Clinical trials: Neck Cancer
Head and Neck Squamous Cell Carcinoma
A Phase II Trial of Tadalafil in Patients With Squamous Cell Carcinoma of the Upper Aero Digestive Tract
Head and neck squamous cell carcinoma (HNSCC) is a lethal solid malignancy with 5 year survival estimates of approximately 50%, and is associated with a high rate of systemic immune impairment as well as evasion of a tumor…
- Trial name
- NCT01697800
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Thyroid Nodule, Thyroid Neoplasms
The Role of an Optical Probe in Thyroid Cancer Diagnosis: Pilot Study
This study will investigate the usefulness of an optical probe in the differentiation of thyroid cancer from normal thyroid tissue in a thyroidectomy specimen.
- Conditions
- Thyroid Nodule, Thyroid Neoplasms, Thyroid Cancer
- Trial name
- NCT01792492
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Medical Center
Cancer of Head and Neck
A Phase II Trial of Proton Pump Inhibitors With Chemotherapy in Patients With Metastatic Head and Neck Cancer
The purpose of this study is to determine if the addition of proton pump inhibitors (PPIs) to standard chemotherapy can improve progression free survival in patients with head and neck cancer.
- Trial name
- NCT02013453
- Testing
- Omeprazole, Carboplatin, 5FU
- Where
- United States
- Sponsor
- University of Michigan Rogel Cancer Center
Head and Neck Cancer
RAD001, Cisplatin and Concurrent Radiation for Locally Advanced, Inoperable Head and Neck Cancer
The purpose of this study is to determine if RAD001, to a maximum dose of 10 mg/day, can be safely administered with cisplatin, and concurrent radiotherapy, for patients with locally advanced, inoperable, squamous cell carcinoma…
- Trial name
- NCT01057277
- Testing
- RAD001(Afinitor)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- howard safran
Head and Neck Cancer
Docetaxel + Cetuximab + Concurrent Re-Irradiation (Intensity - Modulated Radiation Therapy, IMRT) for Patients With Locoregionally Recurrent Head and Neck Cancer
This is a study for patients who have head and neck cancer that has recurred in the body area where they previously received radiation, and for whom surgery is not planned.
- Trial name
- NCT00713219
- Testing
- IMRT, cetuximab, docetaxel
- Where
- 6 sites in United States
- Volunteers
- 14 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nasopharyngeal Carcinoma
Induction Chemotherapy and Immunotherapy Combined Radiotherapy With or Without Concurrent Chemotherapy for Stage III-IVa NPC
The purpose of this study is to compare induction chemotherapy (gemcitabine+cisplatin) plus immunotherapy with concurrent chemoradiotherapy (CCRT) or RT alone in patients with stage III-IVa nasopharyngeal carcinoma(NPC), in order…
- Trial name
- NCT06095167
- Testing
- without concurrent cisplatin chemotherapy, with concurrent cisplatin chemotherapy
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Fujian Cancer Hospital
Head and Neck Cancer
Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer
RATIONALE: Studying gene mutations in samples of DNA from patients with head and neck cancer and a family history of cancer may help doctors learn more about the development of cancer in families.
- Trial name
- NCT00482872
- Testing
- gene expression analysis, mutation analysis, polymerase chain reaction
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanderbilt University Medical Center
Carcinoma, Squamous Cell, Carcinoma, Squamous Cell of Head and Neck
Super-Selective Intraarterial Infusion of Cetuximab (Erbitux) With or Without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck
This is an open-label, non-randomized, two arm, Phase I research study of superselective intraarterial Cetuximab (Erbitux) with or without radiation therapy for treatment of recurrent unresectable squamous cell carcinoma of the…
- Trial name
- NCT02438995
- Testing
- Intraarterial Cetxuimab (Erbitux)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Northwell Health
Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)
Pulsed Dose Chemotherapy Plus Pembrolizumab in Recurrent/Metastatic HNSCC
The rationale for the new sequence of pulsed dose chemotherapy proposed in this trial is based on the hypotheses that current standard dosing of chemotherapy plus pembrolizumab ultimately suppresses the immune system and has a…
- Trial name
- NCT06052839
- Testing
- Pembrolizumab, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dan Zandberg
Cervical Cancer Screening Methods
Project CONTINUITY: Promoting Evidence-Based Cancer Screening Among Underserved Women
Project CONTINUITY (Connecting You to Care in the Community) was developed to increase adherence to cervical cancer screening regimens from initial screening to needed follow-up care by (1) providing personalized approaches to…
- Trial name
- NCT05390567
- Testing
- Participant Choice of HPV Self-Test, Survey: Participant cancer history and cervical cancer prevention/screening knowledge, Participant Choice of Standard of Care in-clinic Pap-test
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Florida
Human Papilloma Virus Infection, Cervical Intraepithelial Neoplasia Grade 2/3
The HPV Self-test as a Test of Cure in Madagascar
The purpose of this study is to find out whether Self-HPV may be an accurate method for the follow-up of women with a history of HPV infection.
