prevention of Nausea and the Emesis Induced by Chemotherapy in Patients Treated With Haematopoietic Progenitors
The purpose of this trial is to determinate the security, tolerability and efficacy of aprepitant plus palonosetron versus granisetron in the prevention of nausea and emesis induced by chemotherapy in patients treated with…
- Trial name
- AMENO-2 (NCT00415103)
- Testing
- Aprepitant, Palonosetron, Granisetron
- Where
- 5 sites in Spain
- Volunteers
- 196 people
- Sponsor
- PETHEMA Foundation
Nausea and Vomiting, Chemotherapy-Induced
To Investigate the Effect of Intravenous Ondansetron on Cardiac Conduction as Compared to Placebo and Moxifloxacin in Healthy Adult Subjects
Ondansetron, also known as Zofran, is a marketed compound used for the prevention of nausea and vomiting. This study, called a thorough QT study, will characterize the effects of a single intravenous (IV) dose of ondansetron on…
- Trial name
- NCT01449188
- Testing
- ondansetron, moxifloxacin, saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Neoplasms, Nausea
Palonosetron in Moderately and Highly Emetogenic Chemotherapy Induced Nausea and Vomiting (Study P04935)(COMPLETED)
The purpose of this study is to evaluate the efficacy and safety of single IV doses of Onicit® (Palonosetron) 0.25 mg in the prevention of acute and delayed nausea and vomiting associated with moderate and highly emetogenic…
- Conditions
- Neoplasms, Nausea, Vomiting
- Trial name
- NCT00684463
- Testing
- Palonosetron
- Volunteers
- 59 people
- Sponsor
- Merck Sharp & Dohme LLC
Multiple Myeloma
Prevention of Delayed CINV After Autologous Transplant: Olanzapine-Containing Regimen vs. Dexamethasone-Containing Regimen
This study employs a prospective, multicenter, randomized, two-arm design aimed at evaluating the efficacy and safety of the FTO regimen in preventing delayed chemotherapy-induced nausea and vomiting (CINV) following high-dose…
- Trial name
- NCT07413809
- Testing
- Fosaprepitant, Tropisetron, Olanzapine
- Where
- China
- Volunteers
- 92 people
- Sponsor
- The Affiliated People's Hospital of Ningbo University
Chemotherapy-induced Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific
Mindfulness Relaxation Compared With Relaxing Music and Standard Symptom Management Education in Treating Patients Who Are Undergoing Chemotherapy For Newly Diagnosed Solid Tumors
RATIONALE: Mindfulness relaxation, a technique to help patients quiet their thoughts and relax their bodies before and during chemotherapy, may reduce or prevent nausea and vomiting.
- Conditions
- Chemotherapy-induced Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific, Breast Cancer, Gastrointestinal Cancer
- Trial name
- NCT00086762
- Testing
- MR Therapy, Relaxing Music (RM) Therapy, Standard Symptom Management
- Where
- 9 sites in United States
- Volunteers
- 474 people
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy Induced Nausea and Vomiting, Quality of Life (QOL)
Vomiting Prevention in Children With Cancer
The goal of this single arm trial is to learn if a machine learning (ML) model predicting the risk of vomiting within the next 96 hours will impact vomiting outcomes in inpatient cancer pediatric patients.
- Conditions
- Chemotherapy Induced Nausea and Vomiting, Quality of Life (QOL), Pediatric Cancer
- Trial name
- NCT06886451
- Testing
- ML-based intervention
- Where
- Canada
- Volunteers
- 1,953 people
- Sponsor
- The Hospital for Sick Children
Chemotherapy-induced Nausea and Vomiting
Prevalence of Delayed Chemotherapy Associated Nausea
This study evaluates the prevalence of delayed chemotherapy induced nausea in adult oncology patients in real clinical practice of day clinics.
