Clinical trials: Negative Symptoms of Schizophrenia
Negative Symptoms in Schizophrenia, Brain Stimulation Intervention
Combining HD-tDCS and iTBS in Treating Negative Symptoms of Schizophrenia
Dysfunction of the dorsolateral prefrontal cortex (DLPFC) is central to the persistence of negative symptoms in schizophrenia. Both HD-tDCS and iTBS targeting the left DLPFC have shown therapeutic benefit.
- Trial name
- NCT07680959
- Testing
- active iTBS followed by active HD-tDCS
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Schizophrenia, Depression
Magnetic Stimulation of the Brain in Schizophrenia or Depression
The primary objective is to evaluate if repetitive transcranial magnetic stimulation (rTMS) with theta burst frequency over dorsomedial prefrontal cortex (DMPFC) is an effective treatment for negative symptoms (anhedonia and…
- Conditions
- Schizophrenia, Depression, Anhedonia, Avolition
- Trial name
- MA-SCH-DEP (NCT02905604)
- Testing
- dmPFC iTBS
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Schizophrenia
The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia
The purpose of this study is to determine whether minocycline are effective in the treatment of negative and cognitive symptoms in schizophrenia.
- Trial name
- NCT01493622
- Testing
- minocycline
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Central South University
Schizophrenia, Schizoaffective Disorder
A Clinical Trial to Examine Effects of Atomoxetine in the Treatment of Negative Symptoms in Patients With Schizophrenia
This study proposes to examine the effect of atomoxetine on quality of life and negative symptoms such as social withdrawal, lack of interest in things, lack of thought content, flat emotions, slowed body movements and lack of…
- Trial name
- NCT00222794
- Testing
- Atomoxetine (Strattera)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Pittsburgh
Schizophrenia Disorder
dACC-Targeted Temporal Interference for Negative and Cognitive Symptoms in Schizophrenia
This randomized, double-blind, sham-controlled trial aims to evaluate the efficacy and safety of dorsal anterior cingulate cortex-targeted temporal interference stimulation in individuals with schizophrenia.
- Trial name
- NCT07658898
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Schizophrenia
Adjunctive SPD489 to Antipsychotic Medication in Clinically Stable Adults With Persistent Predominant Negative Symptoms of Schizophrenia
The primary purpose of this study is to determine whether SPD489 40 mg, 100 mg, and 160 mg are effective and safe in the treatment of Negative Symptoms of Schizophrenia (NSS).
- Trial name
- NCT01738698
- Testing
- SPD489 40mg, SPD489 100mg, SPD489 160mg
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Shire
Schizophrenia
Trial for Antidepressant Treatment for Negative Symptom of Schizophrenia With NRG1 Risk Genotype
The project is a double-blind, randomized, placebo controlled clinical trial comparing 3 groups of schizophrenic subjects, who have no less than moderate degree of negative symptoms and carry the homozygous risk genotype (TT) of…
- Trial name
- TANESN (NCT01078870)
- Testing
- Lexapro, Cymbalta
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia, Schizoaffective Disorder
Efficacy and Safety Study of Escitalopram Augmentation in Treatment Resistant Schizophrenia
A primary hypothesis to be explored here is that, given its pharmacodynamic profile and hypothesized mechanisms associated with schizophrenia, escitalopram will, in comparison to placebo, be effective when added to risperidone or…
- Trial name
- NCT00231335
- Testing
- escitalopram
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Negative Symptoms of Schizophrenia
Efficacy and Mechanisms of Low-intensity Focused Ultrasound on Negative Symptoms in Patients With Schizophrenia
Based on our research background, we hypothesize that LIFUS has neuromodulation effects on brain cortex and the active LIFUS on left-DLPFC would improve negative symptoms in schizophrenia patients.
- Trial name
- NCT04620460
- Testing
- Low-intensity Focused Ultrasound(LIFUS)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Healthy Volunteer
Influence of Emotion in a Test Run Forgetfulness
Currently there is uncertainty on how schizophrenic patients feel pain. Pain has several components including cognitive behavior which allow humans to perceive it as a negative emotion.
