Clinical trials: Neonatal Distress, open to volunteers
Preterm, Ventilator Lung; Newborn
Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound
This study aims to evaluate the effect of non-invasive ventilation (nIPPV) , (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates <37 gestational week with moderate to severe RD using…
- Trial name
- NCT06550219
- Testing
- Nasal humidified heated high flow cannula (NHHHC), Nasal intermittent positive pressure ventilation (NIPPV), Nasal continuous positive airway pressure NCPAP
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome, Acute
Establishment and Evaluation of Prenatal Prevention and Treatment Strategy for NARDS
1. A predictive model for NARDS was established based on perinatal risk factors. Multivariate Logistic regression analysis was used to screen the independent prenatal risk factors for NARDS.
- Trial name
- NCT06188195
- Testing
- Dexamethasone
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin
Respiratory Distress Syndrome, Newborn, Endotracheal Intubation
An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.
This research focuses on one of the most common problems in newborn medicine: breathing difficulties. Breathing problems are the most common reason for admission to our neonatal unit at the National Maternity Hospital.
- Conditions
- Respiratory Distress Syndrome, Newborn, Endotracheal Intubation, Neonatal Intubation Performance, Prematurity
- Trial name
- NINJA (NCT06898801)
- Testing
- Just-in-time video training
- Where
- Ireland
- Volunteers
- 140 people
- Sponsor
- University College Dublin
Intensive Care Units, Neonatal, Infant, Newborn
Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study
Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability. This pilot study investigates whether a quantitative approach - the heterogeneity index, previously only…
- Conditions
- Intensive Care Units, Neonatal, Infant, Newborn, Infant, Premature, Point-of-Care Systems
- Trial name
- NPLUS HI (NCT07117513)
- Where
- 2 sites in Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Bronchopulmonary Dysplasia
Point of Care Lung Ultrasound in Preterm Infants With Respiratory Distress
The goal of this observational study is to learn about the role of bedside lung ultrasound in infants born prematurely with breathing problems.
- Trial name
- NCT05925075
- Testing
- Lung Ultrasound
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Phoenix Children's Hospital
Vascular Filling, Newborn
Impact of Prepartum Intravenous Fluid Intake on Newborn Weight Loss in the First Days of Life
At birth, the infant's weight was measured daily to assess the adequacy of nutritional intake. This indicator can be influenced by various factors related to the mother, her pregnancy, as well as medical interventions during the…
- Conditions
- Vascular Filling, Newborn, Weight Loss, Jaundice
- Trial name
- PERLE (NCT07243054)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Extremely Premature Infant, Pain
Creation of a Scale for Assessing Pain and Discomfort in Extremely Premature Infants (EDEX) Hospitalised in Neonatal Intensive Care, Inspired by the Early Infant Pain and Discomfort Scale (EDIN)
The goal of this study is to develop a new scale for assessing prolonged pain, dedicated to extremely premature infants born before 27 weeks of gestation, adapted to their particular ways of expressing pain and discomfort, which…
- Conditions
- Extremely Premature Infant, Pain, Discomfort Symptoms
- Trial name
- DOU-PREMA (NCT07481331)
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Preterm Labor With Preterm Delivery, Premature Birth
Pharmacokinetics and Placental Transfer of Caffeine
The goal of this study is to learn how a pregnant person's body processes caffeine and how much caffeine crosses the placenta to the baby. A small dose of caffeine will be given to each pregnant participant before delivery.
- Conditions
- Preterm Labor With Preterm Delivery, Premature Birth, Apnea of Prematurity, Respiratory Distress Syndrome
- Trial name
- AnteCaff (NCT07570121)
- Testing
- Caffeine citrate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Prematurity, Respiratory Disease
Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress
Use of caffeine citrate in late-preterm infants with respiratory distress is questionable. Oliphant and colleagues found in a recently published study that caffeine therapy use in late-preterm infants at a loading dose of 20 and…
- Conditions
- Prematurity, Respiratory Disease, Ventilator Lung; Newborn
- Trial name
- CAT/LPT (NCT06026163)
- Testing
- Caffeine citrate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 134 people
- Sponsor
- Ministry of Health, Saudi Arabia
Respiratory Distress Syndrome (Neonatal)
Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital
Our study is a randomized controlled trial that compares two weaning protocols of preterm infants with respiratory distress syndrome who are ventilated on high frequency oscillatory ventilation in order to establish the best…
- Trial name
- NCT07202299
- Testing
- HFOV weaning protocol 1, HFOV weaning protocol 2
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Mansoura University Children Hospital
Tourette Syndrome, Tic Disorders
Evaluating and Promoting Resilience in Adolescents With Tourette Syndrome
This study adapts and tests PRISM (Promoting Resilience in Stress Management), a short skills-based program that teaches resilience, for teens ages 12-18 with Tourette syndrome or persistent tic disorder.
- Conditions
- Tourette Syndrome, Tic Disorders, Persistent (Chronic) Motor or Vocal Tic Disorder
- Trial name
- PRISM-TS (NCT07905898)
- Testing
- PRISM Intervention, Usual care intervention
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Wake Forest University Health Sciences
Lung Ultrasound, Respiratory Distress Syndrome, Newborn
Bedside Ultrasound to Monitor Lung Function and Blood Flow in Newborns Treated With Surfactant
The ULISSES study looks at how doctors use bedside ultrasound to help treat premature babies with breathing problems caused by Respiratory Distress Syndrome (RDS).
- Trial name
- ULISSES (NCT07070167)
- Testing
- Intratracheal administration of surfactant
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Chiesi Poland Sp. z o.o.
Surfactant, Respiratory Distress Syndrome (Neonatal)
Comparing Surfactant Administration Through Supraglottic Airway and Thin Catheter for Preterm Infants
What is this study about? This study is comparing two ways of giving surfactant, a medicine that helps premature infants breathe better.
- Trial name
- SALTI (NCT07030270)
- Testing
- Surfactant Administration through Laryngeal or Supraglottic Airway, Surfactant Administration through Thin Catheter
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Post-extubation Pressures in Preterm Neonates: A CER Study
The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains…
- Conditions
- Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT06552455
- Volunteers
- 1,050 people
- Sponsor
- McMaster Children's Hospital
Respiratory Distress Syndrome
Effect of L-Carnitine Supplementation in Preterm Neonates
The current study is planned to see the effect of L-carnitine supplementation in preterm neonates suffering from RDS among the local population, as there is no such evidence available for the local population and there are…
- Trial name
- NCT07437391
- Testing
- L-carnitine, Standard care
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Muhammad Aamir Latif
Respiratory Distress Syndrome of Newborn, Threatened Premature Labor, Antepartum
Clinical Pharmacology of Dexamethasone in Pregnant Women With Preterm Labor
This study through to the pregnant woman blood concentrations of dexamethasone therapy after research, explore the pharmacokinetic data of dexamethasone in pregnant women, Chinese pregnant women dexamethasone pharmacokinetic…
- Trial name
- NCT05207852
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Dongyang Liu
Respiratory Distress Neonatal
ADINA vs. High Flow Nasal Cannula Comparison Study
This study is to evaluate the feasibility of using a pressure limited nasal cannula system instead of a high flow nasal cannula system in the management of premature babies with respiratory distress.
- Trial name
- NCT03171129
- Testing
- Adaptive Dynamic Inspiratory Nasal Apparatus, High flow Nasal Canula
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Loma Linda University
Respiratory Distress Syndrome (RDS), Newborn
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates
The goal of this clinical trial is to learn if nasal high frequency oscillatory ventilation (nHFOV) works no worse than nasal intermittent mandatory ventilation (NIMV) as early breathing support.
- Conditions
- Respiratory Distress Syndrome (RDS), Newborn, Premature Birth
- Trial name
- NOV-RDS (NCT07837141)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Aga Khan University
Fetal Hypoxia, Fetal Distress
Gemini Flash 3.6 Versus Human Observers for FIGO-Based Interpretation of Intrapartum Cardiotocography
Cardiotocography (CTG) is the standard method for monitoring fetal heart rate and uterine contractions during labor to detect signs of fetal hypoxia.
- Conditions
- Fetal Hypoxia, Fetal Distress, Low Apgar Score, Neonatal Acidemia
- Trial name
- NCT07827222
- Volunteers
- 415 people
- Sponsor
- Assiut University