Clinical trials: Neonatal Diabetes
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution Retina Imaging
To increase the clinical experience of using the rtx1 camera in various retinal disorders and to follow the evolution of structural alterations during retinal diseases using adaptive optics imaging with the rtx1 camera
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IHR (NCT04128150)
- Where
- 3 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Prevalence and Risk Evaluation of Diabetic Complications of the Foot in A Large Canadian Population
The study aims to assess foot complications among patients with diabetes in Canada, using patient data collected during diabetes foot assessments performed by the LMC Chiropody Team between February 27, 2018 and April 17, 2019.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Foot Deformities, Onychauxis
- Trial name
- PEDAL (NCT04327622)
- Where
- Canada
- Volunteers
- 5,084 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Molar Incisor Hypomineralization
Prevalence And Severity Of Molar Incisor Hypomineralization Among A Group Of Children With Type I Diabetes Milletus.
Determine the prevalence of molar incisor hypomineralization among a group of children with type I diabetes millutes, its severity and treatment need via clinical examination of children with type I diabetes millutes .
- Trial name
- NCT06342089
- Testing
- Type I diabetes milletus
- Volunteers
- 238 people
- Sponsor
- Cairo University
Fetal Macrosomatia, Lipid Metabolism Disorders
Influence of TyG Index and TG/HDL-C Ratio on Fetal Macrosomia
Metabolic disorders that can occur during pregnancy, in particular disorders of lipid metabolism and insulin resistance, can have a detrimental effect on pregnancy and the fetus.
- Conditions
- Fetal Macrosomatia, Lipid Metabolism Disorders, Hyperlipidemias
- Trial name
- NCT06463990
- Testing
- TyG index
- Where
- Turkey (Türkiye)
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Birth Defect, Pregnancy Loss
B-vitamin Levels and Adverse Pregnancy Outcomes
This prospective nested case-control study aims to examine the effects of blood vitamin B levels in first-trimester pregnant women on the pregnancy outcomes
- Conditions
- Birth Defect, Pregnancy Loss, Pregnancy Complications, Pregnancy Induced Hypertension
- Trial name
- NCT05073978
- Testing
- No intervention
- Where
- China
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Westlake University
Type 2 Diabetes, Pregnancy
Fat Metabolism in Pregnancy and Neonatal Heart Function in Diabetes
Background: The health of the next generation is likely programmed in the womb (i.e.in utero), and our understanding of how that programming happens will allow us to favorably influence the health of future generations.
- Trial name
- NCT01346527
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pregnancy
Relevance of Ultrasound Screening for Foetal Macrosomia
Management of fetal macrosomia is based on a suspicion of macrosomia (no certainty before birth). This management is an artificial induction of labour for an earlier delivery and therefore a lower fetal weight gain.
- Trial name
- USmacro (NCT04443205)
- Testing
- Data record
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- CHU de Reims
Congenital Heart Disease
Copeptin- Relevance as a Perioperative Marker in Pediatric Cardiac Surgery
This study evaluates the relevance of Copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. Three blood samples are taken of each patient.
- Trial name
- NCT03316508
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Claudia Herbst
Cystic Fibrosis, Cystic Fibrosis Related Diabetes
Role of Glucagon In Glucose Control in Cystic Fibrosis Related Diabetes
This project is designed to begin to characterize the abnormalities of glucagon secretion in subjects with cystic fibrosis related diabetes along the spectrum of glucose tolerance.
- Trial name
- NCT02398383
- Testing
- Oral Glucose Tolerance Test, Mixed Meal Tolerance Test, Hypoglycemic Clamp
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus, Short Stature
Mauriac Syndrome: Isotopic Techniques and Genetic Analysis
Mauriac syndrome (MS) is an entity of individuals combining poorly controlled diabetes mellitus type 1, short stature and glycogenic hepatopathy.
- Conditions
- Diabetes Mellitus, Short Stature, Glycogen Deposition
- Trial name
- NCT04275141
- Testing
- oral glucose load, exercise test
- Where
- 2 sites in Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Lausanne
Healthy Subjects
Effect of Oat Compounds on Postprandial Glucose Response
In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance
- Trial name
- NCT05177172
- Testing
- High beta glucans, Low beta glucans, Low beta glucans + low polar lipids
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Haemophilia, Cardiovascular Disease
Cardiovascular Disease (CVD) in Haemophilia
Life expectancy of hemophilia patients has improved considerably during the past decades and is approaching that of the general population.
- Trial name
- NCT01303900
- Where
- 6 sites in Netherlands, United Kingdom
- Volunteers
- 750 people
- Sponsor
- UMC Utrecht
Gestational Diabetes Mellitus in Pregnancy
Shear Wave Elastography in Gestational Diabetes Mellitus
Our aim was to investigate and compare placental elasticity by using Shear wave elastography (SWE) in patients with gestational diabetes mellitus (GDM) with and without insulin to non-diabetic controls.
- Trial name
- NCT04455880
- Testing
- SWE is a novel noninvasive dynamic ultrasound technique which refers to measurement for quantitative analysis of tissue elasticity
- Where
- Turkey (Türkiye)
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Gulsum Uysal
Macrosomia, Fetal, Gestational Diabetes Mellitus in Pregnancy
New Markers of Glycation to Predict Gestational Diabetes Mellitus and Macrosomia.
Gestational diabetes mellitus (GDM) increases the risk of macrosomia and other adverse pregnancy outcomes. Screening strategies are debated: universal vs.
- Trial name
- GLYCAGEST (NCT06048510)
- Testing
- Pregnant women
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Bordeaux
Gestational Diabetes Mellitus With Baby Delivered
Carbohydrate Counting and DASH Intervention and Pregnancy Outcomes Among Women With Gestational Diabetes
Study is an interventional clinical trial. Pregnant women (aged 25-40 years) diagnosed with GDM (by a 75-g oral glucose tolerance test at 24-28 weeks' gestation) will be recruited conveniently from Obstetrics and Gynecology…
- Trial name
- NCT03244579
- Testing
- Dietary Intervention
- Where
- Jordan
- Volunteers
- 180 people
- Sponsor
- University of Jordan
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis
The purpose of this study is to investigate the utility of a continuous glucose monitor device (CGM) in screening for cystic fibrosis related diabetes.
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis Liver Disease, Pancreatic Steatosis
- Trial name
- CFCGM (NCT03961516)
- Testing
- Frequently Sampled Oral Glucose Tolerance Test and CGM, MRI Pancreas and Liver
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University Hospitals Cleveland Medical Center
Neonatal Diabetes Secondary to Mutation in the Potassium Channel
Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels
The understanding of the molecular mechanisms of neonatal diabetes has deeply changed the therapy of patients carrying mutations in the K-ATP channel.
- Trial name
- NEOGLI (NCT02375828)
- Testing
- Glibenclamide
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes, Prediabetes
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
Vegetarian diets have been associated with a reduced risk of preventable diseases such as type 2 diabetes and cardiovascular disease. These effects may be mediated through direct or indirect pathways.
- Conditions
- Diabetes, Prediabetes, Metabolic Syndrome, Dysglycemia
- Trial name
- NCT02037321
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Permanent Neonatal Diabetes Mellitus
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)
The purpose of this study is to investigate long term response of sulfonylurea and glucose control in children with diabetes due to mutations in ABCC8 that have been switched from insulin injections to sulfonylurea tablets.
- Trial name
- SuResponsSUR (NCT02624830)
- Testing
- Sulfonylurea
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Haukeland University Hospital