- Trial name
- CINrate (NCT04342780)
- Where
- Switzerland
- Volunteers
- 172 people
- Sponsor
- Antje Koller
Tumor, Chemotherapy-induced Nausea and Vomiting
the Efficacy and Safety of 5-HT3 Receptor Antagonist, Dexamethasone or Megestrol Acetate Dispersible Tablets in the Control of Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy
To compare the efficacy and safety of megestrol acetate dispersible tablets combined with 5-HT3 receptor antagonist and dexamethasone triple antiemetic regimen and 5-HT3 receptor antagonist and dexamethasone combined antiemetic…
- Trial name
- NCT04430361
- Testing
- Megestrol, 5-HT3 receptor antagonist, dexamethasone
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan Cancer Hospital
Emesis, Vomiting
Trial to Evaluate Efficacy of Olanzapine With Short-acting 5HT3 Inhibitors in Chemotherapy-induced Nausea & Vomiting (CINV) Prophylaxis
Olanzapine-containing regimens for CINV prophylaxis may provide even better protection than aprepitant-containing regimens.
- Conditions
- Emesis, Vomiting, Nausea Post Chemotherapy, Nausea
- Trial name
- OlaCINV (NCT03478605)
- Testing
- Olanzapine, Aprepitant Pill, Ondansetron
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Cancer
Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis After Receiving Cisplatin
The objective of this study is to assess the efficacy and tolerability of metoclopramide added to standard antiemetic regimen for prophylaxis of cisplatin-induced emesis.
- Trial name
- NCT01093690
- Testing
- metoclopramide
- Where
- Thailand
- Volunteers
- 162 people
- Sponsor
- Mahidol University
Electroacupuncture, Olanzapine-contained Four-drug Antiemetic
Electroacupuncture Plus Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer
This study explores the effectiveness of combining electroacupuncture with olanzapine-containing four-drug antiemetic therapy to mitigate chemotherapy-induced nausea and vomiting (CINV) in patients with breast cancer.
- Conditions
- Electroacupuncture, Olanzapine-contained Four-drug Antiemetic, Nausea and Vomiting
- Trial name
- NCT06314906
- Testing
- Electroacupuncture, Antiemetic Therapy
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Feixue Song
Nausea, Vomiting
A Multicenter, Randomized, Controlled Trial of SCH 619734 for the Treatment of Chemotherapy-Induced Nausea and Vomiting (Study P04351AM2)(COMPLETED)
This is a Phase 2, randomized, multicenter, parallel-group, double-blind, placebo-controlled study of various doses of SCH 619734 in subjects receiving cisplatin-based chemotherapy.
- Trial name
- NCT00394966
- Testing
- SCH 619734 Dose 1, SCH 619734 Dose 2, SCH 619734 Dose 3
- Volunteers
- 450 people
- Sponsor
- Schering-Plough
Lean Body Mass, Cannabis
The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy
An intervention study on the effect of cannabidiol on lean body mass in cancer patients receiving chemotherapy, at the department of Clinical Oncology at Zealand University Hospital, Roskilde, Denmark.
- Conditions
- Lean Body Mass, Cannabis, Cancer, Nausea
- Trial name
- NCT04585841
- Testing
- Cannabidiol
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Copenhagen
Chemotherapy-induced Nausea and Vomiting
The Effect of Acupuncture in Chemotherapy-induced Nausea and Vomiting
Nausea and vomiting are the most common symptoms experienced by cancer patients after chemotherapy. Some patients have to endure such unpleasant symptoms even after using of antiemetic or anti-vomiting medications.The purpose of…
- Trial name
- NCT02369107
- Testing
- Verum acupuncture and medicine
- Volunteers
- 136 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Colon Cancer
Phamacokinetic and Pharmacodynamic Study of Ramosetron in Chemotherapy Induced Nasea and Vomiting
This study is designted to know optimal dose of Ramosteron to control for chemotherapy induced nasea and vomoting (CINV)based on its pharmacokinetics, pharmacodynamic study and clinilcal parameters using Rhodes Index.
- Trial name
- NCT02076529
- Testing
- Ramosetron 0.3mg, Ramosetron 0.45mg, Ramosetron 0.6mg
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Chonnam National University Hospital