Clinical trials: Neoadjuvant Treatment
Renal Failure, Multiple Myeloma
Lenalidomide & High Dose Dexamethasone for Untreated Multiple Myeloma Renal Failure Patients
Primary: To validate the initial dosing recommendations for newly diagnosed MM (Mutiple Myeloma) patients with various degrees of renal failure using pharmacokinetic studies Secondary: To evaluate the safety of lenalidomide and…
- Trial name
- NCT01270932
- Testing
- Lenalidomide and Dexamethasone
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University Health Network, Toronto
Esophageal Squamous Cell Carcinoma
A Prospective Study of Apatinib Plus Concurrent Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma
The purpose of this study is to assess the efficacy and safety of apatinib plus concurrent neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma.
- Trial name
- NCT03857763
- Testing
- Apatinib,Paclitaxel,Cisplatin,RT
- Volunteers
- 40 people
- Sponsor
- Hebei Medical University Fourth Hospital
Breast Cancer
Neoadjuvant Phase II Trial in Patients With T1c Operable, HER2-positive Breast Cancer According to TOP2A Status
The main objective of this multicenter study will therefore be to evaluate pathologic complete response rates of an anthracycline-based regimen [FEC 100 - TAXOTERE® - HERCEPTIN® - PERTUZUMAB] and a non anthracycline-based regimen…
- Trial name
- NeoTOP (NCT02339532)
- Testing
- FEC100, Docetaxel, Trastuzumab
- Where
- 12 sites in France
- Volunteers
- 86 people
- Sponsor
- UNICANCER
Bladder Cancer
Neoadjuvant Chemotherapy in Non Muscle Invasive T1b Bladder Cancer
The aim of our study is to evaluate the benefit of NAC in T1b NMIBC .
- Trial name
- NCT04245618
- Testing
- neoadjuvant chemotherapy ( cisplatin - gemcitabine)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Non-small Cell Lung Cancer
NeoTRACK - Dissection of IO Efficacy in NSCLC by Longitudinal tracKing
Prospective, non-randomized, open-label, single-arm phase II trial to investigate the feasibility and efficacy of combining chemotherapy with tiragolumab and atezolizumab as neoadjuvant and adjuvant treatment for surgical NSCLC…
- Trial name
- NCT05825625
- Testing
- Atezolizumab, Tiragolumab
- Where
- 2 sites in Germany
- Volunteers
- 35 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Prostate Cancer
Neoadjuvant And Adjuvant Abiraterone Acetate + Apalutamide Prostate Cancer Undergoing Prostatectomy
This multicenter randomized phase II trial investigates the impact of intense androgen deprivation on radical prostatectomy (RP) pathologic response and radiographic and tissue biomarkers in localized prostate cancer…
- Trial name
- NCT02903368
- Testing
- Apalutamide, Leuprolide, Prednisone
- Where
- 4 sites in United States
- Volunteers
- 118 people
- Sponsor
- Dana-Farber Cancer Institute
Epithelial Ovarian Cancer
Tinzaparin And Biomarkers After Neoadjuvant Treatment of Ovarian Cancer
Background: Previous findings have indicated antineoplastic properties of tinzaparin (Innohep®), a commonly used anti-coagulant.
- Trial name
- NCT05284552
- Testing
- Tinzaparin Injectable Solution
- Where
- 8 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- University Hospital, Linkoeping
Breast Cancer, Triple Negative Breast Neoplasms
Evaluate the Clinical Benefit of a Post-operative Treatment Associating Radiotherapy + Nivolumab + Ipilimumab Versus Radiotherapy + Capecitabine for Triple Negative Breast Cancer Patients With Residual Disease
To evaluate the clinical benefit of a post-operative adjuvant therapy combining radiotherapy + Nivolumab + Ipilimumab versus radiotherapy + Capecitabine in Triple Negative Breast Cancer (TNBC) patients with residual disease after…
- Trial name
- BreastImmune03 (NCT03818685)
- Testing
- Nivolumab, Ipilimumab, Capecitabine
- Where
- 17 sites in France
- Volunteers
- 95 people
- Sponsor
- Centre Leon Berard
Rectal Cancer
Observation Versus Surgical Resection in Patients With Rectal Cancer Who Achieved Complete Clinical Response After Neoadjuvant Chemoradiotherapy
With the possibility of pathological complete response in surgical specimens, some authors have proposed non-operative management of the patient group, when re-staged after neoadjuvant treatment, have complete clinical response.
- Trial name
- NCT02052921
- Testing
- Rectal resection, Observation
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Breast Cancer
Trastuzumab With or Without Everolimus in Treating Women With Breast Cancer That Can Be Removed By Surgery
RATIONALE: Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00674414
- Testing
- trastuzumab, everolimus, therapeutic conventional surgery
- Where
- 8 sites in France
- Volunteers
- 82 people
- Sponsor
- UNICANCER
Head and Neck Squamous Cell Carcinoma, Oral Cancer
Tirelizumab in Combination With Carboplatin and Albumin-binding Paclitaxel for Neoadjuvant Therapy in HNSCC
In this study, 100 patients with resectable head and neck squamous cell carcinoma (oral squamous cell carcinoma and oropharyngeal squamous cell carcinoma) were enrolled, who were combined with tirelizumab, carboplatin and…
- Trial name
- HNC-SYSU-001 (NCT05941338)
- Testing
- Tirelizumab ,+Carboplatin+albumin-bound paclitaxel
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Renal Cell Carcinoma
Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma
This study will evaluate the effect of investigational drugs, pembrolizumab alone or pembrolizumab with lenvatinib, on the immune systems response to kidney cancer when given before and after surgery to remove kidney cancer.
