Clinical trials: Near-Infrared Spectroscopy
Blood-Brain Barrier Permeability
Blood-brain Barrier Permeability Study in Adults With Meningitis
The purpose of the study is to confirm the applicability and usefulness of the novel method of assessment of the permeability of the blood-brain barrier and in monitoring of the treatment of patients with meningitis.
- Trial name
- NM-BBBP (NCT02902588)
- Testing
- ICG-PULSION, LiMON, Pulsion Medical Systems, Gadolinium (Gadovist, Bayer, Germany)
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
Intermittent Hypoxemia, Apnea of Prematurity
Influence of Oxygen Target Range on Intermittent Hypoxemia in Preterm Infants
In this randomized crossover trial, preterm infants with intermittent hypoxemia and need for supplemental oxygen will be randomized to either Sequence of two different oxygen target ranges (low: 85-89%; high: 91-95%) for a total…
- Trial name
- NCT02743988
- Testing
- Oxygen
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Ulm
Acquired Brain Injury, Traumatic Brain Injury
Pilot Trial for Adults With Acquired Brain Injury
This pilot study will compare a yoga program to a non-yoga exercise program in adults with brain injuries. The investigators will measure possible improvements in balance and heartrate.
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Stroke
- Trial name
- RCT (NCT05793827)
- Testing
- Adapted Hatha Yoga, Low-Impact Exercise
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Colorado State University
NIRS, Tissue Oxygenation
CHECK-NIRS2D-Study
The study investigates how external, physiological, and behavioral factors influence the measurement of regional tissue oxygenation using two-dimensional near-infrared spectroscopy (NIRS) imaging in healthy volunteers.
- Conditions
- NIRS, Tissue Oxygenation, Microvascular Perfusion, Vascular Occlusion Test
- Trial name
- NCT07854431
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Hemorrhagic Stroke, Ischemic Stroke
Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and…
- Conditions
- Hemorrhagic Stroke, Ischemic Stroke, Subacute Stroke, Chronic Stroke Survivors
- Trial name
- NCT07433972
- Testing
- Transcranial direct current stimulation, transcranial alternating current stimulation, Rehabilitation program
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Acute Scrotum, Testicular Torsion
Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion
Testicular torsion is the spontaneous twisting of the testis and its blood vessels, resulting in acute pain, vascular compromise and death of the testicle if unrelieved quickly.
- Trial name
- NIRS (NCT01812109)
- Testing
- Hutchison Technologies Inspectra StO2 SpotCheck Near-Infrared Spectroscopy
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- University of Texas Southwestern Medical Center
Compartment Syndrome
The Application of Near Infrared Spectroscopy (NIRS) in the Detection of Lower Limb Compartment Syndrome
This study aims to determine how infrared spectroscopy compares to continuous compartment pressure monitoring in the detection of compartment syndrome.
- Trial name
- NCT00921271
- Testing
- Monitoring of StO2
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Patent Ductus Arteriosus
Brain, Gut and Kidney Blood Flow During Medical Closure of PDA
The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated…
- Trial name
- NCT00554307
- Testing
- INVOS Cerebral/Somatic oximeter
- Where
- United States
- Sponsor
- University of Louisville
Cardiac Arrest (CA)
Integrated Near-Infrared Spectroscopy and Hemodynamic Monitoring for Cerebral Autoregulation in Post-Cardiac Arrest Care Neuroprognostication
Neurological outcome is the primary outcome for post-cardiac arrest patients. Hypoxic-ischemic brain injury is a key element in post-cardiac arrest syndrome, and remains the leading cause of mortality and morbidity in…
- Trial name
- NCT07875348
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Depression
Transcranial Magnetic Stimulation in Major Depression With EEG and Near Infrared Spectroscopy (NIRS) Monitoring
This a 12- week study (1-4 week screening, 6 weeks treatment, 2 weeks follow-up) outpatient open label clinical trial. Twenty-five subjects diagnosed with depression with a Montgomery Asberg Depression Rating Scale (MADRAS) score…
- Trial name
- NCT01192685
- Testing
- Transcranial Magnetic Stimulation (TMS), near infrared spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston University
Traumatic Brain Injury
Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military
The study includes people who have recently had a traumatic brain injury (TBI) and healthy controls who have not had a TBI and is designed to measure brain blood flow serially after a TBI.
