Clinical trials: Neoadjuvant Radiotherapy
Cutaneous Squamous Cell Carcinoma of the Head and Neck, Head and Neck Cancer
Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma
Cutaneous Squamous Cell Carcinoma (cSCC) is typically associated with a high tumour mutation burden, with the majority caused by Ultraviolet (UV) exposure (Pickering et al., 2014).
- Trial name
- DESQUAMATE (NCT05025813)
- Testing
- Pembrolizumab
- Where
- 3 sites in Australia
- Volunteers
- 27 people
- Sponsor
- Queensland Health
Sarcoma
PET/MR in Assessing Response to Neoadjuvant Radiation Therapy in the Tx of High Grade Sarcomas
Purpose: To assess the utility of PET/MR in assessing response to neoadjuvant radiation therapy in the treatment of high grade sarcomas.
- Trial name
- NCT03076333
- Testing
- PET/MR
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Locally Advanced Thymoma
Neoadjuvant Radiotherapy for Locally Advanced Unresectable Thymoma
The goal of this prospective, randomized, controlled phase II clinical study is to evaluate the efficacy and safety of neoadjuvant radiotherapy in patients with locally advanced unresectable thymoma.
- Trial name
- NCT06924619
- Testing
- neoadjuvant radiotherapy, cisplatin
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Newly Diagnosed Glioblastoma
The Assessment of Immune Response in Newly Diagnosed Glioblastoma Patients Treated With Pembrolizumab
To evaluate the short-term and longer-term safety, tolerability, and effectiveness of neoadjuvant and adjuvant Pembrolizumab on top of standard therapy (Stupp protocol) in patients with Glioblastoma Multiforme (GBM).
- Trial name
- PIRG (NCT05235737)
- Testing
- Pembrolizumab
- Where
- Poland
- Volunteers
- 36 people
- Sponsor
- Medical University of Silesia
Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7, Stage I Nasopharyngeal Undifferentiated Carcinoma AJCC v7
Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer
This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Conditions
- Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7, Stage I Nasopharyngeal Undifferentiated Carcinoma AJCC v7, Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7, Stage II Nasopharyngeal Undifferentiated Carcinoma AJCC v7
- Trial name
- NCT00274937
- Testing
- Amifostine, Cisplatin, Fluorouracil
- Where
- 109 sites in United States, Australia and 1 more
- Volunteers
- 111 people
- Sponsor
- Children's Oncology Group
Oropharynx Cancer
Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)
The majority of head and neck cancer patients do not respond to immunotherapies, and clinical responses are often not durable. However, targeting tumors with stereotactic radiation in combination with immunotherapy while sparing…
- Trial name
- NCT05787639
- Testing
- Evorpacept
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Diego
Nasopharyngeal Carcinoma
Neoadjuvant Chemotherapy and Low-dose Radiotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma（NPC）is common malignant tumor in China. The incidence of NPC in most parts of the world and the country is less than 1/10 million, but the incidence rate in China's Guangdong, Guangxi, Fujian and other…
- Trial name
- NCT05292027
- Testing
- low-dose radiotherapy
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer
Docetaxel, Oxaliplatin, Capecitabine, Fluorouracil, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction
This randomized phase II trial studies how well docetaxel, oxaliplatin, capecitabine, fluorouracil, and radiation therapy works compared with fluorouracil when given together with oxaliplatin and radiation therapy in treating…
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00938470
- Testing
- capecitabine, docetaxel, fluorouracil
- Where
- 187 sites in United States
- Volunteers
- 73 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Esophageal Squamous Cell Cancer
Lymphocyte-sparing Thoracic Radiotherapy for Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors. Although neoadjuvant chemoradiotherapy combined with surgery has significantly improved the survival rate of patients with locally advanced…
- Trial name
- NCT06596954
- Testing
- lymphocyte-sparing radiotherapy, conventional radiotherapy
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Ruijin Hospital
Borderline Resectable Pancreatic Cancer
Phase II Neoadjuvant Chemotheraphy (Gemcitabine and Nab-Paclitaxel vs. mFOLFIRINOX) and Sterotatic Body Radiation Therapy for Borderline Resectable Pancreatic Cancer
This is a prospective, randomized phase II trial. Patients diagnosed with borderline resectable pancreatic adenocarcinoma will be randomly assigned to one of two treatment arms, either mFOLFIRINOX or gemcitabine and…
- Trial name
- NCT02241551
- Testing
- gemcitabine/nab-paclitaxel, mFOLFIRINOX
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Nathan Bahary, MD
Rectal Cancer
Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced HER2-expressing Rectal Cance
After signing the informed consent form, patients who met the inclusion and exclusion criteria were given the full course of neoadjuvant treatment: short-term radiotherapy, followed by 6 consecutive cycles of disitamab vedotin…
- Trial name
- NCT07509424
- Testing
- disitamab vedotin, sintilimab, capecitabine
- Volunteers
- 29 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Soft Tissue Sarcoma
SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma
The goal of this clinical research study is to look at the effectiveness of giving a combination of chemotherapy, immunotherapy, radiation therapy, and surgery to treat soft tissue sarcomas that can be removed by surgery.
