Clinical trials: Neonatal Diabetes
Preterm Labor, Preterm Birth
MIRACLE of LIFE Study
The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
- Trial name
- MoL (NCT06074601)
- Testing
- Mirvie Predictive Test for Adverse Pregnancy Outcomes
- Where
- 10 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Mirvie
Diabetes in Pregnancy, Diabetes, Gestational
Effect of Maternal Diabetes on Brain Development, as Measured by Neonatal Electroencephalogram (EEG)
Alterations in the intrauterine environment can have profound effects on fetal development. Diabetes during gestation results in multiple deleterious short-term outcome differences, and is correlated with long-term developmental…
- Conditions
- Diabetes in Pregnancy, Diabetes, Gestational, Infant, Newborn, Diseases, Perinatal Disorders of Growth and Development
- Trial name
- NCT02968628
- Testing
- Video Electroencephalogram (EEG), Point-of Care Blood Sugar Testing, Medical Record Data Extraction
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Obesity, Myelomeningocele
Extended Criteria For Fetal Myelomeningocele Repair
The purpose of this study is to offer pre-natal Myelomeningocele (MMC) repair surgery to pregnant women with one of the former surgery exclusion factors A BMI of 35-40 kg/m2 Diabetes; patients will require good glycemic control…
- Conditions
- Obesity, Myelomeningocele, Pregnancy, Diabetes Mellitus in Pregnancy
- Trial name
- NCT02664207
- Testing
- Open Fetal Repair of Myelomeningocele
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
Overweight, Obesity
Meta-analyses of Total and Individual Fructose-containing Sugars and Incident Cardiometabolic Disease
Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic and increasing burden of…
- Conditions
- Overweight, Obesity, Dyslipidemia, Hyperlipidemia
- Trial name
- NCT01608620
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Peripheral Artery Disease, Coronary Disease
Evaluation of Patients With Known or Suspected Heart Disease
In this study researchers will admit and evaluate patients with known or suspected heart disease referred to the Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI).
- Conditions
- Peripheral Artery Disease, Coronary Disease, Diabetes and Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT00001313
- Where
- 2 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lipodystrophy, Diabetes
Low Energy Diet and Familial Partial Lipodystrophy
To evaluate the therapeutic efficacy and metabolic impact of a low energy diet (LED) in people with familial partial lipodystrophy and diabetes.
- Conditions
- Lipodystrophy, Diabetes, Diet Modification
- Trial name
- NCT03900286
- Testing
- Total Dietary Replacement
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cardiovascular Abnormalities, Arterial Blood Pressure
Multicenter Study on Cardiovascular and Metabolic Complications in Patients With Biochemically Silent Pheochromocytomas and Paragangliomas
The aim of the study is to characterise the cardiovascular and metabolic complications pre- and post-surgery of patients with biochemically negative PPGL and to compare them with normal individuals and patients with secreting…
- Conditions
- Cardiovascular Abnormalities, Arterial Blood Pressure, Heart Rate, Congestive Heart Failure Chronic
- Trial name
- NCT07316075
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Prediabetes, Gestational Diabetes
Treating Prediabetes in the First Trimester
The investigators plan to study a sample of women with prediabetes (diagnosed by Hemoglobin A1c (HbA1c) 5.7-6.4% or fasting plasma glucose (FPG) 92-125 mg/dL) in the first trimester of pregnancy, and patients will be randomized…
- Trial name
- NCT01926457
- Testing
- Treatment of Prediabetes
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Post Term Pregnancy, Premature Rupture of Membrane
Dilapan-S®: A Multicenter US E-registry
Objective of this registry is to collect a representative set of real world data on the use of Dilapan-S® for pre-induction cervical ripening in daily clinical practice.
- Conditions
- Post Term Pregnancy, Premature Rupture of Membrane, Fetal Growth Retardation, Oligohydramnios
- Trial name
- NCT04451109
- Testing
- Dilapan-S
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Medicem Technology s.r.o.
Cystic Fibrosis, Diabetes Mellitus Type I
Social Determinants in Chronic Disease in British Columbia
Anyone who practices clinical medicine will understand that socially disadvantaged children will have worse health outcomes, no matter what the underlying condition might be.
