Clinical trials: Near-Infrared Spectroscopy
Preeclampsia, Hypertension in Pregnancy
Bedside Monitoring to Identify Impaired Cerebral Autoregulation in Women with Postpartum Hypertension
The purpose of this research study is to develop a protocol for NIRS-based bedside monitoring to identify impaired cerebral autoregulation in women admitted to the high-risk obstetrics unit with postpartum hypertension.
- Trial name
- NCT05155852
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Columbia University
Coronary Artery Disease, Atheroscleroses
Drug-Eluting Balloon Treatment vs. Guideline-Directed Medical Therapy for the Treatment of Lipid-Rich Plaques
The goal of this clinical trial is to find out whether treating vulnerable plaques in the coronary arteries with a drug-coated balloon can make them less dangerous than using standard medication alone.
- Conditions
- Coronary Artery Disease, Atheroscleroses, Cardiovascular Disease, Vulnerable Coronary Plaques
- Trial name
- DELETE-LRP (NCT07107971)
- Testing
- Paclitaxel-eluting balloon
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pediatric Intensive Care Unit
A Critical Appraisal of the Role of Near Infrared Spectroscopy (NIRS) in the Pediatric Intensive Care Unit (PICU)
While near infrared spectroscopy is an exciting technology, scientific rigor is required in order to optimize its appropriate use in the clinical arena.
- Trial name
- NCT01282099
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Akron Children's Hospital
Acute Compartment Syndrome
The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Injured Soldiers
The purpose of this study is to define the reliability and accuracy of Near Infrared Spectroscopy (NIRS) in the detection of intra-compartmental tissue perfusion in injured and noninjured extremities over time.
- Trial name
- NCT01123798
- Testing
- near-infrared spectroscopy
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- J&M Shuler
Heart Diseases
Study of Microcirculation During Extracorporeal Circulation in Cardiac Surgery
The aim of the proposed study is to evaluate microcirculatory alterations in patients undergoing open heart surgery under extracorporeal circulation.
- Trial name
- NCT04058860
- Testing
- NIRS monitoring, Cox monitoring, Sublingual microscopy
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- AHEPA University Hospital
Gastrointestinal Neoplasms
Cerebral Blood Flow During Propofol Anaesthesia
General anaesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered during anaesthesia to maintain blood pressure.
- Trial name
- NCT02951273
- Testing
- Study of cerebral blood flow
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiac Arrest
Prognostic Value With Combined ONSD and NIRS Measurements for Predicting Neurological Outcome After Cardiac Arrest
Cardiac arrest (CA) is a worldwide health problem and is associated with high mortality and morbidity rates. After CA, most patients are exposed to cerebral injury due to anoxic perfusion, resulting in severe neurological…
- Trial name
- NCT05552794
- Testing
- Optic nerve Sheath Diameter (ONSD)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Nevsehir Public Hospital
Autism Spectrum Disorder, Cognitive Behaviour Therapy
Cognitive Behaviour Therapy for Sleep Problems in Children With Autism Spectrum Disorder
Sleep disturbance is very common in children with autism spectrum disorder (ASD),and closely associated with their core symptom, social deficit.This trial investigates the effects of Cognitive behaviour therapy for insomnia…
- Trial name
- NCT04319640
- Testing
- Cognitive behaviour therapy for insomnia, psychoeducation for ASD
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Diabetes Type 2
The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus
The purpose of the study is to compare the effect of empagliflozin, metformin, and the combination of both on the oxidative capacity of skeletal muscle and its microvascular reactivity in individuals with newly diagnosed type 2…
- Trial name
- EMPOWER (NCT07771010)
- Testing
- Empagliflozin (Jardiance®), Metformin, Synjardy® 12.5mg/1000mg film-coated tablets
- Where
- Slovenia
- Volunteers
- 54 people
- Sponsor
- University Medical Centre Ljubljana
Healthy
Use of Near Infrared Spectroscopy to Measure Intracranial ScvO2
The purpose of this study is to determine whether analysis of near infrared absorbance signals that occur at different frequencies might provide information about the difference in oxygen saturation between arterial and venous…
- Trial name
- NCT01746576
- Testing
- Use of impedance threshold device during spontaneous ventilation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Defects, Congenital
NIRS Guidance Trail in Children's Heart Surgery
Heart surgery in young children involves some risks. This study looks at a new type of monitor that may reduce these risks. Near Infrared Reflectance Spectroscopy (NIRS) aims to measure if enough blood reaches vital organs in the…