- Trial name
- NCT07049848
- Testing
- Atezolizumab, Doxorubicin Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer
Study of Vinorelbine and Cisplatin as Induction Therapy With Radiotherapy in Patients With Unresectable NSCLC
Phase II clinical trial with metronomic oral vinorelbine and tri-weekly cisplatin as induction therapy and subsequent concomitantly with radiotherapy (RT) in patients with lung cancer (NSCLC) locally advanced unresectable
- Trial name
- NORA (NCT02709720)
- Testing
- Vinorelbine, Cisplatin, Radiotherapy
- Where
- 18 sites in Spain
- Volunteers
- 68 people
- Sponsor
- Spanish Lung Cancer Group
Limited Stage Small Cell Lung Cancer
The Efficiency of Surgery and Radiotherapy After SHR-1316 (Adebrelimab) and Platinum-containing Doublet Induction Therapy for Limited-stage Small Cell Lung Cancer
To compare the efficiency between surgery and radiotherapy after SHR-1316 (Adebrelimab)and platinum-containing doublet induction therapy for limited-stage small cell lung cancer
- Trial name
- NCT05496166
- Testing
- chemotherapy and SHR-1316(Adebrelimab) comnined with surgery or radiotherapy
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Breast Cancer
Nodal Burden and Nodal Recurrence in Patients With Isolated Tumor Cells After Neoadjuvant Chemotherapy Treated With Axillary Dissection or Nodal Radiation: the OPBC-05/EUBREAST-14R/ICARO Study
The purposes of this multicenter retrospective cohort study are to determine the residual nodal burden in patients with isolated tumor cells detected in the SLN or the clipped node after NAC and to determine oncologic outcomes in…
- Trial name
- ICARO (NCT06464341)
- Testing
- Observational study no intervention
- Where
- 62 sites in United States, Austria and 16 more
- Volunteers
- 583 people
- Sponsor
- University Hospital, Basel, Switzerland
Sarcoma of the Extremity, Stage I Soft Tissue Sarcoma of the Trunk and Extremities
Cabozantinib With Radiation Therapy for the Treatment of Sarcomas of the Extremities
This phase I/II trial studies the side effects and best dose of cabozantinib when given with radiation therapy and how well it works in treating patients with sarcoma of the extremities.
- Conditions
- Sarcoma of the Extremity, Stage I Soft Tissue Sarcoma of the Trunk and Extremities, Stage IA Soft Tissue Sarcoma of the Trunk and Extremities, Stage IB Soft Tissue Sarcoma of the Trunk and Extremities
- Trial name
- NCT04220229
- Testing
- Cabozantinib S-malate, Radiation Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Washington
Brain Metastases, Radiotherapy
Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases
Patients suffering from malignancies in advanced stages often develop brain metastases, which limit both the life span and the quality of life.
- Trial name
- Radcav (NCT05871307)
- Testing
- Preoperative Radiotherapy, Intraoperative Radiation, Postoperative Radiotherapy
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
High-Risk Cancer, Urothelial Carcinoma Bladder
Adjuvant Radiotherapy Versus Observation After Radical Cystectomy in High Risk Urothelial Bladder Cancer
This is a prospective randomized clinical trial in high risk urothelial bladder cancer to compare adjuvant radiotherapy versus observation after radical cyctectomy.
- Trial name
- NCT04740866
- Testing
- Adjuvant Radiotherapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Breast Cancer
Single Pre-Operative Radiation Therapy - With Delayed or No Surgery (SPORT-DNS)
Eligible women will receive neoadjuvant single fraction radiotherapy followed by surgery performed after one year
- Trial name
- SPORT-DNS (NCT05217966)
- Testing
- Radiation: Single Pre-Operative Radiation Therapy
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Rectal Cancer
Efficacy and Toxicity of Total Neoadjuvant Sandwich Treatment Via Short Course Radiotherapy in the Treatment of Stage II and III Rectal Cancer Patients
Several trials showed that total neoadjuvant treatment (TNT) in stage II/III rectal cancer patients had better outcomes when compared with standard neoadjuvant long-course radiotherapy (CRT).
- Trial name
- NCT07095439
- Testing
- Total Neoadjuvant Treatment
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Ain Shams University