Clinical trials: Near-Infrared Spectroscopy
Healthy
De-stressing the Brain: Can Eating Grapes During Periods of Mental Stress Protect Brain and Vascular Health in Young Adults
The main aim of the current study is to investigate whether consuming grapes rich in flavonoids just before mental stress can protect cerebrovascular and peripheral vascular function, mood and cognition, from the negative effects…
- Trial name
- NCT06923722
- Testing
- High-flavonoid grape intervention, Low-flavonoid grape intervention
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Cerebral Palsy, Children
Cerebral Palsy and the Study of Brain Activity During Motor Tasks
Background: Two ways to study the brain while people are moving are near-infrared spectroscopy (NIRS) and electroencephalography (EEG). NIRS uses light to look at blood flow in the brain when it is active.
- Trial name
- NCT01829724
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Premature Infants, Near-infrared Spectroscopy
Cerebral Oxygenation to Guide Medical Interventions in Extremely Preterm Infants
Regional tissue oxygenation (rStO2) can be monitored by near-infrared spectroscopy. The investigators planned a SafeBoosC phase II trial to test if a reduction of the burden of hyper- and hypoxia can be accomplished during the…
- Conditions
- Premature Infants, Near-infrared Spectroscopy, Oximetry
- Trial name
- SafeBoosC-p (NCT01530360)
- Testing
- cerebral oximeter
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Gorm Greisen
Gait Disorder, Sensorimotor
The Effects of Gait Performance and Brain Activity After Robot-assisted Gait Training (RAGT) On Patients With Lower Extremity Thermal Injury
Gait enables individuals to move forward and is considered a natural skill. Gait disturbances are very common in patients with burn injury. Major causes of gait disturbances are pain and joint contractures.
- Trial name
- NCT05988905
- Testing
- robot assited gati training, conventional traiing
- Volunteers
- 40 people
- Sponsor
- Hangang Sacred Heart Hospital
Coronary Artery Disease, Erectile Dysfunction
Pudendal Atherosclerosis by IVUS-NIRS in Men With Coronary Artery Disease
This prospective, single-center, exploratory study will evaluate the association between atherosclerotic and lipid plaque burden in the internal pudendal arteries, assessed by intravascular ultrasound and near-infrared…
- Conditions
- Coronary Artery Disease, Erectile Dysfunction, Atherosclerosis
- Trial name
- PUDENDAL-NIRS (NCT07856199)
- Testing
- Selective Pudendal Angiography, Pudendal IVUS-NIRS Imaging
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Central Militar
Preeclampsia, Maternal Hypertension
PROtecting Maternal Brains From Injury and Stroke
The purpose of this study is to test a new approach to blood pressure management in postpartum preeclampsia. There will be two groups of patients in this early stage single center trial.
- Trial name
- PROMIS (NCT05726279)
- Testing
- NIRS based personalized blood pressure management
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Columbia University
Graft Failure
Intraoperative NIRS of Transplanted Kidney for Prediction of Acute and Sub-acute Injury
This is a prospective, observational cohort study, designed to explore the use of NIRS in kidney transplants. This study will investigate an association between measurements of intra- operative NIRS and post - operative graft…
- Trial name
- NCT04685174
- Testing
- Invos Model 5100C Cerebral/Somatic Oximeter
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Congenital Heart Disease
Analysis of Cerebral Perfusion Using Head Ultrasound and Multisource Detector Near Infrared Spectroscopy (NIRS) Imaging
The purpose of this study is to use an experimental diagnostic tool(NIRS), combined with a known screening tool (cranial ultrasound), to analyze and evaluate cerebral blood flow and oxygenation, and determine if abnormal…
- Trial name
- NCT01082536
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Neonatal Disease
Cerebral Monitoring Using Pulsatile Near Infrared Spectroscopy in Neonates
The transition from fetus to newborn is a complex physiological process. Monitoring this process to detect potential disruptions is critical but remains a challenge.
