Clinical trials: Neck Cancer
Thyroid Nodule
In Vivo Multispectral Optoacoustic Imaging of Thyroid Nodules
Thyroid nodules are common in clinical practice. Head and neck ultrasound is recommended as a routine examination for all patients with thyroid lesions.
- Trial name
- THYNODE (NCT04730726)
- Testing
- MSOT Acuity Echo
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Precancerous Lesions, Conization
A Cohort Study for the Following up of Conization
This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital.
- Conditions
- Precancerous Lesions, Conization, High Grade Intraepithelial Neoplasia, Uterine Cervical Cancer
- Trial name
- NCT03961178
- Testing
- High-risk HPV, TCT
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Thyroid Diseases, Goiter
Thyroidectomy-specific Enhanced Recovery After Surgery (ERAS) Protocol
Thyroidectomy is generally considered a low-to-moderate risk operation; however, postoperative pain, nausea/vomiting, and prolonged hospital stays remain common issues.
- Conditions
- Thyroid Diseases, Goiter, Thyroid Neoplasms
- Trial name
- NCT07575243
- Testing
- Enhanced Recovery After Surgery protocol, Conventional perioperative care
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Assiut University
Cervical Dysplasia
Correlation Between Colposcopist Findings and Digital Cervicography Employing Gynescope System
Correlation between colposcopist findings and digital cervicography employing Gynescope system
- Trial name
- NCT03840187
- Testing
- Digital cervicography
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Barzilai Medical Center
Gynecologic Cancer
AGuIX Gadolinium-based Nanoparticles in Combination With Chemoradiation and Brachytherapy
This is a phase 1 clinical trial evaluating the safety, tolerability of escalating doses of AGuIX-NP in combination with radiation and cisplatin in patients with locally advanced cervical cancer.
- Trial name
- NANOCOL (NCT03308604)
- Testing
- Polysiloxane Gd-Chelates based nanoparticles (AGuIX), External beam radiotherapy (EBRT), Uterovaginal brachytherapy
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Esophageal Cancer
Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002884
- Testing
- chemotherapy, cisplatin, fluorouracil
- Where
- France
- Volunteers
- 326 people
- Sponsor
- Centre Hospitalier Lyon Sud
Nasopharyngeal Cancer, Screening
Cluster Randomized Controlled Screening Trial for NPC
This study is aimed to estimate the effectiveness of an Epstein-Barr virus (EBV) serology-based screening program to reduce nasopharyngeal carcinoma (NPC) mortality in a cluster randomized controlled trial in an NPC high-risk…
- Conditions
- Nasopharyngeal Cancer, Screening, Morality
- Trial name
- CRCSTNPC (NCT00941538)
- Testing
- Experimental: Screening with EBV VCA/EBNA1-IgA testing
- Where
- 2 sites in China
- Volunteers
- 87,600 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Neoplasms, Head and Neck
Study Of Adjuvant Lapatinib In High-Risk Head And Neck Cancer Subjects After Surgery
This is a randomised, double-blind, placebo-controlled, multicentre, global Phase III trial comparing the efficacy of adjuvant oral lapatinib versus placebo in high-risk subjects with head and neck cancer following surgery.