- Trial name
- NCT02811367
- Testing
- HPV test
- Where
- Madagascar
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Oral Squamous Cell Carcinomas, Oral Potentially Malignant Disorder
Heterogeneity of Oral Carcinogenesis: From PrEneoplasia to Invasive Squamous Cell Carcinoma
The goal of this project is to characterise the heterogeneity of all cell populations (tumour cells, stromal and immune microenvironment) present in the tumor and their normal (and OPMD) counterparts by scRNAseq in OSCC patients.
- Trial name
- HOPES (NCT07579507)
- Testing
- Biospecimen, Blood sampling
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Leon Berard
Cervical Cancer, Sentinel Lymph Node
HPV in Sentinel Lymph Nodes of Cervical Cancer Patients
This study examines sentinel lymph node tissue from early stage cervical cancer patients treated with radical surgery and removal of pelvic sentinel lymph nodes (SLN).
- Conditions
- Cervical Cancer, Sentinel Lymph Node, HPV-Related Cervical Carcinoma
- Trial name
- NCT03749707
- Testing
- HPV analysis
- Where
- Denmark
- Volunteers
- 127 people
- Sponsor
- University of Aarhus
Thyroid Cancer
Association Between Cancer Cells and Normal Versus (Vs.) Low Levels of Thyroid Hormones in the Serum
Much experimental data has suggested that thyroid hormones (T3 and T4) may modulate neoplastic cells and that T3/T4 deprivation may remove this stimulus.
- Trial name
- NCT01153945
- Where
- Israel
- Sponsor
- Meir Medical Center
Urinary Retention After Procedure
Donepezil Prevents Urinary Retention After Extensive Total Hysterectomy
Patients were randomly divided into experimental group and control group. The control group received routine postoperative treatment, while the experimental group took donepezil 5mg orally before going to bed every night from the…
- Trial name
- NCT05540977
- Testing
- Donepezil, Usual care
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Esophagus Cancer
Tislelizumab Combined With Chemotherapy for the Perioperative Treatment of Esophageal Squamous Carcinoma
Evaluating the rate of pathologic complete remission in patients with squamous esophageal cancer treated perioperatively with tislelizumab in combination with chemotherapy
- Trial name
- NCT07019181
- Testing
- Tislelizumab, albumin-bound paclitaxel, Nedaplatin
- Volunteers
- 26 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Soft Tissue Sarcomas
Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas
Currently, soft tissue sarcomas (STS) are preoperatively irradiated in a conventionally fractionated regimen of 25 x 2 Gy in five weeks.
- Trial name
- SCOPES (NCT04425967)
- Testing
- pre-operative radiotherapy
- Where
- 4 sites in Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
Squamous Cell Carcinoma, Head and Neck Cancer
T-cell Based Immunotherapy for Head and Neck Cancer
The aim of this study is to investigate the toxicity and immune response of therapy with tumor infiltrating lymphocytes as adjuvant treatment for head and neck cancer after primary operation and radiotherapy.
- Trial name
- NCT00937300
- Testing
- cyclophosphamide, fludarabine, T-cell infusion, and Interleukin-2
- Where
- Denmark
- Sponsor
- Inge Marie Svane
Nasopharyngeal Carcinoma, Nasopharyngeal Cancer
The Protection of Thyroid Function in IMRT for Nasopharyngeal Carcinoma
This study aimed to reduce radiation-induced thyroid injury without compromising control of the cervical region by optimizing the delineation of the cervical lymph node drainage area.
- Conditions
- Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Hypothyroidism
- Trial name
- NCT06268600
- Testing
- Modified neck target volume delineation
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Endometrial Cancer
Sentinel Node in Endometrial Cancer
Phase II, open-label, randomized pilot study. Patients will be randomized (1:1) to receive for sentinel node screening: 1. Radiotracer (RT) via cervical administration and TUMIR 2.
- Trial name
- HYBRIDENDONOD (NCT04492995)
- Testing
- injection via TUMIR of the tracer [99mTc] Tc-albumin nanocoloid-ICG (6 mCi, 4 ml), injection via TUMIR of [99mTc] Tc-albumin nanocoloid (6mCi, 8ml).
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Judit Pich Martínez
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