- Trial name
- pNIRS (NCT05896306)
- Testing
- No intervention
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Heart Defects, Congenital
Congenital Heart Defects and NIRS
Congenital Heart Defects and NIRS
- Trial name
- NCT03411512
- Where
- Slovenia
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Petja Fister, MD, PhD
Aplastic Anemia, Myelodysplastic Syndromes
Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS
Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment.
- Conditions
- Aplastic Anemia, Myelodysplastic Syndromes, Autoimmune Hemolytic Anemia, Functional Near-Infrared Spectroscopy
- Trial name
- AN-CNA (NCT07578675)
- Where
- China
- Volunteers
- 323 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Mental Fatigue
Brain Oxygenation Marker for Cognitive Function in Healthy Adults
This study aims to identify a cortical oxygenation marker for cognitive function using functional Near Infrared Spectroscopy in healthy adults.
- Trial name
- NCT05559034
- Testing
- Cognitive intervention
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
Impact of Dietary Flavanols on Microvascular Function in Young Females During Mental Stress
The aim of this project is to examine whether flavonoids, which are small molecules naturally present in cocoa, as well as fruits and vegetables such as berries, tea, citrus fruits, apple (typically responsible for giving these…
- Trial name
- NCT07864545
- Testing
- High-flavanol cocoa powder, Low-flavanol cocoa powder
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Traumatic Brain Injury, Cerebral Oxygen Saturation
Effectiveness of Dexmedetomidine Versus Sufentanil on Cerebral Oxygen Saturation in Patients With Traumatic Brain Injury
This randomized controlled clinical trial aims to evaluate the effectiveness of dexmedetomidine compared with sufentanil on cerebral oxygen saturation in patients with traumatic brain injury (TBI) undergoing surgery under general…
- Conditions
- Traumatic Brain Injury, Cerebral Oxygen Saturation, NIR Spectroscopy
- Trial name
- DESTIN (NCT07244822)
- Testing
- Dexmedetomidine, Sufentanil
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Universitas Jenderal Soedirman
Blood-Brain Barrier Permeability
Blood-brain Barrier Permeability Study in Adults With Meningitis
The purpose of the study is to confirm the applicability and usefulness of the novel method of assessment of the permeability of the blood-brain barrier and in monitoring of the treatment of patients with meningitis.
- Trial name
- NM-BBBP (NCT02902588)
- Testing
- ICG-PULSION, LiMON, Pulsion Medical Systems, Gadolinium (Gadovist, Bayer, Germany)
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences
Intermittent Hypoxemia, Apnea of Prematurity
Influence of Oxygen Target Range on Intermittent Hypoxemia in Preterm Infants
In this randomized crossover trial, preterm infants with intermittent hypoxemia and need for supplemental oxygen will be randomized to either Sequence of two different oxygen target ranges (low: 85-89%; high: 91-95%) for a total…
- Trial name
- NCT02743988
- Testing
- Oxygen
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Ulm
Vascular Function, Exercise Training
Evaluation of Effects of Exercise Training and ARB in DM Patients
The aims of this clinical trial are to assess the impacts on vascular function tests and circulating biomarkers of a short-term (12-week) low-to-median intensity exercise training or ARBs treatment in patients with DM and…
- Trial name
- NCT01053026
- Testing
- olmesartan
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital
Kidney Injury
Intraoperative Near Infrared Spectroscopy of Kidney for Prediction of Acute and Sub-acute Kidney Injury in Partial Nephrectomy
Intra-operative NIRS measurements of kidney during partial nephrectomy, after reperfusion, for monitoring ischemia and prediction of postoperative renal dysfunction.
- Trial name
- NCT05146947
- Testing
- near infrared spectroscopy
- Volunteers
- 90 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Intraventricular Hemorrhage of Prematurity, Complications of Prematurity
Cerebral Oxygenation and Autoregulation in Preterm Infants
Premature infants are at high risk for variations in blood pressure and oxygenation during the first few days of life. The immaturity of the premature brain may further predispose these infants to death or the development of…
- Trial name
- Early NIRS (NCT02147769)
- Testing
- NIRS monitoring
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Stanford University