Clinical trials: Negative Symptoms of Schizophrenia
Schizophrenia
A Double-Blind Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Negative Symptoms in Schizophrenia
There is pilot data to suggest the therapeutic value of rTMS applied to the left prefrontal cortex in the treatment of negative symptoms.
- Trial name
- rTMS (NCT00168311)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Australia
- Volunteers
- 22 people
- Sponsor
- The Alfred
Schizophrenia
Reboxetine and Citalopram as an Adjunct Treatment to Second Generation Antipsychotics in the Treatment of Negative Symptoms of Schizophrenia
Main objective: To assess the efficacy of two antidepressants of different pharmacological families: citalopram (Selective serotonin reuptake inhibitors, SSRI) and reboxetine (Norepinephrine Reuptake inhibitor, NRI) as adjunct…
- Trial name
- NCT01300364
- Testing
- Reboxetine, citalopram (SSRI)
- Where
- Spain
- Volunteers
- 249 people
- Sponsor
- Fundació Sant Joan de Déu
Schizo-affective Disorder, Non Organic Psychosis
Motivational Intervention for Patients With Schizophrenia
The goal of this clinical trial is to learn if a group therapy called the Positive Emotions Program for Schizophrenia (PEPS) can reduce apathy in adults aged 18 to 60 who have schizophrenia or a related psychotic disorder.
- Conditions
- Schizo-affective Disorder, Non Organic Psychosis, Schizophenia Disorder
- Trial name
- NCT07853079
- Testing
- Positive Emotion Program for Schizophrenia (PEPS), a psychotherapeutic intervention,
- Volunteers
- 88 people
- Sponsor
- University of Geneva, Switzerland
Schizophrenia and Disorders With Psychotic Features
Social Skills Training in Refractory Schizophrenia
Objective Primary: To evaluate the efficacy of social skills training in reducing negative symptoms in patients with refractory schizophrenia, in comparison with control (befriending group).
- Trial name
- SST (NCT00791882)
- Testing
- Social Skills Training
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- University of Sao Paulo
Schizophrenia
20101299: Study to Evaluate the Effect of AMG 747 on Schizophrenia Negative Symptoms
The purpose of this study is to evaluate the effect of AMG 747 on negative symptoms of schizophrenia in patients who are stable on current antipsychotic treatment.
- Trial name
- NCT01568216
- Testing
- AMG 747
- Where
- 38 sites in United States, Australia and 5 more
- Volunteers
- 121 people
- Sponsor
- Amgen
Schizophrenia, Schizoaffective Disorder
Efficacy of Pregnenolone in Patients With Schizophrenia
Four-month trial of pregnenolone or placebo, as an additional medication, to treat negative symptoms and cognitive decline in schizophrenia.
- Trial name
- NCT00615511
- Testing
- pregnenolone
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Weill Medical College of Cornell University
Schizophrenia
A Study of RO4917838 in Combination With Antipsychotic Treatment in Patients With Schizophrenia.
This study will determine the efficacy and safety of RO4917838 in patients with schizophrenia who are stable on current antipsychotic treatment (olanzapine, que tiapine, risperidone, paliperidone or aripiprazole) with prominent…
- Trial name
- NCT00616798
- Testing
- RO4917838, Standard antipsychotic therapy
- Where
- 73 sites in United States, Austria and 8 more
- Volunteers
- 323 people
- Sponsor
- Hoffmann-La Roche
Schizophrenia
Repetitive Transcranial Magnetic Stimulation and Intermittent Theta Burst (iTBS) in Schizophrenia
The pilot studies have showed that theta burst stimulation (TBS) can have the more rapid and durable effects to the apply traditional rTMS protocols.
- Trial name
- NCT01315587
- Testing
- repetitive Transcranial Magnetic Stimulation (Magstim rapid2 ), repetitive Transcranial Magnetic Stimulation (Magstim rapid2), repetitive Transcranial Magnetic Stimulation(Magstim rapid2)
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- University of Tehran
Negative Symptoms in Schizophrenia, Schizophrenia
NST-SPARK: Preliminary Study of an Augmented Reality (AR) App Delivering Recovery-Oriented Cognitive Therapy for Negative Symptoms in Schizophrenia
This study evaluates the feasibility and acceptability of a prototype for NST-SPARK (version 1.5). This is an augmented reality (AR) mobile phone application that uses Recovery-oriented Cognitive Therapy (CT-R) to target negative…
- Conditions
- Negative Symptoms in Schizophrenia, Schizophrenia, Schizoaffective Disorder
- Trial name
- NST-SPARK-1b (NCT06653829)
- Testing
- SPARK
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- North Shore Therapeutics, Inc.