- Trial name
- NIRS (NCT02157597)
- Testing
- NIRS based management, Control
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cerebral Blood Flow, Cerebral Perfusion Pressure
Continous Assessment of Cerebral Autoregulation With Near-infrared Spectroscopy
Cerebral autoregulation can be explained by a tight coupling between oxygen supply and demand of the brain, and is essential to maintain a constant cerebral blood flow (CBF) in the context of changes in cerebral perfusion…
- Trial name
- NCT02959008
- Testing
- measure TOI and BP
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yu Liyun
Postoperative Delirium, Heart Valve Diseases
Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in Heart Valve Surgery
Postoperative delirium is a frequent complication after cardiac surgery. This prospective observational study will evaluate whether cerebral blood flow velocity measured by transcranial Doppler before and during elective heart…
- Trial name
- NCT07858578
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Osman Sila Aydin
Out-Of-Hospital Cardiac Arrest
Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
The main objective of the trial is to find out if there is correlation between cerebral and skeletal muscle oxygenation values during cardiopulmonary resuscitation and if these values can predict return of spontaneous…
- Trial name
- NCT04058925
- Testing
- NIRS device
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- Miha Košir
Juvenile Neuronal Ceroid Lipofuscinosis, Smith-Lemli-Opitz Syndrome
Functional Near-Infrared Spectroscopy (fNIRS) Combined With Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls
Background: Neurocognitive disorders affect how the brain uses oxygen. They may affect mental development in children. These disorders can be studied with imaging scans that use radiation; however, these methods are not ideal for…
- Conditions
- Juvenile Neuronal Ceroid Lipofuscinosis, Smith-Lemli-Opitz Syndrome, Creatine Transporter Deficiency, Niemann-Pick Disease Type C1
- Trial name
- NCT05642221
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Near Infrared Spectroscopy
Cerebral Oximetry in Newborns - Comparing INVOS 5100 and FORE-SIGHT Cerebral Oximeters
Regional tissue oxygenation (rStO2) can be monitored by near infrared spectroscopy. The commercial devices FORE-SIGHT (CASMED) and INVOS (COVIDIEN) will be used simultaneously to test for their relative sensitivity for low oxygen…
- Trial name
- NCT01665287
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Cerebral Oximetry in Management of Post Cardiac Arrest
Resuscitation from a cardiac arrest is a common reason for admission to an intensive care unit (ICU). Because the brain is highly vulnerable to oxygen deprivation, severe brain damage often occurs during a cardiac arrest.
- Conditions
- Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury, Hypoxic-Ischemic Brain Injury
- Trial name
- COMPACT (NCT07829887)
- Testing
- Cerebral oximetry-guided treatment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Carotid Arteriosclerosis, Near Infrared Spectroscopy
Comparison of Cerebral Oximetry and Neurological Status Testing in the Awake Patient in the Detection of Cerebral Ischemia During Carotid Endarterectomy
This randomized controlled study compares two methods of intraoperative cerebral ischemia monitoring during carotid endarterectomy performed under regional anesthesia: neurological testing in the awake patient and near-infrared…
- Trial name
- NCT07485933
- Testing
- Awake Neurological Testing, Near-Infrared Spectroscopy (NIRS) Monitoring
- Where
- Serbia
- Volunteers
- 160 people
- Sponsor
- Clinic for Vascular and Endovascular Surgery, University Clinical Center of Serbia
Physiological Responses to High-Intensity Exercise
Effects of the Q-Collar During High-Intensity Cycling Exercise
This study examined the effects of wearing the Q-Collar during high-intensity cycling exercise. Eleven recreationally trained male participants completed two 5-kilometer cycling time trials: one while wearing the Q-Collar and one…
- Trial name
- NCT07808710
- Testing
- Q-Collar™
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Northern Iowa
Healthy Volunteers, Working Memory Task
Non-invasive Optical Low-frequency Oscillation Study of the Prefrontal Cortex Based on fNIRS
The investigators aimed to investigate the effects of different cognitive load tasks (1-back, 2-back, 3-back) on low-frequency oscillations (LFOs) in the prefrontal cortex of healthy young individuals, analyze the relationship…
- Conditions
- Healthy Volunteers, Working Memory Task, Cognition
- Trial name
- NCT07759648
- Testing
- N-back Visual working memory task
- Where
- China
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College