Clinical trials: Neoadjuvant Systemic Therapy
Location and Biopsy of Axillary Lymph Nodes
Targeted Biopsy of Carbon Nanoparticles Labelled Axillary Node for CN+ Breast Cancer
To explore the feasibility of target biopsy of carbon nanoparticles labelled lymph node after neoadjuvant systemic therapy for cN+ breast cancer, and evaluate whether it can accurately predict axillary lymph node status after…
- Trial name
- NCT04482803
- Testing
- Carbon nanoparticles suspension injection will be injected into or around the cortex of the clinically assessed positive lymph nodes
- Where
- China
- Volunteers
- 159 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cholangiocarcinoma, Intrahepatic
Liver Transplant for Stable, Advanced Intrahepatic Cholangiocarcinoma
Diagnosis of intrahepatic cholangiocarcinoma (iCCA) is an increasingly common form of primary liver cancer, but patients with this diagnosis are not currently eligible for LT.
- Trial name
- NCT04195503
- Testing
- Liver Transplantation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Breast Cancer, Neoadjuvant Therapy
Validation of the CPS+EG, Neo-Bioscore and Modified Neo-Bioscore Staging Systems After PST of BC in China
Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in breast cancer patients. The clinical-pathologic staging system incorporating estrogen receptor (ER)-negative disease and nuclear grade 3 tumor…
- Conditions
- Breast Cancer, Neoadjuvant Therapy, Neoplasm Staging, Estrogen Receptor
- Trial name
- NCT03437837
- Where
- 12 sites in China
- Volunteers
- 1,077 people
- Sponsor
- Peking University First Hospital
Axillary Lymph Node Dissection, Pathological Complete Response
Omission of ALND in Breast Cancer Patients With Axillary pCR
This prospective, single-arm, phase II trial studies axillary lymph node dissection (ALND) to see if it can be safely omitted in breast cancer patients with axillary pathological complete response (pCR) after neoadjuvant systemic…
- Conditions
- Axillary Lymph Node Dissection, Pathological Complete Response, Neoadjuvant Systemic Therapy, Breast Cancer
- Trial name
- NCT05939830
- Testing
- Stained region Lymph Node Biopsy (SrLNB), Regional lymph node radiotherapy (RNI) including the axilla
- Where
- China
- Volunteers
- 92 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Colorectal Cancer, Neoadjuvant Systemic Therapy
Survival Benefit of Primary Tumour Resection Compared to Systemic Therapy Alone in Stage IV Colorectal Cancer Patients
About 20-25 percent of all colorectal cancer patients are diagnosed with International Union Against Cancer (UICC) stage IV disease. The benefit of primary tumor resection in the palliative context is therefore of high concern.
- Trial name
- SurvSysT (NCT06326619)
- Testing
- Primary tumor resection, Systemic Therapy
- Volunteers
- 480 people
- Sponsor
- Medizinische Hochschule Brandenburg Theodor Fontane
Peritoneal Carcinomatosis, Gastric Cancer
Clinical Trial at Neoadjuvant Peritoneal and Systemic Chemotherapy Plus HIPEC in Gastric Carcinomatosis
Implementation of a curative strategy of treatment in peritoneal carcinomatosis of gastric cancer. The goal is to get 1C level of evidence (patient died with "standard" treatment, with this treatment some of them survive) in…
- Trial name
- HIPEC (NCT01342653)
- Testing
- Intraperitoneal and systemic chemotherapy plus maximum cytoreduction plus HIPEC
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Breast Cancer
TIL Relation to pCR After Neoadjuvant Therapy in Breast Cancer Patients
Neoadjuvant systemic treatment for breast cancer (used in locally advanced and operable breast cancer) includes anthracycline based chemotherapy (Doxorubicin/Cyclophosphamide) followed by taxanes (weekly Paclitaxel or Docetaxel)…
- Trial name
- NCT05206396
- Testing
- TIL assessment in pre-existing histopathological specimens
- Where
- Egypt
- Volunteers
- 270 people
- Sponsor
- Ain Shams University
Breast Cancer
Carbon Suspension vs. Metallic Marker for Axillary Lymph Node Marking in Breast Cancer After Neoadjuvant Therapy
This single-center, randomized study aims to compare the intraoperative detection rates of axillary lymph nodes marked with carbon suspension versus metallic markers in breast cancer patients (T1-3N1M0) before neoadjuvant…
- Trial name
- COMET (NCT07106112)
- Testing
- Ultrasound-guided carbon suspension (Black Eye) injection, Ultrasound-guided metallic marker (TWIRL ULTRACOR) placement
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Saint Petersburg State University, Russia
Malignant Female Reproductive System Neoplasm
Physiatry-Led Cancer Prehabilitation During Neoadjuvant Systemic Therapy to Improve Function in Stage III-IVA Gynecologic Cancer Patients
This clinical trial studies whether physiatry-led cancer prehabilitation can be used during systemic treatment before surgery (neoadjuvant systemic treatment [NST]) to improve function in stage III-IVA gynecologic cancer…
- Trial name
- NCT07608445
- Testing
- Educational Intervention, Goal Setting, Interview
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
HER-2 Positive Breast Cancer
Phase II Study of Ultrasound and ctDNA Guided Neoadjuvant Systemic Therapy for Patients With HER2-positive Early Breast Cancer (UC HER Trial)
Although neoadjuvant dual anti-HER2-targeted therapy, pertuzumab and trastuzumab, combined with taxanes increased the pCR rate for patients with early-stage HER2-positive breast cancer when compared with single blockade combined…
- Trial name
- UC HER (NCT07565324)
- Testing
- Lipo-Dox®, Cyclophosphamide, Trastuzumab (Herceptin)
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- National Taiwan University Hospital
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment
1. Study Design This is a single-center, prospective, randomized, controlled, exploratory clinical trial. The study is designed to evaluate and compare the efficacy and safety of two biologic-based induction regimens against…
- Trial name
- NCT07340463
- Testing
- Glucocorticoids, belimumab, Telitacicept
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanjing University School of Medicine
Lupus Nephritis
Minimizing Glucocorticoid Administration in Patients With Proliferative Lupus Nephritis
The aim of the study is to evaluate the efficacy of a therapeutic regimen which decreases glucocorticoid exposure compared with standard therapy in patients with proliferative lupus nephritis during remission induction by…
- Trial name
- GLUREDLUP (NCT05207358)
- Testing
- Rituximab, Mycophenolate Mofetil, Cyclophosphamide
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Institutul Clinic Fundeni
Triple Negative Breast Cancer (TNBC), Early Setting
LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients With Triple Negative Breast Cancer
LESLIE is a multicentric randomized controlled trial in patients with triple negative breast cancer receiving neoadjuvant chemo/immunotherapy (NAT).
- Trial name
- LESLIE (NCT06831955)
- Testing
- Exercise Therapy, Fasting-Mimicking Diet, SOC
- Where
- 10 sites in Belgium
- Volunteers
- 356 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven