Clinical trials: Neonatal Infections
COVID-19, Infant, Newborn, Diseases
Long-term Respiratory Complications in Infants With Perinatal COVID-19
Study outcomes and endpoints: Primary outcome: to assess clinical characteristics of infants with confirmed COVID-19 infection at birth and to evaluate long-term respiratory consequences of neonatal COVID-19 infection.
- Conditions
- COVID-19, Infant, Newborn, Diseases, Respiratory Function Tests
- Trial name
- COLF (NCT05793723)
- Testing
- Pulmonary function testing device
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Covid19
COVID-19 Pregnancy Related Immunological, Clinical and Epidemiological Factors and Perinatal Outcomes
This is a prospective cohort study of pregnant patients at an urban academic center diagnosed with perinatal COVID-19 infection, followed up to 6 weeks postpartum.
- Trial name
- COVID-PRICE (NCT04659759)
- Testing
- COVID-19 exposure, COVID-19 vaccine
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Thomas Jefferson University
Human Milk Fortification, Very Low Birth Weight Baby
Enrichment of Human Milk With Human and Bovine Milk-based Fortifiers for Very Preterm Infants: a Meta-analysis
Research has shown that provision of mother's milk is the optimal way to feed very low birthweight (VLBW) infants. Many infants will require a supplement to mother's milk, pasteurized donor human milk (PDHM) compared to preterm…
- Conditions
- Human Milk Fortification, Very Low Birth Weight Baby, Human Milk Nutrition, Human Milk Feeding
- Trial name
- NCT06870318
- Testing
- No intervention; Observational study
- Where
- 2 sites in Canada, Sweden
- Volunteers
- 355 people
- Sponsor
- The Hospital for Sick Children
HCV Infection, Beta Thalassemia Major
PK of SOF/LED in HCV - Infected Adolescents With Haematological Disorders
This is a prospective, controlled, open-label, pharmacokinetic study. This study aims at studying the PK of sofosbuvir, ledipasvir and sofosbuvir metabolite (GS-331007) in HCV infected children with hematological Disorders.
- Trial name
- NCT04353986
- Testing
- Sofosbuvir and Ledipasvir
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Ain Shams University
Pulmonary Disease, Electrolyte Disorder
Comparison of Success Rates of Femoral Artery Catheterization
The use of USI has eased practical application of interventional procedures, and reduced complications and procedure durations. For vascular interventions with ultrasound imaging, short- or long-section imaging of vascular…
- Conditions
- Pulmonary Disease, Electrolyte Disorder, Metabolic Disease, Sepsis
- Trial name
- NCT02986542
- Testing
- Femoral artery catheterization
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
HIV-1-infection
Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Newborns Exposed to HIV
The goal of this clinical study is to learn more about the study drug, Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF), safety, tolerability, and pharmacokinetics (how B/F/TAF is absorbed, modified, distributed, and…
- Trial name
- NCT07055451
- Testing
- B/F/TAF
- Where
- 7 sites in United States, South Africa
- Volunteers
- 16 people
- Sponsor
- Gilead Sciences
PPROM, Early-Onset Neonatal Sepsis
Predicting EONS in PPROM Patients
An EONS occurred in nearly 14-22 % of the preterm infant of pregnant women with PPROM. To this day no risk prediction is established.
- Trial name
- PEONS (NCT03819192)
- Testing
- microbiome analysis, Conventional cultures, CAAP48 measurement
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Jena University Hospital
Cystic Fibrosis
Efficacy Study of IgY (Antibody Against Pseudomonas) in Cystic Fibrosis Patients
The purpose of this study is to prolong the time to reinfection with Pseudomonas aeruginosa after successfully treated acute or intermittent infection.
- Trial name
- PsAer-IgY (NCT01455675)
- Testing
- IgY
- Where
- 42 sites in Austria, Belgium and 7 more
- Volunteers
- 164 people
- Sponsor
- Mukoviszidose Institut gGmbH
Herpes Simplex Virus
A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease)
This study is to identify if a Novel Antiviral Drug could be used to treat babies with Herpes Simplex Virus (HSV) with central nervous system (CNS) disease.
- Trial name
- NCT01610765
- Testing
- Novel Antiviral Drug
- Where
- 18 sites in United States
- Sponsor
- University of Alabama at Birmingham
Newborn, Infection
Comparison of Peripheral Perfusion Level Between Two Groups of Newborns According to Their Infectious Status Defined by the Criteria of the Center for Disease Control and Prevention (CDC)
Despite advances in medicine, secondary neonatal infection remains a continuing concern because of the associated high morbidity and mortality.