- Trial name
- NCT05733715
- Testing
- Pembrolizumab infusion, Lenvatinib tablet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Organoids, Rectal Cancer
Organoids in Predicting Chemoradiation Sensitivity on Rectal Cancer
Patients with locally advanced rectal cancer will receive biopsy before the standard treatment of neoadjuvant chemoradiation. The investigators are going to establish organoids model from the pre-treatment biopsies and expose…
- Conditions
- Organoids, Rectal Cancer, Chemoradiation
- Trial name
- NCT03577808
- Testing
- Biopsy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhen Zhang
Breast Cancer, Triple Negative Breast Cancer
Safety and Efficacy of Durvalumab Combined to Neoadjuvant Chemotherapy in Localized Luminal B HER2(-) and Triple Negative Breast Cancer.
The study has a phase Ib and a phase II part. The phase Ib aims to evaluate the safety and tolerability of durvalumab in combination with a dose- dense EC regimen in a neoadjuvant setting for early breast cancer.
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, Luminal B
- Trial name
- B-IMMUNE (NCT03356860)
- Testing
- Paclitaxel, Epirubicin, Cyclophosphamide
- Where
- 4 sites in Belgium
- Volunteers
- 57 people
- Sponsor
- Grand Hôpital de Charleroi
Breast Cancer
Neoadjuvant Sequential Administration of Two Gemcitabine Combinations in Operable Breast Cancer
Gemcitabine and anthracycline combination has shown encouraging activity as neoadjuvant chemotherapy in locally advanced breast cancer.
- Trial name
- NCT00191789
- Testing
- gemcitabine, doxorubicin, cisplatin
- Where
- 3 sites in India
- Volunteers
- 65 people
- Sponsor
- Eli Lilly and Company
Soft Tissue Sarcoma, Sarcoma,Soft Tissue
Neoadjuvant Intralesional Injection of Talimogene Laherparepvec
The proposed study is designed to treat locally advanced soft tissue sarcoma (STS) subtypes with neoadjuvant talimogene laherparepvec (TVEC) and preoperative external beam radiation therapy (EBRT).
- Trial name
- NCT06660810
- Testing
- Talimogene Laherparepvec, Neoadjuvant Radiation, Surgery
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- John Rieth
Radiotherapy Side Effect, Chemotherapy Effect
Neoadjuvant Chemotherapy or Chemoradiotherapy in Resectable Oesophageal Carcinoma（NewEC Study）
To provide comprehensive efficacy and safety profiles of neoadjuvant chemoradiotherapy (NCRT) versus neoadjuvant chemotherapy (NCT) versus surgery alone in resectable oesophageal carcinoma.
- Conditions
- Radiotherapy Side Effect, Chemotherapy Effect, Oesophageal Carcinoma, Effect of Drugs
- Trial name
- NCT04027543
- Testing
- Neoadjuvant chemoradiotherapy, Oesophagectomy, Neoadjuvant chemotherapy
- Where
- 3 sites in United States, China
- Volunteers
- 423 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Esophageal Squamous Cell Carcinoma
Neoadjuvant Chemoimmunotherapy Followed by Surgery and Postoperative Radioimmunotherapy
The goal of this study was to explore the efficacy and safety of neoadjuvant chemoimmunotherapy followed by surgery and postoperative radioimmunotherapy in patients with locally advanced esophageal squamous cell carcinoma
- Trial name
- NCT06602843
- Testing
- Neoadjuvant chemoimmunotherapy followed by surgery and postoperative radioimmunotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Anhui Provincial Hospital
Breast Cancer
Multicenter, Phase II Clinical Study of Sacituzumab Tirumotecan (Sac-TMT) in Combination With KL-A167 for Neoadjuvant Treatment of Triple-Negative Breast Cancer
This study is a multicenter phase II trial planning to enroll 40 patients with primary triple-negative breast cancer (tumor size ≥2 cm, clinical lymph node stage cN0-3, M0).
- Trial name
- ST-A-TN (NCT07371208)
- Testing
- SKB264
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Locally Advanced Pancreatic Adenocarcinoma, Chemotherapy Effect
Neoadjuvant Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer (NORPACT-2)
This is a Norwegian prospective observational study that evaluates the resectability rate in patients with borderline resectable and locally advanced pancreatic cancer who received neoadjuvant chemotherapy in a population based…
- Conditions
- Locally Advanced Pancreatic Adenocarcinoma, Chemotherapy Effect, Borderline Resectable Pancreatic Adenocarcinoma, Pancreatectomy
- Trial name
- NCT04423731
- Testing
- Folfirinox
- Where
- Norway
- Volunteers
- 251 people
- Sponsor
- Oslo University Hospital
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