- Trial name
- NCT04058132
- Testing
- Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5%
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Aging, Age Related Hearing Loss
Cognitive Training to Improve Mobility in Middle-aged and Older Adults
The proposed study is designed to evaluate the effect of at-home executive function training on cognition and mobility in older adults with age-related hearing loss (ARHL), older adults with normal hearing, and middle-aged adults.
- Trial name
- HnW (NCT05418998)
- Testing
- Executive function (EF) training
- Where
- Canada
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Laparoscopic Nephrectomy, Cerebral Oxygen Saturation
Pneumoperitoneum and Cerebral Oxygenation
In this study, the changes in cerebral oxygen saturation due to low and high pressure pneumoperitoneum implementation were measured in patients who underwent laparoscopic nephrectomy.
- Trial name
- NCT04671121
- Testing
- Standart pressure pneumoperitoneum, Low pressure pneumoperitoneum
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Ondokuz Mayıs University
Carotid Stenosis
Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy
The aim of this study is comparing the effect on cerebral oxygenation by sevoflurane-remifentanil or propofol-remifentanil anesthesia in patient undergoing carotid endarterectomy.
- Trial name
- NCT02609087
- Testing
- Sevoflurane, Propofol
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Chonnam National University Hospital
Statin Adverse Reaction, Skeletal Myopathy
NIRS to Diagnose SAMS
This proposal seeks to determine whether near infrared spectroscopy (NIRS) can differentiate between patients with confirmed SAMS and those with non-specific muscle complaints.
- Trial name
- NCT03653663
- Testing
- Simvastatin 20 mg
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Stroke
Prognostic Value for Predicting Outcome Using Functional Near-infrared Spectroscopy in Stroke Rehabilitation
To investigate the prognostic value of Functional Near-Infrared Spectroscopy (fNIRS) in stroke rehabilitation with serial measurements.
- Trial name
- NCT04288414
- Testing
- functional near-infrared spectroscopy
- Where
- South Korea
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Cognitive Function, Mood
The Effects of Efalex Active 50+ on Cognitive Performance, Well-being and Cerebral Hemodynamics in Healthy Older Adults
Dietary intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs) is inversely associated with cognitive decline and dementia (e.g. Kalmijn et al. 2004, Heude et al. 2003, Morris et al. 2005, Dullemeijer et al. 2009).
- Conditions
- Cognitive Function, Mood, Well-being, Cerebral Blood Flow
- Trial name
- NCT01185379
- Testing
- Efalex active 50+, DHA rich fish oil
- Where
- United Kingdom
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Near-infrared Spectroscopy, Muscle Oxygenation
Upper Extremity and Muscle Oxygenation
The aim of this study was to measure the acute change in oxygen saturation of skeletal muscle during resistance exercise in the upper extremity using near-infrared spectroscopy.
- Trial name
- NCT06294223
- Testing
- Exercise follow up with near-infrared spectroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Saglik Bilimleri Universitesi
Hypoxia, Infant, Newborn, Diseases
Safeguarding the Brain of Our Smallest Children-IIIv (SafeBoosC-IIIv)
The objective of the SafeBoosC-IIIv trial is to assess benefits and harms of cerebral oximetry in newborns receiving invasive mechanical ventilation. The hypothesis is that: i.
- Trial name
- SafeBoosC-IIIv (NCT05907317)
- Testing
- Cerebral oximetry monitoring device, Usual care
- Where
- Spain
- Volunteers
- 1,610 people
- Sponsor
- Copenhagen Trial Unit, Center for Clinical Intervention Research
Cardiac Catheterization
Validation of Brain Oxygenation Monitor on Pediatric Patients
The aim of this study is calibrate (adjust and tune) the CAS FORE-SIGHT Near-Infrared Spectroscopy (NIRS) monitor when used to measure the tissue oxygen saturation of internal organs (StO2).
- Trial name
- NCT00849940
- Testing
- CAS NIRS FORE-SIGHT oximeter
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Duke University