- Trial name
- NCT02547259
- Testing
- pain words test, negative words test
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Schizophrenia
Efficiency of the French Translation Social Cognition and Interactive Training (SCIT)Program
Social cognition and interaction training (SCIT), a group-based treatment that aims to improve both processing social information and functioning, may be an effective treatment for enhancing the social skills of people with…
- Trial name
- SCIT-VF (NCT02667834)
- Testing
- Social Cognition and Interaction Training (SCIT), therapeutic education program (ETP)
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Hôpital le Vinatier
Schizophrenia
A Study to Evaluate 3 Dose Levels of Luvadaxistat of Adults With Negative Symptoms of Schizophrenia
The purpose of this study is to determine whether add-on luvadaxistat is superior to placebo on the Positive and Negative Syndrome Scale Negative Symptom Factor Score (PANSS NSFS).
- Trial name
- NCT03382639
- Testing
- Luvadaxistat
- Where
- 54 sites in United States, Bulgaria and 6 more
- Volunteers
- 256 people
- Sponsor
- Neurocrine Biosciences
Schizophrenia
Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia
Current medications have only a limited effect on two core symptoms of schizophrenia, negative symptoms and cognitive deficits. Minocycline is a second-generation tetracycline which has a beneficial effect in various neurological…
- Trial name
- NCT02907437
- Testing
- Minocycline, Probiotics
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Beer Yaakov - Ness Ziona Mental Health Center
Schizophrenia, Cognitive Symptoms
PQQ for Cognitive and Negative Symptoms
Schizophrenia is a complex mental disorder characterized by a range of symptoms, including negative symptoms and cognitive impairments.
- Conditions
- Schizophrenia, Cognitive Symptoms, Negative Symptoms
- Trial name
- NCT07393464
- Testing
- Pyrroloquinoline quinone (PQQ)
- Volunteers
- 70 people
- Sponsor
- Tianjin Anding Hospital
Schizophrenia
High-Definition Transcranial Direct Current Stimulation as a Treatment of Negative Symptoms of Schizophrenia
In this study, investigators designed a double-blind randomized trial to prove a more reliable evidence to show how the treatment by using high-definition transcranial direct current stimulation (HD-tDCS) can relieve negative…
- Trial name
- NCT03602716
- Testing
- HD-tDCS
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia
A Placebo-Controlled Trial of Modafinil (Provigil) Added to Clozapine in Patients With Schizophrenia
This pilot study is an eight-week, randomized, double-blind, placebo-controlled, escalating dose trial of the novel vigilance-promoting drug, modafinil, added to a stable dose of clozapine in 40 patients with schizophrenia or…
- Trial name
- NCT00573417
- Testing
- modafinil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- North Suffolk Mental Health Association
Schizophrenia, Schizoaffective Disorder
Treatment of Negative Symptoms of Schizophrenia With Transcranial Magnetic Stimulation (TMS)
This study will test whether repetitive transcranial magnetic stimulation (rTMS) is helpful in treating negative symptoms and social deficits of schizophrenia.
- Trial name
- NCT00517075
- Testing
- Transcranial Magnetic Stimulation (TMS), repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia
A Study of rTMS for Cognitive Deficits in Chronic Patients With Schizophrenia
In this study, we assessed the therapeutic effects and safety of left dorsolateral prefrontal cortex (DLPFC) high-frequency repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia.
- Trial name
- NCT03273439
- Testing
- repetitive TMS
- Volunteers
- 47 people
- Sponsor
- Suzhou Psychiatric Hospital
Schizophrenia
Adjuvant Treatment With a Glycine Uptake Inhibitor in Participants With Negative Symptoms of Schizophrenia (P05695) (MK-8435-001)
The purpose of this study is to determine whether MK-8435 (Org 25935) is more effective than placebo in improving negative symptoms in participants with schizophrenia who are concurrently treated with a stable dose of a second…
- Trial name
- GIANT (NCT00725075)
- Testing
- MK-8435 (Org 25935) 4-8 mg, MK-8435 (Org 25935) 12-16 mg
- Volunteers
- 215 people
- Sponsor
- Merck Sharp & Dohme LLC
Schizophrenia, Schizoaffective Disorder
Theta tACS During Working Memory Training: A Pilot Study of the Effects on Negative Symptoms of Schizophrenia
In this randomized double-blind trial, we investigated whether externally induced left-hemispheric frontoparietal theta synchronization by multi-electrode online theta (6Hz) transcranial alternating current stimulation (tACS)…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Negative Symptoms, Working Memory Training
- Trial name
- NCT04545294
- Testing
- Theta tACS
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Tri-Service General Hospital (TSGH)