- Trial name
- NCT00424255
- Testing
- Lapatinib, Chemoradiation
- Where
- 117 sites in United States, Argentina and 20 more
- Volunteers
- 688 people
- Sponsor
- GlaxoSmithKline
Gastrointestinal Disease, Esophageal Cancer
FDG-PET-CT and Biomarkers in Esophageal Cancer
The goal of this clinical research study is to learn if the results of a positron emission tomography/computed tomography (PET/CT) scan done 10-14 days after beginning chemotherapy and radiation (chemoradiation) can predict how a…
- Trial name
- NCT00833625
- Testing
- PET/CT (FDG PET/CT), Biomarker Testings
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Squamous Cell Carcinoma
Camrelizumab Combined With Apatinib Mesylate for Head and Neck Squamous Cell Carcinoma
This is a prospective, open-labelled study to evaluate the efficacy and safety of camrelizumab combined with apatinib mesylate in the induction treatment of patients with locally advanced head and neck squamous cell carcinoma who…
- Trial name
- IMplus (NCT04440917)
- Testing
- Camrelizumab, Apatinib Mesylate
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Breast Cancer, Lung Cancer
Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2
The goal of this clinical trial is to explore feasibility, acceptability, and effectiveness of end-of-life conversation game "Hello" as a tool to help individuals with various solid cancer types (including: breast…
- Conditions
- Breast Cancer, Lung Cancer, Genito-Urinary Cancer, Colorectal Cancer
- Trial name
- NCT06384417
- Testing
- Hello for Cancer game, Table Topics game
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Head and Neck Neoplasms
DAHANCA 37. Re-irradiation With Proton Radiotherapy
Summary Design Phase II observational Treatment 60 Gy/50 fx / 10W-1 at 1.2 Gy/fx o i.e. EQD2 tumor=56 Gy, EQD2 late=50.4 Gy at α/β= 10 and 3, respectively Proton radiotherapy Concomitant cisplatin for eligible patients*…
- Trial name
- NCT03981068
- Testing
- Re-irradiation
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Danish Head and Neck Cancer Group
Esophageal Neoplasms
Simultaneous Integrated Boost Radiotherapy and Concurrent Nimotuzumab or Chemotherapy for Esophageal Carcinoma
This prospective, non-randomized phase II study aims to compare radiotherapy and concurrent nimotuzumab with concurrent chemoradiotherapy to obtain a non-inferior pCR rate and pathological lymph node metastases rate in premise of…
- Trial name
- NCT02858206
- Testing
- IMRT simultaneous integrated boost, Nimotuzumab, Paclitaxel
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer
Quantitative Fluorescence Endoscopy Using Durvalumab-680LT in Esophageal Cancer
Treatment of patients with locally advanced esophageal cancer (EC) is multidisciplinary and consists of neoadjuvant therapy followed by surgical removal of the esophageal tumor and potentially tumor positive lymph nodes.
- Trial name
- OPTIC (NCT05450484)
- Testing
- Fluorescence endoscopy using durvalumab-680LT
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- University Medical Center Groningen
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
This phase II/III compares the standard therapy (chemotherapy plus cetuximab) versus adding bevacizumab to standard chemotherapy, versus combination of just bevacizumab and atezolizumab in treating patients with head and neck…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma
- Trial name
- NCT05063552
- Testing
- Atezolizumab, Bevacizumab, Biospecimen Collection
- Where
- 172 sites in United States
- Volunteers
- 430 people
- Sponsor
- National Cancer Institute (NCI)
Salivary Gland Cancer, Thyroid Cancer
Sacituzumab Govitecan in Metastatic Salivary Gland and Thyroid Cancers (SG-SGTC)
The goal of this clinical trial is to learn if the drug, sacituzumab govitecan, works to treat: 1. Salivary gland cancers that have spread to other parts of the body or come back after previous treatment, and cannot be removed by…
- Trial name
- TROP2 (NCT06923826)
- Testing
- Sacituzumab govitecan
- Where
- Singapore
- Volunteers
- 32 people
- Sponsor
- National University Hospital, Singapore
Head and Neck Cancer
CONNECTing Head and Neck Caregivers to Supportive Care Resources
The purpose of this research is to determine feasibility and acceptability of randomized pilot trial to evaluate a technology-based intervention (CONNECT) to empower and educate caregivers about the benefits of supportive care…
- Trial name
- CONNECT-HNC (NCT03875885)
- Testing
- CONNECT, CONTROL
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Colorectal Cancer, Nasopharyngeal Cancer
A Study of Lymphangiogenesis in Colorectal and Nasopharyngeal Cancer
1. To determine the association between LVD and clinico-pathologic variables in archived colorectal cancer and Nasopharyngeal carcinoma specimens 2.
- Trial name
- NCT00943891
- Testing
- Tumor biopsies
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- National University Hospital, Singapore
Head and Neck Cancer
MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as specialized types of magnetic resonance imaging (MRI), may help in planning radiation therapy that does less damage to normal tissues.
- Trial name
- NCT00984074
- Testing
- blood-oxygen-level-dependent functional magnetic resonance imaging, diffusion tensor imaging, dynamic contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Oesophageal Cancer
Role of Radiotherapy Following Oesophageal Stenting in Cancer
To assess the benefits of oesophageal stenting and external beam radiotherapy over oesophageal stenting alone in patients with inoperable oesophageal cancer
- Trial name
- NCT01179074
- Testing
- oesophageal stenting with self expandable metal stent, Oesophageal stent followed by external beam radiotherapy
- Where
- India
- Volunteers
- 84 people
- Sponsor
- All India Institute of Medical Sciences
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