- Trial name
- NCT03117907
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pneumonia, Meningitis
Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea
The National Health Plan 2001-2010 calls for investigation of the feasibility of pneumococcal vaccines for Papau New Guinea. The Papua New Guinea (PNG) Institute of Medical Research, the Telethon Institute for Child Health…
- Conditions
- Pneumonia, Meningitis, Otitis Media
- Trial name
- NCT00219401
- Testing
- Pneumococcal 7 valent conjugate vaccine (Prevenar®)
- Where
- Papua New Guinea
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Papua New Guinea Institute of Medical Research
Infection; Newborn
Salivary Profiling in Infants Treated for Suspected Sepsis: The SPITSS Study
The aim of this study is to develop a faster, safer, and more accurate method for determining if a newborn has an infection. This study involves analyzing saliva for markers of infection and inflammation known as cytokines.
- Trial name
- SPITSS (NCT05490212)
- Testing
- Single Molecule Array (SiMoA)
- Where
- 3 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- Tufts Medical Center
Hypospadias
Antibiotic Use in Distal Hypospadias Repair
Hypospadias is a common condition where the opening of the penis is not located at the tip, but along the underside of the penis. It is estimated to occur in 1/300 live male births, making it one of the most common birth defects.
- Trial name
- NCT03275519
- Testing
- Randomization to not receive prophylactic antibiotics after surgery., Randomization to receive prophylactic antibiotics after surgery
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors
This pilot trial studies different high-dose chemotherapy regimens with or without total-body irradiation (TBI) to compare how well they work when given before autologous stem cell transplant (ASCT) in treating patients with…
- Conditions
- Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
- Trial name
- NCT00536601
- Testing
- etoposide, cyclophosphamide, carmustine
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Roswell Park Cancer Institute
Septic Shock
Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock
object name: Lung ultrasound-guided fluid resuscitation in neonatal septic shock. type of study: prospective observational study.
- Trial name
- LUGFRINSS (NCT06144463)
- Testing
- lung ultrasound-guided fluid resuscitation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangdong Second Provincial General Hospital
Hepatitis B
Long Term Follow-Up Study 16-20 Years After Hepatitis B Vaccination in Newborns of Mothers Who Were Seropositive for Hepatitis B Envelope Antigen (HBeAg) & Hepatitis B Surface Antigen (HBsAg)
This study is performed to evaluate the persistence of anti-hepatitis B surface antigen (HBs) antibodies up to 16, 17, 18, 19 and 20 years after administration of the first dose of the study vaccine, Engerix-B™.
- Trial name
- NCT00240539
- Testing
- Blood sampling
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Congenital Disorders
Chlorhexidine Swabs Effectiveness in Reducing Blood Stream Infections
Children's Healthcare of Atlanta (Children's) is collaborating with Child Health Corporation of America (CHCA) in the nationwide effort to reduce catheter related blood stream infections (BSIs).
- Trial name
- NCT00485992
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Children's Healthcare of Atlanta
Hypersensitivity, Immediate
Clinical and Immunological Evaluation of Children With Allergies
This study will evaluate children with allergies and collect medical data and biological specimens from them periodically to learn more about the diseases and gain information that may be useful in developing new treatments.
- Trial name
- NCT00102570
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atopic Dermatitis, Alopecia Areata
A Longitudinal Observational Study of Patients Undergoing Therapy for IMISC
TARGET-DERM is a longitudinal, observational study of adult and pediatric patients being managed for Atopic Dermatitis and other Immune-Mediated Inflammatory Skin Conditions (IMISC) in usual clinical practice.
- Conditions
- Atopic Dermatitis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
- Trial name
- TARGET-DERM (NCT03661866)
- Where
- 62 sites in United States, Canada and 2 more
- Volunteers
- 15,000 people
- Sponsor
- Target PharmaSolutions, Inc.
Hepatitis C, Hemophilia
Pegasys® Plus Ribavirin in Hemophilic Patients With Hepatitis C Virus Infection
Hemophilic patients are a known high risk groups for acquiring the hepatitis C. The surveillance data from Ministry Of Health in IR.Iran had shown that 60% of them are infected with HCV infection.
- Trial name
- NCT00707772
- Testing
- PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)
- Where
- Iran
- Volunteers
- 400 people
- Sponsor
- Baqiyatallah Medical Sciences University
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