- Conditions
- Cystic Fibrosis, Diabetes Mellitus Type I, Chronic Renal Insufficiency
- Trial name
- NCT02203084
- Testing
- Social Determinants Questionnaire
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of British Columbia
Neonatal Hypoglycemia, Gestational Diabetes Mellitus (GDM)
COntinuous Glucose Monitoring in nEwborns of Mothers With Insulin-Treated Gestational Diabetes Mellitus
The purpose of this study is to determine whether continuous glucose monitoring (CGM) improves the detection and management of neonatal hypoglycaemia in newborns of mothers with insulin-treated gestational diabetes.
- Trial name
- COMET-GDM (NCT07462793)
- Testing
- Dexcom ONE Continuous Glucose Monitoring System
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Chronic Kidney Diseases, Diabetes
KidneYou - Innovative Digital Therapy
The aim of the study is to assess the improvement of health in patients affected by CKD when they are exposed to non-pharmacological treatment strategies as nutritional program (NP), physical activity program (PA) and mindfulness…
- Conditions
- Chronic Kidney Diseases, Diabetes, Arterial Hypertension, Chronic Glomerulonephritis
- Trial name
- NCT05286632
- Testing
- KidneYou APP
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Advice Pharma Group srl
Generalized Lipodystrophy
A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months.
- Trial name
- NCT06548100
- Testing
- mibavademab
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Regeneron Pharmaceuticals
Diabetes, Congenital Heart Disease
The Roles of Trust and Respect in Patient Reactions to Race-based and Personalized Medicine Vignettes: An Experimental Study
Background: Genetic research has implications for drug development and marketing. Race-based medicine may be able to provide specific treatment for populations with increased disease-specific morbidity and mortality.
- Conditions
- Diabetes, Congenital Heart Disease, Hypertension
- Trial name
- NCT00911833
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Cystic Fibrosis
A Pilot and Feasibility Study to Evaluate High vs Low Glycemic Index Mixed Meal Tolerance Test in Adolescents and Young Adults With Cystic Fibrosis
The goal of this study is to determine the extent to which excess dietary simple sugars serve as a secondary mediating factor in Cystic fibrosis-related diabetes (CFRD) development.
- Trial name
- NCT06350149
- Testing
- Sugar Sweetened Beverages (SSB), Hi GI, Lo GI
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Pregnancy, Fetal Macrosomia
Correlation Between Placental Thickness in the Second and Third Trimester and Fetal Weight
The aim of this prospective longitudinal study was to investigate the relationship between placental thickness during the second and third trimesters and placental and birth weights.
- Conditions
- Pregnancy, Fetal Macrosomia, Intrauterine Growth Restriction
- Trial name
- NCT02473991
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Diabetes
Identification and Characterization of Monogenic Diabetes
Type 1 Diabetes is a multifactorial disease, with a strong genetic contribution of HLA genes, and minor contributions of many additional genes.
- Trial name
- DIAGENE (NCT01481623)
- Testing
- Constitution of a biological bank, Metabolic studies
- Where
- France
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Short Stature
Mauriac Syndrome: Isotopic Techniques and Genetic Analysis
Mauriac syndrome (MS) is an entity of individuals combining poorly controlled diabetes mellitus type 1, short stature and glycogenic hepatopathy.
- Conditions
- Diabetes Mellitus, Short Stature, Glycogen Deposition
- Trial name
- NCT04275141
- Testing
- oral glucose load, exercise test
- Where
- 2 sites in Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Lausanne
AMD - Age-Related Macular Degeneration, Retinitis Pigmentosa (RP)
Retinal Investigation Using Optos OCT Device
Retinal investigation using OCT with control and diseased eyes
- Conditions
- AMD - Age-Related Macular Degeneration, Retinitis Pigmentosa (RP), Diabetic Retinopathy, Control Patients
- Trial name
- NCT06846151
- Testing
- retinal functional imaging
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Hypoglycemia
Glucagon in the Treatment of Hypoglycemia in Newborn Infants of Diabetic Mothers
Thesis Infants of diabetic mothers are at high risk to develop hypoglycemia after birth. After birth, glucose and ketone bodies are the main substrates of brain energy.
- Trial name
- NCT00434772
- Testing
- glucagon
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center