Schizophrenia, Negative Symptoms in Schizophrenia
Optimal rTMS for Cognitive Deficits and Negative Symptoms in Schizophrenia
Negative symptoms and cognition decline are major challenges in clinical management of schizophrenia. Dorsomedial prefrontal cortex (DLPFC) has been highly involved in the mechanisms of negative symptoms and cognitive symptoms of…
- Conditions
- Schizophrenia, Negative Symptoms in Schizophrenia, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation
- Trial name
- NCT05599373
- Testing
- Bilateral Active Repetitive transcranial magnetic stimulation (rTMS), Left Active Repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Mental Health Center
Schizoaffective Disorder, Schizophrenia
Genetic Study of Schizophrenia
This large ongoing study at NIMH investigates the neurobiology of schizophrenia by identifying susceptibility genes, evaluating their impact on brain function to better understand how to treat and prevent this illness.
- Trial name
- NCT00001486
- Where
- United States
- Volunteers
- 4,914 people
- Sponsor
- National Institute of Mental Health (NIMH)
Schizophrenia
The Mid-term Effect of Repeated Transcranial Magnetic Stimulation on Schizophrenia
Medications have a poor effect on negative symptoms and cognitive function in schizophrenia. In the past, most of the studies on repetitive transcranial magnetic stimulation intervention in patients with schizophrenia used…
- Trial name
- NCT03940898
- Testing
- repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Mental Health Center
Psychotic Disorders
RUFUS - Group Rumination-focused CBT for Negative Symptoms
Abstract - -- Introduction: Psychosis spectrum disorders are characterized by both positive and negative symptoms, but whereas there is good effect of treatment on positive symptoms, there is still a scarcity of effective…
- Trial name
- RUFUS (NCT05851950)
- Testing
- group rumination focused cognitive behavioural therapy, Treatment as usual
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Schizophrenia
Tolerability, Safety and Efficacy of the H1-coil Deep Transcranial Magnetic Stimulation in Subjects With Negative Symptoms and Cognitive Deficits of Schizophrenia
Objectives:The purpose of the study is to explore the efficacy and safety of H1-Coil deep brain rTMS in subjects with negative symptoms and cognitive deficits of schizophrenia (deficit syndrome), currently treated with atypical…
- Trial name
- NCT00685321
- Testing
- H1 deep TMS coil
- Where
- 2 sites in Israel
- Volunteers
- 45 people
- Sponsor
- Shalvata Mental Health Center
Negative Type; Schizophrenic, Anhedonia
Motive-specific Intervention for Negative Symptoms in Schizophrenia
The aim of this study is to test a therapeutic intervention to reduce negative symptomatic among schizophrenia patients. Since the intervention can take place within an inpatient stay, it is a short intervention.
- Conditions
- Negative Type; Schizophrenic, Anhedonia, Apathy
- Trial name
- MoNSS (NCT04793438)
- Testing
- Motive-specific intervention, Supportive conversations
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Schizophrenia
Evaluation of the H1-coil Deep TMS in the Treatment of Negative Symptoms and Cognitive Deficit in Schizophrenia
The study evaluates the feasibility of using a 4 week stimulation protocol with the deep TMS H-coils for the treatment of negative symptoms and cognitive deficit in schizophrenia patients
- Trial name
- NCT00445926
- Testing
- deep TMS H-coil
- Where
- Israel
- Sponsor
- Shalvata Mental Health Center
Schizophrenia
A Study of RO4917838 in Participants With Persistent, Predominant Negative Symptoms of Schizophrenia (NN25310)
This multi-center, randomized, double-blind, parallel-group, placebo-controlled study will evaluate the efficacy and safety of RO4917838 in participants with persistent, predominant negative symptoms of schizophrenia.
- Trial name
- NCT01192867
- Testing
- RO4917838, Antipshychotics (Standard of Care)
- Where
- 122 sites in United States, Argentina and 12 more
- Volunteers
- 629 people
- Sponsor
- Hoffmann-La Roche
Schizophrenia, Negative Symptoms in Schizophrenia
Treatment of Negative Symptoms of Schizophrenia by rTMS
The purpose of this study is to assess the effectiveness of rTMS on the negative symptoms of schizophrenia in real conditions. It will also provide a regulatory framework to rTMS treatments under these conditions.
- Trial name
- SN RENAT (NCT06595654)
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Psychosis, Schizophrenia
Goals in Focus: CBT for Motivational Negative Symptoms of Psychosis
This pilot feasibility trial aims to evaluate the "Goals in Focus" intervention for motivational negative symptoms in people with psychosis.
- Conditions
- Psychosis, Schizophrenia, Negative Symptoms With Primary Psychotic Disorder
- Trial name
- GIF (NCT05252039)
- Testing
- Goals in Focus
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Hamburg-Eppendorf
Schizophrenia
The Effects AZD8529 on Cognition and Negative Symptoms in Schizophrenics
The purpose of this study is to assess if AZD8529 improves performance on neurobehavioral probes of attention, working memory and affective reactivity in patients with schizophrenia.
- Trial name
- NCT00986531
- Testing
- AZD8529
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- AstraZeneca